Levofloxacin carboxylic acid

Product Name: Levofloxacin carboxylic acid
CAS No.: 100986-89-8
Chemical Name: Levofloxacin carboxylic acid
Synonyms: Levofloxacin Related CoMpound B;8,9-difluoro-3-methyl-6-oxo-2,3-dihydro-6H-1-oxa-3a-aza-phenalene-5-carboxylic acid;S-(-)-9,10-DIFLUORO-2,3-DIHYDRO-3-METHYL-7-OXO-7H-PYRIDO-[1,2,3-DE] [1,4]-BENZOXAZINE-6-CARBOXYLIC ACID;(S)-(-)-9,10-Difluoro-2,3-dihydro-3-methyl-7-oxo-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic acid 97%;7H-Pyrido[1;oxacin Q-Acid;10-difluoro-2;Levofloxacin-8;Levofloxacin USP RC B;LevofloxacinQ-Acid>
CBNumber: CB7337190
Molecular Formula: C13H9F2NO4
Formula Weight: 281.21
MOL File: 100986-89-8.mol

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Levofloxacin carboxylic acid Property

Melting point:: >300 °C (lit.)
Boiling point:: 459.2±45.0 °C(Predicted)
Density: 1.61±0.1 g/cm3(Predicted)
storage temp.: Sealed in dry,Room Temperature
solubility: DMSO (Slightly)
pka: 4.87±0.40(Predicted)
color: White
optical activity: [α]20/D -64°, c = 1% in DMSO
InChI: InChI=1S/C13H9F2NO4/c1-5-4-20-12-9(15)8(14)2-6-10(12)16(5)3-7(11(6)17)13(18)19/h2-3,5H,4H2,1H3,(H,18,19)/t5-/m0/s1
InChIKey: NVKWWNNJFKZNJO-YFKPBYRVSA-N
SMILES: O1C2=C(F)C(F)=CC3C(=O)C(C(O)=O)=CN(C2=3)[C@@H](C)C1
CAS DataBase Reference: 100986-89-8(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38-36/37/3
Safety Statements: 26-36
WGK Germany: 3
HS Code: 29349990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: PHR2229
Product name: Levofloxacin Related Compound B
Purity: Pharmaceutical Secondary Standard; Certified Reference Material
Packaging: 100mg
Price: $593
Updated: 2025/07/31

Sigma-Aldrich

Product number: 570877
Product name: (S)-(?)-9,10-Difluoro-2,3-dihydro-3-methyl-7-oxo-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic acid
Purity: 97%
Packaging: 5g
Price: $41.3
Updated: 2025/07/31

Sigma-Aldrich

Product number: 1362125
Product name: Levofloxacin Related Compound B
Purity: United States Pharmacopeia (USP) Reference Standard
Packaging: 35mg
Price: $1200
Updated: 2025/07/31

TCI Chemical

Product number: L0238
Product name: Levofloxacin Q-Acid
Purity: >98.0%(HPLC)(T)
Packaging: 1g
Price: $61
Updated: 2025/07/31

TCI Chemical

Product number: L0238
Product name: Levofloxacin Q-Acid
Purity: >98.0%(HPLC)(T)
Packaging: 5g
Price: $184
Updated: 2025/07/31

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Levofloxacin carboxylic acid Chemical Properties,Usage,Production

Chemical Properties

White Solid

Uses

Levofloxacin intermediate.

Definition

ChEBI: Ofloxacin impurity a is a member of quinolines.

Synthesis

106939-34-8

100986-89-8

Levofloxacin carboxylic acid was synthesized using ethyl (S)-9,10-difluoro-3-methyl-7-oxo-3,7-dihydro-2H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxylate as starting material in the following steps: 1. to the residue after recovery of DMF was added acetic acid followed by 65 mL of water at room temperature and mixed with stirring. 2. sulfuric acid was slowly added dropwise, and when the dropwise addition was complete, it was heated to reflux and kept at reflux for 1 hour. 3. upon completion of the reaction, cooled to room temperature and subjected to filtration. 4. The filter cake was washed with 65 mL of water and subsequently dried to give 43.98 g of levodicyclic acid, the content of which was determined to be 96.22%. 5. The acetic acid was spun back through acetic acid and spun to dryness. 6. The filtrate was washed with water and filtered again to give 4.81 g of levulinic acid at 61.28%. 7. The recycled water and acetic acid can be recycled separately to minimize waste discharge and reduce raw material costs. 8. For the synthesis of tetrafluorobenzoyl chloride, the total yield after four steps was 87%.

References

[1] Patent: EP368410, 1990, A3
[2] Chemical and pharmaceutical bulletin, 1987, vol. 35, # 5, p. 1896 - 1902
[3] Bioorganic and Medicinal Chemistry Letters, 2003, vol. 13, # 23, p. 4213 - 4216
[4] Patent: WO2006/48889, 2006, A1. Location in patent: Page/Page column 18
[5] Patent: US4985557, 1991, A

Levofloxacin carboxylic acid Preparation Products And Raw materials

Raw materials

Preparation Products

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Levofloxacin carboxylic acid Suppliers

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View Lastest Price from Levofloxacin carboxylic acid manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD

Product: Levofloxacin carboxylic acid 100986-89-8
Price: US $0.00-0.00/Kg/Drum
Min. Order: 1KG
Purity: 98.5%min
Supply Ability: 10 TONS
Release date: 2021-06-18

Hebei Chuanghai Biotechnology Co., Ltd

Product: Levofloxacin carboxylic acid 100986-89-8
Price: US $10.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 5tons
Release date: 2024-11-29

Hebei Yanxi Chemical Co., Ltd.

Product: Levofloxacin carboxylic acid 100986-89-8
Price: US $0.00/kg
Min. Order: 1kg
Purity: 99.00%
Supply Ability: 20tons
Release date: 2024-03-26

100986-89-8, Levofloxacin carboxylic acidRelated Search:

Folic acid Methyl acetate Tribenuron methyl 2,6-Lutidine Levofloxacin Azamethiphos 2-Chloro-5-chloromethylpyridine Oxygen-fluorine acid Chromium picolinate 2,4,6-Collidine Methyl salicylate 2-chloro-6-trichloromethylpyridine 4-Methylpyridine Ethyl 2-(Chlorosulfonyl)acetate Kresoxim-methyl Thiophanate-methyl Citric acid METSULFURON METHYL

Levefluorocarboxylic Acid

Levofloxacin Related Compound B (35 mg) ((S)-9,10,difluro-3-methyl-7-oxo-2,3-dihydro-7H-pyrido[1,2,3-de][1,4]benzoxazine-6-carboxylic acid)

Levo Q Acid(oxa-2,3 dihydro-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic Acid

7H-Pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylicacid,9,10-difluoro-2,3-dihydro-3-Methyl-7-oxo-,(3S)-

(S)-(-)-9,10-Difluoro-2,3-dihydro-3-Methyl-7-oxo-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic acid, 97+%

(3S)-9,10-Difluoro-2,3-dihydro-3-Methyl-7-oxo-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic Acid

(S)-(-)-9,10-Difluoro-2,3-dihydro-3-methyl-7-oxo-7H-pyrido[1,2,3-de][1,4]benzoxadine-6-carboxylic Acid

Levofloxacin USP Related CoMpound B (EP IMpC)

Levofloxacin Difluoro Carboxylic Acid

(S)-9,10-difluoro-3-Methyl-7-oxo-3,7-dihydro-2H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxylic acid

(S)-(-)-9,10-Difluoro-3-Methyl-7-oxo-2,3-dihydro-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic acid, 97+%

Levofloxacin Related Compound B (35 mg) ((S)-9,10,difluoro-3-methyl-7-oxo-2,3-dihydro-7H-pyrido[1,2,3-de][1,4]benzoxazine-6-carboxylic acid)

(S)-(-)-9,10-Difluoro-2,3-dihydro-3-methyl-7-oxo-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic acid 97%

S-(-)-9,10-DIFLUORO-2,3-DIHYDRO-3-METHYL-7-OXO-7H-PYRIDO-[1,

Levofloxacin USP RC B

(S)-9,10-Difluoro-3-methyl-7-oxo-3,7-dihydro-2H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxylic a

(-)-9,10-DIFLUORO-3(S)-METHYL-7-OXO-2,3-DIHYDRO-7H-PYRIDO (1,2,3-DE)-1,4-BENZOXAZINE-6-CARBOXYLIC ACID

8,9-difluoro-3-methyl-6-oxo-2,3-dihydro-6H-1-oxa-3a-aza-phenalene-5-carboxylic acid

LEVOFLUOROCARBOXYLIC ACID

S(-)-9,10-DIFL-2,3-DIHYDRO-3-ME-7H-PYRI&

(-)-9,10-DIFLUORO-3(S)-METHYL-7-OXO-2,3-DIHYDRO-7H- PYRIDO (1,2,3-DE)-1,4-BENZOXAZINE-6-CARBOXYLIC ACID

S-(-)-9,10-DIFLUORO-2,3-DIHYDRO-3-METHYL-7-OXO-7H-PYRIDO-[1,2,3-DE][1,4]-BENZOXAZINE-6-CARBOXYLIC ACID

9,10-Difluoro-3(S)-methyl-7-oxo-2,3-dihyd

9,10-DIFLUORO-2,3-DIHYDRO-3-(S)-METHYL-7-OXO-7H-PY

S-(-)-9,10-DIFLUORO-2,3-DIHYDRO-3-METHYL-7-OXO-7H-PYRIDO-[1,2,3-DE] [1,4]-BENZOXAZINE-6-CARBOXYLIC ACID

9,10-Difluoro-2,3-dihydro-3-methyl-7-oxo-(3S)-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic acid

Levofloxacin carboxylic acid

(-)-9,10-DIFLUORO-3(S)-METHL-7-OXO-2,3-DIHYDRO-7H-PRYIDO[1,2,3-DE]1,2-BENZOX-AZINE-6-CARBOXYLICACID

Levofloxacin EP Impurity C

(S)-9,10,difluro-3-Methyl-7-oxo-2,3-dihydro-7H-pyrido[1,2,3-de][1,4]benzoxazine-6-carboxylic acid

Levofloxacin Related CoMpound B

Levofloxacin Carboxylic Acid (Levofloxacin Difluoro IMpurity)

9,10-DIFLUORO-3-(S)-METHYL-7-OXO

Levofloxacin Related Compound B(USP)

Levofloxacin Impurity H

Levofloxacin ImpurityⅡ:LevofloxacinImpurity A{ (3RS)-9,10-Difluoro-2,3-dihydro-3-methyl-7-oxo-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic Acid}

Ofloxacin ImpurityⅠ(Impurity A)

Levofloxacin-8

Levofloxacin?EP Impurity F

LevofloxacinQ-Acid&gt

oxacin Q-Acid

Levofloxacin EP Impurity F (Levofloxacin Related Compound B)

Levofloxacin carboxylic acid USP/EP/BP

LEVOFLOXACIN ACID USP/EP/BP

Levofloxacin carboxylic acidr

USP Levofloxacin Related Compound B

Levofloxacin Q-acid (Levofloxacin Impurity)

Levofloxacin EP Impurity F/ Levofloxacin Related Compound B (Levofloxacin Difluoro Carboxylic Acid)

Levofloxacin USP RC B/ Q Acid

Levofloxacin Carboxylic Acid833

(S)-(?)-9,1-Difluoro-2,3-dihydro-3-methyl-7-oxo-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic acid

Levofloxacin Related Compound B (G0M041)

Levofloxacin Related Compound B ((S)-9,10,difluoro-3-methyl-7-oxo-2,3-dihydro-7H-pyrido[1,2,3-de][1 (1362125)

(3S)-9,10-difluoro-3-methyl-7-oxo-2,3-dihydro-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic Acid

Levoxyfluorocarboxylic acid

(S)-(-)-9,10-Difluoro-2,3-dihydro-3-methyl-7-oxo-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic Acid [Levofloxacin Q-Acid

Levofloxacin Hemihydrate Impurity F

Levofloxacin Hemihydrate EP Impurity F