2-Chloro-3-hydroxypyridine
- Product Name
- 2-Chloro-3-hydroxypyridine
- CAS No.
- 6636-78-8
- Chemical Name
- 2-Chloro-3-hydroxypyridine
- Synonyms
- 2-CHLOROPYRIDIN-3-OL;2-CHLORO-3-PYRIDINOL;2-chloro-3-pyridino;2-chlorpyridin-3-ol;oro-3-hydroxypyridine;3-Pyridinol, 2-chloro-;2-CHLORO-PYRIDINE-3-OL;2-Chloro-3-pyridinol,98%;2-CHLORO-3-HYDROXYPYRIDINE;2-chloro-3-hdyroxypyridine
- CBNumber
- CB2192084
- Molecular Formula
- C5H4ClNO
- Formula Weight
- 129.54
- MOL File
- 6636-78-8.mol
2-Chloro-3-hydroxypyridine Property
- Melting point:
- 170-172 °C (lit.)
- Boiling point:
- 316.2±22.0 °C(Predicted)
- Density
- 1.2309 (rough estimate)
- refractive index
- 1.4510 (estimate)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- pka
- 4.32±0.10(Predicted)
- form
- Powder
- color
- Light beige
- BRN
- 2216
- InChI
- InChI=1S/C5H4ClNO/c6-5-4(8)2-1-3-7-5/h1-3,8H
- InChIKey
- RSOPTYAZDFSMTN-UHFFFAOYSA-N
- SMILES
- C1(Cl)=NC=CC=C1O
- CAS DataBase Reference
- 6636-78-8(CAS DataBase Reference)
- NIST Chemistry Reference
- 2-Chloro-3-pyridinol(6636-78-8)
Safety
- Hazard Codes
- Xi,Xn
- Risk Statements
- 36/37/38-20/21/22
- Safety Statements
- 26-37/39-24/25-36
- WGK Germany
- 3
- RTECS
- UU7707000
- HazardClass
- IRRITANT
- HS Code
- 29333990
- Storage Class
- 11 - Combustible Solids
- Hazard Classifications
- Eye Irrit. 2
Skin Irrit. 2
STOT SE 3
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 116203
- Product name
- 2-Chloro-3-hydroxypyridine
- Purity
- 98%
- Packaging
- 25g
- Price
- $93
- Updated
- 2025/07/31
- Product number
- 116203
- Product name
- 2-Chloro-3-hydroxypyridine
- Purity
- 98%
- Packaging
- 5g
- Price
- $35
- Updated
- 2023/01/07
- Product number
- C1152
- Product name
- 2-Chloro-3-hydroxypyridine
- Purity
- >98.0%(GC)(T)
- Packaging
- 10g
- Price
- $39
- Updated
- 2025/07/31
- Product number
- C1152
- Product name
- 2-Chloro-3-hydroxypyridine
- Purity
- >98.0%(GC)(T)
- Packaging
- 25g
- Price
- $77
- Updated
- 2025/07/31
- Product number
- C381308
- Product name
- 2-Chloro-3-hydroxypyridine
- Packaging
- 100mg
- Price
- $75
- Updated
- 2021/12/16
2-Chloro-3-hydroxypyridine Chemical Properties,Usage,Production
Chemical Properties
light beige powder
Uses
2-Chloro-3-hydroxypyridine has been used in the preparation of 3-hydroxypyridine-2( 1 H)-selone. It has also been used in the synthesis of all four possible benzo[4,5]furopyridine tricyclic heterocycles: benzo[4,5]furo[2,3-b]pyridine, benzo[4,5]furo[2,3-c]pyridine, benzo[4,5]furo[3,2-c]pyridine, and benzo[4,5]furo[3,2-b]pyridine. the synthesis involves α and γ-activation of chloropyridines, as well as palladium-mediated reactions.
Synthesis
163083-47-4
6636-78-8
GENERAL METHOD: To a solution of 2-chloro-3-pyridyl trifluoromethanesulfonate (0.3 mmol) in anhydrous toluene (5 mL) was added Cs2CO3 (3 equiv). The reaction suspension was heated at 80 °C (oil bath temperature) with stirring for 15 hours. Upon completion of the reaction, the crude reaction mixture was quenched with ethyl acetate (~5 mL) and saturated aqueous ammonium chloride solution (~10 mL). The aqueous layer was separated and extracted with ethyl acetate (2 x 10 mL). The organic layers were combined, dried with anhydrous MgSO4 and concentrated under reduced pressure to give the crude product 2-chloro-3-hydroxypyridine. Finally, the product was purified by fast column chromatography on silica gel.
References
[1] Tetrahedron Letters, 2013, vol. 54, # 51, p. 7078 - 7079
2-Chloro-3-hydroxypyridine Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2-Chloro-3-hydroxypyridine manufacturers
- Product
- 2-Chloro-3-hydroxypyridine 6636-78-8
- Price
- US $1.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 10 mt
- Release date
- 2024-11-21
- Product
- 2-Chloro-3-hydroxypyridine 6636-78-8
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.00%
- Supply Ability
- 100 Tons Min
- Release date
- 2021-09-24
- Product
- 2-Chloro-3-hydroxypyridine 6636-78-8
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-10