Tetrabutylammonium fluoride
- Product Name
- Tetrabutylammonium fluoride
- CAS No.
- 429-41-4
- Chemical Name
- Tetrabutylammonium fluoride
- Synonyms
- TBAF;TBAF in THF;TETRABUTYLAMMONIUM FLUORIDE HYDRATE;Tetrabutylammonium fluoride solution;Tetrabutylazanium fluoride;Tetrabutylammonium Fluoride (TBAF);TETRABUTYL AMMONIUM FLUORIDE IN THF (I M);Tetrabutylammonium Fluoride (70-75% in Water);Tetrabutylammonium Fluoride (1mol/L in Tetrahydrofuran) [for Catalyst of acylation, silylation and cleavage of Silyl Ether];TABF
- CBNumber
- CB8740854
- Molecular Formula
- C16H36FN
- Formula Weight
- 261.46
- MOL File
- 429-41-4.mol
Tetrabutylammonium fluoride Property
- Melting point:
- 62-63 °C(lit.)
- Density
- 0.953 g/mL at 25 °C
- refractive index
- n20/D 1.456
- Flash point:
- 1 °F
- storage temp.
- 2-8°C
- solubility
- Miscible with terahydrofuran, acetonitrile, dimethyl sulfoxide and organic solvents.
- form
- Solution
- color
- Clear light greenish to brown
- Water Solubility
- Insoluble in water.
- Sensitive
- Hygroscopic
- Merck
- 14,9187
- BRN
- 3570522
- Exposure limits
- ACGIH: TWA 2.5 mg/m3
NIOSH: IDLH 250 mg/m3 - CAS DataBase Reference
- 429-41-4(CAS DataBase Reference)
- EPA Substance Registry System
- 1-Butanaminium, N,N,N-tributyl-, fluoride (429-41-4)
Safety
- Hazard Codes
- C,F,Xi
- Risk Statements
- 34-19-11-36/37/38-40-37
- Safety Statements
- 26-27-36/37/39-45-33-29-16-36
- RIDADR
- UN 3261 8/PG 2
- WGK Germany
- 3
- F
- 3
- Hazard Note
- Flammable/Irritant
- TSCA
- Yes
- HazardClass
- 3
- PackingGroup
- II
- HS Code
- 29239000
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H411Toxic to aquatic life with long lasting effects
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P273Avoid release to the environment.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 216143
- Product name
- Tetrabutylammonium fluoride solution
- Purity
- 1.0 M in THF
- Packaging
- 1l
- Price
- $487.35
- Updated
- 2025/07/31
- Product number
- 216143
- Product name
- Tetrabutylammonium fluoride solution
- Purity
- 1.0 M in THF
- Packaging
- 2.5l
- Price
- $1050
- Updated
- 2025/07/31
- Product number
- T1125
- Product name
- Tetrabutylammonium Fluoride (ca. 1mol/L in Tetrahydrofuran)[for Catalyst of acylation, silylation and cleavage of Silyl Ether]
- Packaging
- 25mL
- Price
- $54
- Updated
- 2025/07/31
- Product number
- T1125
- Product name
- Tetrabutylammonium Fluoride (ca. 1mol/L in Tetrahydrofuran)[for Catalyst of acylation, silylation and cleavage of Silyl Ether]
- Packaging
- 100mL
- Price
- $129
- Updated
- 2025/07/31
- Product number
- 02-5012
- Product name
- Tetrabutylammonium fluoride, 1M in THF
- Packaging
- 0.05mole
- Price
- $60
- Updated
- 2024/03/01
Tetrabutylammonium fluoride Chemical Properties,Usage,Production
Chemical Properties
Clear light greenish to amber or brown solution
Uses
Catalyst for etherification of alcohols and phenols with alkyl halides Catalyst for benzylation reactions.
Uses
Tetrabutylammonium fluoride is a reagent in organic syntheses in addition, condensation, base-catalyzed cyclization reactions, fluorination and desulfonylation reactions and as a deprotecting agent. Typically dried prior to use.
Uses
Tetrabutylammonium fluoride (TBAF) is a commonly used organic soluble fluoride salt. It is used as a base, a phase transfer catalyst, and as a fluoride source. In the research field of fluoride sensor development, TBAF is used as an easy to handle and measurable fluoride anion source. The fluoride in TBAF, once dissolved, can be thought of as a free fluoride with little interaction with the ammonium cation. Since TBAF should not absorb light at wavelengths greater than 240nm, it is useful to monitor sensing reactions with visible spectroscopy.
Definition
ChEBI: Tetrabutylammonium fluoride is a fluoride salt and a tetrabutylammonium salt. It has a role as a phase-transfer catalyst.
Synthesis
392-56-3
10442-39-4
1217-44-3
429-41-4
Synthesis of TBAF; Anhydrous tetrabutylammonium fluoride (TBAF):; 0.67 g of tetrabutylammonium cyanide (TBACN) was dissolved in 2.5 ml of tetrahydrofuran (THF) and the resulting solution was cooled to -65 °C. In a separate vessel, 0.3 mL of hexafluorobenzene (C6F6) was dissolved in 0.5 mL of THF and cooled to -65°C. The hexafluorobenzene solution was slowly added to the cooled TBACN solution and the mixture was gradually warmed (over 4 hours) to -15°C. During the reaction, the solution changed from colorless to yellow-green and precipitated a white solid. The mixture was cooled again to -65 °C, the solid was collected by filtration and washed twice with cold THF. All separation operations need to be carried out below -36°C. The resulting white or light yellow TBAF solid can be stored in a refrigerator at -36°C for a short period of time. If the reaction mixture is used directly, the overall yield of TBAF exceeds 95% (based on TBACN, as verified by burst experiments with benzyl chloride). Isolated yields of the solid product ranged from 40% to 70%, depending on the efficiency of the washing and filtration steps.1H NMR ((CD3)2SO) δ 3.23 (8H, m), 1.56 (8H, m), 1.28 (8H, sextuple peak, J = 7.31 Hz), 0.86 (12H, t, J = 7.31 Hz); 19F NMR ((CD3)2SO) δ -72.6 ppm(s); 13C NMR ((CD3)2SO) δ 57.5, 23.1, 19.2, 13.5 ppm.
References
[1] Patent: US2006/89514, 2006, A1. Location in patent: Page/Page column 5
[2] Patent: US2006/89514, 2006, A1. Location in patent: Page/Page column 5
[3] Patent: US2006/89514, 2006, A1. Location in patent: Page/Page column 5
[4] Patent: US2006/89514, 2006, A1. Location in patent: Page/Page column 5
[5] Patent: US2006/89514, 2006, A1. Location in patent: Page/Page column 5
Tetrabutylammonium fluoride Preparation Products And Raw materials
Raw materials
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View Lastest Price from Tetrabutylammonium fluoride manufacturers
- Product
- Tetrabutylammonium fluoride 429-41-4
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 10 mt
- Release date
- 2024-11-20
- Product
- Tetranbutylammoniumfluoride 429-41-4
- Price
- US $70.00/kg
- Min. Order
- 1kg
- Purity
- 99
- Supply Ability
- 5000
- Release date
- 2024-05-29
- Product
- Tetrabutylammonium fluoride 429-41-4
- Price
- US $60.00/kg
- Min. Order
- 1kg
- Purity
- 99
- Supply Ability
- 5000
- Release date
- 2024-05-16