ChemicalBook > CAS DataBase List > 1-Methylpiperazine

1-Methylpiperazine

Product Name
1-Methylpiperazine
CAS No.
109-01-3
Chemical Name
1-Methylpiperazine
Synonyms
N-METHYLPIPERAZINE;methylpiperazine;NMPRZ;4-Methylpiperazine;N-Methylpiperazin;Piperazine,1-methyl-;CL046;AKOS BBS-00003665;1-methyl-piperazin;METHYLPIPERAZINE-N
CBNumber
CB4478526
Molecular Formula
C5H12N2
Formula Weight
100.16
MOL File
109-01-3.mol
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1-Methylpiperazine Property

Melting point:
-6 °C
Boiling point:
138 °C(lit.)
Density 
0.903 g/mL at 25 °C(lit.)
vapor density 
3.5 (vs air)
vapor pressure 
12 hPa (20 °C)
refractive index 
n20/D 1.466(lit.)
Flash point:
108 °F
storage temp. 
2-8°C
solubility 
Chloroform (Soluble), Methanol (Soluble)
pka
pK1:4.94(+2);pK2:9.09(+1) (25°C,μ=0.1)
form 
Liquid
Specific Gravity
0.903
color 
Clear
PH
11-12 (50g/l, H2O, 20℃)
explosive limit
1.2-9.9%(V)
Water Solubility 
soluble
Sensitive 
Hygroscopic
BRN 
102724
InChIKey
PVOAHINGSUIXLS-UHFFFAOYSA-N
LogP
-0.57 at 25℃
Surface tension
30.65mN/m at 298.15K
CAS DataBase Reference
109-01-3(CAS DataBase Reference)
NIST Chemistry Reference
Piperazine, 1-methyl-(109-01-3)
EPA Substance Registry System
Piperazine, 1-methyl- (109-01-3)
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Safety

Hazard Codes 
T,F,C,Xi
Risk Statements 
10-21-23-34-36/37/38-20/21
Safety Statements 
16-26-36/37/39-45-36
RIDADR 
UN 2734 8/PG 2
WGK Germany 
2
RTECS 
TM1225000
Autoignition Temperature
320 °C
Hazard Note 
Flammable/Toxic/Corrosive/Store under nitrogen
TSCA 
Yes
HazardClass 
3
PackingGroup 
III
HS Code 
29335995
Toxicity
LD50 orally in Rabbit: 2547 mg/kg LD50 dermal Rabbit 1341 mg/kg
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H226Flammable liquid and vapour

H312Harmful in contact with skin

H314Causes severe skin burns and eye damage

H331Toxic if inhaled

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P370+P378In case of fire: Use … for extinction.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
Y0000886
Product name
Cyclizine impurity A
Purity
European Pharmacopoeia (EP) Reference Standard
Packaging
15 mg
Price
$156
Updated
2025/07/31
Sigma-Aldrich
Product number
8.05859
Product name
1-Methylpiperazine
Purity
for synthesis
Packaging
5ml
Price
$35.9
Updated
2025/07/31
Sigma-Aldrich
Product number
BP1118
Product name
1-Methylpiperazine
Purity
British Pharmacopoeia (BP) Reference Standard
Packaging
15MG
Price
$234
Updated
2025/07/31
Sigma-Aldrich
Product number
8.05859
Product name
1-Methylpiperazine
Purity
for synthesis
Packaging
250ML
Price
$123
Updated
2025/07/31
Sigma-Aldrich
Product number
130001
Product name
1-Methylpiperazine
Purity
99%
Packaging
5g
Price
$37.6
Updated
2025/07/31
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1-Methylpiperazine Chemical Properties,Usage,Production

Chemical Properties

clear liquid

Uses

1-Methylpiperazine is used in the preparation of 2-(4-Methyl-1-piperazinylmethyl)acrylophenone(MPMAP)

Uses

1-Methylpiperazine is used in the preparation of 2-(4-methyl-1-piperazinylmethyl)acrylophenone. It is involved in the preparation of 1-(4-methoxy-phenyl)-4-methyl-piperazine by reacting with 1-chloro-4-methoxy-benzene. It acts as an intermediate in the synthesis of active pharmaceutical ingredients like ofloxacin, rifampicin, clozapine, sildenafil, trifluoperazine and zopiclone. Further, it is used as a mimic template in the preparation of molecularly imprinted microspheres. In addition to this, it is used in the generation of difunctional strong anion-exchange stationary phase from a 1,4-diazacyclohexane derivative.

Definition

ChEBI: 1-Methylpiperazine is a N-methylpiperazine.

Hazard

Moderate fire risk.

Flammability and Explosibility

Flammable

Safety Profile

Poison by intraperitoneal route. Moderately toxic by inhalation, ingestion, and skin contact. A severe skin and eye irritant. Flammable liquid when exposed to heat or flame; can react with oxidizing materials. To fight fire, use alcohol foam, CO2, dry chemical. When heated to decomposition it emits toxic fumes of NOx.

1-Methylpiperazine Preparation Products And Raw materials

Raw materials

PIPERAZINE DIHYDROCHLORIDE PIPERAZINE HEXAHYDRATE Carbon dioxide Piperazine Methanol

Preparation Products

AZIMILIDE 3-(4-Methylpiperazin-1-yl)aniline 2-(4-Methylpiperazin-1-yl)pyrimidine-5-carbaldehyde 2-(4-Methylpiperazin-1-yl)-6-(trifluoromethyl)pyrimidine-4-carbonitrile 1-Amino-4-methylpiperazine Zopiclone 1-METHYLPIPERAZINE DIHYDROCHLORIDE 2-(4-Methylpiperazin-1-yl)pyrimidine-5-carbonyl chloride 2-(4-Methylpiperazin-1-yl)-6-(trifluoromethyl)pyrimidine-4-carboxamide (2-(4-Methylpiperazin-1-yl)-6-(trifluoromethyl)pyrimidin-4-yl)methanamine 3-(4-Methylpiperazin-1-ylmethyl)benzoic acid 2-(4-Methylpiperazin-1-yl)pyrimidine-5-carboxylic acid 2-(4-Methylpiperazin-1-yl)pyrimidine-5-carbonitrile Chlorcyclizine hydrochloride Levofloxacin (3,4-DIAMINO-PHENYL)-(4-METHYL-PIPERAZIN-1-YL)-METHANONE 2-(4-Methylpiperazin-1-yl)pyrimidine-5-carboxamide (2-(4-Methylpiperazin-1-yl)-6-(trifluoromethyl)pyrimidin-4-yl)methanol Ethyl 2-(4-methylpiperazin-1-yl)pyrimidine-5-carboxylate 3-[(4-METHYLPIPERAZIN-1-YL)METHYL]BENZALDEHYDE (4-METHYL-PIPERAZIN-1-YL)-ACETIC ACID Ethyl 2-(4-methylpiperazin-1-yl)-6-(trifluoromethyl)pyrimidine-4-carboxylate 3-Hydrazinyl-1-(4-methylpiperazin-1-yl)propan-1-one CHLORCYCLIZINE 2-(4-Methylpiperazin-1-yl)pyrimidin-5-amine 1-AdaMantanethylaMine 1-FORMYL-4-METHYLPIPERAZINE 4-(4-METHYLPIPERAZINOMETHYL)BENZOIC ACID (2-(4-Methylpiperazin-1-yl)pyrimidin-5-yl)methanol 2-(4-Methylpiperazin-1-yl)-6-(trifluoromethyl)pyrimidine-4-carbaldehyde Clozapine 1-METHYL-4-(3-NITROPHENYL)PIPERAZINE 4-[(4-Methylpiperazin-1-yl)methyl]aniline 2-(4-Methylpiperazin-1-yl)-6-(trifluoromethyl)pyrimidine-4-carboxylic acid 2-(4-Methylpiperazin-1-yl)-6-(trifluoromethyl)pyrimidin-4-amine 4-(4-Methylpiperazino)aniline 1-METHYL-4-(4-NITROPHENYL)PIPERAZINE 2-Hydrazinyl-1-(4-methylpiperazin-1-yl)ethanone 1-METHYL-4-(4-NITROBENZYL)PIPERAZINE 1-methyl-4-nitrosopiperazine
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View Lastest Price from 1-Methylpiperazine manufacturers

Hebei Chuanghai Biotechnology Co., Ltd
Product
1-Methylpiperazine 109-01-3
Price
US $10.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
10 mt
Release date
2024-11-22
Sinoway Industrial co., ltd.
Product
1-Methylpiperazine 109-01-3
Price
US $0.00/Kg/Bag
Min. Order
2Kg/Bag
Purity
99% up, High Density
Supply Ability
20 tons
Release date
2023-10-19
Hebei Yanxi Chemical Co., Ltd.
Product
1-Methylpiperazine 109-01-3
Price
US $50.00/kg
Min. Order
1kg
Purity
0.99
Supply Ability
10000
Release date
2023-09-18

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