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Neostigmine bromide

Product Name
Neostigmine bromide
CAS No.
114-80-7
Chemical Name
Neostigmine bromide
Synonyms
Prostigmi;Neostigmin;Neoesserin;prostigmin;Juvastigmin;PROSTIGMINE;stigmosanbromide;stigmanolbromide;eustigminbromide;neoserinebromide
CBNumber
CB3677212
Molecular Formula
C12H19BrN2O2
Formula Weight
303.2
MOL File
114-80-7.mol
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Neostigmine bromide Property

Melting point:
175-177 °C(lit.)
Density 
1.4344 (rough estimate)
refractive index 
1.5410 (estimate)
storage temp. 
Inert atmosphere,Room Temperature
solubility 
H2O: 1 g/mL
form 
powder
color 
white
PH
5.2~6.2 (100g/l, 25℃)
Water Solubility 
1 g/ mL
Merck 
14,6464
EPA Substance Registry System
Benzenaminium, 3-[[(dimethylamino)carbonyl]oxy]-N,N,N-trimethyl-, bromide (114-80-7)
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Safety

Hazard Codes 
T+,T
Risk Statements 
26/27/28-36/37/38-42/43-25
Safety Statements 
22-26-36/37/39-45-37/39-28A
RIDADR 
UN 2811 6.1/PG 2
WGK Germany 
3
RTECS 
BR3150000
HazardClass 
6.1(a)
PackingGroup 
II
HS Code 
29239000
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H300Fatal if swallowed

H310Fatal in contact with skin

H315Causes skin irritation

H317May cause an allergic skin reaction

H319Causes serious eye irritation

H330Fatal if inhaled

H334May cause allergy or asthma symptoms or breathing difficulties if inhaled

H335May cause respiratory irritation

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P284Wear respiratory protection.

P320Specific treatment is urgent (see … on this label).

P330Rinse mouth.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P302+P350IF ON SKIN: Gently wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
N2001
Product name
Neostigmine bromide
Purity
≥98% (HPLC and titration), powder
Packaging
1g
Price
$97.1
Updated
2021/03/22
Sigma-Aldrich
Product number
N0500000
Product name
Neostigmine bromide
Purity
European Pharmacopoeia (EP) Reference Standard
Price
$190
Updated
2021/03/22
Sigma-Aldrich
Product number
1459001
Product name
Neostigmine bromide
Purity
United States Pharmacopeia (USP) Reference Standard
Packaging
200mg
Price
$350
Updated
2020/08/18
TCI Chemical
Product number
N0358
Product name
Neostigmine Bromide
Purity
>99.0%(T)
Packaging
5g
Price
$89
Updated
2021/03/22
TCI Chemical
Product number
N0358
Product name
Neostigmine Bromide
Purity
>99.0%(T)
Packaging
25g
Price
$259
Updated
2021/03/22
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Neostigmine bromide Chemical Properties,Usage,Production

Chemical Properties

Crystalline Solid

Uses

antiscorbutic, antiviral

Uses

Cholinergic; miotic; antidote (curare)

General Description

Neostigmine bromide, (m-hydroxyphenyl)trimethylammonium bromide dimethylcarbamateor the dimethylcarbamic ester of 3-hydroxyphenyltrimethylammoniumbromide (Prostigmin bromide), is usedas an antidote to nondepolarizing neuromuscular blockingdrugs and in the treatment of myasthenia gravis. It occurs asa bitter, odorless, white, crystalline powder. It is soluble inwater and alcohol. The crystals are much less hygroscopicthan those of neostigmine methylsulfate and thus may beused in tablets. Solutions are stable and may be sterilized byboiling. Aqueous solutions are neutral to litmus.

Clinical Use

Use of physostigmine, as a prototype of an indirect-actingparasympathomimetic drug, facilitated the development ofstigmine, in which a trimethylamine group was placed para toa dimethylcarbamate group in benzene. Better inhibition ofcholinesterase was observed when these groups were placedmeta to each other as in neostigmine, a more active and usefulagent. Although physostigmine contains a methylcarbamatefunctional group, greater chemical stability towardhydrolysis was obtained with the dimethylcarbamyl group inneostigmine.

Safety Profile

Poison by ingestion, subcutaneous, intravenous, and intraperitoneal routes. When heated to decomposition it emits very toxic fumes of Br-, NH3, and NOx. See also CARBAMATES and BROMIDES.

Purification Methods

Crystallise neostigmine bromide from EtOH/diethyl ether. Its solubility in H2O is ~50%. [Beilstein 13 III 939.] (It is cholinergic and highly TOXIC.) The starting material 3-dimethylcarbamoyl-N,N-dimethylaniline [59-99-4] has b 195o/20mm [Beilstein 13 III 936], and its picrate has m 138o (from EtOH).

Neostigmine bromide Preparation Products And Raw materials

Raw materials

Preparation Products

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Neostigmine bromide Suppliers

J & K SCIENTIFIC LTD.
Tel
010-82848833- ;010-82848833-
Fax
86-10-82849933
Email
jkinfo@jkchemical.com;market6@jkchemical.com
Country
China
ProdList
96815
Advantage
76
Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel
21-61259100-
Fax
86-21-61259102
Email
sh@meryer.com
Country
China
ProdList
40264
Advantage
62
TCI (Shanghai) Development Co., Ltd.
Tel
021-67121386 / 800-988-0390
Fax
021-67121385
Email
Sales-CN@TCIchemicals.com
Country
China
ProdList
24555
Advantage
81
Energy Chemical
Tel
021-58432009-
Fax
021-58436166
Email
sales8178@energy-chemical.com
Country
China
ProdList
43494
Advantage
61
Adamas Reagent, Ltd.
Tel
400-600-9262
Email
bxy@titansci.com
Country
China
ProdList
13915
Advantage
59
Shanghai Longsheng chemical Co.,Ltd.
Tel
021-58099652-8005;021-58099637-8009
Fax
021-58099609
Email
bin.wu@shlschem.com;sales@shlschem.com
Country
China
ProdList
9827
Advantage
59
Chemsky(shanghai)International Co.,Ltd.
Tel
021-50135380
Email
shchemsky@sina.com
Country
China
ProdList
32358
Advantage
50
Chengdu XiYa Chemical Technology Co., Ltd.
Tel
;
Fax
0539-6365991
Email
sale@xiyashiji.com;3007716753@qq.com
Country
China
ProdList
10578
Advantage
57
Syntechem Co.,Ltd
Tel
Please Email
Fax
E-Mail Inquiry
Email
info@syntechem.com
Country
China
ProdList
13009
Advantage
57
Tianjin heowns Biochemical Technology Co., Ltd.
Tel
400 638 7771
Email
sales@heowns.com
Country
China
ProdList
14457
Advantage
57
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View Lastest Price from Neostigmine bromide manufacturers

Dideu Industries Group Limited
Product
Neostigmine bromide USP/EP/BP 114-80-7
Price
US $1.10/g
Min. Order
1g
Purity
99.9%
Supply Ability
100 Tons min
Release date
2021-07-27
Hebei Guanlang Biotechnology Co., Ltd.
Product
Neostigmine bromide 114-80-7
Price
US $10.00/PCS
Min. Order
1KG
Purity
99%
Supply Ability
10 mt
Release date
2021-03-11
career henan chemical co
Product
Neostigmine bromide 114-80-7
Price
US $2.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
100kg
Release date
2018-12-23

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