(1R,3s,5S)-3-(3-Isopropyl-5-methyl-4H-1,2,4-triazol-4-yl)-8-azabicyclo[3.2.1]octane

Product Name: (1R,3s,5S)-3-(3-Isopropyl-5-methyl-4H-1,2,4-triazol-4-yl)-8-azabicyclo[3.2.1]octane
CAS No.: 423165-07-5
Chemical Name: (1R,3s,5S)-3-(3-Isopropyl-5-methyl-4H-1,2,4-triazol-4-yl)-8-azabicyclo[3.2.1]octane
Synonyms: UK 408027;Maraviroc Intermediate 2;Maraviroc interMediate(Tropinone);(1R,3s,5S)-3-(3-Isopropyl-5-methyl-4H-1,2,4-triazol-4-yl)-8-...;Des[1-(4,4-difluorocyclohexanecarboxamido)-1-phenylpropyl] Maraviroc;3-(3-isopropyl-5-methyl-4H-1,2,4-triazol-4-yl)-8-azabicyclo[3.2.1]octane;exo-3-(3-Isopropyl-5-methyl-4H-1,2,4-triazol-4-yl)-8-azabicyclo[3.2.1]octane;3-(3-Isopropyl-5-methyl-4H-1,2,4-triazol-4-yl)-exo-8-azabicyclo[3.2.1]octane;(1R,5S)-3-(3-methyl-5-propan-2-yl-1,2,4-triazol-4-yl)-8-azabicyclo[3.2.1]octane;(3-exo)-3-(3-Isopropyl-5-methyl-4H-1,2,4-triazol-4-yl]-8-azabicyclo[3.2.1]octane
CBNumber: CB31564885
Molecular Formula: C13H22N4
Formula Weight: 234.35
MOL File: 423165-07-5.mol

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(1R,3s,5S)-3-(3-Isopropyl-5-methyl-4H-1,2,4-triazol-4-yl)-8-azabicyclo[3.2.1]octane Property

Melting point:: 117 ºC
Boiling point:: 402.4±55.0 °C(Predicted)
Density: 1.31
storage temp.: Keep in dark place,Inert atmosphere,2-8°C
solubility: Chloroform
form: Solid
pka: 10.71±0.40(Predicted)
color: Off-White to Pale Yellow
InChI: InChI=1/C13H22N4/c1-8(2)13-16-15-9(3)17(13)12-6-10-4-5-11(7-12)14-10/h8,10-12,14H,4-7H2,1-3H3/t10-,11+,12-
InChIKey: CEIRCCADSFHOQD-ZSBIGDGJNA-N
SMILES: C(C1=NN=C(C)N1[C@@H]1C[C@H]2CC[C@H](N2)C1)(C)C |&1:7,9,12,r|

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Safety

HS Code: 2933592000

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: D288810
Product name: Des[1-(4,4-difluorocyclohexanecarboxamido)-1-phenylpropyl]Maraviroc
Packaging: 10mg
Price: $235
Updated: 2021/12/16

AK Scientific

Product number: 5843AB
Product name: (1R,3s,5S)-3-(3-Isopropyl-5-methyl-4H-1,2,4-triazol-4-yl)-8-azabicyclo[3.2.1]octane
Packaging: 5g
Price: $437
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: APN0000582
Product name: MARAVIROC INTERMEDIATE
Purity: 95.00%
Packaging: 1MG
Price: $837.38
Updated: 2021/12/16

Medical Isotopes, Inc.

Product number: 8909
Product name: Des[1-(4,4-difluorocyclohexanecarboxamido)-1-phenylpropyl]Maraviroc
Packaging: 1mg
Price: $975
Updated: 2021/12/16

Ark Pharm

Product number: AK103286
Product name: exo-3-(3-Isopropyl-5-methyl-4H-1,2,4-triazol-4-yl)-8-azabicyclo[3.2.1]octane
Purity: 95+%
Packaging: 100mg
Price: $60
Updated: 2021/12/16

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(1R,3s,5S)-3-(3-Isopropyl-5-methyl-4H-1,2,4-triazol-4-yl)-8-azabicyclo[3.2.1]octane Chemical Properties,Usage,Production

Chemical Properties

Off-White to Pale Yellow Solid

Uses

A metabolite of Maraviroc.

Synthesis

A solution of 8-benzyl-3-(3-isopropyl-5-methyl-[1,2,4]triazol-4-yl)-8-aza-bicyclo[3.2.1]octane (2.0 g, 6.17 mmol) in methanol (30 mL) was treated with 10% palladium on carbon (0.25 g) under a hydrogen atmosphere (50 psi) at ambient temperature, overnight. The mixture was filtered through a pad of Celite and the filtrate was concentrated to give (1R,3s,5S)-3-(3-Isopropyl-5-methyl-4H-1,2,4-triazol-4-yl)-8-azabicyclo[3.2.1]octane. Yield: 1.36 g (94%).

(1R,3s,5S)-3-(3-Isopropyl-5-methyl-4H-1,2,4-triazol-4-yl)-8-azabicyclo[3.2.1]octane Preparation Products And Raw materials

Raw materials

Preparation Products

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(1R,3s,5S)-3-(3-Isopropyl-5-methyl-4H-1,2,4-triazol-4-yl)-8-azabicyclo[3.2.1]octane Suppliers

Canada 1 China 90 Germany 1 India 7 United Kingdom 1 United States 4 Global 104

Yaopu(Shanghai) Pharmaceutical Technology Co., Ltd

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Shanghai T&W Pharmaceutical Co., Ltd.

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Biocompounds Pharmaceutical Inc.

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View Lastest Price from (1R,3s,5S)-3-(3-Isopropyl-5-methyl-4H-1,2,4-triazol-4-yl)-8-azabicyclo[3.2.1]octane manufacturers

Hebei Yanxi Chemical Co., Ltd.

Product: (1R,3s,5S)-3-(3-Isopropyl-5-methyl-4H-1,2,4-triazol-4-yl)-8-azabicyclo[3.2.1]octane 423165-07-5
Price: US $0.00/kg
Min. Order: 1kg
Purity: 0.99
Supply Ability: 20tons
Release date: 2023-10-07

Henan Fengda Chemical Co., Ltd

Product: (1R,3s,5S)-3-(3-Isopropyl-5-methyl-4H-1,2,4-triazol-4-yl)-8-azabicyclo[3.2.1]octane 423165-07-5
Price: US $101.00-1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: g-kg-tons, free sample is available
Release date: 2023-12-28

Honest Joy Holdings Limited

Product: (1R,3s,5S)-3-(3-Isopropyl-5-methyl-4H-1,2,4-triazol-4-yl)-8-azabicyclo[3.2.1]octane 423165-07-5
Price: US $0.00/KG
Min. Order: 1KG
Purity: 98.8%
Supply Ability: 100 tons
Release date: 2022-01-17

423165-07-5, (1R,3s,5S)-3-(3-Isopropyl-5-methyl-4H-1,2,4-triazol-4-yl)-8-azabicyclo[3.2.1]octaneRelated Search:

Bensulfuron methyl Thiophanate-methyl ISOPROPYL LAURATE Isopropyl alcohol 2,2,4-Trimethylpentane 1-OCTANESULFONIC ACID, SODIUM SALT, MONOHYDRATE N-OCTANE 1-Bromooctane Methyl acrylate Methylparaben Kresoxim-methyl Methyl Methyl bromide 6-ACETHYOXY-8-METHYL-8-AZABICYCLO(3.2.1)OCTAN-3-ONE 2-CARBOMETHOXY-3-TROPINONE (+/-)-exo-6-Hydroxytropinone N-Carbethoxy-4-tropinone N-Boc-Nortropinone

(3-Exo)-3-[3-methyl-5-(1-methylethyl)-4H-1,2,4-triazol-4-yl] -8-Azabicyclo[3.2.1]octane

Des[1-(4,4-difluorocyclohexanecarboxamido)-1-phenylpropyl] Maraviroc

UK 408027

(1R,3s,5S)-3-(3-Isopropyl-5-methyl-4H-1,2,4-triazol-4-yl)-8-azabicyclo[3.2.1]octane

8-Azabicyclo[3,2,1]octane3-[3-methyl-5-(1-methlethyl)-4H-1,2,4-triazol-4-yl]-, (3-exo)-

Maraviroc Intermediate 2

Maraviroc interMediate(Tropinone)

(3-exo)-3-(3-Isopropyl-5-methyl-4H-1,2,4-triazol-4-yl]-8-azabicyclo[3.2.1]octane

(3-exo)-3-[3-Methyl-5-(prop-2-yl)-4H-1,2,4-triazol-4-yl]-8-azabicyclo[3.2.1]octane, 4-[(3-exo)-8-Azabicyclo[3.2.1]oct-3-yl]-3-isopropyl-5-methyl-4H-1,2,4-triazole

(1R,3s,5S)-rel-3-(3-Isopropyl-5-methyl-4H-1,2,4-triazol-4-yl)-8-azabicyclo[3.2.1]octane

exo-3-(3-Isopropyl-5-methyl-4H-1,2,4-triazol-4-yl)-8-azabicyclo[3.2.1]octane

3-(3-isopropyl-5-methyl-4H-1,2,4-triazol-4-yl)-8-azabicyclo[3.2.1]octane

8-Azabicyclo[3.2.1]octane, 3-[3-methyl-5-(1-methylethyl)-4H-1,2,4-triazol-4-yl]-, (3-exo)-

(1R,5S)-3-(3-methyl-5-propan-2-yl-1,2,4-triazol-4-yl)-8-azabicyclo[3.2.1]octane

(1R,3s,5S)-3-(3-Isopropyl-5-methyl-4H-1,2,4-triazol-4-yl)-8-...

3-(3-Isopropyl-5-methyl-4H-1,2,4-triazol-4-yl)-exo-8-azabicyclo[3.2.1]octane

423165-07-5

Chiral Reagents

Metabolites & Impurities