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1-Methylpiperazine

Product Name
1-Methylpiperazine
CAS No.
109-01-3
Chemical Name
1-Methylpiperazine
Synonyms
N-METHYLPIPERAZINE;methylpiperazine;NMPRZ;4-Methylpiperazine;N-Methylpiperazin;Piperazine,1-methyl-;CL046;AKOS BBS-00003665;1-methyl-piperazin;METHYLPIPERAZINE-N
CBNumber
CB4478526
Molecular Formula
C5H12N2
Formula Weight
100.16
MOL File
109-01-3.mol
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1-Methylpiperazine Property

Melting point:
-6 °C
Boiling point:
138 °C(lit.)
Density 
0.903 g/mL at 25 °C(lit.)
vapor density 
3.5 (vs air)
vapor pressure 
12 hPa (20 °C)
refractive index 
n20/D 1.466(lit.)
Flash point:
108 °F
storage temp. 
2-8°C
solubility 
Chloroform (Soluble), Methanol (Soluble)
pka
pK1:4.94(+2);pK2:9.09(+1) (25°C,μ=0.1)
form 
Liquid
Specific Gravity
0.903
color 
Clear
PH
11-12 (50g/l, H2O, 20℃)
explosive limit
1.2-9.9%(V)
Water Solubility 
soluble
Sensitive 
Hygroscopic
BRN 
102724
InChIKey
PVOAHINGSUIXLS-UHFFFAOYSA-N
LogP
-0.57 at 25℃
CAS DataBase Reference
109-01-3(CAS DataBase Reference)
NIST Chemistry Reference
Piperazine, 1-methyl-(109-01-3)
EPA Substance Registry System
Piperazine, 1-methyl- (109-01-3)
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Safety

Hazard Codes 
T,F,C,Xi
Risk Statements 
10-21-23-34-36/37/38-20/21
Safety Statements 
16-26-36/37/39-45-36
RIDADR 
UN 2734 8/PG 2
WGK Germany 
2
RTECS 
TM1225000
Autoignition Temperature
320 °C
Hazard Note 
Flammable/Toxic/Corrosive/Store under nitrogen
TSCA 
Yes
HazardClass 
3
PackingGroup 
III
HS Code 
29335995
Toxicity
LD50 orally in Rabbit: 2547 mg/kg LD50 dermal Rabbit 1341 mg/kg
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H226Flammable liquid and vapour

H312Harmful in contact with skin

H314Causes severe skin burns and eye damage

H331Toxic if inhaled

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P370+P378In case of fire: Use … for extinction.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
8.05859
Product name
1-Methylpiperazine
Purity
for synthesis
Packaging
5ml
Price
$35
Updated
2024/03/01
Sigma-Aldrich
Product number
BP1118
Product name
1-Methylpiperazine
Purity
British Pharmacopoeia (BP) Reference Standard
Packaging
15MG
Price
$229
Updated
2024/03/01
Sigma-Aldrich
Product number
8.05859
Product name
1-Methylpiperazine
Purity
for synthesis
Packaging
250ML
Price
$120
Updated
2024/03/01
Sigma-Aldrich
Product number
130001
Product name
1-Methylpiperazine
Purity
99%
Packaging
5g
Price
$36.5
Updated
2024/03/01
Sigma-Aldrich
Product number
14549
Product name
1-Methylpiperazine
Purity
analytical standard
Packaging
5ml
Price
$70.8
Updated
2024/03/01
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1-Methylpiperazine Chemical Properties,Usage,Production

Chemical Properties

clear liquid

Uses

1-Methylpiperazine is used in the preparation of 2-(4-Methyl-1-piperazinylmethyl)acrylophenone(MPMAP)

Uses

1-Methylpiperazine is used in the preparation of 2-(4-methyl-1-piperazinylmethyl)acrylophenone. It is involved in the preparation of 1-(4-methoxy-phenyl)-4-methyl-piperazine by reacting with 1-chloro-4-methoxy-benzene. It acts as an intermediate in the synthesis of active pharmaceutical ingredients like ofloxacin, rifampicin, clozapine, sildenafil, trifluoperazine and zopiclone. Further, it is used as a mimic template in the preparation of molecularly imprinted microspheres. In addition to this, it is used in the generation of difunctional strong anion-exchange stationary phase from a 1,4-diazacyclohexane derivative.

Definition

ChEBI: 1-Methylpiperazine is a N-methylpiperazine.

Hazard

Moderate fire risk.

Flammability and Explosibility

Flammable

Safety Profile

Poison by intraperitoneal route. Moderately toxic by inhalation, ingestion, and skin contact. A severe skin and eye irritant. Flammable liquid when exposed to heat or flame; can react with oxidizing materials. To fight fire, use alcohol foam, CO2, dry chemical. When heated to decomposition it emits toxic fumes of NOx.

1-Methylpiperazine Preparation Products And Raw materials

Raw materials

Preparation Products

AZIMILIDE 3-(4-Methylpiperazin-1-yl)aniline 2-(4-Methylpiperazin-1-yl)pyrimidine-5-carbaldehyde 2-(4-Methylpiperazin-1-yl)-6-(trifluoromethyl)pyrimidine-4-carbonitrile 1-Amino-4-methylpiperazine Zopiclone 1-METHYLPIPERAZINE DIHYDROCHLORIDE 2-(4-Methylpiperazin-1-yl)pyrimidine-5-carbonyl chloride 2-(4-Methylpiperazin-1-yl)-6-(trifluoromethyl)pyrimidine-4-carboxamide (2-(4-Methylpiperazin-1-yl)-6-(trifluoromethyl)pyrimidin-4-yl)methanamine 3-(4-Methylpiperazin-1-ylmethyl)benzoic acid 2-(4-Methylpiperazin-1-yl)pyrimidine-5-carboxylic acid 2-(4-Methylpiperazin-1-yl)pyrimidine-5-carbonitrile CHLORCYCLIZINE HYDROCHLORIDE Levofloxacin (3,4-DIAMINO-PHENYL)-(4-METHYL-PIPERAZIN-1-YL)-METHANONE 2-(4-Methylpiperazin-1-yl)pyrimidine-5-carboxamide (2-(4-Methylpiperazin-1-yl)-6-(trifluoromethyl)pyrimidin-4-yl)methanol Ethyl 2-(4-methylpiperazin-1-yl)pyrimidine-5-carboxylate 3-[(4-METHYLPIPERAZIN-1-YL)METHYL]BENZALDEHYDE (4-METHYL-PIPERAZIN-1-YL)-ACETIC ACID Ethyl 2-(4-methylpiperazin-1-yl)-6-(trifluoromethyl)pyrimidine-4-carboxylate 3-Hydrazinyl-1-(4-methylpiperazin-1-yl)propan-1-one CHLORCYCLIZINE 2-(4-Methylpiperazin-1-yl)pyrimidin-5-amine 1-AdaMantanethylaMine 1-FORMYL-4-METHYLPIPERAZINE 4-(4-METHYLPIPERAZINOMETHYL)BENZOIC ACID (2-(4-Methylpiperazin-1-yl)pyrimidin-5-yl)methanol 2-(4-Methylpiperazin-1-yl)-6-(trifluoromethyl)pyrimidine-4-carbaldehyde Clozapine 1-METHYL-4-(3-NITROPHENYL)PIPERAZINE 4-[(4-Methylpiperazin-1-yl)methyl]aniline 2-(4-Methylpiperazin-1-yl)-6-(trifluoromethyl)pyrimidine-4-carboxylic acid 2-(4-Methylpiperazin-1-yl)-6-(trifluoromethyl)pyrimidin-4-amine 4-(4-Methylpiperazino)aniline 1-METHYL-4-(4-NITROPHENYL)PIPERAZINE 2-Hydrazinyl-1-(4-methylpiperazin-1-yl)ethanone 1-METHYL-4-(4-NITROBENZYL)PIPERAZINE 1-methyl-4-nitrosopiperazine
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1-Methylpiperazine Suppliers

Yangzhou xinhua chemical co. LTD
Tel
0514-80917051 13813168106
Email
sales@xinhuachen.com.cn
Country
China
ProdList
1
Advantage
58
Shanghai Song Yuan Chemical Technology Co., Ltd.
Tel
010-1234567 18521000990
Fax
86-021-33275113
Email
sonyuanchemical@163.com
Country
China
ProdList
6490
Advantage
50
Shandong Vantage Specialty Chemicals Biotechnology Co., Ltd.
Tel
133-96369453 18678026865
Fax
0536-2101172
Email
sdfantai@163.com
Country
China
ProdList
851
Advantage
58
Weifang Qianyuan Biotechnology Co., Ltd.
Tel
18678041314 18765609661
Email
2547772582@qq.com
Country
China
ProdList
505
Advantage
58
Changzhou Hengda Chemical Co., Ltd
Tel
0519-83404796 18115053796
Fax
0519-83404796
Email
hengda-chem.com
Country
China
ProdList
8
Advantage
58
Weifang Mingran Chemical Co., Ltd.
Tel
15066331899,0536-2082396,117761326 15063661899
Fax
0536-2082397
Email
mingranchem@163.com
Country
China
ProdList
429
Advantage
58
QUALITY CONTROL SOLUTIONS LTD.
Tel
15920483169
Email
ORDERS@QCSRM.COM
Country
China
ProdList
18735
Advantage
58
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel
4006608290; 18621169109
Fax
86-21-61259102
Email
market03@meryer.com
Country
China
ProdList
40241
Advantage
62
Alfa Aesar
Tel
400-6106006
Fax
021-67582001/03/05
Email
saleschina@alfa-asia.com
Country
China
ProdList
30132
Advantage
84
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View Lastest Price from 1-Methylpiperazine manufacturers

Sinoway Industrial co., ltd.
Product
1-Methylpiperazine 109-01-3
Price
US $0.00/Kg/Bag
Min. Order
2Kg/Bag
Purity
99% up, High Density
Supply Ability
20 tons
Release date
2023-10-19
Henan Fengda Chemical Co., Ltd
Product
1-Methylpiperazin 109-01-3
Price
US $8.00-0.80/KG
Min. Order
1KG
Purity
99%
Supply Ability
g-kg-tons, free sample is available
Release date
2024-01-22
Hebei Yanxi Chemical Co., Ltd.
Product
1-Methylpiperazine 109-01-3
Price
US $50.00/kg
Min. Order
1kg
Purity
0.99
Supply Ability
10000
Release date
2023-09-18

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