Description References
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1-AdaMantanethylaMine

Description References
Product Name
1-AdaMantanethylaMine
CAS No.
13392-28-4
Chemical Name
1-AdaMantanethylaMine
Synonyms
1-Adaman;RiMantidine;RIMANTADINE;AKOS B022266;1-Rimantadine;AKOS NCG1-0034;LEVOFLOXACIN HCL;1-Adamantanethylamine;RiMantadine (FluMadine);1-Adamantanemethylamine
CBNumber
CB7122907
Molecular Formula
C12H21N
Formula Weight
179.3
MOL File
13392-28-4.mol
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1-AdaMantanethylaMine Property

Boiling point:
248°C
Density 
1.033
Flash point:
99°C
pka
11.17±0.29(Predicted)
CAS DataBase Reference
13392-28-4(CAS DataBase Reference)
NIST Chemistry Reference
1-Adamantanemethylamine, «alpha»-methyl-(13392-28-4)
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Safety

HazardClass 
IRRITANT
Hazardous Substances Data
13392-28-4(Hazardous Substances Data)
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
180378
Product name
1-Adamantanemethylamine
Purity
98%
Packaging
1 g
Price
$133
Updated
2021/12/16
Biorbyt Ltd
Product number
orb134362
Product name
Rimantadine (Flumadine)
Purity
>99%
Packaging
100 mg
Price
$510
Updated
2021/12/16
AK Scientific
Product number
G879
Product name
Rimantadine
Packaging
5g
Price
$298
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
API0024288
Product name
RIMANTADINE
Purity
95.00%
Packaging
1G
Price
$648.81
Updated
2021/12/16
Biorbyt Ltd
Product number
orb134362
Product name
Rimantadine (Flumadine)
Purity
>99%
Packaging
250 mg
Price
$765
Updated
2021/12/16
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1-AdaMantanethylaMine Chemical Properties,Usage,Production

Description

Rimantadine (Brand name: Flumadine) is a kind of RNA synthesis inhibitor that used as an orally administrated antiviral drug in the prophylaxis and for the treatment of influenza. It is capable of shortening the duration and alleviated the symptoms of influenza. However, it is now not recommended for the treatment of influenza any longer due to the emergence of resistance problem since 2009. Its mechanism of action is not fully understood. It is indicated that it take effects through inhibiting the viral replication through possibly inhibiting the uncoating process of the virus. The virus M2 protein (an ion channel) seems to play an important role in the susceptibility of influenza A virus to the treatment of Rimantadine.

References

https://www.drugbank.ca/drugs/DB00478
https://en.wikipedia.org/wiki/Rimantadine

Uses

Rimantadine act by blocking the M2 ion channel which is required for uptake of protons into the interior of the virus to permit acid-promoted viral uncoating (decapsidation).

brand name

Flumadine (Forest).

General Description

Resistant variants of influenza type A have been recoveredfrom rimantadine-treated patients.Resistance with inhibitory concentrations increased morethan 100-fold have been associated with single nucleotidechanges that lead to amino acid substitutions in the transmembranedomain of M2. rimantadineshare cross-susceptibility and resistance.

Pharmaceutical Applications

An analog of amantadine, supplied as the hydrochloride for oral administration.

Mechanism of action

Rimantadine hydrochloride (α-methyl-1-adamantanemethylamine hydrochloride) is a synthetic adamatane derivative that is structurally and pharmacologically related to amantadine. It appears to be more effective than amantadine hydrochloride against influenza A, with fewer CNS side effects. Rimantadine hydrochloride is thought to interfere with virus uncoating by inhibiting the release of specific proteins. It may act by inhibiting RT or the synthesis of virus-specific RNA, but it does not inhibit virus adsorption or penetration. It appears to produce a virustatic effect early in the virus replication. It is used widely in Russia and Europe.

Pharmacokinetics

Oral absorption: >90%
Cmax 100 mg oral (every 12 h): 0.4–0.5 mg/L after 2–6 h
Plasma half-life: c. 35 h
Volume of distribution: Very large
Plasma protein binding: c. 40%
Absorption and distribution
Single- and multiple-dose pharmacokinetic studies in elderly patients and young adults are remarkably similar. The steadystate concentration in nasal mucus develops by day 5 at a concentration approximately 1.5-fold higher than plasma.
Metabolism
In contrast to amantadine, rimantadine is extensively metabolized in the liver by hydroxylation and glucuronidation.
Excretion
Less than 20% is excreted unchanged in the urine and most of the breakdown products are excreted by this route. Thus, the plasma half-life is much less affected by renal dysfunction than that of amantadine.

Clinical Use

rimantadine is used for the treatment of diseases caused by influenza A strains.

Clinical Use

Prophylaxis and treatment of influenza A H1N1 infections Since prolonged administration is well tolerated by elderly patients, the drug is preferable to amantadine.

Side effects

Rimantadine has significantly fewer side effects than amantadine at equivalent doses, perhaps because of differences in pharmacokinetics, since with equal doses the blood levels are considerably lower. CNS side effects are not significantly higher than placebo.

1-AdaMantanethylaMine Preparation Products And Raw materials

Raw materials

Preparation Products

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1-AdaMantanethylaMine Suppliers

Sichuan Zhongbang Pharma CO.,LTD
Tel
0830-2585019
Fax
0830-2589033
Email
sales2@zhongbangst.com
Country
China
ProdList
99
Advantage
69
J & K SCIENTIFIC LTD.
Tel
010-82848833- ;010-82848833-
Fax
86-10-82849933
Email
jkinfo@jkchemical.com;market6@jkchemical.com
Country
China
ProdList
96815
Advantage
76
Wuhan Chemwish Technology Co., Ltd
Tel
86-027-67849912
Fax
86-027-87531808
Email
sales@chemwish.com
Country
China
ProdList
35909
Advantage
56
Capot Chemical Co., Ltd
Tel
+86 (0) 571 85 58 67 18
Fax
0086-571-85864795
Email
sales@capotchem.com
Country
China
ProdList
18227
Advantage
66
LGM Pharma
Tel
1-(800)-881-8210
Fax
615-250-9817
Email
inquiries@lgmpharma.com
Country
United States
ProdList
1938
Advantage
70
Nanjing Chemlin Chemical Co., Ltd
Tel
Fax
+86-25-83453306
Email
info@chemlin.com.cn
Country
China
ProdList
20007
Advantage
64
XiaoGan ShenYuan ChemPharm co,ltd
Tel
0712-2580635- ;0712-2580635
Email
1791901229@qq.com;1791901229@qq.com;
Country
China
ProdList
8925
Advantage
52
Beijing Isomersyn Technology CO;LTD
Tel
010-82954736-
Email
sales@isomersyn.com
Country
China
ProdList
3298
Advantage
57
BOC Sciences
Email
info@bocsci.com
Country
United States
ProdList
21113
Advantage
65
Shanghai T&W Pharmaceutical Co., Ltd.
Tel
+86 21 61551611
Fax
+86 21 50676805
Country
China
ProdList
9914
Advantage
58
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View Lastest Price from 1-AdaMantanethylaMine manufacturers

Hebei Yirun Sega Biological Technology Co. Ltd
Product
Rimantadine 13392-28-4
Price
US $200.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
500ton/Month
Release date
2021-11-05
Hebei Zhanyao Biotechnology Co. Ltd
Product
Rimantadine 13392-28-4
Price
US $10.00/Kg/Bag
Min. Order
1Kg/Bag
Purity
99%
Supply Ability
20 Tons
Release date
2021-11-03
Dideu Industries Group Limited
Product
1-AdaMantanethylaMine USP/EP/BP 13392-28-4
Price
US $1.10/g
Min. Order
1g
Purity
99.9%
Supply Ability
100 Tons min
Release date
2021-07-19

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