2-Fluoropyridine-6-carboxylic acid
- Product Name
- 2-Fluoropyridine-6-carboxylic acid
- CAS No.
- 402-69-7
- Chemical Name
- 2-Fluoropyridine-6-carboxylic acid
- Synonyms
- 65753;2-Fluoroyridine-6;6-FLUOROPICOLINIC ACID;uoro-2-pyridinecarboxyL;5-Amino-6-chloro-4-picoline;2-Fluoroyridine-6-carboxylicacid;2-Fluoropyridine-6-carboxylicaci;6-Fluoro-2-pyridinecarboxylicacid;2-FLUOROPYRIDINE-6-CARBOXYLIC ACID;2-FLUORO-6-PYRIDINECARBOXYLIC ACID
- CBNumber
- CB0426291
- Molecular Formula
- C6H4FNO2
- Formula Weight
- 141.1
- MOL File
- 402-69-7.mol
2-Fluoropyridine-6-carboxylic acid Property
- Melting point:
- 139-143 °C (lit.)
- Boiling point:
- 306.3±22.0 °C(Predicted)
- Density
- 1.419±0.06 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- pka
- 3.30±0.10(Predicted)
- form
- Powder or Crystalline Powder
- color
- White to yellow to pale brown
- CAS DataBase Reference
- 402-69-7(CAS DataBase Reference)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 593664
- Product name
- 6-Fluoro-2-pyridinecarboxylic acid
- Purity
- 97%
- Packaging
- 250mg
- Price
- $118
- Updated
- 2023/06/20
- Product number
- F0837
- Product name
- 6-Fluoro-2-pyridinecarboxylic Acid
- Purity
- >98.0%(T)
- Packaging
- 1g
- Price
- $53
- Updated
- 2025/07/31
- Product number
- F0837
- Product name
- 6-Fluoro-2-pyridinecarboxylic Acid
- Purity
- >98.0%(T)
- Packaging
- 5g
- Price
- $181
- Updated
- 2025/07/31
- Product number
- 4H57-3-26
- Product name
- 2-Fluoropyridine-6-carboxylic acid
- Purity
- 98%
- Packaging
- 1g
- Price
- $96
- Updated
- 2021/12/16
- Product number
- JK272076
- Product name
- 2-Fluoropyridine-6-carboxylicacid
- Purity
- 97%
- Packaging
- 1g
- Price
- $75
- Updated
- 2021/12/16
2-Fluoropyridine-6-carboxylic acid Chemical Properties,Usage,Production
Chemical Properties
White to light yellow powder
Synthesis
407-22-7
402-69-7
General procedure for the synthesis of 6-fluoro-2-pyridinecarboxylic acid from 2-fluoro-6-methylpyridine: to a solution of 2-fluoro-6-methylpyridine (2.5 g, 22.5 mmol) in water (170 ml) was added potassium permanganate (KMnO?, 2 g, 12.65 mmol) in batches and the mixture was heated to reflux. Subsequently, potassium permanganate (KMnO?, 8 g, 50.63 mmol) was added in batches and heating to reflux was continued for 3 hours. After completion of the reaction, the mixture was cooled and the precipitate was removed by filtration. The filtrate was acidified with hydrochloric acid (HCl) solution and subsequently concentrated under reduced pressure. The residue was ground with hot ethanol (EtOH), the solid was collected by filtration and the filtrate was concentrated to dryness under reduced pressure. 6-Fluoro-2-pyridinecarboxylic acid was finally obtained as a white solid (1.7 g, 53% yield); melting point 137 °C.
References
[1] Patent: WO2004/13135, 2004, A1. Location in patent: Page 46-47
[2] Patent: WO2004/13138, 2004, A2. Location in patent: Page 22
[3] Journal of Fluorine Chemistry, 2011, vol. 132, # 8, p. 541 - 547
[4] Journal of the American Chemical Society, 1949, vol. 71, p. 4152
2-Fluoropyridine-6-carboxylic acid Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2-Fluoropyridine-6-carboxylic acid manufacturers
- Product
- 2-Fluoropyridine-6-carboxylic acid 402-69-7
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98.0%
- Supply Ability
- 10000KGS
- Release date
- 2025-05-29
- Product
- 2-Fluoropyridine-6-carboxylic acid 402-69-7
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.0% min
- Supply Ability
- 100 tons min
- Release date
- 2021-05-25
- Product
- 2-Fluoropyridine-6-carboxylic acid 402-69-7
- Price
- US $5.00-0.10/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2024-04-08