2-Chloro-4-hydroxypyridine

Product Name: 2-Chloro-4-hydroxypyridine
CAS No.: 17368-12-6
Chemical Name: 2-Chloro-4-hydroxypyridine
Synonyms: 2-CHLOROPYRIDIN-4-OL;12.15;2-CHLORO-4-PYRIDINOL;2-Chloro-4-hydroxypy;4-Pyridinol, 2-chloro-;Oliceridine Impurity 18;2-chloro-1H-pyridin-4-one;2-CHLORO-4-HYDROXYPYRIDINE;2-Chloro-4-hydroxylpyridine;2-Chloro-4-hydroxypyridine95%
CBNumber: CB7307520
Molecular Formula: C5H4ClNO
Formula Weight: 129.54
MOL File: 17368-12-6.mol

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2-Chloro-4-hydroxypyridine Property

Melting point:: 169-172°C
Boiling point:: 401.8±25.0 °C(Predicted)
Density: 1.392±0.06 g/cm3(Predicted)
storage temp.: Inert atmosphere,Room Temperature
solubility: soluble in Methanol
form: powder to crystal
pka: 7.94±0.10(Predicted)
color: White to Light yellow to Light orange
InChI: InChI=1S/C5H4ClNO/c6-5-3-4(8)1-2-7-5/h1-3H,(H,7,8)
InChIKey: VBEHFOMFHUQAOW-UHFFFAOYSA-N
SMILES: C1(Cl)=NC=CC(O)=C1
CAS DataBase Reference: 17368-12-6(CAS DataBase Reference)

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Safety

Hazard Codes: Xi,Xn
Risk Statements: 36/37/38-22
Safety Statements: 26-36
HS Code: 2933399990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

TCI Chemical

Product number: C2516
Product name: 2-Chloro-4-hydroxypyridine
Purity: >97.0%(GC)(T)
Packaging: 1g
Price: $18
Updated: 2025/07/31

TCI Chemical

Product number: C2516
Product name: 2-Chloro-4-hydroxypyridine
Purity: >97.0%(GC)(T)
Packaging: 5g
Price: $69
Updated: 2025/07/31

TRC

Product number: C585913
Product name: 2-Chloro-4-hydroxypyridine
Packaging: 2.5g
Price: $75
Updated: 2021/12/16

AK Scientific

Product number: J53798
Product name: 2-Chloro-4-hydroxypyridine
Packaging: 25g
Price: $55
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FC55412
Product name: 2-Chloro-4-hydroxypyridine
Packaging: 25g
Price: $90
Updated: 2021/12/16

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2-Chloro-4-hydroxypyridine Chemical Properties,Usage,Production

Chemical Properties

White crystal

Uses

2-Chloro-4-hydroxypyridine is a chemical that is used as a building block for various organic synthesis reactions.

Preparation

2-Chloro-4-hydroxypyridine can be produced by the reaction of chloroform and pyridine, which results in the formation of 2-chloro-4-hydroxypyridine.

Reactions

2-Chloro-4-hydroxypyridine has been shown to react with copper metal under dehydrogenative conditions to form monochloropyridine. It also reacts with tribromide to form tribromopyridine and with graphene oxide to form hydroxypyridinium bromide. Lastly, it reacts with an organic solvent such as acet.

Synthesis

14432-12-3

17368-12-6

The general procedure for the synthesis of 2-chloro-4-hydroxypyridine from 2-chloro-4-aminopyridine is as follows: in a round-bottomed flask, 2-chloro-4-aminopyridine (3.0 g, 23.3 mmol) was dissolved in 40% sulfuric acid solution (50 g). The solution was stirred at 0 °C and sodium nitrite (1.93 g, 28.0 mmol) was added slowly. After addition, the reaction mixture was stirred continuously at room temperature for 24 hours. Upon completion of the reaction, the reaction solution was neutralized by dropwise addition of aqueous sodium hydroxide and aqueous sodium bicarbonate. Subsequently, the organic phase was extracted with ethyl acetate. The organic phase was dried over anhydrous magnesium sulfate, filtered, distilled to remove the solvent and dried under reduced pressure to give 2-chloro-4-hydroxypyridine (light brown solid, 2.78 g, 92% yield). The product was characterized by 1H-NMR (270 MHz, DMSO-d6): δ 11.20 (s, 1H, -OH), 8.09 (d, 1H, J = 5.4 Hz, ArH), 6.81 (s, 1H, ArH), 6.77 (d, 1H, J = 2.2 Hz, ArH).

References

[1] Patent: WO2009/11447, 2009, A2. Location in patent: Page/Page column 37-38

2-Chloro-4-hydroxypyridine Preparation Products And Raw materials

Raw materials

Preparation Products

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2-Chloro-4-hydroxypyridine Suppliers

Americas 1 China 248 Europe 4 France 3 Germany 5 India 13 Japan 2 Switzerland 1 The Netherlands 1 United Kingdom 12 United States 44 Global 334

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View Lastest Price from 2-Chloro-4-hydroxypyridine manufacturers

Hebei Chuanghai Biotechnology Co., Ltd

Product: 2-Chloro-4-hydroxypyridine 17368-12-6
Price: US $10.00-8.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 10 mt
Release date: 2024-12-06

Dideu Industries Group Limited

Product: 2-Chloro-4-hydroxypyridine 17368-12-6
Price: US $1.10/g
Min. Order: 1g
Purity: 99.00%
Supply Ability: 100 Tons Min
Release date: 2021-09-24

Zhuozhou Wenxi import and Export Co., Ltd

Product: 2-Chloro-4-hydroxypyridine 17368-12-6
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-11

17368-12-6, 2-Chloro-4-hydroxypyridineRelated Search:

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2-CHLORO-4-HYDROXYPYRIDINE

2-CHLORO-4-PYRIDINOL

2-CHLOROPYRIDIN-4-OL

4-Pyridinol,2-chloro-(7CI,8CI,9CI)

2-Chloro-4-hydroxypyridine HCl Salt

2-CHLORO-4-HYDROXYPYRIDINE 99%

2-Chloro-4-hydroxypyridine hydrochloride

2-chloro-1H-pyridin-4-one

12.15

2-Chloro-4-hydroxypy

2-Chloro-4-hydroxylpyridine

4-Pyridinol, 2-chloro-

2-Chloro-4-hydroxypyridine95%

2-Chloro-4-hydroxypyridine &gt

2-Chloro-4-hydroxypyridine ISO 9001：2015 REACH

Oliceridine Impurity 18

17368-12-6

78067-36-0

13768-12-6

CHIRAL CHEMICALS

PYRIDINE

blocks

Pyridines