Nisoldipine

Product Name: Nisoldipine
CAS No.: 63675-72-9
Chemical Name: Nisoldipine
Synonyms: Sular;NisoL;Syseor;SYSCOR;Nisocor;NORVASC;Nikameal;ZADIPINA;BAYMYCARD;Nisomynard
CBNumber: CB5147166
Molecular Formula: C20H24N2O6
Formula Weight: 388.41
MOL File: 63675-72-9.mol

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Nisoldipine Property

Melting point:: 147-148°C
Boiling point:: 503.3±50.0 °C(Predicted)
Density: 1.205±0.06 g/cm3(Predicted)
storage temp.: room temp
solubility: DMSO: >10mg/mL
form: powder
pka: 2.67±0.70(Predicted)
color: yellow
Merck: 14,6565
InChIKey: VKQFCGNPDRICFG-UHFFFAOYSA-N
CAS DataBase Reference: 63675-72-9(CAS DataBase Reference)
NIST Chemistry Reference: Nisoldipine(63675-72-9)

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Safety

Hazard Codes: Xn
Risk Statements: 20/21/22
Safety Statements: 36
WGK Germany: 3
RTECS: US7975600
HS Code: 2933399090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: N0165
Product name: Nisoldipine
Purity: ≥98% (HPLC)
Packaging: 10mg
Price: $84.1
Updated: 2024/03/01

Sigma-Aldrich

Product number: N0165
Product name: Nisoldipine
Purity: ≥98% (HPLC)
Packaging: 50mg
Price: $351
Updated: 2024/03/01

TCI Chemical

Product number: N0900
Product name: Nisoldipine
Purity: >98.0%(HPLC)(N)
Packaging: 1g
Price: $91
Updated: 2024/03/01

TCI Chemical

Product number: N0900
Product name: Nisoldipine
Purity: >98.0%(HPLC)(N)
Packaging: 5g
Price: $227
Updated: 2024/03/01

Alfa Aesar

Product number: H37972
Product name: Nisoldipine
Purity: 98%
Packaging: 1g
Price: $119
Updated: 2023/06/20

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Nisoldipine Chemical Properties,Usage,Production

Description

Nisoldipine D4 is another long-acting dihydropyridine calcium channel blocker effective in the treatment of hypertension and angina pectoris. It is reported to have little or no cardiodepressive activity and to be more effective than nifedipine in reducing blood pressure in hypertensives. Nisoldipine has also been shown to be effective in the management of congestive heart failure. Reduction in dosage is necessary in patients with hepatic, but not renal impairment.

Chemical Properties

Nisoldipine D4 is Light Tan Crystals

Originator

Bayer AG (Germany)

Uses

Dihydropyridine calcium channel blocker. Antihypertensive and antianginal

Uses

urease inhibitor

Uses

Labeled Nisoldipine, intended for use as an internal standard for the quantification of Nisoldipine by GC- or LC-mass spectrometry.

Definition

ChEBI: A dihydropyridine that is 1,4-dihydropyridine which is substituted by methyl groups at positions 2 and 6, a methoxycarbonyl group at position 3, an o-nitrophenyl group at position 4, and an isobutoxycarbonyl group at position 5. The racemate, calcium channel blocker, is used in the treatment of hypertension and angina pectoris.

Manufacturing Process

Boiling a solution of 12.7 g of 2'-nitrobenzylideneacetoacetic acid methyl ester and 7.1 g of β-amino-crotonic acid isopropyl ester in 50 ml of methanol for 10 hours yielded 2,6-dimethyl-4-(2'-nitrophenyl)-1,4-dihydropyridine-3,5- dicarboxylic acid 3-methyl ester-5-isopropyl ester of melting point 174°C (from ethanol). Yield 48% of theory.

brand name

Sular (Sciele);Baymycard.

Therapeutic Function

Coronary vasodilator

General Description

In vitro studies show that the effects ofnisoldipine, 1,4-dihydro-2, 6-dimethyl-4-(2-nitrophenyl)-3,5-pyridinecarboxylic acid methyl 2-methylpropyl ester(Sular), on contractile processes are selective, with greaterpotency on vascular smooth muscle than on cardiac muscle.
Nisoldipine is highly metabolized, with five majormetabolites identified. As with most of the dihydropyridines,the cytochrome P450 (CYP) 3A4 isozyme is mainlyresponsible for the metabolism of nisoldipine. The majorbiotransformation pathway appears to involve the hydroxylationof the isobutyl ester side chain. This particular metabolitehas approximately 10% of the activity of the parentcompound.

Biochem/physiol Actions

L-type (CaV1.2) calcium channel blocker; dihydropyridine-type calcium channel blocker with selectivity for smooth muscle (CaV1.2b) over cardiac muscle (CaV1.2a). Arterial vasodilator and antihypertensive agent.

Nisoldipine Preparation Products And Raw materials

Raw materials

Methyl 3-aminocrotonate 2-Nitrobenzaldehyde Isobutyl acetoacetate

Preparation Products

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Nisoldipine Suppliers

Americas 1 Belgium 1 Brazil 1 Canada 5 China 271 Europe 4 France 2 Germany 4 India 24 Italy 2 Japan 4 Poland 2 United Kingdom 9 United States 42 Global 372

J & K SCIENTIFIC LTD.

Tel: 010-82848833 400-666-7788
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

3B Pharmachem (Wuhan) International Co.,Ltd.

Tel: 821-50328103-801 18930552037
Fax: 86-21-50328109
Email: 3bsc@sina.com
Country: China
ProdList: 15848
Advantage: 69

Chembest Research Laboratories Limited

Tel: 021-20908456
Fax: 021-58180499
Email: sales@BioChemBest.com
Country: China
ProdList: 6011
Advantage: 61

TAIYUAN RHF CO.,LTD.

Tel: +86 351 7031519
Fax: +86 351 7031519
Email: sales@RHFChem.com
Country: China
ProdList: 2341
Advantage: 56

TCI (Shanghai) Development Co., Ltd.

Tel: 021-67121386
Fax: 021-67121385
Email: Sales-CN@TCIchemicals.com
Country: China
ProdList: 24539
Advantage: 81

ShangHai DEMO Chemical Co.,Ltd

Tel: 400-021-7337 2355568890
Fax: 0086-21-50182339
Email: sales@demochem.com
Country: China
ProdList: 2572
Advantage: 57

JinYan Chemicals(ShangHai) Co.,Ltd.

Tel: 13817811078
Fax: 86-021-50426522,50426273
Email: sales@jingyan-chemical.com
Country: China
ProdList: 9984
Advantage: 60

Jia Xing Isenchem Co.,Ltd

Tel: 0573-85285100 18627885956
Fax: 0573-85285100
Email: isenchem@163.com
Country: China
ProdList: 9551
Advantage: 66

Pure Chemistry Scientific Inc.

Tel: 001-857-928-2050 or 1-888-588-9418
Fax: 001-617-206-9595
Email: sales@chemreagents.com
Country: United States
ProdList: 10194
Advantage: 62

LGM Pharma

Tel: 1-(800)-881-8210
Fax: 615-250-9817
Email: inquiries@lgmpharma.com
Country: United States
ProdList: 2127
Advantage: 70

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View Lastest Price from Nisoldipine manufacturers

Henan Tengmao Chemical Technology Co. LTD

Product: Nisoldipine 63675-72-9
Price: US $220.00-210.00/kilograms
Min. Order: 1kilograms
Purity: 99%
Supply Ability: 5000 tons
Release date: 2023-07-10

Henan Tengmao Chemical Technology Co. LTD

Product: Nisoldipine 63675-72-9
Price: US $220.00-210.00/kilograms
Min. Order: 1kilograms
Purity: 99%
Supply Ability: 5000 tons
Release date: 2023-07-19

Henan Tengmao Chemical Technology Co. LTD

Product: Nisoldipine 63675-72-9
Price: US $110.00-90.00/kilograms
Min. Order: 1kilograms
Purity: 99%
Supply Ability: 5000 tons
Release date: 2023-12-28

63675-72-9, NisoldipineRelated Search:

Dimethyl sulfate Dimethyl carbonate 2,5-PYRIDINEDICARBOXYLIC ACID 4-Nitrobenzoic acid ETHANE Dihydromyrcenol Quinolinic acid N,N-Dimethylformamide Dimethyl sebacate 2,6-Lutidine Dimethyl fumarate Dimethyl sulfide Dimethyl sulfoxide Dimethyl ether Nitrendipine Nicardipine Nimodipine Doxazosin

3-Isobutyl 5-Methyl 2,6-diMethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate

1,4-dihydro-2,6-dimethyl-4-(2-nitrophenyl)-3,5-pyridinedicarboxylic acid-3-methyl 5-(2-methylpropyl) ester

(±)-Isobutyl methyl 1,4-dihydro-2,6-dimethyl-4-(o-nitrophenyl)-3,5-pyridinedicarboxylate

1,4-Dihydro-2,6-dimethyl-4-(2-nitrophenyl)-3,5-pyridinedicarboxylic acid 3-methyl 5-isobutyl ester

Nikameal

Ninobarucin

Nisomynard

3-Methyl 5-(2-Methylpropyl) (4R)-2,6-diMethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate

Nisoldipine (Sular)

3,5-Pyridinedicarboxylicacid, 1,4-dihydro-2,6-diMethyl-4-(2-nitrophenyl)-, 3-Methyl 5-(2-Methylpropyl)ester

Nisoldipine-d4

methyl 2-methylpropyl 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate

Nisoldipine, >=99%

Nisoldipine(BAY-k 5552

2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid O3-methyl ester O5-(2-methylpropyl) ester

5-pyridinedicarboxylicacid,1,4-dihydro-2,6-dimethyl-4-(2-nitrophenyl)-met

hyl2-methylpropylester

BAYMYCARD

BAY K 5552

ZADIPINA

ISOBUTYL METHYL (- 1,4-DIHYDRO-2,6-DIMETHYL-4-(2-NITROPHENYL)-3,5-PYRIDINEDICARBOXYLATE

Baymycard, Norvasc, Syscor, Zadipina, 1,4-Dihydro-2,6-dimethyl-4-(2-nitrophenyl)-3,5-pyridinedicarboxylic Acid Methyl 2-methylpropyl Ester

3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(2-nitrophenyl)-, methyl 2-methylpropyl ester (9CI)

Nisocor

Sular

Syseor

2，6-Dimethyl-4-(2-nitmphenyl)-1，4-dihydro-3，5-pyridinedicarboxylic acid methyl 2-methylpropyl ester

NORVASC

NISOLDIPINE

NISOLIDIPINE

SYSCOR

Nisoldipin

1,4-DIHYDRO-2,6-DIMETHYL-4-(2-NITROPHENYL)-3,5-PYRIDINEDICARBOXYLIC ACID METHYL 2-METHYLPROPYL ESTER

Nisoldipine-d6

Nisoldipine&gt

Nisoldipine Nisoldipine

NisoL

1,4-Dihydro-2,6-dimethyl-4-(2-nitrophenyl)-3,5-pyridinedicarboxylic Acid Isobutyl Methyl Ester

Nisoldipine USP/EP/BP

NisoldipineQ: What is Nisoldipine Q: What is the CAS Number of Nisoldipine Q: What is the storage condition of Nisoldipine Q: What are the applications of Nisoldipine

hexakis(dihydrogen phosphate)

63675-72-9

C20H18N2O6D6

C20H24N2O6

Calcium channel

Cardiovascular APIs

Active Pharmaceutical Ingredients

All Inhibitors

Inhibitors

Intermediates & Fine Chemicals

Pharmaceuticals