Methyl trifluoromethanesulfonate
- Product Name
- Methyl trifluoromethanesulfonate
- CAS No.
- 333-27-7
- Chemical Name
- Methyl trifluoromethanesulfonate
- Synonyms
- METHYL TRIFLATE;METHYL TRIFLUOROMETHANESULPHONATE;Methyl trifluoromethanesulfate;Methyl trifluoroMethanesulfona;Methyl trifluoromethanesulfote;methyltrifluoromethanesulfinate;METHYL TRIFLUROMETHANESULFONATE;METHYL TRIFLUOROMETHANESULFONATE;Methyltrifluoromethanesulphonate98%;Methyl trifluoromethanesulfonate ,96%
- CBNumber
- CB9131563
- Molecular Formula
- C2H3F3O3S
- Formula Weight
- 164.1
- MOL File
- 333-27-7.mol
Methyl trifluoromethanesulfonate Property
- Boiling point:
- 94-99 °C(lit.)
- Density
- 1.45 g/mL at 25 °C(lit.)
- refractive index
- n20/D 1.326(lit.)
- Flash point:
- 101 °F
- storage temp.
- 2-8°C
- solubility
- Chloroform (Sparingly), Ethyl Acetate (Slightly)
- form
- Liquid
- Specific Gravity
- 1.450
- color
- Clear colorless to yellow
- Sensitive
- Air Sensitive
- BRN
- 774772
- Stability:
- Hygroscopic, Moisture Sensitive, Volatile
- InChI
- InChI=1S/C2H3F3O3S/c1-8-9(6,7)2(3,4)5/h1H3
- InChIKey
- OIRDBPQYVWXNSJ-UHFFFAOYSA-N
- SMILES
- C(F)(F)(F)S(OC)(=O)=O
- CAS DataBase Reference
- 333-27-7(CAS DataBase Reference)
- EPA Substance Registry System
- Methyl trifluoromethanesulfonate (333-27-7)
Safety
- Hazard Codes
- C,T
- Risk Statements
- 10-34-20/21/22
- Safety Statements
- 26-36/37/39-45-16
- RIDADR
- UN 2920 8/PG 2
- WGK Germany
- 3
- F
- 10
- Hazard Note
- Highly Toxic/Corrosive
- TSCA
- T
- HazardClass
- 3.2
- PackingGroup
- III
- HS Code
- 29049020
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H226Flammable liquid and vapour
H314Causes severe skin burns and eye damage
H330Fatal if inhaled
- Precautionary statements
-
P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P233Keep container tightly closed.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 164283
- Product name
- Methyl trifluoromethanesulfonate
- Purity
- ≥98%
- Packaging
- 10g
- Price
- $83.8
- Updated
- 2024/03/01
- Product number
- 8.18035
- Product name
- Methyl trifluoromethanesulfonate
- Purity
- for synthesis
- Packaging
- 10ml
- Price
- $102
- Updated
- 2024/03/01
- Product number
- 164283
- Product name
- Methyl trifluoromethanesulfonate
- Purity
- ≥98%
- Packaging
- 50g
- Price
- $300
- Updated
- 2024/03/01
- Product number
- T2029
- Product name
- Methyl Trifluoromethanesulfonate
- Purity
- >98.0%(GC)
- Packaging
- 5g
- Price
- $40
- Updated
- 2024/03/01
- Product number
- T2029
- Product name
- Methyl Trifluoromethanesulfonate
- Purity
- >98.0%(GC)
- Packaging
- 25g
- Price
- $180
- Updated
- 2024/03/01
Methyl trifluoromethanesulfonate Chemical Properties,Usage,Production
Chemical Properties
clear colourless to yellow liquid
Uses
Methyl trifluoromethanesulfonate is used as a powerful methylating reagent in chemistry. Further, it is used in the conversion of amines to methyl ammonium triflates. In addition, it is also used in Suzuki reaction.
Application
Methyl trifluoromethanesulfonate, a methylating agent, is commonly used for the pre-methylation of polysaccharides under mild basic conditions.
In the determination of polysulfides, zerovalent sulfur in sulfide-rich water wells, and polysulfide species in electrolyte of a lithium–sulfur battery using chromatography-based techniques.
In reactions with potassium enolates.
For the conversion of amines to methyl ammonium triflates.
Additionally, methyl trifluoromethanesulfonate has been utilized in the production of 2-Benzyloxy-1-methylpyridinium trifluoromethanesulfonate.
General Description
Methyl trifluoromethane sulfonate is a brown liquid. Insoluble in water. (NTP, 1992) This material is a very reactive methylating agent, also known as methyl triflate.
Air & Water Reactions
Highly flammable. Insoluble in water.
Reactivity Profile
Methyl trifluoromethanesulfonate is sensitive to heat. . Esters react with acids to liberate heat along with alcohols and acids. Strong oxidizing acids may cause a vigorous reaction that is sufficiently exothermic to ignite the reaction products. Heat is also generated by the interaction of esters with caustic solutions. Flammable hydrogen is generated by mixing esters with alkali metals and hydrides.
Health Hazard
ACUTE/CHRONIC HAZARDS: When heated to decomposition Methyl trifluoromethanesulfonate emits toxic fumes.
Fire Hazard
Methyl trifluoromethanesulfonate is combustible.
Toxicology
Methyl trifluoromethanesulfonate is extremely hazardous. All possible precautions should be taken to avoid inhalation or absorption through the skin. This material is extremely destructive to the tissue of the mucous membranes and upper respiratory tract, eyes, and skin. Inhalation may be fatal as a result of spasm, inflammation, and edema of the larynx and bronchi, chemical pneumonitis, and pulmonary edema. Use in a fume hood. Although there has yet to be a reported human fatality, several cases were reported for methyl fluorosulfonate (LC50 (rat, 1 h) = 5 ppm), and methyl triflate is expected to have similar toxicity based on available evidence.
Synthesis
Methyl trifluoromethanesulfonate is commercially available, however it may also be prepared in the laboratory by treating dimethyl sulfate with triflic acid.
CF3SO2OH + (CH3O)2SO2 → CF3SO2OCH3 + CH3OSO2OH
Purification Methods
Methyl trifluoromethanesulfonate (methyl triflate) [333-27-7] M 164.1, b 97 -97.5o/736mm, 9 9o/~760mm, 100-102o/~760mm, d 4 1.496, n D 1.3238. It is a strong methylating agent but is corrosive and POISONOUS. Fractionate it carefully and collecting the middle fraction (use an efficient fume cupboard) and keep away from moisture. It is a POWERFUL ALKYLATING AGENT and a strong IRRITANT. [IR: Gramstad & Haszeldine J Chem Soc 173 1956 , J Chem Soc 4069 1957 .] Trifluoromethanesulfonic acid (triflic acid) [1493-13-6] M 151.1, boils higher (b 162o/atm), has a pKa of 3.10, and is TOXIC and hygroscopic. [Hansen J Org Chem 30 4322 1965, Kurz & El-Nasr J Am Chem Soc 104 5823 1982, Beilstein 3 IV 34.]
Methyl trifluoromethanesulfonate Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Methyl trifluoromethanesulfonate manufacturers
- Product
- methyl trifluoromethanesulfonate 333-27-7
- Price
- US $0.00-0.00/Kg
- Min. Order
- 1Kg
- Purity
- 99.9%
- Supply Ability
- 200tons
- Release date
- 2024-04-09
- Product
- Methyl trifluoromethanesulfonate 333-27-7
- Price
- US $0.00/KG
- Min. Order
- 25KG
- Purity
- 98%min
- Supply Ability
- 30tons/month
- Release date
- 2023-02-08
- Product
- Methyl trifluoromethanesulfonate 333-27-7
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 50000KG/month
- Release date
- 2023-09-06