5-Bromo-2-fluoropyridine

Product Name: 5-Bromo-2-fluoropyridine
CAS No.: 766-11-0
Chemical Name: 5-Bromo-2-fluoropyridine
Synonyms: 5-BROMO-2-FLUOROPYRIDINE;5-Brom-2-fluorpyridin;3-BROMO-6-FLUOROPYRIDINE;5-BROMO-2-FLUO;2-Fluoro-5-bromopyri;2-FLUORO-5-BORMOPYRIDINE;3-fluoro-5-bromopyridine;2-Floro-5-Bromo Pyridine;2-FLUORO-5-BROMO PYRIDINE;5-Bromo-2-fluoropyridine>
CBNumber: CB0344067
Molecular Formula: C5H3BrFN
Formula Weight: 175.99
MOL File: 766-11-0.mol

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5-Bromo-2-fluoropyridine Property

Boiling point:: 162-164 °C750 mm Hg(lit.)
Density: 1.71 g/mL at 25 °C(lit.)
refractive index: n20/D 1.5325(lit.)
Flash point:: 165 °F
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
solubility: DMSO (Slightly), Methanol (Slightly)
pka: -2.79±0.10(Predicted)
form: Liquid
color: Clear colorless yellow
Specific Gravity: 1.710
BRN: 1363171
InChI: InChI=1S/C5H3BrFN/c6-4-1-2-5(7)8-3-4/h1-3H
InChIKey: MYUQKYGWKHTRPG-UHFFFAOYSA-N
SMILES: C1(F)=NC=C(Br)C=C1
CAS DataBase Reference: 766-11-0(CAS DataBase Reference)

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Safety

Hazard Codes: Xi,Xn
Risk Statements: 36/37/38-22
Safety Statements: 26-36/37-37/39
RIDADR: UN2810
WGK Germany: 3
Hazard Note: Irritant
HazardClass: 6.1
PackingGroup: III
HS Code: 29339900

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 520438
Product name: 5-Bromo-2-fluoropyridine
Purity: 99%
Packaging: 5g
Price: $22.54
Updated: 2025/07/31

TCI Chemical

Product number: B2705
Product name: 5-Bromo-2-fluoropyridine
Purity: >98.0%(GC)
Packaging: 5g
Price: $96
Updated: 2025/07/31

TCI Chemical

Product number: B2705
Product name: 5-Bromo-2-fluoropyridine
Purity: >98.0%(GC)
Packaging: 25g
Price: $248
Updated: 2025/07/31

TRC

Product number: F588785
Product name: 2-Fluoro-5-bromopyridine
Packaging: 10g
Price: $150
Updated: 2021/12/16

Apolloscientific

Product number: PC10362
Product name: 5-Bromo-2-fluoropyridine
Purity: 99%
Packaging: 5g
Price: $10
Updated: 2021/12/16

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5-Bromo-2-fluoropyridine Chemical Properties,Usage,Production

Description

5-Bromo-2-fluoropyridine is a halogenated pyridine that has been used as a molecular scaffold for many Active Pharmaceutical Ingredients (APIs) such as Neuropeptide Y Receptor Y5 Inhibitors, SARS-CoV-2 Major Protease Inhibitors, and Indoleamine-2,3-Dioxygenase-1 Inhibitors in cancer immunotherapy. 5-Bromo-2-fluoropyridine is also an ideal building block for semiconductors, due to its aromaticity and electron deficiency. A host material of 5-(5-(2,4,6-triiso-propylphenyl)pyridin-2-yl)-5H-benzo[d]benzo-[4,5]imidazo[1,2-a]imidazole is synthesized from 5-bromo-2-fluoropyridine for OLED applications.

Chemical Properties

5-Bromo-2-fluoropyridine is a colourless or yellowish liquid compound with a density of 1.71 g/cm3 at 25° C; boiling point of 162-164° C (lit.) at 750 mmHg; stored at room temperature.

Uses

5-Bromo-2-fluoropyridine is used in the synthesis of heteroaromatic and aniline derivatives of piperidines as potent ligands used for vesicular acetylcholine transport. Also used in the synthesis of benzofurano[3,2-d]pyrimidin-2-one derived inhbitors.

Synthesis

403-45-2

766-11-0

A. Synthesis of 2-fluoro-5-bromopyridine: 2.2 g (15.6 mmol) of 6-fluoronicotinic acid, 5.1 g of red mercuric oxide (HgO) and 1.2 ml of bromine were dissolved in 100 ml of carbon tetrachloride (CCl4) to form a suspension. The reaction was carried out under reflux conditions for 5 hours and subsequently cooled to room temperature. The reaction mixture was filtered through diatomaceous earth and the filtrate was concentrated under vacuum. The residue was dissolved in hexane, filtered again and the filtrate was concentrated under vacuum to give 1.73 g (63% yield) of 2-fluoro-5-bromopyridine, the product being a light yellow oil.

References

[1] Patent: US5618821, 1997, A

5-Bromo-2-fluoropyridine Preparation Products And Raw materials

Raw materials

Hexane N,N-Dimethylformamide Potassium hydroxide Hydrogen peroxide Ethyl acetate 2-Amino-5-bromopyridine Tetrabutylammonium fluoride Sulfuric acid

Preparation Products

5-BROMO-2-FLUOROPYRIDINE-3-CARBALDEHYDE

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5-Bromo-2-fluoropyridine Suppliers

Americas 1 Belgium 1 Canada 2 China 416 Europe 3 France 2 Germany 8 India 42 Italy 1 Japan 2 Jordan 1 Slovakia 1 Switzerland 2 Ukraine 1 United Kingdom 17 United States 52 Global 552

Beijing DeLee Pharma Technology Co.,Ltd.

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JIANGYIN RUISHIPHARM CO.,LIMITED

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J & K SCIENTIFIC LTD.

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Liaoning Tianhua Chemical Co., Ltd.

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INTATRADE GmbH

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future industrial shanghai co., ltd

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View Lastest Price from 5-Bromo-2-fluoropyridine manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD

Product: 5-Bromo-2-fluoropyridine 766-11-0
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1000kg
Release date: 2025-07-15

Shaanxi Dideu New Materials Co. Ltd

Product: 5-Bromo-2-fluoropyridine 766-11-0
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 99.0%
Supply Ability: 10000KGS
Release date: 2025-05-29

Hebei Chuanghai Biotechnology Co., Ltd

Product: 2-Fluoro-5-bromopyridine 766-11-0
Price: US $10.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 5tons
Release date: 2024-12-02

766-11-0, 5-Bromo-2-fluoropyridineRelated Search:

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766-11-0

Fluoropyridines

Bromopyridines

Halopyridines

Building Blocks

Heterocyclic Building Blocks

Halogenated Heterocycles

Pyridines

Variety of halogenated heterocyclic series

Halogenated

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Boronic Acid

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Heterocyclic Building Blocks

Fluorine series

Pyridine Series

blocks

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Pyridine

pharmacetical

Pyridines derivates

Fluorin-contained pyridine series