ChemicalBook > CAS DataBase List > 4-Nitrobenzenesulfonyl chloride
4-Nitrobenzenesulfonyl chloride
- Product Name
- 4-Nitrobenzenesulfonyl chloride
- CAS No.
- 98-74-8
- Chemical Name
- 4-Nitrobenzenesulfonyl chloride
- Synonyms
- NsCl;4-NITROBENZENE-1-SULFONYL CHLORIDE;P-NITROBENZENESULFONYL CHLORIDE;p-Nitrophenylsulfonyl chloride;Nosylchloride;4-NitrobenzenesuL;4-Nitrobenzenesulfon;nosyl ch202-697-9loride;4-Nitrophenylsulfonylchloride;4-Nitrophenylsulfonyl chloride
- CBNumber
- CB7298161
- Molecular Formula
- C6H4ClNO4S
- Formula Weight
- 221.62
- MOL File
- 98-74-8.mol
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4-Nitrobenzenesulfonyl chloride Property
- Melting point:
- 75 °C
- Boiling point:
- 143-144 °C (1.5002 mmHg)
- Density
- 1.602 (estimate)
- vapor pressure
- 0.009Pa at 20℃
- refractive index
- 1.6000 (estimate)
- Flash point:
- 143-144°C/1.5mm
- storage temp.
- Store below +30°C.
- solubility
- soluble in Toluene
- form
- Powder
- color
- yellow
- PH
- 1 (H2O, 20℃)
- Water Solubility
- Insoluble
- Sensitive
- Moisture Sensitive
- BRN
- 746543
- Stability:
- Moisture Sensitive
- LogP
- 2.1 at 20℃
- CAS DataBase Reference
- 98-74-8(CAS DataBase Reference)
- NIST Chemistry Reference
- 4-Nitrobenzenesulphonyl chloride(98-74-8)
- EPA Substance Registry System
- Benzenesulfonyl chloride, 4-nitro- (98-74-8)
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Safety
- Hazard Codes
- C
- Risk Statements
- 34-52/53
- Safety Statements
- 26-36/37/39-45-61
- RIDADR
- UN 3261 8/PG 2
- WGK Germany
- 3
- F
- 21
- Hazard Note
- Corrosive/Moisture Sensitive
- TSCA
- Yes
- HazardClass
- 8
- PackingGroup
- II
- HS Code
- 29049085
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Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H317May cause an allergic skin reaction
H318Causes serious eye damage
- Precautionary statements
-
P202Do not handle until all safety precautions have been read and understood.
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P308+P313IF exposed or concerned: Get medical advice/attention.
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N-Bromosuccinimide Price
Sigma-Aldrich
- Product number
- 272248
- Product name
- 4-Nitrobenzenesulfonyl chloride
- Purity
- 97%
- Packaging
- 5g
- Price
- $36.4
- Updated
- 2024/03/01
Sigma-Aldrich
- Product number
- 170925
- Product name
- 4-Nitrobenzenesulfonyl chloride
- Purity
- technical grade, 90%
- Packaging
- 25g
- Price
- $33.78
- Updated
- 2024/03/01
TCI Chemical
- Product number
- N0144
- Product name
- 4-Nitrobenzenesulfonyl Chloride
- Purity
- >98.0%(GC)(T)
- Packaging
- 5g
- Price
- $16
- Updated
- 2024/03/01
TCI Chemical
- Product number
- N0144
- Product name
- 4-Nitrobenzenesulfonyl Chloride
- Purity
- >98.0%(GC)(T)
- Packaging
- 25g
- Price
- $43
- Updated
- 2024/03/01
Alfa Aesar
- Product number
- A18512
- Product name
- 4-Nitrobenzenesulfonyl chloride, 97%
- Packaging
- 25g
- Price
- $71.5
- Updated
- 2024/03/01
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4-Nitrobenzenesulfonyl chloride Chemical Properties,Usage,Production
Chemical Properties
yellow to brown powder
Uses
4-Nitrobenzenesulfonyl chloride is used as an intermediate for the synthesis of pharmaceuticals like foscmprenavir, darunavir and amprenavir. It is involved in the preparation of N-nosyl-alpha-amino acid for peptide synthesis. It is also used for stereoselective α-glucosylation of partially protected carbohydrates in association with silver tri-fluoromethanesulfonate, N,N-dimethylacetamide and triethylamine. It is widely used for the synthesis of hydroxylamines of sulfadiazine, sulfamethoxazole and [Cu(bipy)2Cl](nbs) (1) (bipy = 2,2'-bipyridine, nbs = 4-nitrobenzenesulfonate).
Uses
4-Nitrobenzenesulfonyl chloride was used in the synthesis of
- [Cu(bipy)2Cl](nbs) (1) (bipy = 2,2′-bipyridine, nbs = 4-nitrobenzenesulfonate)
- hydroxylamines of sulfadiazine and sulfamethoxazole
- solution phase peptide using N-nosyl-α-amino acids.
Uses
4-Nitrobenzenesulfonyl Chloride is used in the preparation of N-Nosyl-α-amino acid for peptide synthesis.
Production Methods
4,4'-Dinitrodiphenyldisulfide [100-32-3], produced by reaction of 4-chloronitrobenzene with sodium disulfide, is treated with chlorine in HCl – HNO3 by a process similar to that used for 2-nitrobenzenesulfonyl chloride.
Flammability and Explosibility
Not classified
4-Nitrobenzenesulfonyl chloride Preparation Products And Raw materials
Raw materials
Preparation Products
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4-Nitrobenzenesulfonyl chloride Suppliers
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- 0571-86236268
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- China
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- China
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View Lastest Price from 4-Nitrobenzenesulfonyl chloride manufacturers
Henan Fengda Chemical Co., Ltd
- Product
- 4-Nitrobenzenesulfonyl chloride 98-74-8
- Price
- US $100.00-1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2023-12-25
Firsky International Trade (Wuhan) Co., Ltd
- Product
- 4-Nitrobenzenesulfonyl chloride 98-74-8
- Price
- US $30.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 20T
- Release date
- 2023-10-09
Wuhan wingroup Pharmaceutical Co., Ltd
- Product
- 4-Nitrobenzenesulfonyl chloride 98-74-8
- Price
- US $30.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 20 Tons
- Release date
- 2023-01-04
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