5-Chloro-2-(methylamino)benzophenone

Product Name: 5-Chloro-2-(methylamino)benzophenone
CAS No.: 1022-13-5
Chemical Name: 5-Chloro-2-(methylamino)benzophenone
Synonyms: Ro 5-4365;Methyl-aMino ketone;Diazepam Impurity D;Diazepam Impurity C;Diazepam Impurity A;Diazepam Impurity 9;Diazapam Impurity D;TeMazepaM IMpurity A;Diazepam benzophenone;Diazepam EP impurity D
CBNumber: CB6355175
Molecular Formula: C14H12ClNO
Formula Weight: 245.7
MOL File: 1022-13-5.mol

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5-Chloro-2-(methylamino)benzophenone Property

Melting point:: 93-95 °C (lit.)
Boiling point:: 421.9±35.0 °C(Predicted)
Density: 1.234±0.06 g/cm3(Predicted)
storage temp.: Keep in dark place,Inert atmosphere,Room temperature
solubility: Chloroform (Slightly), Dichloromethane (Slightly), DMSO (Slightly), Methanol (Very Slightly)
pka: pKa 1.45±0.04(7% EtOH in H2O,t =25,0.02 to 0.40M in HCl) (Uncertain)
form: Solid
color: Light Yellow to Yellow
BRN: 882187
Stability:: Stable. Incompatible with strong oxidizing agents.
InChI: InChI=1S/C14H12ClNO/c1-16-13-8-7-11(15)9-12(13)14(17)10-5-3-2-4-6-10/h2-9,16H,1H3
InChIKey: WPNMLCMTDCANOZ-UHFFFAOYSA-N
SMILES: C(C1=CC(Cl)=CC=C1NC)(C1=CC=CC=C1)=O
CAS DataBase Reference: 1022-13-5(CAS DataBase Reference)
NIST Chemistry Reference: Methanone, [5-chloro-2-(methylamino)phenyl]phenyl-(1022-13-5)
EPA Substance Registry System: Methanone, [5-chloro-2-(methylamino)phenyl]phenyl- (1022-13-5)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-37/39
WGK Germany: 3
RTECS: DJ0414000
TSCA: TSCA listed
HS Code: 2933999552
Storage Class: 11 - Combustible Solids
Hazard Classifications: Eye Irrit. 2
Skin Irrit. 2
STOT SE 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 1644319
Product name: Temazepam Related Compound A
Purity: United States Pharmacopeia (USP) Reference Standard
Packaging: 15mg
Price: $680
Updated: 2025/07/31

Sigma-Aldrich

Product number: 1185020
Product name: Diazepam Related Compound A
Purity: United States Pharmacopeia (USP) Reference Standard
Packaging: 25mg
Price: $1300
Updated: 2025/07/31

TCI Chemical

Product number: C2281
Product name: 5-Chloro-2-(methylamino)benzophenone
Purity: >98.0%(GC)
Packaging: 25g
Price: $72
Updated: 2025/07/31

Sigma-Aldrich

Product number: 191353
Product name: 5-Chloro-2-(methylamino)benzophenone
Purity: 99%
Packaging: 10g
Price: $41.23
Updated: 2025/07/31

TRC

Product number: C369020
Product name: 5-Chloro-2-(methylamino)benzophenone
Packaging: 10g
Price: $70
Updated: 2021/12/16

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5-Chloro-2-(methylamino)benzophenone Chemical Properties,Usage,Production

Chemical Properties

solid

Uses

5-Chloro-2-(methylamino)benzophenone was used in the simultaneous determination of hydrazine and benzylhydrazine in isocarboxazid raw material and tablet formulations by gas chromatography.

Uses

5-Chloro-2-(methylamino)benzophenone is an impurity of 1,4- Temazepam (T017200) as well as a decompoition product of Diazepam and other 1,4-benzodiazepine derivatives.

Synthesis

Weigh 231g of 2-amino-5-chlorobenzophenone, 900g of dimethyl carbonate and 70g of NaY molecular sieves with high silica-aluminum ratio and small grain NaY molecular sieves in a reaction flask. Stirred and heated up to 80??C. After holding the reaction for 8h, a sample was taken and analyzed, and the content of raw material 2-amino-5-chlorobenzophenone in the reaction solution was measured to be 0.2%, and the reaction could be stopped.

Pass water cooling to room temperature, filtration to remove the catalyst, the filtrate is transferred to a reduced-pressure steaming flask, the unreacted dimethyl carbonate evaporated under reduced pressure, the residue is recrystallized with ethanol to obtain yellow needle crystals, that is, 221g of 2-methylamino-5-chlorobenzophenone, 90.2% yield, melting point of 94.0-95.1 ?? C, HPLC purity of 98.9%.

5-Chloro-2-(methylamino)benzophenone Preparation Products And Raw materials

Raw materials

2-Furoic acid Isoxazole Dimethyl sulfate

Preparation Products

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5-Chloro-2-(methylamino)benzophenone Suppliers

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View Lastest Price from 5-Chloro-2-(methylamino)benzophenone manufacturers

Shaanxi Dideu New Materials Co. Ltd

Product: 5-Chloro-2-(methylamino)benzophenone 1022-13-5
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1000kg
Release date: 2025-12-29

Hebei Chuanghai Biotechnology Co., Ltd

Product: 5-Chloro-2-(methylamino)benzophenone 1022-13-5
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 500000kg
Release date: 2024-11-01

Hebei Chuanghai Biotechnology Co,.LTD

Product: 5-Chloro-2-(methylamino)benzophenone 1022-13-5
Price: US $5.70/kg
Min. Order: 10kg
Purity: 99%
Supply Ability: 10000kg
Release date: 2024-08-21

1022-13-5, 5-Chloro-2-(methylamino)benzophenoneRelated Search:

2-Cyclopropylmethylamino-5-chlorobenzophenone 5-Chloro-2-(methylamino)benzophenone 2-Chloro-N-[4-chloro-2-(2-chlorobenzoyl)phenyl]acetamide 2-Bromo-N-[4-chloro-2-(2-chlorobenzoyl)phenyl]acetamide 2'-BENZOYL-2,4'-DICHLOROACETANILIDE 2-BROMOACETAMIDO-5-CHLOROBENZOPHENONE N-(2-BENZOYL-4-CHLOROPHENYL)FORMAMIDE DIAZEPAM IMP. D (EP): [5-CHLORO-2-(METHYLAMINO)PHENYL]PHENYLMETHANONE (5-CHLORO-2-(METHYLAMINO)BENZOPHENONE) TEMAZEPAM IMP. A (EP): [5-CHLORO-2-(METHYLAMINO)PHENYL]PHENYLMETHANONE(5-CHLORO-2-(METHYLAMINO)BENZOPHENONE) N3-[4-CHLORO-2-(2-CHLOROBENZOYL)PHENYL]-2-CHLORONICOTINAMIDE AURORA 3316 (2-[(2-BROMOETHYL)AMINO]-5-CHLOROPHENYL)(PHENYL)METHANONE AURORA 9232 DIETHYL 2-[(2-BENZOYL-4-CHLOROANILINO)METHYLENE]MALONATE 10-BUTYL-2-CHLORO-9(10H)-ACRIDONE SALOR-INT L449652-1EA N-(2-BENZOYL-4-CHLOROPHENYL)-2,2,2-TRIFLUOROACETAMIDE N-(2-BENZOYL-4-CHLOROPHENYL)-2-THIOPHENECARBOXAMIDE

(5-chloro-2-(methylamino)phenyl)phenyl-methanon

DiazepaM Related CoMpound A

TeMazepaM Related CoMpound A

Chloro-2-(MethylaMino)benzoph

Diazepam Impurity A

Diazepam Impurity C

Diazepam Impurity D

Diazepam EP impurity D

Diazepam Impurity. D (EP)

2-METHYLAMINO-5-CHLORO BENZOPHENONE 99.0+%

Methyl-aMino ketone

Diazepam Related Compound A (25 mg) (2-methylamino-5-chlorobenzophenone)

Temazepam Related Compound A (15 mg) (5-chloro-2-methylaminobenzophenone)

Ro 5-4365

TeMazepaM IMpurity A

Diazepam Impurity 4（Diazepam EP Impurity D）

[5-chloro-2-(methylamino)phenyl]phenyl-methanon

[5-Chloro-2-(methylamino)phenyl]phenylmethanone

5-chloro-2-(methylamino)-benzophenon

Benzophenone, 2-acetamido-5-chloro-

Benzophenone, 5-chloro-2-(methylamino)-

Diazepam benzophenone

Diazepam, acid hydrolyzed

Methanone, [5-chloro-2-(methylamino)phenyl]phenyl-

2-METHYLAMINO-5-CHLORO BENZOPHENONE

5-CHLORO-2-(METHYLAMINO)BENZOPHENONE

5-CHLORO-2-(METHYLAMINO)BENZOPHENONE, 99 %

5-Chloro-2-(methylamino)benzophenone &gt

Diazepam Impurity 9

Temazepam EP Impurity A

Temazepam Related Compound A (5-chloro-2-methylaminobenzophenone) (1644319)

Diazepam Related Compound A (2-methylamino-5-chlorobenzophenone) (1185020)

Diazapam Impurity D

Diazepam USP Related Compound A

Temazepam USP Related Compound A

5-Chloro-2-(methylamino)benzophenone, ≥ 98.0%

5-Chloro-2-(methylamino)benzophenone in methanol

5-Chloro-2-(methylamino)phenyl]-phenylmethanone (5-Chloro-2-(methylamino)benzophenone)

5-Chloro-2-methylaminobenzophenone RS

Temazepam EP Impurity A (Diazepam EP Impurity D, Diazepam USP Related Compound A)

1022-13-5

CH3NHC6H3ClCOC6H5

C14H12NOCl

C14H12ClNO

AMINE

Carbonyl Compounds

C13 to C14

Building Blocks

Ketones

Organic Building Blocks

API intermediates

C13 to C14

Carbonyl Compounds

Ketones

Aromatic Benzophenones & Derivatives (substituted)

K00001

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