Methyl bromide Property
- Melting point:
- −94 °C(lit.)
- Boiling point:
- 4 °C(lit.)
- 3.3 g/mL at 25 °C(lit.)
- vapor density
- 3.3 (20 °C, vs air)
- vapor pressure
- 1420 mm Hg ( 20 °C)
- refractive index
- Flash point:
- -34 °C
- storage temp.
- water: soluble
- Colorless gas
- explosive limit
- Water Solubility
- 1.522 g/100 mL
- Henry's Law Constant
- 0.72 at 21 °C (Gan and Yates, 1996)
- Exposure limits
- NIOSH REL: IDLH 250 ppm; OSHA PEL: C 20 ppm; ACGIH TLV: TWA 5 ppm.
- Stable. Incompatible with oxidizing agents, strong acids. This is an ozone-depleting chemical, and its use is restricted in many countries.
- CAS DataBase Reference
- 74-83-9(CAS DataBase Reference)
- 3 (Vol. 41, Sup 7, 71) 1999
- NIST Chemistry Reference
- Methyl bromide(74-83-9)
- EPA Substance Registry System
- Methyl bromide (74-83-9)
- Hazard Codes
- Risk Statements
- Safety Statements
- UN 1062 2.3
- WGK Germany
- DOT Classification
- 2.3, Hazard Zone C (Gas poisonous by inhalation)
- HS Code
- Hazardous Substances Data
- 74-83-9(Hazardous Substances Data)
- LC for rats in air (6 hrs): 514 ppm (Irish)
- Signal word
- Hazard statements
H225Highly Flammable liquid and vapour
H280Contains gas under pressure; may explode if heated
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
H336May cause drowsiness or dizziness
H341Suspected of causing genetic defects
H370Causes damage to organs
H373May cause damage to organs through prolonged or repeated exposure
H400Very toxic to aquatic life
H420Harms public health and the environment by destroying ozone in the upper atmosphere
- Precautionary statements
P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P273Avoid release to the environment.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P281Use personal protective equipment as required.
P311Call a POISON CENTER or doctor/physician.
P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P370+P378In case of fire: Use … for extinction.
P403+P235Store in a well-ventilated place. Keep cool.
- Product number
- Product name
- Bromomethane solution
- certified reference material, 200?μg/mL in methanol
Methyl bromide Chemical Properties,Usage,Production
Methyl bromide (CH3Br) is a halogenated aliphatic hydrocarbon. It is a colorless gas at room temperature and standard pressure.It is 3 times heavier than air. It is odorless except at high concentrations, when it has a burning taste and sweet, chloroformlike smell. Commercially, it is available as a liquefied gas. Some formulations also contain chloropicrin or amyl acetate as a warning agent.
Methyl bromide has been used to treat dry packaged foods in mills and warehouses as well as used as a soil fumigant to control nematodes and fungi.
Methyl bromide was used as an anesthetic in the early 1900s, but fatalities halted this practice. Today, methyl bromide is used widely as a fumigant for all types of dry food stuffs, in grain elevators, mills, ships, warehouses, green-houses, and food-processing facilities for the control of nematodes, fungi, and weeds. It is also used as an insecticide, fire extinguisher, and refrigerant, although its domestic use was banned in 1987. Methyl bromide is also used as a methylating chemical in manufacturing and as a low-boiling solvent for extracting oils from nuts, seeds, and flowers. It is termed a structural or commodity fumigant, which is a class term from the Environmental Protection Agency.
Historically, poisonings involving the general public were mainly associated with the methyl bromide used in fire extinguishers. Other poisoning involved unauthorized entry into buildings being fumigated with methyl bromide.
Methyl bromide has a threshold limit value–time weighted average (TLV-TWA) of 5 ppm and the IDLH concentration is 2,000 ppm. The Occupational Safety and Health Administration (OSHA) permissible exposure limit is 20 ppm.
Methyl bromide is very irritating to the lower respiratory tract. It is thought that the parent compound is responsible for the toxicity of the methyl bromide, with the mechanism of toxicity possibly having to do with its ability to methylate sulfhydryl enzymes. Exposure to high concentrations of methyl bromide can lead to pulmonary edema or hemorrhage, and typically of delayed onset (several hours after exposure). Symptoms of acute intoxication include those consistent with central nervous system depression such as headache, dizziness, throat irritation, nausea, cough visual disturbances, vomiting, and ataxia. Exposures to very high concentrations can lead to unconsciousness. In cases of exposure to fatal levels of methyl bromide, death typically occurs within 4–6h to 1–2 days postexposure, with the cause of death being respiratory or cardiovascular failure resulting from pulmonary edema. Dermal exposure to liquid methyl bromide can cause skin damage in the form of burning, itching, and blistering. Treatment of methyl bromide poisoning is symptomatic and also includes removal of contaminated clothing. The USEPA Office of Pesticide Programs has classified methyl bromide as Not Likely to be Carcinogenic in Humans.
The mode of action of methyl bromide is still not understood. Several mechanisms of toxicity are postulated, including the direct cytotoxic effect of the intact methyl bromide molecule or toxicity due to one of its metabolites.
Methyl bromide is a potent alkylating agent with high affinity for sulfhydryl and amino groups. It reacts in vitro with a number of sulfhydrylcontaining enzymes and causes irreversible inhibition of microsomal metabolism. It binds to amine groups in amino acids, interfering with protein synthesis and function. Also it may methylate many other cellular components such as GSH, proteins, DNA, and RNA.The methanethiol and formaldehyde metabolites may have a role in neurologic and visual changes. The bromide ion concentrations are insufficient to explain methyl bromide toxicity.
Methyl bromide is a colorless liquid or gas with
practically no odor. It is a poisonous gas at
room temperature and atmospheric pressure. At
high concentrations, it has a chloroform-like
odor. Detection of lower concentrations is often
facilitated by a warning odorant, chloropicrin,
which is added by the manufacturer.
Methyl bromide is flammable only in the range of 10 percent to 16 percent by volume in air. Its physical properties do not meet the definition of a flammable gas as defined by DOT and TC. The onset of thermal decomposition occurs at approximately 752°F (400°C).
Methyl bromide is a colorless gas with a chloroform-like odor at high concentrations. A liquid below 3.3C. Shipped as a liquefied compressed gas.
Colorless liquid or gas with an odor similar to chloroform at high concentrations. Ruth (1986) reported odor threshold concentrations ranging from 80 to 4,000 mg/m3.
An organic compound, present in the atmosphere as the result of both natural (oceanic production) and anthropogenic (use as a soil fumigant) sources; this compound is the largest single source of bromine to the stratosphere, with a tropospheric mixing ratio of about 10 parts per trillion (by volume).
The primary pre-harvest uses of methyl bromide are as fumigant to control a broad spectrum of insects, nematodes, bacteria, fungi and weeds in grapes, vegetables and strawberries cultivation. Major postharvest use is in the quarantine control of agricultural commodities such as the disinfestation of potatoes and tomatoes.
Methyl bromide is used as a fumigant forpest control, for degreasing wool, and as a methylating agent. Its use as a refrigerant andin fire extinguishers is restrained because ofits health hazards.
The commercial manufacture of methyl bromide is based on the reaction of hydrogen bromide with methanol. The hydrogen bromide used could be generated in situ from bromine and a reducing agent. The uses of sulfur or hydrogen sulfide as reducing agents are described, the latter process having the advantage. A new continuous process for the production of methyl bromide from methanol and aqueous HBr in the presence of a silica supported heteropolyacid catalyst has recently been described. Methyl bromide can also be coproduced with other organic bromine compounds by the reaction of the methanol solvent with hydrogen bromide formed as a by-product. The processes include coproduction of methyl bromide with bromostyrenes, tribromophenol, potassium and sodium bromide, and especially tetrabromo bisphenol A.
ChEBI: A one-carbon compound in which the carbon is attached by single bonds to three bromine atoms and one hydrogen atom. It is produced naturally by marine algae.
Methyl bromide is present in the atmosphere as the result of both natural (oceanic production) and anthropogenic (use as a soil fumigant) sources; this compound is the largest single source of bromine to the stratosphere, with a tropospheric mixing ratio of about 10 parts per trillion (by volume). Methyl bromide reacts with several nucleophiles and is a useful methylation agent for the preparation of ethers, sulfides, amines, etc. Tertiary amines are methylated by methyl bromide to form quaternary ammonium bromides. The reactivity of methyl bromide is summarized in Figure 1.图
Journal of the American Chemical Society, 75, p. 1148, 1953. Applications of the Hunsdiecker Silver Salt Degradation. The Preparation of Dibromides and Tribromides. DOI: 10.1021/ja01101a041
Colorless highly toxic volatile liquid or a gas. Boiling point 3.56°C (38.41°F). Usually odorless, but has a sweetish chloroform-like odor at high concentrations. Used as an insecticide, a rodenticide, a fumigant, a nematocide, a chemical intermediate and as a fire extinguishing agent.
Air & Water Reactions
Nonflammable over a wide range of concentrations in air. Slightly soluble in water (about 1.75 g/100 mL of solution at 20° C). Reacts slowly with water to give methyl alcohol and hydrobromic acid. [K-O Vol. 4].
Methyl bromide is incompatible with metals, dimethyl sulfoxide, ethylene oxide. [Lewis]. Can give flammable products if mixed with potassium hydroxide, sodium hydroxide and other strong bases. Methyl bromide in a steel tank reacted with an aluminum tube (part of the level gauge) producing methyl aluminum bromide. When the latter was subsequently exposed to air, enough heat was produced to ignite the Methyl bromide -compressed air mixture above the liquid layer. The ensuing explosion shattered the tank (also incompatible with zinc, magnesium, and alloys)[Chem. Eng. Pro. 58(8). 1962]. A reaction between Methyl bromide and dimethyl sulfoxide resulted in an explosion that shattered the apparatus [NFPA 491M. 1991].
Toxic by ingestion, inhalation, and skin absorption; strong irritant to skin and upper respiratory tract. Questionable carcinogen.
Methyl bromide is a dangerous cumulative poison with delayed symptoms of central nervous system intoxication that may appear as long as several months after exposure. High concentrations can produce fatal pulmonary edema. Chronic exposure can cause central nervous system depression and kidney injury. It may cause severe and permanent brain damage. Severe neurological signs may appear when there is a sudden exposure to high concentrations following continuous slight exposure. Methyl bromide has practically no odor or irritating effects and therefore no warning, even at hazardous concentrations.
When heated to decomposition, Methyl bromide emits toxic fumes of bromides. Hazardous polymerization may not occur.
Fumigant, Herbicide, Insecticide, Nematicide: The primary use of methyl bromide is as an insect fumigant to control insects, nematodes, weeds and pathogens in more than 100 crops and for soil, grain storage, warehouses, mills, ships, etc. Use of methyl bromide in the U.S. will be phased out under the requirements of the Montreal Protocol, with some exemptions. Methyl bromide is also used as a chemical intermediate and a methylating agent, a refrigerant, a herbicide, a fire-extinguishing agent, a low-boiling solvent in aniline dye manufacture, for degreasing wool, for extracting oils from nuts, seeds, and flowers, and in ionization chambers. It is used as an intermediate in the manufacture of many drugs. A U.S. EPA restricted Use Pesticide (RUP), NO INERT. Still actively registered for use in the U.S. (2013). As of March 18, 2005, the use of methyl bromide in the EU was banned for most purposes, including quarantine and pre-shipment fumigations.Registered for use in the U.S.
BROM-O-GAS®; BROM-OSOL ®; DAWSON® 100; DOWFUME®; EDCO®; EMBAFUME®; HALON 1001®; ISCOBROME®; KAYAFUME®; MATABROM®; METHO-GAS®; M-B-C FUMIGANT®; R 40B1®; ROTOX®; TERABOL®; TERR-O-GAS®; ZYTOX®
Dry methyl bromide is inert and noncorrosive in the presence of most structural metals. However, in the presence of impurities such as alcohols and water, reactions will take place on zinc, tin, and iron surfaces. Aluminum and its alloys should not be used for methyl bromide service because of the formation of trimethyl aluminum, which is pyrophoric.
Suspected carcinogen with experimental carcinogenic data. A human poison by inhalation. Human systemic effects by inhalation: anorexia, nausea or vomiting. Corrosive to skin; can produce severe burns. Human mutation data reported. A powerful fumigant gas that is one of the most toxic of the common organic hahdes. It is hemotoxic and narcotic with delayed action. The effects are cumulative and damaging to nervous system, hdneys, and lung. Central nervous system effects include blurred vision, mental confusion, numbness, tremors, and speech defects. Methyl bromide is reported to be eight times more toxic on inhalation than ethyl bromide. Moreover, because of its greater volatility, it is a much more frequent cause of poisoning. Death following acute poisoning is usually caused by its irritant effect on the lungs. In chronic poisoning, death is due to injury to the central nervous system. Fatal poisoning has always resulted from exposure to relatively high concentrations of methyl bromide vapors (from 8600 to 60,000 ppm). Nonfatal poisoning has resulted from exposure to concentrations as low as 100-500 ppm. In addtion to injury to the lung and central nervous system, the kidneys may be damaged, with development of albuminuria and, in fatal cases, cloudy swelhng and/or tubular degeneration. The liver may be enlarged. There are no characteristic blood changes. Mixtures of 10-1 5 percent with air may be ignited with difficulty. Moderately explosive when exposed to sparks or flame. Forms explosive mixtures with air within narrow limits at atmospheric pressure, with wider limits at higher pressure. The explosive sensitivity of mixtures with air may be increased by the presence of aluminum, magnesium, zinc, or their alloys. Incompatible with metals, dunethyl sulfoxide, ethylene oxide. To fight fire, use foam, water, CO2, dry chemical. When heated to decomposition it emits toxic fumes of Br-. See also BROMIDES
Methyl bromide is used in fire extinguishers; as a fumigant in pest control and as a methylation agent in industry as an insect fumigant for soil, grain, warehouses, mills, ships, etc. It is also used as a chemical intermediate and a methylating agent; a refrigerant; a herbicide; a low-boiling solvent in aniline dye manufacture; for degreasing wool; for extracting oils from nuts, seeds, and flowers; and in ionization chambers. It is used as an intermediate in the manufacture of many drugs.
Methyl bromide is toxic. The vapor is odorless
at low concentrations and nonirritating to the
skin or eyes during exposure; therefore, detection
of overexposure is not possible until the
onset of symptoms. Early symptoms of overexposure
are dizziness, headache, nausea and
vomiting, weakness, and collapse. Lung edema
may develop 2 to 48 hours after exposure, accompanied
by cardiac irregularities. These effects
may cause death. Repeated overexposures
can result in blurred vision, staggering gait, and
mental imbalance, with probable recovery after
a period of no exposure. Blood bromide levels
suggest the occurrence, but not the degree, of
exposure. Treatment is symptomatic.
ACGIH recommends the Threshold Limit Value-Time-Weighted Average (TLV- TWA) of I ppm (3.9 mg/m3 ) for methyl bromide. The TLV- TWA is the time-weighted average concentration for a normal 8-hour workday and a 40-hour workweek, to which nearly all workers may be repeatedly exposed, day after day, without adverse effect.
Data on the carcinogenicity of bromomethane for oral exposure are lacking, but oral exposure is unlikely due to the volatility of bromomethane. A 1-year study in dogs consuming bromomethane-exposed food found no evidence of carcinogenicity. Data on carcinogenicity in humans following inhalation exposure in humans are not available. Animal inhalation studies exist but do not demonstrate evidence of bromomethane-induced carcinogenic changes. They include studies in F344 and Wistar rats, and in B6C3F1 and Crj:BDF1. The EPA descriptor for cancer is “inadequate information to assess the carcinogenic potential of bromomethane in humans.” Specifically, IRIS states: “Inadequate human and animal data: a single mortality study from which direct exposure associations could not be deduced and studies in several animal species with too few animals, too brief exposure or observation time for adequate power.” Bromomethane has shown genotoxicity. NAS reported that although methyl bromide is genotoxic without metabolic activation and has been shown to alkylate DNA in different organs in in vivo studies, there is no clear evidence of oncogenicity under experimental conditions used in the chronic inhalation studies with rat and mice.
Drinking water standard: No MCLGs or MCLs have been proposed, however, a DWEL of 50 μg/L was recommended (U.S. EPA, 2000).
Photolytic. When methyl bromide and bromine gas (concentration = 3%) was irradiated
at 1850 ?, methane was produced (Kobrinsky and Martin, 1968).
Chemical/Physical. Methyl bromide hydrolyzes in water forming methanol and hydrobromic acid. The estimated hydrolysis half-life in water at 25°C and pH 7 is 20 days (Mabey and Mill, 1978). Forms a voluminous crystalline hydrate at 0–5°C (Keith and Walters, 1992).
When methyl bromide was heated to 550°C in the absence of oxygen, methane, hydrogen, bromine, ethyl bromide, anthracene, pyrene and free radicals were produced (Chaigneau et al., 1966).
Emits toxic bromide fumes when heated to decomposition (Lewis, 1990).
Methyl bromide degrades in aqueous and soil environments mainly via dehalogenation to yield bromide ions with the incorporation of the methyl carbon moiety into polar natural components.
Methyl bromide (Bromomethane) should be kept stored in sealed containers to keep it from evaporating.
UN1062 Methyl bromide, Hazard Class: 2.3; Labels: 2.3-Poisonous gas, Inhalation Hazard Zone C. Cylinders must be transported in a secure upright position, in a well-ventilated truck. Protect cylinder and labels from physical damage. The owner of the compressed gas cylinder is the only entity allowed by federal law (49CFR) to transport and refill them. It is a violation of transportation regulations to refill compressed gas cylinders without the express written permission of the owner
Purify it by bubbling through conc H2SO4, followed by passage through a tube containing glass beads coated with P2O5. Also purify it by distillation from AlBr3 at -80o, by passage through a tower of KOH pellets and by partial condensation. [Beilstein 1 IV 68.]
Methyl bromide is hydrolysed at neutral pH to methanol and bromide
ion. The DT50s of methyl bromide in water at 17 and 25 °C were 21 and
75 days, respectively (Jeffers and Wolfe, 1996a; Mabey and Mill, 1978;
Moelwyn-Hughes, 1938). Aqueous photolysis is not a major environmental
In the upper and mid stratosphere (>20 km), photodegradation of MeBr with hydroxy radicals is reported to yield various products such as Br, BrO and HBr (Honaganahalli and Seiber, 1996).
Methyl bromide is a methylating agent and can bind irreversibly to sulfhydryl groups of enzymes and proteins. Methyl bromideinduced neurotoxicity has been attributed to its inhibition of the detoxification enzyme glutathione-S-transferase (GST), and depletion of glutathione in the brain. The degeneration of rat olfactory epithelium may also be related to the inhibition of GST as well as the generally high metabolic activity at this site. Glutathione involvement in the toxicity is demonstrated by the higher survival in rats given exogenous glutathione when exposed to a lethal dose of methyl bromide. Methyl bromide genotoxicity may be associated withDNAalkylation. The role of bromide is unclear because its level has not correlated with the symptoms of poisoning in humans.
Attacks aluminum to form spontaneously flammable aluminum trimethyl. Incompatible with strong oxidizers, aluminum, dimethylsulfoxide, ethylene oxide; water. Attacks zinc, magnesium, alkali metals and their alloys. Attacks some rubbers and coatings. Methyl bromide reacts with water to generate hydrobromic acid and methanol but the reaction is so slow that it can be disregarded for most practical purposes.
Consult with environmental regulatory agencies for guidance on acceptable disposal practices. Generators of waste containing this contaminant (≥100 kg/mo) must conform to EPA regulations governing storage, transportation, treatment, and waste disposal. A poisonous gas. Must be handled by experts: the recommended disposal procedure is to spray the gas into the fire box of an incinerator equipped with an afterburner and scrubber (alkali).
Occupational workers should use appropriate ventilation during production and formulation of bromomethane at the workplace. The ventilation must be suffi cient to maintain the levels of bromomethane below the prescribed OEL. Local exhaust ventilation at source or vapor extraction may also be used. Gloves or rubber boots should not be used as the liquid or concentrated vapor may be trapped inside them
Methyl bromide is sold either as a pure compound, 99.8 percent minimum, or with an odorant, chloropicrin (typically 2 percent).
Methyl bromide Preparation Products And Raw materials
Methyl bromide Suppliers
- 010-82848833- ;010-82848833-
- 021-54306202- ; ;
- 400-1166-196;028-84555506- ;028-84555506-
- +86 (573) 82222445 (0)18006601000 QQ:452520369
- +86 (573) 82222643
View Lastest Price from Methyl bromide manufacturers
- Methyl bromide 74-83-9
- US $0.10/KG
- Min. Order
- Supply Ability
- 1000 tons
- Release date
- Methyl bromide 74-83-9
- US $780.00/ML
- Min. Order
- Supply Ability
- Release date