ChemicalBook > CAS DataBase List > 2-Chloro-4-hydroxypyridine

2-Chloro-4-hydroxypyridine

Product Name
2-Chloro-4-hydroxypyridine
CAS No.
17368-12-6
Chemical Name
2-Chloro-4-hydroxypyridine
Synonyms
2-CHLOROPYRIDIN-4-OL;12.15;2-CHLORO-4-PYRIDINOL;2-Chloro-4-hydroxypy;4-Pyridinol, 2-chloro-;Oliceridine Impurity 18;2-chloro-1H-pyridin-4-one;2-CHLORO-4-HYDROXYPYRIDINE;2-Chloro-4-hydroxylpyridine;2-Chloro-4-hydroxypyridine95%
CBNumber
CB7307520
Molecular Formula
C5H4ClNO
Formula Weight
129.54
MOL File
17368-12-6.mol
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2-Chloro-4-hydroxypyridine Property

Melting point:
169-172°C
Boiling point:
401.8±25.0 °C(Predicted)
Density 
1.392±0.06 g/cm3(Predicted)
storage temp. 
Inert atmosphere,Room Temperature
solubility 
soluble in Methanol
form 
powder to crystal
pka
7.94±0.10(Predicted)
color 
White to Light yellow to Light orange
InChI
InChI=1S/C5H4ClNO/c6-5-3-4(8)1-2-7-5/h1-3H,(H,7,8)
InChIKey
VBEHFOMFHUQAOW-UHFFFAOYSA-N
SMILES
C1(Cl)=NC=CC(O)=C1
CAS DataBase Reference
17368-12-6(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi,Xn
Risk Statements 
36/37/38-22
Safety Statements 
26-36
HS Code 
2933399990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

TCI Chemical
Product number
C2516
Product name
2-Chloro-4-hydroxypyridine
Purity
>97.0%(GC)(T)
Packaging
1g
Price
$18
Updated
2025/07/31
TCI Chemical
Product number
C2516
Product name
2-Chloro-4-hydroxypyridine
Purity
>97.0%(GC)(T)
Packaging
5g
Price
$69
Updated
2025/07/31
TRC
Product number
C585913
Product name
2-Chloro-4-hydroxypyridine
Packaging
2.5g
Price
$75
Updated
2021/12/16
AK Scientific
Product number
J53798
Product name
2-Chloro-4-hydroxypyridine
Packaging
25g
Price
$55
Updated
2021/12/16
Biosynth Carbosynth
Product number
FC55412
Product name
2-Chloro-4-hydroxypyridine
Packaging
25g
Price
$90
Updated
2021/12/16
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2-Chloro-4-hydroxypyridine Chemical Properties,Usage,Production

Chemical Properties

White crystal

Uses

2-Chloro-4-hydroxypyridine is a chemical that is used as a building block for various organic synthesis reactions. 

Preparation

2-Chloro-4-hydroxypyridine can be produced by the reaction of chloroform and pyridine, which results in the formation of 2-chloro-4-hydroxypyridine.

Reactions

2-Chloro-4-hydroxypyridine has been shown to react with copper metal under dehydrogenative conditions to form monochloropyridine. It also reacts with tribromide to form tribromopyridine and with graphene oxide to form hydroxypyridinium bromide. Lastly, it reacts with an organic solvent such as acet.

Synthesis

14432-12-3

17368-12-6

The general procedure for the synthesis of 2-chloro-4-hydroxypyridine from 2-chloro-4-aminopyridine is as follows: in a round-bottomed flask, 2-chloro-4-aminopyridine (3.0 g, 23.3 mmol) was dissolved in 40% sulfuric acid solution (50 g). The solution was stirred at 0 °C and sodium nitrite (1.93 g, 28.0 mmol) was added slowly. After addition, the reaction mixture was stirred continuously at room temperature for 24 hours. Upon completion of the reaction, the reaction solution was neutralized by dropwise addition of aqueous sodium hydroxide and aqueous sodium bicarbonate. Subsequently, the organic phase was extracted with ethyl acetate. The organic phase was dried over anhydrous magnesium sulfate, filtered, distilled to remove the solvent and dried under reduced pressure to give 2-chloro-4-hydroxypyridine (light brown solid, 2.78 g, 92% yield). The product was characterized by 1H-NMR (270 MHz, DMSO-d6): δ 11.20 (s, 1H, -OH), 8.09 (d, 1H, J = 5.4 Hz, ArH), 6.81 (s, 1H, ArH), 6.77 (d, 1H, J = 2.2 Hz, ArH).

References

[1] Patent: WO2009/11447, 2009, A2. Location in patent: Page/Page column 37-38

2-Chloro-4-hydroxypyridine Preparation Products And Raw materials

Raw materials

Preparation Products

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2-Chloro-4-hydroxypyridine Suppliers

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View Lastest Price from 2-Chloro-4-hydroxypyridine manufacturers

Hebei Chuanghai Biotechnology Co., Ltd
Product
2-Chloro-4-hydroxypyridine 17368-12-6
Price
US $10.00-8.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
10 mt
Release date
2024-12-06
Dideu Industries Group Limited
Product
2-Chloro-4-hydroxypyridine 17368-12-6
Price
US $1.10/g
Min. Order
1g
Purity
99.00%
Supply Ability
100 Tons Min
Release date
2021-09-24
Zhuozhou Wenxi import and Export Co., Ltd
Product
2-Chloro-4-hydroxypyridine 17368-12-6
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-11

17368-12-6, 2-Chloro-4-hydroxypyridineRelated Search:

4-Hydroxypyridine 2-Chloro-5-chloromethylpyridine 2-Chloro-4-iodopyridine Clopidol 2-Chloro-4-bromopyridine 2-Chloro-4-fluoropyridine 4(1H)-Pyrimidinone, 2-chloro- (9CI) 2,3,5,6-TETRAFLUOROTHIOPHENOL PENTAFLUOROBENZENESULFENYL CHLORIDE PENTAFLUOROBENZENESULFONYL CHLORIDE 6-Chloro-2-hydroxypyridine,2-Chloro-6-hydroxypyridine, 98+% 2-Chloro-3-hydroxypyridine 2-CHLORO-5-HYDROXYPYRIDINE 99+%,2-CHLORO-5-HYDROXYPYRIDINE 98%,2-CHLORO-5-HYDROXYPYRIDINE PENTAFLUOROTHIOPHENOL 4-TRIFLUOROMETHYL-2,3,5,6-TETRAFLUOROTHIOPHENOL 2,3,5,6-tetrafluoro-4-mercapto-Benzoic acid Difluorochloromethane PENTAFLUOROPHENYL SULFIDE

  • 2-CHLORO-4-HYDROXYPYRIDINE
  • 2-CHLORO-4-PYRIDINOL
  • 2-CHLOROPYRIDIN-4-OL
  • 4-Pyridinol,2-chloro-(7CI,8CI,9CI)
  • 2-Chloro-4-hydroxypyridine HCl Salt
  • 2-CHLORO-4-HYDROXYPYRIDINE 99%
  • 2-Chloro-4-hydroxypyridine hydrochloride
  • 2-chloro-1H-pyridin-4-one
  • 12.15
  • 2-Chloro-4-hydroxypy
  • 2-Chloro-4-hydroxylpyridine
  • 4-Pyridinol, 2-chloro-
  • 2-Chloro-4-hydroxypyridine95%
  • 2-Chloro-4-hydroxypyridine &gt
  • 2-Chloro-4-hydroxypyridine ISO 9001：2015 REACH
  • Oliceridine Impurity 18
  • 17368-12-6
  • 78067-36-0
  • 13768-12-6
  • CHIRAL CHEMICALS
  • PYRIDINE
  • blocks
  • Pyridines