4-Nitrobenzoic acid
- Product Name
- 4-Nitrobenzoic acid
- CAS No.
- 62-23-7
- Chemical Name
- 4-Nitrobenzoic acid
- Synonyms
- 4-NITROBENZOIC ACID;PNBA;4-Nitrobenzoic;p-nitrobenzoic;PARA-NITROBENZOATE;-Nitrobenzoic Acid;19/KG;nitrodracylicacid;4-Nitrobenzoesure;Nitrodracylic acid
- CBNumber
- CB4252540
- Molecular Formula
- C7H5NO4
- Formula Weight
- 167.12
- MOL File
- 62-23-7.mol
4-Nitrobenzoic acid Property
- Melting point:
- 237-240 °C(lit.)
- Boiling point:
- 295.67°C (rough estimate)
- Density
- 1.61
- refractive index
- 1.6280 (estimate)
- Flash point:
- 237 °C
- storage temp.
- Store below +30°C.
- solubility
- 0.42g/l
- pka
- 3.41(at 25℃)
- form
- Crystalline Powder
- color
- Light yellow
- PH
- 3.1 (0.42g/l, H2O, 20℃)(saturated solution)
- Water Solubility
- <0.1 g/100 mL at 26 ºC
- Merck
- 14,6589
- BRN
- 973593
- Specific Activity
- 50-60 mCi/mmol
- Concentration
- 0.1 mCi/ml
- Solvent
- Ethanol
- Stability:
- Stable. Combustible. Incompatible with strong oxidizing agents, cyanides, strong bases.
- InChIKey
- OTLNPYWUJOZPPA-UHFFFAOYSA-N
- LogP
- 1.890
- CAS DataBase Reference
- 62-23-7(CAS DataBase Reference)
- NIST Chemistry Reference
- Benzoic acid, 4-nitro-(62-23-7)
- EPA Substance Registry System
- p-Nitrobenzoic acid (62-23-7)
Safety
- Hazard Codes
- Xn
- Risk Statements
- 22-41-36
- Safety Statements
- 26-39-24/25
- WGK Germany
- 1
- RTECS
- DH5075000
- TSCA
- Yes
- HS Code
- 29163900
- Hazardous Substances Data
- 62-23-7(Hazardous Substances Data)
- Toxicity
- LD50 orally in Rabbit: 1960 mg/kg
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H341Suspected of causing genetic defects
H351Suspected of causing cancer
- Precautionary statements
-
P202Do not handle until all safety precautions have been read and understood.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P308+P313IF exposed or concerned: Get medical advice/attention.
N-Bromosuccinimide Price
- Product number
- 8.00646
- Product name
- 4-Nitrobenzoic acid
- Purity
- for synthesis
- Packaging
- 100g
- Price
- $43.4
- Updated
- 2024/03/01
- Product number
- 8.00646
- Product name
- 4-Nitrobenzoic acid
- Purity
- for synthesis
- Packaging
- 500g
- Price
- $59.4
- Updated
- 2024/03/01
- Product number
- PHR2339
- Product name
- 4-Nitrobenzoic Acid
- Purity
- Pharmaceutical Secondary Standard; Certified Reference Material
- Packaging
- 100MG
- Price
- $534
- Updated
- 2024/03/01
- Product number
- 8.00646
- Product name
- 4-Nitrobenzoic acid
- Purity
- for synthesis
- Packaging
- 50kg
- Price
- $2200
- Updated
- 2024/03/01
- Product number
- 461091
- Product name
- 4-Nitrobenzoic acid
- Purity
- 98%
- Packaging
- 1kg
- Price
- $44.46
- Updated
- 2024/03/01
4-Nitrobenzoic acid Chemical Properties,Usage,Production
Chemical Properties
light yellow crystalline powder
Uses
4-Nitrobenzoic Acid is used in the synthesis of anti-Trypanosoma cruzi agents in the treatment of chagas disease.
Production Methods
p-Nitrobenzoic acid is produced commercially by the oxidation of 4-nitrotoluene with molecular oxygen. Oxidation with 15 % nitric acid at 175 ℃ produces the acid in 88.5 % yield. An interesting method involves the nitration and subsequent oxidation of polystyrene. This method uses the steric hindrance of the polymer chain to improve the para to ortho ratio of the product.
Definition
ChEBI: A nitrobenzoic acid having the nitro group at the 4-position.
Synthesis Reference(s)
Tetrahedron Letters, 26, p. 2387, 1985 DOI: 10.1016/S0040-4039(00)94834-2
Journal of the American Chemical Society, 72, p. 5012, 1950 DOI: 10.1021/ja01167a051
General Description
Odorless pale yellow crystals.
Air & Water Reactions
Insoluble in water.
Reactivity Profile
p-Nitrobenzoic acid is incompatible with strong oxidizers. p-Nitrobenzoic acid is also incompatible with strong bases (potassium hydroxide). p-Nitrobenzoic acid may react with cyanides.
Fire Hazard
p-Nitrobenzoic acid is combustible.
Toxicology
Among various nitroaromatics, 4-nitrobenzoic acid (4-NBA) is one of the simplest and basic derivates of the explosives. Moreover, 4-NBA harms human health and causes severe water and atmosphere pollution. 4-Nitrobenzoic acid is stable, toxic, and non-biodegradable. US/Zn0 was found to degrade more than 85% of 4-nitrobenzoic acid in 30 min. There was an apparent synergistic effect between ultrasound and Zn[1-2].
Purification Methods
Purify it as for 3-nitrobenzoic acid above. The amide has m 201.6o (from H2O). [Beilstein 9 III 1537, 9 IV 1072.]
References
[1] Shan Chong. “Ultrasound/Zn0 for aqueous 4-nitrobenzoic acid degradation.” Desalination and Water Treatment 322 1 (2016): 24990–24998.
[2] Xue-Huan Xin . “A luminescent barium-based metal-organic framework: Synthesis, structure and efficient detection of 4-nitrobenzoic acid.” Inorganic Chemistry Communications 97 (2018): Pages 129-133.
4-Nitrobenzoic acid Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 4-Nitrobenzoic acid manufacturers
- Product
- p-Nitrobenzoic acid 62-23-7
- Price
- US $10.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 20 ton
- Release date
- 2024-11-19
- Product
- 4-Nitrobenzoic acid 62-23-7
- Price
- US $62.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 5000kg/week
- Release date
- 2024-05-24
- Product
- P-Nitrobenzoic acid 62-23-7
- Price
- US $0.00/kg
- Min. Order
- 1000kg
- Purity
- 99.9%
- Supply Ability
- 10000ton
- Release date
- 2024-01-25