ChemicalBook > CAS DataBase List > Oxygen-fluorine acid

Oxygen-fluorine acid

Product Name
Oxygen-fluorine acid
CAS No.
82419-35-0
Chemical Name
Oxygen-fluorine acid
Synonyms
OFLOXACIN Q ACID;Ofloxacin Carboxylic Acid;Ofloxacin-1;AURORA 21894;Olfoxacin Acid;Oxygen-fluorine;AKOS BBS-00001807;OXYGEN-FLUORINE ACID;OTAVA-BB BB0111050010;DIFLUOROCARBOYLIC ACID
CBNumber
CB9427004
Molecular Formula
C13H9F2NO4
Formula Weight
281.21
MOL File
82419-35-0.mol
More
Less

Oxygen-fluorine acid Property

Melting point:
320-322 °C (lit.)
Boiling point:
459.2±45.0 °C(Predicted)
Density 
1.61±0.1 g/cm3(Predicted)
storage temp. 
2-8°C
solubility 
DMSO (Slightly, Heated)
pka
4.87±0.40(Predicted)
form 
solid
color 
Off-White
BRN 
4202751
CAS DataBase Reference
82419-35-0(CAS DataBase Reference)
More
Less

Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36
WGK Germany 
3
HS Code 
29349990
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More
Less

N-Bromosuccinimide Price

Sigma-Aldrich
Product number
PHR2234
Product name
Ofloxacin Impurity A
Purity
certified reference material, pharmaceutical secondary standard
Packaging
100mg
Price
$457
Updated
2025/07/31
Sigma-Aldrich
Product number
472670
Product name
9,10-Difluoro-2,3-dihydro-3-methyl-7-oxo-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic acid
Purity
97%
Packaging
5g
Price
$47.32
Updated
2025/07/31
TCI Chemical
Product number
O0404
Product name
9,10-Difluoro-2,3-dihydro-3-methyl-7-oxo-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic Acid
Purity
>98.0%(HPLC)
Packaging
5g
Price
$75
Updated
2025/07/31
TCI Chemical
Product number
O0404
Product name
9,10-Difluoro-2,3-dihydro-3-methyl-7-oxo-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic Acid
Purity
>98.0%(HPLC)
Packaging
25g
Price
$261
Updated
2025/07/31
Usbiological
Product number
009538
Product name
9,10-Difluoro-2,3-dihydro-3-methyl-7-oxo-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic Acid|
Packaging
1g
Price
$425
Updated
2021/12/16
More
Less

Oxygen-fluorine acid Chemical Properties,Usage,Production

Chemical Properties

Grey-Yellow Powder

Uses

9,10-Difluoro-2,3-dihydro-3-methyl-7-oxo-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic Acid (Ofloxacin EP Impurity A) is an Ofloxacin intermediate.

General Description

(S)-(-)-9,10-Difluoro-2,3-dihydro-3-methyl-7-oxo-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic acid may be used in the preparation of the following:

  • kynurenine aminotransferase II (KAT II) inhibitor, [(S)-(-)-9-(4-aminopiperazine-1-yl)-8-fluoro-3-methyl-6-oxo-2,3,5,6-tetrahydro-4H-1-oxa-3a-aza-phenalene-5-carboxylic acid]
  • fused-ring derivatives
  • N-desmethyllevofloxacin

Synthesis

178233-30-2

429-41-4

82419-35-0

Example 1: Preparation of 9,10-difluoro-2,3-dihydro-3-methyl-7-oxo-7H-pyrido[1,2,3-de][1,4]benzoxazine-6-carboxylic acid (I). 220 mg (0.447 mmol) of ethyl 2-(2-nitro-3,4,5-trifluorobenzoyl)-3-(1-tert-butyldimethylsilylmethoxypropan-2-ylamino)acrylate (II) was dissolved in 10 mL of tetrahydrofuran and the solution was cooled to 0 °C. To this solution 0.41 g (1.56 mmol) of tetrabutylammonium fluoride in tetrahydrofuran was added dropwise and stirred for 30 min. Subsequently, the reaction mixture was heated to reflux for 30 minutes. 2 mL of 10% aqueous potassium hydroxide solution was added and refluxing was continued for 30 minutes. After cooling to room temperature, the reaction mixture was filtered to remove insoluble material. The filtrate was concentrated under reduced pressure (25 °C/10 mmHg) and 20 mL of water was added to the residue. The aqueous phase was washed once with 5 mL of chloroform and then the pH was slowly adjusted to 3 with 1 N hydrochloric acid solution. the precipitate was collected by filtration, washed sequentially with 5 mL of water and 5 mL of a mixture of ethanol and ether (1:4, v/v/v), and dried to give 108 mg of the target product (86% yield). The melting point of the product was 308 °C (decomposition); NMR (TFA-d1) δ ppm: 9.39 (1H, s), 8.10 (1H, dd, J = 10.8 Hz), 5.11-5.26 (1H, m), 4.79 (1H, dd, J = 2.12 Hz), 4.65 (1H, dd, J = 2.12 Hz), 1.82 (3H, d. J = 6.7 Hz).

References

[1] Patent: US5952494, 1999, A

Oxygen-fluorine acid Preparation Products And Raw materials

Raw materials

Sodium hydride Ethyl 2,3,4,5-tetrafluorobenzoyl acetate Acetic anhydride Potassium hydroxide Triethyl orthoformate DL-Alaninol Tetrahydrofuran Hydrochloric acid Dimethyl sulfoxide

Preparation Products

More
Less

Oxygen-fluorine acid Suppliers

Americas 1 Austria 1 Belgium 2 Canada 2 China 209 Europe 1 Germany 1 India 23 Japan 2 Switzerland 1 Ukraine 1 United Kingdom 6 United States 32 Global 282
AKos Consulting & Solutions GmbH
Tel
--
Fax
--
Email
akos@akosgmbh.de
Country
Germany
ProdList
6717
Advantage
72
More
Less

View Lastest Price from Oxygen-fluorine acid manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD
Product
Oxygen-fluorine acid 82419-35-0
Price
US $0.00/Kg/Drum
Min. Order
1KG
Purity
98%min
Supply Ability
1000kg
Release date
2021-11-03
Hebei Yanxi Chemical Co., Ltd.
Product
Oxygen-fluorine acid 82419-35-0
Price
US $0.00/kg
Min. Order
1kg
Purity
98.50%
Supply Ability
20tons
Release date
2023-09-14
Henan Fengda Chemical Co., Ltd
Product
Oxygen-fluorine acid 82419-35-0
Price
US $36.00-1.20/kg
Min. Order
1kg
Purity
99%
Supply Ability
g-kg-tons, free sample is available
Release date
2024-04-16

82419-35-0, Oxygen-fluorine acidRelated Search:

Methyl salicylate Dihydromyrcenol 1-AdaMantanethylaMine Oxygen Ofloxacin Levofloxacin Tribenuron methyl Basic Violet 1 Methylparaben Methyl acrylate Kresoxim-methyl Methanol Levofloxacin carboxylic acid Piperazine 1-Piperazinecarbaldehyde 2,3,4,5-Tetrafluorobenzoyl chloride 7H-Pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic acid, 10-amino-9-fluoro-2,3-dihydro-3-methyl-7-oxo-, (S)- (9CI) Methyl

  • 9,10-DIFLUORO-2,3-DIHYDRO-3-METHYL-7-OXO-7H-PYRIDO[1,2,3-DE]-1,4-BENZ-OXAZINE-6-CARBOXYLIC ACID
  • 9,10-difluoro-2,3-dihydro-3-methyl-7-oxo-7h-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxyllic acid
  • 9,10-DIFLUORO-3-METHYL-7-OXO-2,3-DIHYDRO-7H-[1,4]OXAZINO[2,3,4-IJ]QUINOLINE-6-CARBOXYLIC ACID
  • AURORA 21894
  • AKOS BBS-00001807
  • OXYGEN-FLUORINE ACID
  • OTAVA-BB BB0111050010
  • 9,10-Difluoro-2,3-Dihydro-3-Methyl-7-Oxo-7h-Pyroido(1,2,3-De)(1,4)Benzoxazine-6-Carboxylic Acid
  • Oxygen fluorine acid(FPA)
  • DIFLUOROCARBOYLIC ACID
  • 9,10-DIFLUORO-2,3-DIHYDRO-3-ME-7-OXO-7H- PYRIDO(1,2,3-DE)1,4-BENZOXAZINE-6-COOH
  • OFLOXACIN Q ACID
  • 9,10-Difluoro-3-Methyl-7-Oxo-2,3-Dihydro 7-H-Pyrido-1,2,3-DE]-1,4-Benzoxyazine-6-Carboxylic Acid
  • Oxygen-fluorine
  • 9,10-Difluoro-3-methyl-7-oxo-2,3-dihydro-7H-pyrido[1,2,3-de][1,4]benzoxazine-6-carboxylicacid
  • 9,10-Difluoro-2,3-dihydro-3-methyl-7-oxo-7H-pyrido[1,2,3de]-1,4-benzoxazine
  • 9,10-Difluoro-2,3-dihydro-3-methyl-7-oxo-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic
  • (RS)-9,10-Difluro-3-methyl-7-oxo-2,3-dihydro-7H-pyrido[1,2,3-de][1,4]benzoxazine-6-carboxylic acid (FPA)
  • 9,10-difluoro-3-methyl-7-oxo-3,7-dihydro-2H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxylic acid
  • Ofloxacin Impurity 4(Ofloxacin EP Impurity A)
  • 9,10-Difluoro-2,3-dihydro-3-methyl-7-oxo-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic Acid (RS-Ofloxacin Carboxylic Acid)
  • Ofloxacin EP IMpurity A
  • (RS)-9,10-Difluoro-2,3-dihydro-3-methyl-7-oxo-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic acid
  • 9,10-Difluoro-2,3-dihydro-3-methyl-7-oxo-7H-pyrido[1,2,3-DE]-1,4-benz-oxazine-6-carboxylic acid ,97%
  • 9,10-difluoro-2,3-dihydro-3-me-7-oxo-7h-pyrido-1,
  • Oxygen-fluorine acid ,98%
  • 9,10-DIFLUORO-2,3-DIHYDRO-3-METHYL-7-OXO-7H-PYRIDO[1,2,3-DE]-1,4-BENZOXAZINE-6-CARBO
  • 7H-PYRIDO[1,2,3-DE]-1,4-BENZOXAZINE-6-CARBOXYLICACID,9,10-DIFLUORO-2,3-DIHYDRO-3-METHYL-7-OXO
  • Olfoxacin Acid
  • Ofloxacin Impurity A(EP)
  • Ofloxacin-1
  • Levofloxacin Hydrochloride ImpurityⅡ: Impurity A(9,10-Difluoro-2,3-dihydro-3-methyl-7-oxo-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic Acid (RS-Ofloxacin Carboxylic Acid))
  • Ofloxacin Carboxylic Acid
  • 6,7-Difluoro-2-methyl-10-oxo-4-oxa-1-azatricyclo[7.3.1.0^{5,13}]trideca-5(13),6,8,11-tetraene-11-carboxylic acid
  • RS-Ofloxacin Carboxylic Acid
  • 9,10-Difluoro-2,3-dihydro-3-methyl-7-oxo-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylicAcid&gt
  • Ofloxacin impurity A CRS
  • (RS)-9,10-Difluoro-3-methyl-7-oxo-2
  • (+/-)9,10-Difluoro-2,3-dihydro-3-methyl-7-oxo-7H-pyrido[1,2,3-de][1,4]lbenzoxazine-6-carboylic acid
  • Ofloxacin EP Impurity A (Ofloxacin Difluoro Carboxylic Acid)
  • Ofloxacin impurity A (O0120010)
  • Levofloxacin Hydrochloride ImpurityⅡ: Impurity A(9,10-Difluoro-2,3-dihydro-3-methyl-7-oxo-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic Acid_x000b_(RS-Ofloxacin Carboxylic Acid))
  • Oxygen-fluorineacid Ethambutol dihydrochloride
  • (RS)-9,10-Difluoro-3-methyl-7-oxo-2,3-dihydro-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic Acid
  • 9,10-Difluoro-2,3-dihydro-3-methyl-7-oxo-7<i>H</i>-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic acid
  • Levofloxacin Hydrochloride ImpurityⅡ: Impurity A(9,10-Difluoro-2,3-dihydro-3-methyl-7-oxo-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic Acid (RS-Ofloxacin Carboxylic Acid))
  • (RS)-9,10-Difluoro-3-methyl-7-oxo-2,3-dihydro-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic Acid (FPA)
  • Ofloxacin Imp. A (EP): (3RS)-9,10-difluoro-3-methyl -7-oxo-2,3-dihydro-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic acid
  • 9,10-Difl/1/3/9/7/1/5/1/4/0/0/7/uoro-3-Methyl-7-Oxo-
  • 82419-35-0
  • C13H9F2NO4
  • C13H8F2NO4
  • Heterocyclic Building Blocks
  • Benzoxazines
  • Building Blocks
  • Various Intermediates
  • Intermediates
  • Intermediates & Fine Chemicals