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N-Methylpiperidine

Product Name
N-Methylpiperidine
CAS No.
626-67-5
Chemical Name
N-Methylpiperidine
Synonyms
1-METHYLPIPERIDINE;NMPPR;N-MEPIP;lk20;1-Pipecoline;piperidine soL;1-METHYLPIPERDINE;N-METHYLPIPERIDINE;1-methyl-piperidin;N-methylpepiridine
CBNumber
CB3260320
Molecular Formula
C6H13N
Formula Weight
99.17
MOL File
626-67-5.mol
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N-Methylpiperidine Property

Melting point:
-50 °C
Boiling point:
106-107 °C (lit.)
Density 
0.816 g/mL at 25 °C (lit.)
vapor pressure 
35.7hPa at 20℃
refractive index 
n20/D 1.438
Flash point:
38 °F
storage temp. 
−20°C
solubility 
Chloroform (Sparingly), Methanol (Slightly)
pka
10.08(at 25℃)
form 
Liquid
color 
Clear colorless
PH
12 (100g/l, H2O, 20℃)
explosive limit
1.1-9.9%(V)
Water Solubility 
miscible
BRN 
1073
Dielectric constant
2.5899999999999999
LogP
1.15 at 25℃
CAS DataBase Reference
626-67-5(CAS DataBase Reference)
NIST Chemistry Reference
Piperidine, 1-methyl-(626-67-5)
EPA Substance Registry System
Piperidine, 1-methyl- (626-67-5)
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Safety

Hazard Codes 
C,F,T
Risk Statements 
11-34-20/22-39/23/24/25-23/24/25-67-22-10-37
Safety Statements 
7-16-26-36/37/39-45-9-33
RIDADR 
UN 3286 3/PG 2
WGK Germany 
3
RTECS 
TN1225000
3-10
TSCA 
Yes
HazardClass 
3
PackingGroup 
II
HS Code 
29333999
Toxicity
LD50 intraperitoneal in mouse: 400mg/kg
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H225Highly Flammable liquid and vapour

H314Causes severe skin burns and eye damage

H331Toxic if inhaled

H412Harmful to aquatic life with long lasting effects

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P273Avoid release to the environment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
M72609
Product name
N-Methylpiperidine
Purity
99%
Packaging
100ml
Price
$37.9
Updated
2024/03/01
Sigma-Aldrich
Product number
M72609
Product name
N-Methylpiperidine
Purity
99%
Packaging
500ml
Price
$145
Updated
2024/03/01
TCI Chemical
Product number
M0403
Product name
1-Methylpiperidine
Purity
>99.0%(GC)
Packaging
25mL
Price
$16
Updated
2024/03/01
TCI Chemical
Product number
M0403
Product name
1-Methylpiperidine
Purity
>99.0%(GC)
Packaging
500mL
Price
$120
Updated
2024/03/01
Alfa Aesar
Product number
L03398
Product name
1-Methylpiperidine, 99%
Packaging
10g
Price
$27.65
Updated
2024/03/01
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N-Methylpiperidine Chemical Properties,Usage,Production

Description

This simple piperidine derivative has been obtained from Girgensohnia diptera Bge. It is optically inactive and furnishes a crystalline picrate, m.p. 15 I-2°C and a picrolonate, m.p. 226°C.

Chemical Properties

CLEAR COLOURLESS LIQUID

Uses

Reactant for: ·sp3 C-H Bond activation with ruthenium(II) catalysts and C(3)-alkylation of cyclic amines ·One-pot synthesis of Z-cinnamic acids Reactant for synthesis of: ·Unsymmetrical ureas ·Antibacterial imidazolium, pyrrolidinium, and piperidinium salts ·C1-C16 segment of goniodomin A via palladium-catalyzed organostannane thioester coupling ·Multi-targeted inhibitors of insulin-like growth factor-1 receptor and members of ErbB-family receptor kinases

Uses

1-Methylpiperidine is a reactant for sp3 C-H Bond activation with ruthenium(II) catalysts and C(3)-alkylation of cyclic amines, One-pot synthesis of Z-cinnamic acids. It is used in the synthesis of Unsymmetrical ureas, Antibacterial imidazolium, pyrrolidinium, and piperidinium salts, C1-C16 segment of goniodomin A via palladium-catalyzed organostannane thioester coupling.

Uses

Reactant for:

  • sp3 C-H Bond activation with ruthenium(II) catalysts and C(3)-alkylation of cyclic amines
  • One-pot synthesis of Z-cinnamic acids

Reactant for synthesis of:
  • Unsymmetrical ureas
  • Antibacterial imidazolium, pyrrolidinium, and piperidinium salts
  • C1-C16 segment of goniodomin A via palladium-catalyzed organostannane thioester coupling
  • Multi-targeted inhibitors of insulin-like growth factor-1 receptor and members of ErbB-family receptor kinases

General Description

A colorless liquid with the odor of pepper. Density 0.816 g / cm3 and flash point 38°F. May irritate skin and eyes. Vapors heavier than air. Used as a solvent and to make other chemicals.

Air & Water Reactions

Highly flammable. Soluble in water.

Reactivity Profile

N-Methylpiperidine neutralizes acids in exothermic reactions to form salts plus water. May be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen may be generated in combination with strong reducing agents, such as hydrides.

Health Hazard

May cause toxic effects if inhaled or ingested/swallowed. Contact with substance may cause severe burns to skin and eyes. Fire will produce irritating, corrosive and/or toxic gases. Vapors may cause dizziness or suffocation. Runoff from fire control or dilution water may cause pollution.

Fire Hazard

Flammable/combustible material. May be ignited by heat, sparks or flames. Vapors may form explosive mixtures with air. Vapors may travel to source of ignition and flash back. Most vapors are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements, tanks). Vapor explosion hazard indoors, outdoors or in sewers. Runoff to sewer may create fire or explosion hazard. Containers may explode when heated. Many liquids are lighter than water.

Flammability and Explosibility

Highly flammable

Safety Profile

Poison by intraperitoneal and subcutaneous routes. A very dangerous fire hazard when exposed to heat or flame. When heated to decomposition it emits toxic fumes of NOx.

References

Jurashevskii, Stepanov,J. Gen. Chem. USSR, 9,2203 (1939)

N-Methylpiperidine Preparation Products And Raw materials

Raw materials

Preparation Products

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N-Methylpiperidine Suppliers

Shanghai LanRun Chemical Co., Ltd.
Tel
021-69515658 ; 69515628 13701998368
Fax
021-69515998
Email
longrunchem@163.com
Country
China
ProdList
3921
Advantage
50
3B Pharmachem (Wuhan) International Co.,Ltd.
Tel
821-50328103-801 18930552037
Fax
86-21-50328109
Email
3bsc@sina.com
Country
China
ProdList
15848
Advantage
69
Alfa Aesar
Tel
400-6106006
Fax
021-67582001/03/05
Email
saleschina@alfa-asia.com
Country
China
ProdList
30132
Advantage
84
TCI (Shanghai) Development Co., Ltd.
Tel
021-67121386
Fax
021-67121385
Email
Sales-CN@TCIchemicals.com
Country
China
ProdList
24539
Advantage
81
Energy Chemical
Tel
021-021-58432009 400-005-6266
Fax
021-58436166
Email
sales8178@energy-chemical.com
Country
China
ProdList
44751
Advantage
61
Capot Chemical Co., Ltd
Tel
+86 (0) 571 85 58 67 18
Fax
0086-571-85864795
Email
sales@capotchem.com
Country
China
ProdList
18217
Advantage
66
Beijing Ouhe Technology Co., Ltd
Tel
010-82967028 13552068683
Fax
+86-10-82967029
Email
2355560935@qq.com
Country
China
ProdList
12426
Advantage
60
JinYan Chemicals(ShangHai) Co.,Ltd.
Tel
13817811078
Fax
86-021-50426522,50426273
Email
sales@jingyan-chemical.com
Country
China
ProdList
9984
Advantage
60
Shanghai Hanhong Scientific Co.,Ltd.
Tel
021-54306202 13764082696;
Email
info@hanhongsci.com
Country
China
ProdList
42982
Advantage
64
Shanghai Ennopharm Co., Ltd.
Tel
+86 (21) 6435-5022
Country
China
ProdList
4271
Advantage
65
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View Lastest Price from N-Methylpiperidine manufacturers

Hebei Guanlang Biotechnology Co,.LTD
Product
N-Methylpiperidine 626-67-5
Price
US $10.00/KG
Min. Order
1KG
Purity
95%
Supply Ability
10 ton
Release date
2023-03-24
Zhuozhou Wenxi import and Export Co., Ltd
Product
N-Methylpiperidine 626-67-5
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-06-27
Hebei Miaobian Biotechnology Co., Ltd
Product
N-Methylpiperidine 626-67-5
Price
US $10.00/KG
Min. Order
1KG
Purity
99.99
Supply Ability
10Ton
Release date
2021-03-16

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