4-Aminobenzamidine dihydrochloride
- Product Name
- 4-Aminobenzamidine dihydrochloride
- CAS No.
- 2498-50-2
- Chemical Name
- 4-Aminobenzamidine dihydrochloride
- Synonyms
- P-AMINOBENZAMIDINE DIHCL;4-AMINOBENZAMIDINE HCL SALT;P-AMINOBENZAMIDINE DIHYDROCHLORIDE;SC-67235;4-Aminobenzamidine HCl;4-Aminobenzamidine2HCl;Dabigatran Impurity 89;π-Aminobenzamidine 2HCl;4-Aminobenzimidamide 2HCl;4-Aminobenzamidindihydrochlorid
- CBNumber
- CB4377267
- Molecular Formula
- C7H11Cl2N3
- Formula Weight
- 208.09
- MOL File
- 2498-50-2.mol
4-Aminobenzamidine dihydrochloride Property
- Melting point:
- >300 °C(lit.)
- storage temp.
- 2-8°C
- solubility
- DMSO (Slightly), Water
- form
- Fine Crystalline Powder
- color
- White to yellow
- Sensitive
- Hygroscopic
- BRN
- 3692927
- Stability:
- Hygroscopic
- InChI
- InChI=1S/C7H9N3.2ClH/c8-6-3-1-5(2-4-6)7(9)10;;/h1-4H,8H2,(H3,9,10);2*1H
- InChIKey
- GHEHNICLPWTXJC-UHFFFAOYSA-N
- SMILES
- C1(C=CC(N)=CC=1)C(=N)N.Cl.Cl
- CAS DataBase Reference
- 2498-50-2(CAS DataBase Reference)
Safety
- Hazard Codes
- Xi,Xn
- Risk Statements
- 36/37/38-22
- Safety Statements
- 26-37/39-36
- WGK Germany
- 3
- RTECS
- CV6126500
- F
- 3-10-21
- HS Code
- 29252900
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- 06880
- Product name
- 4-Aminobenzamidine dihydrochloride
- Purity
- BioReagent, suitable for fluorescence, ≥99.0% (TLC)
- Packaging
- 5g
- Price
- $217
- Updated
- 2025/07/31
- Product number
- 06880
- Product name
- 4-Aminobenzamidine dihydrochloride
- Purity
- BioReagent, suitable for fluorescence, ≥99.0% (TLC)
- Packaging
- 1g
- Price
- $49.4
- Updated
- 2022/05/15
- Product number
- A2115
- Product name
- 4-Aminobenzamidine Dihydrochloride
- Purity
- >98.0%(N)
- Packaging
- 5g
- Price
- $85
- Updated
- 2025/07/31
- Product number
- A2115
- Product name
- 4-Aminobenzamidine Dihydrochloride
- Purity
- >98.0%(N)
- Packaging
- 25g
- Price
- $319
- Updated
- 2025/07/31
- Product number
- 857661
- Product name
- 4-Aminobenzamidine dihydrochloride
- Purity
- 98%
- Packaging
- 1g
- Price
- $63.8
- Updated
- 2025/07/31
4-Aminobenzamidine dihydrochloride Chemical Properties,Usage,Production
Chemical Properties
white to yellowish fine crystalline powder
Uses
4-Aminobenzamidine dihydrochloride is a synthetic diamidine derivative that acts as a urokinase inhibitor as well as trypsin inhibitor. It is used as a ligand in affinity chromatography for purification and immobilization of enzymes.
Application
4-Aminobenzamidine dihydrochloride can be used to synthesize:
Orally active fibrinogen receptor antagonists based on benzamidines.
Benzamidine derivatives that are selective and potent serine protease inhibitors.
Novel pyrrolo [3,2-c] quinolines that are structural analogs of topoisomerase inhibitors such as coralyne and fagaronine.
Synthesis of a selective inhibitor of PRMT1 (SKLB-639)
Preparation
4-Aminobenzamididine dihydrochloride is obtained by cyanation, addition, amination and reduction of 4-nitrobenzoic acid.
Definition
ChEBI: P-Aminobenzamidine dihydrochloride is an organic molecular entity.
Synthesis
25412-75-3
2498-50-2
In a three-necked flask equipped with a reflux condenser tube and a mechanical stirring device, 15.0 g of 4-nitrobenzenecarboximidamide (IV) prepared from Example 2, 20 mL of acetic acid, 45 mL of water, and 45 mL of ethanol (V water: V ethanol=1:1) were added, and the reaction was stirred and refluxed at 60° C. until complete dissolution. Subsequently, 20.3 g of iron powder (n4-nitrobenzenecarboximidamide IV: n iron powder = 1:4) was added to the reaction system, and the reaction was warmed up to 80 °C and continued to be stirred and refluxed for 4 hours. After completion of the reaction, it was filtered while hot. The filtrate was adjusted to pH 11~12 with 20% NaOH solution, at which time a large amount of flocculent precipitation was generated, and after filtration, the filtrate was adjusted to pH 1~2 with concentrated hydrochloric acid. the solution was concentrated until the crystals precipitated, and the resulting crystals were dried in vacuum at 100 ℃ to obtain 17.9 g of 4-nitrobenzenecarboximidamide dihydrochloride (I), as a white solid with 94.7% yield and 99.51% HPLC purity.
References
[1] Patent: CN104163778, 2016, B. Location in patent: Paragraph 0056; 0057
4-Aminobenzamidine dihydrochloride Preparation Products And Raw materials
Raw materials
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View Lastest Price from 4-Aminobenzamidine dihydrochloride manufacturers
- Product
- 4-Aminobenzamidine dihydrochloride 2498-50-2
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- Customise
- Release date
- 2025-10-28
- Product
- 4-Aminobenzamidine dihydrochloride 2498-50-2
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 98%min
- Supply Ability
- 30tons/month
- Release date
- 2023-02-08
- Product
- 4-Aminobenzamidine dihydrochloride 2498-50-2
- Price
- US $30.00/kg
- Min. Order
- 1kg
- Purity
- 0.99
- Supply Ability
- 100 tons
- Release date
- 2024-08-09