Nilvadipine
- Product Name
- Nilvadipine
- CAS No.
- 75530-68-6
- Chemical Name
- Nilvadipine
- Synonyms
- ESCOR;SKF-;fk235;ARC029;Nivadip;Nivadil;FR-34235;CL 287389;BAY-e-6927;SKF-102362
- CBNumber
- CB9223154
- Molecular Formula
- C19H19N3O6
- Formula Weight
- 385.37
- MOL File
- 75530-68-6.mol
Nilvadipine Property
- Melting point:
- 148-150°C
- Boiling point:
- 511.83°C (rough estimate)
- Density
- 1.3937 (rough estimate)
- refractive index
- 1.5900 (estimate)
- storage temp.
- Keep in dark place,Sealed in dry,2-8°C
- solubility
- DMSO: soluble15mg/mL, clear
- form
- powder
- pka
- -0.81±0.70(Predicted)
- color
- white to beige
- Merck
- 14,6545
- Stability:
- Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
N-Bromosuccinimide Price
- Product number
- SML0945
- Product name
- Nilvadipine
- Purity
- ≥98% (HPLC)
- Packaging
- 10mg
- Price
- $58.2
- Updated
- 2024/03/01
- Product number
- SML0945
- Product name
- Nilvadipine
- Purity
- ≥98% (HPLC)
- Packaging
- 50mg
- Price
- $163
- Updated
- 2024/03/01
- Product number
- N0899
- Product name
- Nilvadipine
- Purity
- >95.0%(N)
- Packaging
- 1g
- Price
- $108
- Updated
- 2024/03/01
- Product number
- N0899
- Product name
- Nilvadipine
- Purity
- >95.0%(N)
- Packaging
- 5g
- Price
- $322
- Updated
- 2024/03/01
- Product number
- 21243
- Product name
- Nilvadipine
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $32
- Updated
- 2024/03/01
Nilvadipine Chemical Properties,Usage,Production
Description
Nilvadipine is a new, second-generation calcium channel blocker effective in the treatment of hypertension and angina pectoris. Its potent inhibitory effect on the stimulated chemotaxis of smooth muscle cells and protective action against calcium deposition suggest that nilvadipine may be useful for preventing and treating atherosclerosis.
Chemical Properties
Yellow Prisms
Originator
Fujisawa (Japan)
Uses
Used as an antihypertensive and antianginal.
Uses
antihypertensive;calcium channel blocker
Definition
ChEBI: Nilvadipine is an isopropyl ester, a methyl ester, a nitrile and a dihydropyridine.
Manufacturing Process
To a solution of isopropyl ester of 6-formyl-5-methoxycarbonyl-2-methyl-4-(3- nitrophenyl)-1,4-dihydropyridine- 3-carboxylic acid (4.5 g) in acetic acid (35 ml) were added hydroxylamine hydrochloride (0.97 g) and sodium acetate (1.43 g), and the mixture was stirred at ambient temperature for 2.5 hours. After acetic anhydride (4.14 g) was added to this reaction mixture, the mixture was stirred at ambient temperature for 1.5 hours and at 95-100°C for additional 4 hours. The acetic acid and the excess of acetic anhydride were removed in vacuum, followed by adding water to the residue and it was neutralized with a saturated aqueous solution of sodium bicarbonate. This aqueous suspension was extracted twice with ethyl acetate, and the combined extract was washed with water, dried over anhydrous magnesium sulfate and evaporated to dryness under reduced pressure to give a reddish-brown oil (4.88 g), which was chromatographed over silica gel (150 g) with a mixture of benzene and ethyl acetate (10:1 by volume) as an eluent to give a crude crystals (2.99 g). These were recrystallized from ethanol to give yellow prisms (1.89 g) of isopropyl ester of 6-cyano-5-methoxycarbonyl-2-methyl-4-(3- nitrophenyl)-1,4-dihydropyridine-3-carboxylic acid melting point 148-150°C (yellow prisms from ethanol); [α]D20 = 222.4° (c = 1 in methanol).
brand name
Nivadil
Therapeutic Function
Calcium entry blocker, Antihypertensive
References
1) Paris?et al. (2014),?The spleen tyrosine kinase (Syk) regulates Alzheimer amyloid-β production and Tau hyperphosphorylation; J. Biol. Chem.,?289?33927 2) Rosenthal (1994),?Nilvadipine: profile of a new calcium antagonist. An overview; J. Cardiovasc. Pharmacol. 24 Suppl 2?S92 3) Nimmrich and Eckert (2013),?Calcium channel blockers and dementia; Br. J. Pharmacol.?169?1203 4) Otori?et al. (2003),?Protective effect of nilvadipine against glutamate neurotoxicity in purified retinal ganglion cells; Brain Res.?961?213
Nilvadipine Preparation Products And Raw materials
Raw materials
Preparation Products
Nilvadipine Suppliers
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View Lastest Price from Nilvadipine manufacturers
- Product
- Nilvadipine 75530-68-6
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.9%
- Supply Ability
- 100 Tons min
- Release date
- 2021-08-06
- Product
- Nilvadipine 75530-68-6
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 99.0%
- Supply Ability
- 500 MT
- Release date
- 2020-05-11
- Product
- Nilvadipine 75530-68-6
- Price
- US $7.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 1000KG
- Release date
- 2018-08-21