Diethyl 1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylate

Product Name: Diethyl 1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylate
CAS No.: 1149-23-1
Chemical Name: Diethyl 1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylate
Synonyms: diethyl 2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate;DILUDINE;hantzschester;ethidine;1,4-DIHYDRO-2,6-DIMETHYL-3,5-PYRIDINEDICARBOXYLIC ACID DIETHYL ESTER;1,4-dihydro-2,6-dimethyL;rr116;etidin;diethone;DIETHANE
CBNumber: CB4757520
Molecular Formula: C13H19NO4
Formula Weight: 253.29
MOL File: 1149-23-1.mol

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Diethyl 1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylate Property

Melting point:: 178-183 °C(lit.)
Boiling point:: 351.8±42.0 °C(Predicted)
Density: 1.104±0.06 g/cm3(Predicted)
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
solubility: Soluble in organic solvents.
pka: 3.50±0.70(Predicted)
form: Solid
color: Yellow
λmax: 374nm(EtOH)(lit.)
InChI: InChI=1S/C13H19NO4/c1-5-17-12(15)10-7-11(13(16)18-6-2)9(4)14-8(10)3/h14H,5-7H2,1-4H3
InChIKey: LJXTYJXBORAIHX-UHFFFAOYSA-N
SMILES: C1(C)NC(C)=C(C(OCC)=O)CC=1C(OCC)=O
CAS DataBase Reference: 1149-23-1(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26
WGK Germany: 2
RTECS: US7970100
HS Code: 29333990
Toxicity: LD50 oral in dog: > 12gm/kg

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 120227
Product name: Diethyl 1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylate
Purity: 95%
Packaging: 1G
Price: $76.1
Updated: 2025/07/31

Sigma-Aldrich

Product number: 120227
Product name: Diethyl 1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylate
Purity: 95%
Packaging: 10G
Price: $469
Updated: 2025/07/31

Sigma-Aldrich

Product number: 120227
Product name: Diethyl 1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylate
Purity: 95%
Packaging: 50G
Price: $1930
Updated: 2025/07/31

TCI Chemical

Product number: D3775
Product name: Diethyl 1,4-Dihydro-2,6-dimethyl-3,5-pyridinedicarboxylate
Purity: >98.0%(HPLC)(N)
Packaging: 5g
Price: $24
Updated: 2025/07/31

TCI Chemical

Product number: D3775
Product name: Diethyl 1,4-Dihydro-2,6-dimethyl-3,5-pyridinedicarboxylate
Purity: >98.0%(HPLC)(N)
Packaging: 25g
Price: $59
Updated: 2025/07/31

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Diethyl 1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylate Chemical Properties,Usage,Production

Chemical Properties

Light green solid

Uses

Diethyl 1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylate is a hydrogen source in conjugate reduction and organocatalytic reductive amination. It is used as a hydrogen source in organocatalytic reductive amination and conjugate reduction.

Uses

3,5-Dicarboethoxy-2,6-dimethyl-1,4-dihydropyridine is a dihydropyridine derivative that have been tested for antimicrobial activities.

Application

Diethyl 1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylate (DTP) was used to study the mechanism of electrochemical oxidation of DTP in ethanol/water solutions on a glassy carbon electrode.

Hazard

H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
H335 (100%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Toxicology

rat LD50 intraperitoneal >16 gm/kg
mouse LD50 oral >32 gm/kg
mouse LD50 intraperitoneal >30 gm/kg
dog LD50 oral >12 gm/kg

Synthesis

Diethyl 1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylate is prepared by the reaction of formaldehyd and ethyl acetoacetate in the presence of an inert gas.

Synthesis

Hantzsch Dihydropyridine (Pyridine) Synthesis reaction allows the preparation of dihydropyridine derivatives by condensation of an aldehyde with two equivalents of a β-ketoester in the presence of ammonia. Diethyl 1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylate can be produced by using this method.

Purification Methods

recrystallization from EtOH or flash chromatography with petroleum/ethyl acetate (7:3)

Diethyl 1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylate Preparation Products And Raw materials

Raw materials

Ethanol Hexamethylenetetramine

Preparation Products

Benidipine Nicardipine Glutaraldehyde Imazosulfuron Nilvadipine

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Diethyl 1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylate Suppliers

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View Lastest Price from Diethyl 1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylate manufacturers

Wuhan JiyunZen Tech Co., Ltd.

Product: Diethyl 1149-23-1
Price: US $5.00-0.50/KG
Min. Order: 0.10000000149011612KG
Purity: 99% hplc
Supply Ability: 5000kg
Release date: 2025-06-12

Henan Suikang Pharmaceutical Co.,Ltd.

Product: Diethyl 1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylate 1149-23-1
Price: US $0.00/kg
Min. Order: 25kg
Purity: 99.0%
Supply Ability: 1tons
Release date: 2024-04-26

Hebei Zhuanglai Chemical Trading Co.,Ltd

Product: Dihydropyridine 1149-23-1
Price: US $180.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 20ton
Release date: 2024-06-03

1149-23-1, Diethyl 1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylateRelated Search:

Dimethyl carbonate Dacthal Ethylene glycol diethyl ether Pyridine hydrobromide 2,6-Lutidine Dimethyl phthalate Dimethyl sulfate N,N-Dimethylformamide Quinolinic acid Dimethyl fumarate Dimethyl sulfoxide Dimethyl disulfide 2,5-PYRIDINEDICARBOXYLIC ACID Mefenpyr-diethyl Diethyl oxalate Diethyl malonate Dimethyl ether ETHANE

DILUDINE

DIETHYL 2,6-DIMETHYL-1,4-DIHYDRO-3,5-PYRIDINEDICARBOXYLATE

DIETHYL 2,6-DIMETHYL-1,4-DIHYDROPYRIDINEDICARBOXYLATE

DIETHYL 1,4-DIHYDRO-2,6-DIMETHYL-3,5-PYRIDINEDICARBOXYLATE

AURORA 4780

3,5-DICARBETHOXY-2,6-DIMETHYL-1,4-DIHYDROPYRIDINE

3,5-BIS(CARBOETHOXY)-2,6-DIMETHYL-1,4-DIHYDROPYRIDINE

2,6-DIMETHYL-1,4-DIHYDROPYRIDINE-3,5-DICARBOXYLIC ACID DIETHYL ESTER

2,6-dimethyl-3,5-diethoxycarbonyl-1,4-dihydropyridine

1,4-DIHYDRO-2,6-DIMETHYL-3,5-PYRIDINEDICARBOXYLIC ACID DIETHYL ESTER

RARECHEM AQ NN 0171

5-pyridinedicarboxylicacid,1,4-dihydro-2,6-dimethyl-diethylester

diethone

ethidine

etidin

hantzsch’sdihydropyridine

hantzschester

rr116

1,4-Dihydro-2,6-dimethyl-3,5-pyridinedicarboxylic Acid Diethyl Ester Hantzsch Ester

1,4-diethyl-2,6-diMethyl-1,4-dihydropyridine-3,5-dicarboxylate

3,5-Dicarboethoxy-2,6-dimethyl-1,4-dihydropyridine

Diethyl 1,4-dihydro-2,6-diMethyl-3,5- pyridinedicarboxylat

Diethyl 1,4-dihydro-2,6-diMethyl-3,5-pyridinedicarboxylate, 98%, 98%

1,4-dihydro-2,6-dimethyL

Diethyl1,4-dihydro-2,6-dimethylpyridine-3,5-dicarboxylate,98%

Two hydropyridine

3,5-diethyl 2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate

Dihy**yridine

1,4-diethyl-2,6-dimethyl-4H-pyridine-3,5-dicarboxylate

Diethyl-1,4-dihydro-2,6-dimethylpyridin-3,5-dicarboxylat

DIETHYL1,4-DIHYDRO-2,6-DIMETHYL-3,5-PYRIDINEDICARBOXYLATE(DILUDIN)

diethyl 1,4-dihydro-2,6-dimethylpyridine-3,5-dicarboxylate

Dihydropyridinum

Dihydropyride

2,6-Dimethyl-3.5-Diethylester-1.4-Diludine

DILOXANIDEFUROATE

DIETHANE

Diethyl-1,4-dihydro-2,6-diMethyl-3,5-pyridine carboxylate

1,4-Dihydro-2,6-dimethylpyridine-3,5-dicarboxylic acid diethyl ester

1.4-dihydro-2.6-dimethyl-3.5-pyridinedicarboxylate

diethyl 2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate

3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-, 3,5-diethyl ester

Diethyl 1,4-dihydro-3,5-pyridinecarboxylate, 95%

Diethyl 1,4-dihydro-

Lilium pumilum DC.

Diethyl1,4-Dihydro-2,6-dimethyl-3,5-pyridinedicarboxylate&gt

-3,5-pyridinedicarboxyL

Diethyl 1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylate USP/EP/BP

4-dihydro-2

5-pyridinedicarboxylate

6-dimethyl-3

Diethyl 1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxy

Feed Medication Additives

Diethyl 1,4-dihydro-3,5-pyridinecarboxylate, 95%,

Diethyl 1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarbox

Diethyl 1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarbo

1,4 Dihydro, 3,5,di-carboethoxy 2,6 dimethyl pyridine

Aminocaproic Acid Impurity 16