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4-Nitrobenzenesulfonyl chloride

Product Name
4-Nitrobenzenesulfonyl chloride
CAS No.
98-74-8
Chemical Name
4-Nitrobenzenesulfonyl chloride
Synonyms
NsCl;4-NITROBENZENE-1-SULFONYL CHLORIDE;P-NITROBENZENESULFONYL CHLORIDE;p-Nitrophenylsulfonyl chloride;Nosylchloride;4-NitrobenzenesuL;4-Nitrobenzenesulfon;nosyl ch202-697-9loride;4-Nitrophenylsulfonylchloride;4-Nitrophenylsulfonyl chloride
CBNumber
CB7298161
Molecular Formula
C6H4ClNO4S
Formula Weight
221.62
MOL File
98-74-8.mol
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4-Nitrobenzenesulfonyl chloride Property

Melting point:
75 °C
Boiling point:
143-144 °C (1.5002 mmHg)
Density 
1.602 (estimate)
vapor pressure 
0.009Pa at 20℃
refractive index 
1.6000 (estimate)
Flash point:
143-144°C/1.5mm
storage temp. 
Store below +30°C.
solubility 
soluble in Toluene
form 
Powder
color 
yellow
PH
1 (H2O, 20℃)
Water Solubility 
Insoluble
Sensitive 
Moisture Sensitive
BRN 
746543
Stability:
Moisture Sensitive
LogP
2.1 at 20℃
CAS DataBase Reference
98-74-8(CAS DataBase Reference)
NIST Chemistry Reference
4-Nitrobenzenesulphonyl chloride(98-74-8)
EPA Substance Registry System
Benzenesulfonyl chloride, 4-nitro- (98-74-8)
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Safety

Hazard Codes 
C
Risk Statements 
34-52/53
Safety Statements 
26-36/37/39-45-61
RIDADR 
UN 3261 8/PG 2
WGK Germany 
3
21
Hazard Note 
Corrosive/Moisture Sensitive
TSCA 
Yes
HazardClass 
8
PackingGroup 
II
HS Code 
29049085
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H317May cause an allergic skin reaction

H318Causes serious eye damage

Precautionary statements

P202Do not handle until all safety precautions have been read and understood.

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P308+P313IF exposed or concerned: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
272248
Product name
4-Nitrobenzenesulfonyl chloride
Purity
97%
Packaging
5g
Price
$36.4
Updated
2024/03/01
Sigma-Aldrich
Product number
170925
Product name
4-Nitrobenzenesulfonyl chloride
Purity
technical grade, 90%
Packaging
25g
Price
$33.78
Updated
2024/03/01
TCI Chemical
Product number
N0144
Product name
4-Nitrobenzenesulfonyl Chloride
Purity
>98.0%(GC)(T)
Packaging
5g
Price
$16
Updated
2024/03/01
TCI Chemical
Product number
N0144
Product name
4-Nitrobenzenesulfonyl Chloride
Purity
>98.0%(GC)(T)
Packaging
25g
Price
$43
Updated
2024/03/01
Alfa Aesar
Product number
A18512
Product name
4-Nitrobenzenesulfonyl chloride, 97%
Packaging
25g
Price
$71.5
Updated
2024/03/01
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4-Nitrobenzenesulfonyl chloride Chemical Properties,Usage,Production

Chemical Properties

yellow to brown powder

Uses

4-Nitrobenzenesulfonyl chloride is used as an intermediate for the synthesis of pharmaceuticals like foscmprenavir, darunavir and amprenavir. It is involved in the preparation of N-nosyl-alpha-amino acid for peptide synthesis. It is also used for stereoselective α-glucosylation of partially protected carbohydrates in association with silver tri-fluoromethanesulfonate, N,N-dimethylacetamide and triethylamine. It is widely used for the synthesis of hydroxylamines of sulfadiazine, sulfamethoxazole and [Cu(bipy)2Cl](nbs) (1) (bipy = 2,2'-bipyridine, nbs = 4-nitrobenzenesulfonate).

Uses

4-Nitrobenzenesulfonyl chloride was used in the synthesis of

  • [Cu(bipy)2Cl](nbs) (1) (bipy = 2,2′-bipyridine, nbs = 4-nitrobenzenesulfonate)
  • hydroxylamines of sulfadiazine and sulfamethoxazole
  • solution phase peptide using N-nosyl-α-amino acids.

Uses

4-Nitrobenzenesulfonyl Chloride is used in the preparation of N-Nosyl-α-amino acid for peptide synthesis.

Production Methods

4,4'-Dinitrodiphenyldisulfide [100-32-3], produced by reaction of 4-chloronitrobenzene with sodium disulfide, is treated with chlorine in HCl – HNO3 by a process similar to that used for 2-nitrobenzenesulfonyl chloride.

Flammability and Explosibility

Not classified

4-Nitrobenzenesulfonyl chloride Preparation Products And Raw materials

Raw materials

Preparation Products

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4-Nitrobenzenesulfonyl chloride Suppliers

Hangzhou Xinshuo New Material Technology Co., Ltd.
Tel
0571-86236268
Email
3762199508@qq.com
Country
China
ProdList
41
Advantage
58
Taizhou Pukai Pharmaceutical Technology Co. LTD
Tel
13626608877
Email
sales@pancare.com.cn
Country
China
ProdList
4
Advantage
58
Energy Chemical
Tel
021-021-58432009 400-005-6266
Fax
021-58436166
Email
sales8178@energy-chemical.com
Country
China
ProdList
44689
Advantage
61
Suzhou Highfine Biotech Co., Ltd
Tel
0512-68311833 13962195826
Fax
0512-68417696
Email
wuhao@highfine.com
Country
China
ProdList
499
Advantage
75
Sichuan Kulinan Technology Co., Ltd
Tel
400-1166-196 18981987031
Fax
028-84555506 800101999
Email
cdhxsj@163.com
Country
China
ProdList
11707
Advantage
57
Tianjin Branch Chong pharmaceutical intermediates Co., Ltd.
Tel
022-60116533 13207668525
Fax
022-60979672
Email
saleskc@scipharmacn.com
Country
China
ProdList
684
Advantage
58
TOKYO CHEMICAL INDUSTRY CO., LTD.
Tel
03-36680489
Fax
03-3668-0520
Email
Sales-JP@TCIchemicals.com
Country
Japan
ProdList
28387
Advantage
80
TCI Europe
Tel
320-37350700
Fax
+32 (0)37350701
Email
sales@tcieurope.eu
Country
Europe
ProdList
23671
Advantage
75
TCI AMERICA
Tel
800-4238616
Fax
+1-888-520-1075 / +1-503-283-1987
Email
sales@tciamerica.com
Country
Americas
ProdList
23653
Advantage
75
Chengdu HuaXia Chemical Reagent Co. Ltd
Tel
400-1166-196 13458535857
Fax
QQ:800101999
Email
cdhxsj@163.com
Country
China
ProdList
13350
Advantage
58
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View Lastest Price from 4-Nitrobenzenesulfonyl chloride manufacturers

Henan Fengda Chemical Co., Ltd
Product
4-Nitrobenzenesulfonyl chloride 98-74-8
Price
US $100.00-1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
g-kg-tons, free sample is available
Release date
2023-12-25
Firsky International Trade (Wuhan) Co., Ltd
Product
4-Nitrobenzenesulfonyl chloride 98-74-8
Price
US $30.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
20T
Release date
2023-10-09
Wuhan wingroup Pharmaceutical Co., Ltd
Product
4-Nitrobenzenesulfonyl chloride 98-74-8
Price
US $30.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
20 Tons
Release date
2023-01-04

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