Overview Chemical Properties Reactions Application as acylation catalysts References
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4-Dimethylaminopyridine

Overview Chemical Properties Reactions Application as acylation catalysts References
Product Name
4-Dimethylaminopyridine
CAS No.
1122-58-3
Chemical Name
4-Dimethylaminopyridine
Synonyms
DMAP;26DCLPY;(4-DMAP);DMAP 25 G;AURORA KA-6495;4-DiMethylaMin;4-DMA PYRIDINA;JACS-1122-58-3;DMAP solution;AKOS BBS-00004314
CBNumber
CB9852862
Molecular Formula
C7H10N2
Formula Weight
122.17
MOL File
1122-58-3.mol
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4-Dimethylaminopyridine Property

Melting point:
112 °C
Boiling point:
162 °C
Density 
0.906 g/mL at 25 °C
vapor pressure 
0.169 hPa at 20 °C
refractive index 
n20/D 1.431
Flash point:
110 °C
storage temp. 
Store below +30°C.
solubility 
methanol: 50 mg/mL, clear
pka
pKa (20°): 9.7
form 
prilled
color 
off-white to yellow
Odor
characteristic odor
PH
11 (60g/l, H2O, 20℃)
PH Range
9.7 (10% aq soln)
Water Solubility 
76 g/L (25 ºC)
Merck 
14,3389
BRN 
110354
Stability:
Stable. Incompatible with acids, oxidizing agents.
CAS DataBase Reference
1122-58-3(CAS DataBase Reference)
NIST Chemistry Reference
4-Pyridinamine, N,N-dimethyl-(1122-58-3)
EPA Substance Registry System
4-(Dimethylamino)pyridine (1122-58-3)
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Safety

Hazard Codes 
T,C,T+,Xn,F
Risk Statements 
25-34-24/25-36/37/38-27-36-24-20-61-40-23/24/25-67-66-21/22-11-36/37-22-19
Safety Statements 
36/37/39-45-28A-26-28-36/37-53-27-22-16
RIDADR 
UN 2811 6.1/PG 2
WGK Germany 
3
RTECS 
US8400000
Autoignition Temperature
420 °C
Hazard Note 
Toxic/Corrosive
TSCA 
T
HazardClass 
8
PackingGroup 
II
HS Code 
29333999
Toxicity
LD50 orally in Rabbit: 140 mg/kg LD50 dermal Rabbit 90 mg/kg
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H225Highly Flammable liquid and vapour

H301Toxic if swalloed

H302Harmful if swallowed

H310Fatal in contact with skin

H311Toxic in contact with skin

H314Causes severe skin burns and eye damage

H315Causes skin irritation

H318Causes serious eye damage

H319Causes serious eye irritation

H335May cause respiratory irritation

H336May cause drowsiness or dizziness

H351Suspected of causing cancer

H402Harmful to aquatic life

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P262Do not get in eyes, on skin, or on clothing.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P273Avoid release to the environment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P337+P313IF eye irritation persists: Get medical advice/attention.

P370+P378In case of fire: Use … for extinction.

P405Store locked up.

P403+P235Store in a well-ventilated place. Keep cool.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
107700
Product name
4-(Dimethylamino)pyridine
Purity
ReagentPlus , ≥99%
Packaging
5g
Price
$19.3
Updated
2021/03/22
Sigma-Aldrich
Product number
8.20499
Product name
4-(Dimethylamino)pyridine
Purity
for synthesis
Packaging
5 g
Price
$20.63
Updated
2021/03/22
Sigma-Aldrich
Product number
8.51055
Product name
DMAP
Purity
4-(Dimethylamino)pyridine Novabiochem?
Packaging
25 g
Price
$38.3
Updated
2021/03/22
Sigma-Aldrich
Product number
8.20499
Product name
4-(Dimethylamino)pyridine
Purity
for synthesis
Packaging
25 g
Price
$44.58
Updated
2021/03/22
Sigma-Aldrich
Product number
8.51055
Product name
DMAP
Purity
4-(Dimethylamino)pyridine Novabiochem?
Packaging
100 g
Price
$105
Updated
2021/03/22
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4-Dimethylaminopyridine Chemical Properties,Usage,Production

Overview

4-Dimethylaminopyridine is highly powerful catalyst of organic synthesis. The treatment of substrates such as alcohols, phenols and amines with acetic anhydride (or acetyl chloride) in the presence of pyridine has provided a general acetylation method since the turn of the 20th century. However, this approach often proves to be unsatisfactory for the acetylation of deactivated substrates. It was not until the late 1960’s that certain 4-dialkylaminopyridines were found (independently by two research groups)[1, 2] to be much superior to pyridine as catalysts for difficult acetylations or acylations, in general.

Figure 1 the chemical structure of DMAP

4-Dialkylaminopyridines were soon found to have general applicability for catalysis of a wide variety of reactions. 4-dimethylaminopyridine’s (DMAP) wide applicability has been frequently reviewed since the first review appeared in 1978. [3] The accelerating pace of reported applications for DMAP and the availability of DMAP in commercial quantities, at modest prices, have continued to stimulate great interest in its use as a catalyst in the fields of organic, polymer, analytical and biochemistry. Today there are thousands of examples of the use of DMAP in far ranging fields of chemistry in both patents and the research literature. Many full-scale production processes utilizing DMAP have been and are being operated. Several pharmaceutical and agricultural products that rely on DMAP’s superior catalytic properties in their synthetic sequences have been produced for years. Since 1976 more than 11,000 US patents have been granted which mention DMAP or dimethylaminopyridine.
The functional groups and class of compounds that are involved in the reactions with DMAP include alcohols, amines, arenes, azides, carbenes, enols, epoxides, hydrazines, hydroxylamines, phenols, thiols, lipids, sugars, aminoacids, peptides, alkaloids, steroids, terpenes, and others. Reactions that have been published in the literature using DMAP fall into, but are not limited to, the following types of reactions: Acylation; Acetylation; Alkylation; Benzoylation; Bischler-Naperalski cyclization, Carbonylation; Carbo-diimidation; Cyclization; Dehydration; Esterificaton; Indole Synthesis; Nucleophilic Substitution; Rearrangement; Silylation; Sulfonamidation; Sulfonation; Tritylation; Formylation; Carbamoylation; Phosphorylation; Lactonization; Pivaloylation; Dakin-West Reaction; Baylis-Hillman Reaction.

Chemical Properties

DMAP (m.p. 112-113°C) and PPY (m.p. 57-58°C)[4] are colorless, crystalline substances which are very soluble in methanol, ethyl acetate, chloroform, methylene chloride, 1,2-dichloroethane, acetone, and acetic acid and less soluble in cold hexane, cyclohexane, and water. DMAP can be recrystallized from ethyl acetate and PPY from pentane or hexane. The basicities of DMAP[5] and PPY in water as well as the dipole moment of DMAP[7-9] in benzene and dioxane have been determined by several groups. Of especial interest are the thermodynamic investigations concerned with the protonation of DMAP in water[11] and calculations whereby the influence of substituents on the basicity has been determined[6, 9, 10].

Reactions

DMAP reacts readily with electrophilic reagents. It is possible to quaternize DMAP in high yield with either methyl iodide or ethyl bromide, decomposes quantitatively in the presence of aqueous alkali to N-methy1-4-pyridone[17].
Addition of DMAP to S, S'-diethyl-S, S'-dimethyl-S, S-1, 2vinylenedisulfonium salts results in the smooth formation of the salt with concomitant generation of ethyl methyl sulfide[19]. Reaction of DMAP with acetylenedicarboxylic acid leads spontaneously to the bis-adduct in high yields[20].
On reaction with perbenzoic acid the strongly polar N-oxide is formed. Nitration of DMAP with HNO3/H2SO4 gives the 3-nitro derivatives in 81 % yield and, under forcing condition; the 3,5-dinitro compounds are obtained[16]. Reaction with O-(p-toluenesulfony1)hydroxylamine affords the N-amino compound in 67% yield which is isolated as the perchlorate. By treatment with D2O it is possible to selectively exchange the a-protons in DMAP, with DClO4 to exchange the P-protons to furnish and with D2O/NaOD to replace all aromatic protons by deuterium[18].

Application as acylation catalysts

Acylation of alcohol
The high catalytic activity of DMAP and PPY can be used for acylating sterically hindered secondary or tertiary alcohols with carboxylic anhydrides or acyl halides when the pyridine method fails. In most cases, it is necessary to use only 0.05-0.2 mol of catalyst per mol of substance and the acid that is formed can be bound with an equivalent amount of trimethylamine[21, 22] or pyridine[20]. Such solvents as hexane, toluene, benzene, methylene chloride, chloroform, ethyl acetate, tetrahydrofuran, triethylamine, pyridine, or acetic anhydride are suitable for use with these catalysts.
Among the tertiary alcohols which can be easily acylated with DMAP and PPY, mention should be made of l-methyl cyclohexanol, 1-ethynylcyclohexanol, 1,l-diphenylethanol, linalool, l, l-dimethoxy-2-methyl-3-buten-2-ol, 5,5-dimethoxy-2-methyI-3-pentyn-2-ol, and cis-4- (1-hydroxyisopropyl)-2-methylcyclohexanone.
Acylation of phenols
In the acylation of phenols, DMAP and PPY effect a similar increase in reaction rate as is found in the case of alcohols. Hence, the method is of interest for the acylation of sterically hindered phenols. For example, mesitol can be smoothly acetylated with acetic anhydride/DMAP to 2,5-ditert-butylphenol and analogous compounds can be transformed into acyl derivatives of the type in high yields[24]. 11,12-Dihydroglaziovine smoothly affords the acyl derivative[23, 25].
Acylation of amines
DMAP and PPY have been seldom used for the acylation of amines. The kinetic investigations of Lituinenko and Kirichenko [26] have shown that an enormous increase in reaction rate is observed when acylations are carried out in aprotic solvents. These authors have determined the following relative rate constants (in parentheses) for the amine-catalyzed acylation of m-chloroaniline with benzoyl chloride in benzene: N, N-dimethylaniline (0.1); triethylamine (0.072); 2,6-dimethylpyridine (0.03); pyridine (1.80); 4-methylpyridine (10.0); and DMAP (10600).
Acylation of enolates
Acylations involving CH-acid compounds which can be performed with pyridine or triethylamine as catalyst are found to proceed at a much higher rate when DMAP or PPY is used. The Dakin-West reaction of N-acyl amino acids, in which a 2-oxazolin-5-one is acetylated at C-4 with a carboxylic anhydride in pyridine with formation of a new C-C bond, has been extensively investigated[27]. The combination products, consisting of the ambident oxazolin-5-one anions and N-acylpyridinium cations initially formed under kinetic control, are transformed via the ion pair into the thermodynamically most stable product[28]. Decarboxylative ring opening by the subsequently formed carboxylic acid yields the a-acyl amino ketone[29, 30].
Reactions of isocyanates
Pyridine-catalyzed reactions of isocyanates with carboxylic acids to form amides are found to be strongly accelerated on replacement of pyridine by DMAP. Phenylacetic acid is found to react with phenyl isocyanate in 1,2-dichloroethane at 24°C to give the amide in 66 % yield in less than 5 min; whereas on using the same amount of pyridine only 53% could be isolated after 2h. With triethylamine, only very little is formed besides diphenylurea[31].
Miscellaneous Applications
DMAP has been used in the hardening of epoxy resins with dicyanodiamine, in the transformation of nitriles into thionamides, and in the transfer of silyl groups to tertiary hydroxyl groups[32, 33].
Transfer of Functional Groups
Dimethylarninopyridinium salts are interesting reagents for the transfer of acyl and also cyano and phosphono groups in aqueous medium[34, 35].

References

  1. Litvinenko, L. M.; Kirichenko, A. I. Dok. Akad. Nauk SSSR, Ser. Khim. 1967, 176, 97;
  2. Steglich, W.; Höfle, G. Angew. Chem. 1969, 81, 1001; Angew. Chem. Int. Ed. 1969, 8, 981.
  3. Scriven, E. F. V.; 4-Dialkylaminopyridines: Super Acylation and Alkylation Catalysts; Chem. Soc. Rev.
  4. H. Vorbriiggen, Angew. Chem. 84, 348 (1972); Angew. Chem. Int.
  5. Ed. Engl. 11, 305 (1972). L. Pentimalli, Gazz. Chim. Ital. 94, 902 (1964).
  6. R. W Taft, C. A. Grob, J . Am. Chem. SOC. 96, 1236 (1974).
  7. C. W N. Cumper, A. Singleton, J . Chem. SOC. B 1967, 1096.
  8. A. R. Katritzky, E. Fi! Randall, L. E. Sutton, J. Chem. SOC. 1957 1769.
  9. H. Lumbroso, J. Barassin, Bull. SOC. Chim. Fr. 1965, 3143.
  10. C. D. Johnson, I. Roberts, P. G. Taylor, J. Chem. SOC.C hem. Commun 1977, 897.
  11. M. R. Chakrabarty, C. S. Handloser, M. W Mosher, J. Chem. SOC. Perkin Trans. I1 1973, 938
  12. Pyridine syntheses, 1st Communication.-2nd Communication: H. Vorbriiggen, J. Kottwitz, K. Krolikiewicz, Chem. Ber., in preparation. This publication gives a complete survey of the various syntheses of DMAP and PPY; H. Vorbriiggen, DOS 2517774 (1975), Schering AG; Chem. Abstr. 86, 55293d (1977).
  13. W Steglich, G. Hofle, Tetrahedron Lett. 1970, 4727.
  14. E. Koenigs, H. Friedrich, H. Jurany, Ber. Dtsch. Chem. Ges. 58, 2571 (1925).
  15. A. C. Satterthwait, W P. Jencks, J. Am. Chem. SOC. 96, 7031 (1974).
  16. A. G. Burton, R. D. Frampton, C. D. Johnson, A. R. Katritzky, J. Chem. SOC. Perkin Trans. 11 1972, 1940.
  17. G. B. Barlin, J. A. Benbow, J . Chem. SOC. Perkin Trans. I1 1975,1385.
  18. J. A. Zoltewicz, J. D. Meyer, Tetrahedron Lett. 1968, 421.
  19. H. Braun, A. Amann, M. Richter, Angew. Chem. 89,488 (1977); Angew. Chem. lnt. Ed. Engl. 16, 471 (1977).
  20. B. P. Schaffner, H. Wehrli, Helv. Chim. Acta 55, 2563 (1972).
  21. 4-Dialkylaminopyridines as acylation catalysts, 4th Communication.-3rd Communication: G. Hofle, W Steglich, Synthesis 1972, 619.
  22. W Steglich, G. Hofle, Angew. Chem. 81, 1001 (1969); Angew. Chem. Int. Ed. Engl. 8, 981 (1969).
  23. J. E. McMurry, J . H. Musser, M. S. Ahmad, L. C. Blaszczak, J. Org. Chem. 40, 1829 (1975).
  24. D. J. Zwanenburg, W A. P. Reynen, Synthesis 1976, 624.
  25. 1. S. Bindra, A. Grodski, J. Org. Chem. 42, 910 (1977).
  26. H. Paulsen, H. Hohne, Carhohydr. Res. 58, 484 (1977).
  27. W Steglich, G. Hiiye, Tetrahedron Lett. 1968, 1619.
  28. W Steglich, G. HoJe, Chem. Ber. 104, 3644 (1971).
  29. W Steglich, G. HoJe, Chem. Ber. 102, 1129 (1969).
  30. G. HiiJe, A. Prox, W Steglich, Chem. Ber. 105, 1718 (1972).
  31. P. W Henniger, J. K. Van der Drift, DOS 2235390 (1973), Koninklijke Nederlandsche Gist-en Spiritusfabriek N. V.; Chem. Abstr. 78, 124608j
  32. J. Maurer, DOS 180867O(US Pat. 3530093) (1967), Ciba-Geigy; Chem. Abstr. 71, 1032541 (1969).
  33. P . C . Sriuastaua, M, Pickering, L. B. Allen, D. G. Streeter, M . 7: Campbell, J. R. Witkowski, R. W Sidwell, R. K. Robins, J. Med. Chem. 20, 256 (1977).
  34. S. D. Larsen, S. A. Monti, J. Am. Chem. SOC. 99, 8015 (1977).
  35. M. Wakselman, E. Guibl-Jampel, Tetrahedron Lett. 1970, 1521.

Chemical Properties

White solid

Uses

A highly efficient catalyst for acylation reactions.

Uses

4-Dimethylaminopyridine is a versatile hypernucleophilic acylation catalyst, it is used to improve the yield, reduce the reaction time, improving relaxation process conditions. Widely used in perfumes, dyes, pigments, pesticides, pharmaceuticals and polymer compounds and other fields. Also used as a catalyst for the synthesis of polyurethane, a curing agent and a blowing catalyst.

Uses

DMAP is a useful highly basic nucleophilic catalyst for a variety of reactions such as esterifications with anhydrides, the Baylis-Hillman reaction, hydrosilylations, tritylation, the Steglich rearrangement.

Uses

In a wide variety of organic syntheses as a catalyst.

Uses

A highly fluorescent adenosine analogue, which in a dimethoxytrityl, phosphoramidite protected form, can be site-specifically inserted into oligonucleotides through a 3?5?phosphodiester linkage using an automated DNA synthesizer

Purification Methods

Recrystallise DMAP from toluene [Sadownik et al. J Am Chem Soc 108 7789 1986]. [Beilstein 22 V 112.] § A polystyrene supported version (PS-DMAP) is commercially available.

4-Dimethylaminopyridine Preparation Products And Raw materials

Raw materials

Preparation Products

1-[4-(TRIFLUOROMETHYL)PYRIMID-2-YL]PIPERAZINE 2-Hydroxy-4-(trifluoromethyl)pyrimidine 2-Chloro-4-(trifluoromethyl)pyrimidine Docetaxel 1-(2-PYRROLIDINOETHYL)PIPERAZINE 5-(TRIFLUOROMETHYL)-1-METHYL-1H-PYRAZOLE 1-TERT-BUTYL-5-(TRIFLUOROMETHYL)-1H-PYRAZOLE-4-CARBALDEHYDE PIPERAZINE-1,4-DICARBOXYLIC ACID TERT-BUTYL ESTER METHYL ESTER 2-Hydrazinyl-1-morpholinoethanone 4-TRIFLUOROMETHYL-N-METHYLANILINE 97 1-METHYL-3-(TRIFLUOROMETHYL)-1H-PYRAZOLE 1-ACETYL-5-BROMOINDOLINE N4-Benzoylcytosine 2-Acetylamino-4-methylpyridine 1-TERT-BUTYL-5-(TRIFLUOROMETHYL)-1H-PYRAZOLE Boc-L-beta-Homoproline BETA-(4-ACETOXYPHENYL)PROPIONIC ACID 2-(METHYLTHIO)-4-(TRIFLUOROMETHYL)PYRIMIDINE TERT-BUTYL 5-FORMYLTHIAZOL-2-YLCARBAMATE 1-TERT-BUTYL-4-BROMO-5-(TRIFLUOROMETHYL)-1H-PYRAZOLE 3-Hydrazinyl-1-(4-methylpiperazin-1-yl)propan-1-one Aniracetam MONO-METHYL SUCCINATE 2-Aminoisonicotinic acid 2-AMINO-ISONICOTINIC ACID ETHYL ESTER 4-AMINOBENZANILIDE 4-BROMO-5-(TRIFLUOROMETHYL)-1-PHENYL-1H-PYRAZOLE 1-TERT-BUTYL-3-(TRIFLUOROMETHYL)-1H-PYRAZOLE METHYL 6-[(TERT-BUTOXYCARBONYL)AMINO]NICOTINATE 4-BROMO-1-METHYL-3-(TRIFLUOROMETHYL)-1H-PYRAZOLE 5-(TRIFLUOROMETHYL)-1-METHYL-1H-PYRAZOLE-4-CARBALDEHYDE 2-ACETAMIDOPYRIDINE-3-CARBOXYLIC ACID 1-TERT-BUTYL-4-BROMO-3-(TRIFLUOROMETHYL)-1H-PYRAZOLE 3-Hydrazinyl-1-morpholinopropan-1-one 2'-BROMOACETANILIDE LIMAPROST 4-BROMO-5-(TRIFLUOROMETHYL)-1-METHYL-1H-PYRAZOLE 2,2,2-TRIFLUORO-1-(3-(TRIFLUOROMETHYL)-1-PHENYL-1H-PYRAZOL-4-YL)ETHANONE 2-Hydrazinyl-1-(4-methylpiperazin-1-yl)ethanone (2R)-(-)-Glycidyl tosylate
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4-Dimethylaminopyridine Suppliers

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JIANGSU B-WIN CHEMICAL INDUSTRY CO.,LTD.
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Shandong Vantage Specialty Chemicals Biotechnology Co., Ltd.
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View Lastest Price from 4-Dimethylaminopyridine manufacturers

Hebei Zhanyao Biotechnology Co. Ltd
Product
4-Dimethylaminopyridine 1122-58-3
Price
US $101.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
20 Tons
Release date
2021-10-14
Dideu Industries Group Limited
Product
4-Dimethylaminopyridine 1122-58-3
Price
US $1.10/g
Min. Order
1g
Purity
99.00%
Supply Ability
100 Tons Min
Release date
2021-09-29
Hebei Crovell Biotech Co Ltd
Product
4-Dimethylaminopyridine 1122-58-3
Price
US $10.70/Kg/Drum
Min. Order
10g
Purity
99%
Supply Ability
10000kg
Release date
2021-06-29

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  • 4-DiMethylaMinopyridine, 99% 25GR
  • 4-DiMethylaMinopyridine, 99% 5GR
  • DMAP N-(4-Pyridyl)dimethylamine
  • Valacyclovir IMpurity-G
  • DMAP)4-DiMethylaMinopyr