Oxygen-fluorine acid

Product Name: Oxygen-fluorine acid
CAS No.: 82419-35-0
Chemical Name: Oxygen-fluorine acid
Synonyms: OFLOXACIN Q ACID;Ofloxacin Carboxylic Acid;Ofloxacin-1;AURORA 21894;Olfoxacin Acid;Oxygen-fluorine;AKOS BBS-00001807;OXYGEN-FLUORINE ACID;OTAVA-BB BB0111050010;DIFLUOROCARBOYLIC ACID
CBNumber: CB9427004
Molecular Formula: C13H9F2NO4
Formula Weight: 281.21
MOL File: 82419-35-0.mol

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Oxygen-fluorine acid Property

Melting point:: 320-322 °C (lit.)
Boiling point:: 459.2±45.0 °C(Predicted)
Density: 1.61±0.1 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: DMSO (Slightly, Heated)
pka: 4.87±0.40(Predicted)
form: solid
color: Off-White
BRN: 4202751
CAS DataBase Reference: 82419-35-0(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36
WGK Germany: 3
HS Code: 29349990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: PHR2234
Product name: Ofloxacin Impurity A
Purity: certified reference material, pharmaceutical secondary standard
Packaging: 100mg
Price: $457
Updated: 2025/07/31

Sigma-Aldrich

Product number: 472670
Product name: 9,10-Difluoro-2,3-dihydro-3-methyl-7-oxo-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic acid
Purity: 97%
Packaging: 5g
Price: $47.32
Updated: 2025/07/31

TCI Chemical

Product number: O0404
Product name: 9,10-Difluoro-2,3-dihydro-3-methyl-7-oxo-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic Acid
Purity: >98.0%(HPLC)
Packaging: 5g
Price: $75
Updated: 2025/07/31

TCI Chemical

Product number: O0404
Product name: 9,10-Difluoro-2,3-dihydro-3-methyl-7-oxo-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic Acid
Purity: >98.0%(HPLC)
Packaging: 25g
Price: $261
Updated: 2025/07/31

TRC

Product number: D445745
Product name: 9,10-Difluoro-2,3-dihydro-3-methyl-7-oxo-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylicAcid(RS-OfloxacinCarboxylicAcid)
Packaging: 10g
Price: $255
Updated: 2021/12/16

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Oxygen-fluorine acid Chemical Properties,Usage,Production

Chemical Properties

Grey-Yellow Powder

Uses

9,10-Difluoro-2,3-dihydro-3-methyl-7-oxo-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic Acid (Ofloxacin EP Impurity A) is an Ofloxacin intermediate.

General Description

(S)-(-)-9,10-Difluoro-2,3-dihydro-3-methyl-7-oxo-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic acid may be used in the preparation of the following:

kynurenine aminotransferase II (KAT II) inhibitor, [(S)-(-)-9-(4-aminopiperazine-1-yl)-8-fluoro-3-methyl-6-oxo-2,3,5,6-tetrahydro-4H-1-oxa-3a-aza-phenalene-5-carboxylic acid]
fused-ring derivatives
N-desmethyllevofloxacin

Synthesis

178233-30-2

429-41-4

82419-35-0

Example 1: Preparation of 9,10-difluoro-2,3-dihydro-3-methyl-7-oxo-7H-pyrido[1,2,3-de][1,4]benzoxazine-6-carboxylic acid (I). 220 mg (0.447 mmol) of ethyl 2-(2-nitro-3,4,5-trifluorobenzoyl)-3-(1-tert-butyldimethylsilylmethoxypropan-2-ylamino)acrylate (II) was dissolved in 10 mL of tetrahydrofuran and the solution was cooled to 0 °C. To this solution 0.41 g (1.56 mmol) of tetrabutylammonium fluoride in tetrahydrofuran was added dropwise and stirred for 30 min. Subsequently, the reaction mixture was heated to reflux for 30 minutes. 2 mL of 10% aqueous potassium hydroxide solution was added and refluxing was continued for 30 minutes. After cooling to room temperature, the reaction mixture was filtered to remove insoluble material. The filtrate was concentrated under reduced pressure (25 °C/10 mmHg) and 20 mL of water was added to the residue. The aqueous phase was washed once with 5 mL of chloroform and then the pH was slowly adjusted to 3 with 1 N hydrochloric acid solution. the precipitate was collected by filtration, washed sequentially with 5 mL of water and 5 mL of a mixture of ethanol and ether (1:4, v/v/v), and dried to give 108 mg of the target product (86% yield). The melting point of the product was 308 °C (decomposition); NMR (TFA-d1) δ ppm: 9.39 (1H, s), 8.10 (1H, dd, J = 10.8 Hz), 5.11-5.26 (1H, m), 4.79 (1H, dd, J = 2.12 Hz), 4.65 (1H, dd, J = 2.12 Hz), 1.82 (3H, d. J = 6.7 Hz).

References

[1] Patent: US5952494, 1999, A

Oxygen-fluorine acid Preparation Products And Raw materials

Raw materials

Sodium hydride Ethyl 2,3,4,5-tetrafluorobenzoyl acetate Acetic anhydride Potassium hydroxide Triethyl orthoformate DL-Alaninol Tetrahydrofuran Hydrochloric acid Dimethyl sulfoxide

Preparation Products

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Oxygen-fluorine acid Suppliers

Americas 1 Austria 1 Belgium 2 Canada 2 China 209 Europe 1 Germany 1 India 23 Japan 2 Switzerland 1 Ukraine 1 United Kingdom 6 United States 32 Global 282

J & K SCIENTIFIC LTD.

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Meryer (Shanghai) Chemical Technology Co., Ltd.

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3B Pharmachem (Wuhan) International Co.,Ltd.

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Beijing dtftchem Technology Co., Ltd.

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Adamas Reagent, Ltd.

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Shanghai Hanhong Scientific Co.,Ltd.

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Chemsky（shanghai）International Co.,Ltd.

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ShangHai YuanYe Biotechnology Co., Ltd.

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S.Z. PhyStandard Bio-Tech. Co., Ltd.

Tel: 0755-4000505016 13380397412
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ProdList: 5158
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View Lastest Price from Oxygen-fluorine acid manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD

Product: Oxygen-fluorine acid 82419-35-0
Price: US $0.00/Kg/Drum
Min. Order: 1KG
Purity: 98%min
Supply Ability: 1000kg
Release date: 2021-11-03

Hebei Yanxi Chemical Co., Ltd.

Product: Oxygen-fluorine acid 82419-35-0
Price: US $0.00/kg
Min. Order: 1kg
Purity: 98.50%
Supply Ability: 20tons
Release date: 2023-09-14

Henan Fengda Chemical Co., Ltd

Product: Oxygen-fluorine acid 82419-35-0
Price: US $36.00-1.20/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: g-kg-tons, free sample is available
Release date: 2024-04-16

82419-35-0, Oxygen-fluorine acidRelated Search:

Methyl salicylate Dihydromyrcenol 1-AdaMantanethylaMine Oxygen Ofloxacin Levofloxacin Tribenuron methyl Basic Violet 1 Methylparaben Methyl acrylate Kresoxim-methyl Methanol Levofloxacin carboxylic acid Piperazine 1-Piperazinecarbaldehyde 2,3,4,5-Tetrafluorobenzoyl chloride 7H-Pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic acid, 10-amino-9-fluoro-2,3-dihydro-3-methyl-7-oxo-, (S)- (9CI) Methyl

9,10-DIFLUORO-2,3-DIHYDRO-3-METHYL-7-OXO-7H-PYRIDO[1,2,3-DE]-1,4-BENZ-OXAZINE-6-CARBOXYLIC ACID

9,10-difluoro-2,3-dihydro-3-methyl-7-oxo-7h-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxyllic acid

9,10-DIFLUORO-3-METHYL-7-OXO-2,3-DIHYDRO-7H-[1,4]OXAZINO[2,3,4-IJ]QUINOLINE-6-CARBOXYLIC ACID

AURORA 21894

AKOS BBS-00001807

OXYGEN-FLUORINE ACID

OTAVA-BB BB0111050010

9,10-Difluoro-2,3-Dihydro-3-Methyl-7-Oxo-7h-Pyroido(1,2,3-De)(1,4)Benzoxazine-6-Carboxylic Acid

Oxygen fluorine acid(FPA)

DIFLUOROCARBOYLIC ACID

9,10-DIFLUORO-2,3-DIHYDRO-3-ME-7-OXO-7H- PYRIDO(1,2,3-DE)1,4-BENZOXAZINE-6-COOH

OFLOXACIN Q ACID

9,10-Difluoro-3-Methyl-7-Oxo-2,3-Dihydro 7-H-Pyrido-1,2,3-DE]-1,4-Benzoxyazine-6-Carboxylic Acid

Oxygen-fluorine

9,10-Difluoro-3-methyl-7-oxo-2,3-dihydro-7H-pyrido[1,2,3-de][1,4]benzoxazine-6-carboxylicacid

9,10-Difluoro-2,3-dihydro-3-methyl-7-oxo-7H-pyrido[1,2,3de]-1,4-benzoxazine

9,10-Difluoro-2,3-dihydro-3-methyl-7-oxo-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic

(RS)-9,10-Difluro-3-methyl-7-oxo-2,3-dihydro-7H-pyrido[1,2,3-de][1,4]benzoxazine-6-carboxylic acid (FPA)

9,10-difluoro-3-methyl-7-oxo-3,7-dihydro-2H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxylic acid

Ofloxacin Impurity 4(Ofloxacin EP Impurity A)

9,10-Difluoro-2,3-dihydro-3-methyl-7-oxo-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic Acid (RS-Ofloxacin Carboxylic Acid)

Ofloxacin EP IMpurity A

(RS)-9,10-Difluoro-2,3-dihydro-3-methyl-7-oxo-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic acid

9,10-Difluoro-2,3-dihydro-3-methyl-7-oxo-7H-pyrido[1,2,3-DE]-1,4-benz-oxazine-6-carboxylic acid ,97%

9,10-difluoro-2,3-dihydro-3-me-7-oxo-7h-pyrido-1,

Oxygen-fluorine acid ,98%

9,10-DIFLUORO-2,3-DIHYDRO-3-METHYL-7-OXO-7H-PYRIDO[1,2,3-DE]-1,4-BENZOXAZINE-6-CARBO

7H-PYRIDO[1,2,3-DE]-1,4-BENZOXAZINE-6-CARBOXYLICACID,9,10-DIFLUORO-2,3-DIHYDRO-3-METHYL-7-OXO

Olfoxacin Acid

Ofloxacin Impurity A(EP)

Ofloxacin-1

Levofloxacin Hydrochloride ImpurityⅡ: Impurity A(9,10-Difluoro-2,3-dihydro-3-methyl-7-oxo-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic Acid(RS-Ofloxacin Carboxylic Acid))

Ofloxacin Carboxylic Acid

6,7-Difluoro-2-methyl-10-oxo-4-oxa-1-azatricyclo[7.3.1.0^{5,13}]trideca-5(13),6,8,11-tetraene-11-carboxylic acid

RS-Ofloxacin Carboxylic Acid

9,10-Difluoro-2,3-dihydro-3-methyl-7-oxo-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylicAcid&gt

Ofloxacin impurity A CRS

(RS)-9,10-Difluoro-3-methyl-7-oxo-2

(+/-)9,10-Difluoro-2,3-dihydro-3-methyl-7-oxo-7H-pyrido[1,2,3-de][1,4]lbenzoxazine-6-carboylic acid

Ofloxacin EP Impurity A (Ofloxacin Difluoro Carboxylic Acid)

Ofloxacin impurity A (O0120010)

Levofloxacin Hydrochloride ImpurityⅡ: Impurity A(9,10-Difluoro-2,3-dihydro-3-methyl-7-oxo-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic Acid_x000b_(RS-Ofloxacin Carboxylic Acid))

Oxygen-fluorineacid Ethambutol dihydrochloride

(RS)-9,10-Difluoro-3-methyl-7-oxo-2,3-dihydro-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic Acid

9,10-Difluoro-2,3-dihydro-3-methyl-7-oxo-7<i>H</i>-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic acid

Levofloxacin Hydrochloride ImpurityⅡ: Impurity A(9,10-Difluoro-2,3-dihydro-3-methyl-7-oxo-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic Acid(RS-Ofloxacin Carboxylic Acid))

(RS)-9,10-Difluoro-3-methyl-7-oxo-2,3-dihydro-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic Acid (FPA)

Ofloxacin Imp. A (EP): (3RS)-9,10-difluoro-3-methyl -7-oxo-2,3-dihydro-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic acid

9,10-Difl/1/3/9/7/1/5/1/4/0/0/7/uoro-3-Methyl-7-Oxo-

82419-35-0

C13H9F2NO4

C13H8F2NO4

Heterocyclic Building Blocks

Benzoxazines

Building Blocks

Various Intermediates

Intermediates

Intermediates & Fine Chemicals