4-Hydroxypyridine

Product Name: 4-Hydroxypyridine
CAS No.: 626-64-2
Chemical Name: 4-Hydroxypyridine
Synonyms: PYRIDIN-4-OL;4-PYRIDINOL;4HYDROXYPRIDINE;4-Hydroxypyride;1H-Pyridin-4-ol;Compound Fr14055;4-HYDROXYPYRIDINE; 4-Hydroxypyridone ;TIMTEC-BB SBB000030;4-hydroxyl pyridine
CBNumber: CB6303828
Molecular Formula: C5H5NO
Formula Weight: 95.1
MOL File: 626-64-2.mol

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4-Hydroxypyridine Property

Melting point:: 150-151 °C (lit.)
Boiling point:: 230-235 °C/12 mmHg (lit.)
Density: 1.1418 (rough estimate)
refractive index: 1.5939 (estimate)
Flash point:: 221 °C
storage temp.: Keep in dark place,Inert atmosphere,Room temperature
solubility: DMSO (Slightly), Methanol (Slightly)
form: Powder or Chunks
pka: 3.2(at 20℃)
color: Beige to light brown
Water Solubility: Soluble
BRN: 105800
InChIKey: GCNTZFIIOFTKIY-UHFFFAOYSA-N
LogP: -1.300 (est)
CAS DataBase Reference: 626-64-2(CAS DataBase Reference)
NIST Chemistry Reference: 4-Pyridinol(626-64-2)
EPA Substance Registry System: 4-Pyridinol (626-64-2)

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Safety

Hazard Codes: Xi,Xn
Risk Statements: 36/37/38-41-37/38-22
Safety Statements: 26-36-37/39-39
WGK Germany: 3
RTECS: UU7701450
F: 3-8-10
Hazard Note: Harmful/Irritant
TSCA: Yes
HazardClass: IRRITANT
HS Code: 29339900

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H318Causes serious eye damage

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 120618
Product name: 4-Hydroxypyridine
Purity: 95%
Packaging: 25g
Price: $66.8
Updated: 2024/03/01

Sigma-Aldrich

Product number: 120618
Product name: 4-Hydroxypyridine
Purity: 95%
Packaging: 100g
Price: $184
Updated: 2024/03/01

Sigma-Aldrich

Product number: CDS013613
Product name: 4-hydroxypyridine
Purity: AldrichCPR
Packaging: 1G
Price: $68.1
Updated: 2023/06/20

TCI Chemical

Product number: H0332
Product name: 4-Hydroxypyridine
Purity: >99.0%(GC)
Packaging: 25g
Price: $80
Updated: 2024/03/01

Alfa Aesar

Product number: A14586
Product name: 4-Hydroxypyridine, 97%
Packaging: 25g
Price: $54.65
Updated: 2024/03/01

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4-Hydroxypyridine Chemical Properties,Usage,Production

Description

4-Hydroxypyridine, available from pyridylpyridinium chloride hydrochloride, is the substrate for diodone and its n-propyl ester, propyliodone. 4-Hydroxypyridine (4-HP) is a non-nucleophilic analog of the product phenol found to bind specifically to and stabilize the aminoacrylate intermediate. When 4-HP is added to Tyrosine phenol-lyase (TPL) reactions, an absorption peak at 340 nm is observed. The formation of the 340 nm peak correlates with the decay of the quinonoid intermediate peak at 505 nm, with a clean isosbestic point, and the observed rate constants show an inverse dependence on the concentration of 4-HP. These results confirm that the observed peak at 340 nm is due to the formation of the amino acrylate intermediate[1-2].

Chemical Properties

Beige crystalline powder

Uses

4-Hydroxypyridine was used in the synthesis of (Ag₃MoO₃F₃) (Ag₃MoO₄)Cl by hydro(solvato)thermal methods. It was used as model compound to study the natural photodegradation of representative aquatic environmental contaminants.

Definition

ChEBI: A monohydroxypyridine that is pyridine in which the hydrogen at position 4 has been replaced by a hydroxy group.

Purification Methods

Crystallise 4-pyridone from H2O or wet CHCl3 as the monohydrate. It loses H2O on drying in vacuo over H2SO4. Store it over KOH because it is hygroscopic.[Beilstein 21 III/IV 446, 21/7 V 152.]

References

[1] Yates, F. S. “2.09 – Pyridines and their Benzo Derivatives: (vi) Applications.”Comprehensive Heterocyclic Chemistry 2 (1984): 511-524.
[1] Robert S Phillips, Olivia Bauer. “Characterization of aminoacrylate intermediates of pyridoxal-5’-phosphate dependent enzymes.” Methods in enzymology 685 (2023): 199–224.

4-Hydroxypyridine Preparation Products And Raw materials

Raw materials

Preparation Products

2,4-DICHLORO-5-NITROPYRIDINE 3-AMINO-4-METHOXYPYRIDINE 3,4-Diaminopyridine 4-Dimethylaminopyridine

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4-Hydroxypyridine Suppliers

Americas 1 Belgium 1 Canada 1 China 459 Europe 4 Germany 5 India 59 Ireland 1 Japan 4 Jordan 1 Russia 1 Slovakia 1 South Korea 2 Switzerland 3 The Netherlands 2 Ukraine 1 United Kingdom 10 United States 55 USA 1 Global 612

Jinan Dexinjia Bio&Tech Co., Ltd

Tel: 0531-82375886 13001715031
Fax: 0531-82375893
Email: 3517280075@qq.com
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BTC Pharmaceutical CO. Ltd

Tel: 0513-0513-68015397 18862996710
Fax: 0513-68015394
Email: sales12@btcpharm.com
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J & K SCIENTIFIC LTD.

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Meryer (Shanghai) Chemical Technology Co., Ltd.

Tel: 021-61259108 18621169109
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Email: market03@meryer.com
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future industrial shanghai co., ltd

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Email: sales@jonln.com
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Alfa Aesar

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TAIYUAN RHF CO.,LTD.

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TCI (Shanghai) Development Co., Ltd.

Tel: 021-67121386
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ShangHai DEMO Chemical Co.,Ltd

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Energy Chemical

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View Lastest Price from 4-Hydroxypyridine manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD

Product: 4-Hydroxypyridine 626-64-2
Price: US $0.00/Kg/Drum
Min. Order: 1KG
Purity: 98%min
Supply Ability: 1000kgs
Release date: 2021-11-10

Hebei Weibang Biotechnology Co., Ltd

Product: 4-Hydroxypyridine 626-64-2
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 10 mt
Release date: 2024-11-11

Shanghai UCHEM Inc.

Product: 4-Hydroxypyridine 626-64-2
Price: US $225.00/kg
Min. Order: 1kg
Purity: 0.97
Supply Ability: 25kg
Release date: 2023-11-17

626-64-2, 4-HydroxypyridineRelated Search:

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Hydroxypyridine(Gamma-)

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4-oxo-1,4-dihydropyridine

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Compound Fr14055

626-64-2

C5H4NO

Building Blocks

C5

Heterocyclic Building Blocks

Pyridines

Other series

Pyridine Series

Building Blocks

C5

Chemical Synthesis

Heterocyclic Building Blocks

Pyridine

Heterocyclic Compounds

Pyridines

bc0001

626-64-2