Description Chemical Properties Uses References
ChemicalBook > CAS DataBase List > Dimethyl sulfate

Dimethyl sulfate

Description Chemical Properties Uses References
Product Name
Dimethyl sulfate
CAS No.
77-78-1
Chemical Name
Dimethyl sulfate
Synonyms
NSC 56194;ai3-52118;Methanesulfate;METHYL SULFATE;Dimethylsulfat;Dimetilsolfato;Methylsulphate;Dimethylsulfaat;DIMETHYL SULFATE;sulfatedemethyle
CBNumber
CB9854316
Molecular Formula
C2H6O4S
Formula Weight
126.13
MOL File
77-78-1.mol
More
Less

Dimethyl sulfate Property

Melting point:
-32 °C
Boiling point:
188 °C(lit.)
Density 
1.333 g/mL at 25 °C(lit.)
vapor density 
4.3 (vs air)
vapor pressure 
0.7 mm Hg ( 25 °C)
refractive index 
n20/D 1.386(lit.)
Flash point:
182 °F
storage temp. 
2-8°C
solubility 
ethanol: 0.26 g/mL, clear, colorless
form 
Liquid
color 
Clear colorless
Odor
Almost odorless
Water Solubility 
2.8 g/100 mL (18 ºC)
Merck 
13,3282
BRN 
635994
Exposure limits
TLV/PEL-TWA skin 0.1 ppm (0.52 mg/m3 ) (ACGIH, OSHA, NIOSH) IDLH 10 ppm (NIOSH).
Stability:
Stable; combustible. Incompatible with strong oxidizing agents, strong bases including ammonia. Moisture-sensitive.
CAS DataBase Reference
77-78-1(CAS DataBase Reference)
IARC
2A (Vol. 4, Sup 7, 71) 1999
NIST Chemistry Reference
Sulfuric acid, dimethyl ester(77-78-1)
EPA Substance Registry System
Dimethyl sulfate (77-78-1)
More
Less

Safety

Hazard Codes 
T+
Risk Statements 
45-25-26-34-43-68
Safety Statements 
53-45-61
RIDADR 
UN 1595 6.1/PG 1
WGK Germany 
2
RTECS 
WS8225000
21
Autoignition Temperature
495 °C
HazardClass 
6.1(a)
PackingGroup 
I
HS Code 
29209090
Hazardous Substances Data
77-78-1(Hazardous Substances Data)
Toxicity
LD50 orally in rats: 440 mg/kg (Smyth)
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H301Toxic if swalloed

H314Causes severe skin burns and eye damage

H317May cause an allergic skin reaction

H330Fatal if inhaled

H341Suspected of causing genetic defects

H350May cause cancer

Precautionary statements

P201Obtain special instructions before use.

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P308+P313IF exposed or concerned: Get medical advice/attention.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

More
Less

N-Bromosuccinimide Price

Sigma-Aldrich
Product number
320293
Product name
Dimethyl sulfate
Purity
≥99%
Packaging
1l
Price
$77.3
Updated
2021/03/22
Sigma-Aldrich
Product number
41610
Product name
Dimethyl sulfate
Purity
puriss. p.a., ≥99.0% (GC)
Packaging
1l
Price
$124
Updated
2021/03/22
Sigma-Aldrich
Product number
D186309
Product name
Dimethyl sulfate
Purity
≥99.5%
Packaging
18 L
Price
$1170
Updated
2021/03/22
Sigma-Aldrich
Product number
D186309
Product name
Dimethyl sulfate
Purity
≥99.8%
Packaging
18l-kl
Price
$1450
Updated
2020/08/18
Sigma-Aldrich
Product number
D186309
Product name
Dimethyl sulfate
Purity
≥99.8%
Packaging
500ml
Price
$78.5
Updated
2021/03/22
More
Less

Dimethyl sulfate Chemical Properties,Usage,Production

Description

Dimethyl sulfate (chemical formula: (CH3O)2SO2) is an odorless, corrosive, oily liquid which can release toxic fumes during heating. It can be synthesized through the esterification of sulfuric acid with methanol, and alternatively by the distillation of methyl hydrogen sulfate.

In industry, dimethyl sulfate is used as a methylating agent for the manufacture of many organic chemicals. It can be used for methylation of phenols, amines, and thiol. Moreover, it can be used for base sequencing and DNA chain cleavage since it can rupture the imidazole rings present in guanine. It can also be used for protein-DNA interaction analysis. However, its vapor is toxic to eyes and lungs, can do harm to our body. It is a potential carcinogen based on known experimental data.

Chemical Properties

Dimethyl sulfate is a colorless, oily liquid that is slightly soluble in water. It has a faint, onion-like odor; the odor threshold has not been established. The vapor pressure for dimethyl sulfate is 0.5 mm Hg at 20 °C, and it has a log octanol/water partition coefficient (log Kow ) of 0.032.

Uses

Dimethyl sulphate has been used since the beginning of the century as a methylating agent in the preparation of organic chemical products and colouring agents, in the perfume industry, and in other processes. It is a colourless or yellowish liquid of oily consistency which vaporizes at 50℃. and has a slight piquant smell. Both the liquid and the vapour are vesicants and by virtue of this property may be used in warfare.

References

https://en.wikipedia.org/wiki/Dimethyl_sulfate
https://pubchem.ncbi.nlm.nih.gov/compound/dimethyl_sulfate#section=Top

Description

Dimethyl sulfate is a colorless, oily liquid with a faint, onionlike odor. It is soluble in water, ether, dioxane, acetone, benzene, and other aromatic hydrocarbons, miscible with ethanol, and sparingly soluble in carbon disulfide. It is stable under normal temperatures and pressures, but hydrolyzes rapidly in water at or above 18 ℃.
Dimethyl sulfate has been produced commercially since at least the 1920s. One production method is continuous reaction of dimethyl ether with sulfur trioxide. In 2009, dimethyl sulfate was produced by 33 manufacturers worldwide, including 1 in the United States, 14 in China, 5 in India, 5 in Europe, 6 in East Asia, and 2 in Mexico, and was available from 44 suppliers, including 16 US suppliers. There are no data on US imports or exports of dimethyl sulfate. Reports filed from 1986 through 2002 under the US Environmental Protection Agency’s Toxic Substances Control Act Inventory Update Rule indicate that US production plus imports of dimethyl sulfate totaled 10–50 million pounds. The simplest way of synthesizing dimethyl sulfate is by esterification of sulfuric acid with methanol as follows:2CH3OH+ H2SO4→(CH3)2SO4 + 2H2O

Chemical Properties

Dimethyl sulfate is essentially odorless. The specific gravity of this colorless, corrosive, oily liquid is 1.3322 g/cm3. Dimethyl sulfate is soluble in ether, dioxane, acetone, benzene, and other aromatic hydrocarbons. It is sparingly soluble in carbon disulfide and aliphatic hydrocarbons, and only slightly soluble in water (28 g/l at 18 °C) (O'Neil, 2006).

Uses

Dimethyl Sulfate is a diester of methanol and sulfuric acid. Dimethyl Sulfate is commonly used as a reagent for the methylation of phenols, amines, and thiols. Dimethyl Sulfate is an effective and widely used probe for sequence-specific protein-DNA interactions

Uses

Diethyl sulfate is used as an ethylating agentin many organic syntheses. It is also usedas an accelerator in the sulfation of ethyleneand as an intermediate in certain sulfonationreactions (Merck 1996).

Uses

It is used as a methylating agent in themanufacture of many organic compounds,such as, phenols and thiols. Also, it is used inthe manufacture of dyes and perfumes, andas an intermediate for quaternary ammoniumsalts. It was used in the past as a militarypoison.

Preparation

Dimethyl sulfate is prepared by distillation of an oleum/methanol mixture; technical production using dimethyl ether and SO3 has also been reported (NLM, 2013).

Definition

ChEBI: The dimethyl ester of sulfuric acid.

General Description

Dimethyl sulfate is a colorless oily liquid, odorless to a faint onion-like odor. Dimethyl sulfate is very toxic by inhalation. Dimethyl sulfate is a combustible liquid and has a flash point of 182°F. Dimethyl sulfate is slightly soluble in water and decomposed by water to give sulfuric acid with evolution of heat. Dimethyl sulfate is corrosive to metals and tissue.

Air & Water Reactions

Water soluble.

Reactivity Profile

Pure Dimethyl sulfate and concentrated aqueous ammonia react extremely violently with one another, as is the case for tertiary organic bases, [NFPA 491M, 1991]. Dimethyl sulfate ignites in contact with unheated barium chlorite, due to the rapid formation of unstable methyl chlorite. The product of methylating an unnamed material at 110°C was alloyed to remain in a reactor for 80 min. before the reactor exploded. This involved a sulfur ester such as Dimethyl sulfate, [MCA Case History No. 1786].

Health Hazard

Dimethyl sulfate is extremely hazardous because of its lack of warning properties and delayed toxic effects. The vapor of this compound is extremely irritating to the skin, eyes, and respiratory tract, and contact with the liquid can cause very severe burns to the eyes and skin. Ingestion of dimethyl sulfate causes burns to the mouth, throat, and gastrointestinal tract. The effects of overexposure to dimethyl sulfate vapor may be delayed. After a latent period of 10 hours or more, headache and severe pain to the eyes upon exposure to light may occur, followed by cough, tightness of the chest, shortness of breath, difficulty in swallowing and speaking, vomiting, diarrhea, and painful urination. Fatal pulmonary edema may develop. Systemic effects of dimethyl sulfate include damage to the liver and kidneys. Dimethyl sulfate is listed by IARC in Group 2A ("probable human carcinogen") and is classified as a "select carcinogen" under the criteria of the OSHA Laboratory Standard. Data indicate that dimethyl sulfate does not specifically harm unborn animals; dimethyl sulfate is not a developmental toxin. It is a strong alkylating agent and does produce genetic damage in animals and in bacterial and mammalian cell cultures.

Flammability and Explosibility

Dimethyl sulfate is a combustible liquid (NFPA rating = 2). Toxic dimethyl sulfate vapors are produced in a fire. Carbon dioxide or dry chemical extinguishers should be used to fight dimethyl sulfate fires.

Chemical Reactivity

Reactivity with Water Slow, non-hazardous reaction; Reactivity with Common Materials: Corrodes metal when wet; Stability During Transport: Stable; Neutralizing Agents for Acids and Caustics: Sodium bicarbonate or lime; Polymerization: Not pertinent; Inhibitor of Polymerization: Not pertinent.

Safety Profile

Confirmed carcinogen with experimental carcinogenic, tumorigenic, and teratogenic data. Human poison by inhalation. Experimental poison by ingestion, inhalation, intravenous, and subcutaneous routes. Other experimental reproductive effects. Human mutation datareported. A corrosive irritant to skin, eyes, and mucous membranes. There is no odor or initial irritation to give warning of exposure. On brief, dd exposures, conjunctivitis, catarrhal inflammation of the mucous membranes of the nose, throat, larynx, and trachea, and possibly some reddening of the skin develop after the latent period. With longer, heavier exposures, the cornea shows clouding, the irritation changes to the nasopharynx are more marked, and after 6 to 8 hours pulmonary edema may develop. Death may occur in 3 or 4 days. The liver and kidneys are frequently damaged. Spang of the liquid on the skin can cause ulceration and localnecrosis. In patients surviving severe exposure, there may be serious injury of the liver and hdneys, with suppression of urine, jaunlce, albuminuria, and hematuria appearing. Death, resulting from the hdney or liver damage, may be delayed for several weeks. Flammable when exposed to heat, flame, or oxidizers. Can react with oxidizing materials. Violent reaction with NH4OH and NaN3. To fight fire, use water, foam, CO2, dry chemical. When heated to decomposition it emits toxic fumes of SOx See also SULFATES.

Carcinogenicity

Dimethyl sulfate is reasonably anticipated to be a human carcinogenbased on sufficient evidence of carcinogenicity from studies in experimental animals.

Environmental Fate

Chemical/Physical. Hydrolyzes in water (half-life = 1.2 h) to methanol and sulfuric acid (Robertson and Sugamori, 1966) via the intermediate methyl sulfuric acid (Du Pont, 1999a)

storage

work with dimethyl sulfate should be conducted in a fume hood to prevent exposure by inhalation, and appropriate impermeable gloves and safety goggles should be worn at all times to prevent skin and eye contact.

Incompatibilities

Dimethyl sulfate can react violently with ammonium hydroxide, sodium azide, and strong oxidizers.

Waste Disposal

Excess dimethyl sulfate and waste material containing this substance should be placed in a covered metal container, clearly labeled, and handled according to your institution's waste disposal guidelines.

More
Less

Dimethyl sulfate Suppliers

Linyi yuanbo chemical co. LTD
Tel
Email
13854961943@139.com
Country
China
ProdList
1
Advantage
58
Shanghai Song Yuan Chemical Technology Co., Ltd.
Tel
010-1234567
Fax
86-021-33275113
Email
sonyuanchemical@163.com
Country
China
ProdList
6561
Advantage
50
Chengdu HuaNa Chemicals Co., Ltd.
Tel
13699069380
Fax
-
Email
515238037@qq.com
Country
China
ProdList
3678
Advantage
55
Dalian Idery Biotechnology Co., Ltd.
Tel
0411-62696576- ;0411-66160116-
Fax
0411-66160116
Email
dlidery@yeah.net;2721310367@qq.com
Country
China
ProdList
88
Advantage
58
Nanjing Vital Chemical Co., Ltd.
Tel
025-87193546-
Fax
025-87193546
Email
chemweiao@163.com;
Country
China
ProdList
9076
Advantage
60
Nanjing Xiezun Chemical Co., Ltd.
Tel
025-85620080-
Fax
025-85620080
Email
1919348357@qq.com;
Country
China
ProdList
28
Advantage
60
Shanghai Wei Nie Chemical Technology Co., Ltd.
Email
657990292@qq.com
Country
CHINA
ProdList
292
Advantage
58
Shandong Zhongqiang Chemical Technology Co., Ltd
Tel
Email
413235920@qq.com
Country
China
ProdList
25
Advantage
58
Liling Chuangli Technology Co. LTD
Tel
0534-8101711-
Fax
0534-8101711
Email
sales@chuanglichem.com
Country
China
ProdList
46
Advantage
58
J & K SCIENTIFIC LTD.
Tel
010-82848833- ;010-82848833-
Fax
86-10-82849933
Email
jkinfo@jkchemical.com;market6@jkchemical.com
Country
China
ProdList
96815
Advantage
76
More
Less

View Lastest Price from Dimethyl sulfate manufacturers

Hebei Crovell Biotech Co Ltd
Product
Dimethyl sulfate 77-78-1
Price
US $10.60/KG
Min. Order
1KG
Purity
99%
Supply Ability
5000kg
Release date
2021-06-30
Shijiazhuang tongyang Import and Export Co., LTD
Product
Dimethyl sulfate 77-78-1
Price
US $10.00/KG
Min. Order
10g
Purity
99
Supply Ability
50 Ton/Tons per Month
Release date
2021-08-12
Zhuozhou Wenxi import and Export Co., Ltd
Product
Dimethyl sulfate 77-78-1
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-11

77-78-1, Dimethyl sulfateRelated Search:


  • DIMETHYLSULFATE,REAGENT
  • Dimethylsulfate,98%
  • DIMETHYL SULFATE 99 % MIN.
  • DIMETHYL SULFATE MOLECULAR BIOLOGY*REAGE NT
  • DIMETHYL SULFATE 99+%
  • Dimethylsulphate99%
  • DIMETHYL SULFATE[FOR ACETAMIPRID]
  • Dimethylsulfate (chemical production)
  • Dimethyl sulfuric acid
  • Sulfuric acid dimethyl
  • Methanesulfate
  • Dimethyl sulfateMethyl sulfate
  • Dimethyl sulfate, synthesis grade
  • NSC 56194
  • DiMethyl sulfate, 99+%, AcroSeal
  • DIMETHYL SULFATE FOR SYNTHESIS
  • METHYL SULFATE
  • DIMETHYL SULPHATE
  • DIMETHYL SULFATE
  • AKOS BBS-00004221
  • SULFURIC ACID DIMETHYL ESTER
  • SULPHURIC ACID DIMETHYL ESTER
  • dimethylesterkyselinysirove
  • dimethylesterkyselinysirove(czech)
  • dimethylmonosulfate
  • Dimethylsulfaat
  • Dimethylsulfat
  • dimethylsulfat(czech)
  • Dimetilsolfato
  • DMS (Methyl sulfate)
  • dms(methylsulfate)
  • Dwumetylowy siarczan
  • dwumetylowysiarczan
  • dwumetylowysiarczan(polish)
  • Methyl sulfate, Me2SO4
  • Methyle (sulfate de)
  • methyle(sulfatede)
  • methyle(sulfatede)(french)
  • Methylsulphate
  • Rcra waste number U103
  • rcrawastenumberu103
  • Sulfate de methyle
  • Sulfate dimethylique
  • sulfatededimethyle
  • sulfatededimethyle(french)
  • sulfatedemethyle
  • sulfatedemethyle(french)
  • sulfatedimethylique
  • sulfatedimethylique(french)
  • sulfatodedimetilo
  • ai3-52118
  • Dimethoxysulfone
  • Dimethyl monosulfate
  • Dimethylester kyseliny sirove
  • dimethylesterkyselinysi
  • Clopidogrel Impurity N
  • Glimepiride Impurity 32
  • DimethylSulfate&gt