Doxazosin
- Product Name
- Doxazosin
- CAS No.
- 74191-85-8
- Chemical Name
- Doxazosin
- Synonyms
- UK 33274;UK 33,274;DOXAZOSIN;Doxazosin base;DOXAZOSINMESYTL;DOXAZOSIN(CARDULAR);Doxazosin USP/EP/BP;Doxazosin (UK 33274);Doxazosin Mesylate USP;DOXAZOSIN(SUBJECTTOPATENTFREE)
- CBNumber
- CB7216507
- Molecular Formula
- C23H25N5O5
- Formula Weight
- 451.48
- MOL File
- 74191-85-8.mol
Doxazosin Property
- Melting point:
- 289-290°C
- Boiling point:
- 718.0±70.0 °C(Predicted)
- Density
- 1.371±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- Soluble in DMSO
- form
- Powder
- pka
- 6.52±0.50(Predicted)
- CAS DataBase Reference
- 74191-85-8(CAS DataBase Reference)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H302Harmful if swallowed
H314Causes severe skin burns and eye damage
H373May cause damage to organs through prolonged or repeated exposure
H411Toxic to aquatic life with long lasting effects
- Precautionary statements
-
P260Do not breathe dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P273Avoid release to the environment.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P330+P331IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P310Immediately call a POISON CENTER or doctor/physician.
P363Wash contaminated clothing before reuse.
P391Collect spillage. Hazardous to the aquatic environment
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- B1209
- Product name
- Doxazosin
- Packaging
- 100mg
- Price
- $142
- Updated
- 2021/12/16
- Product number
- API0002486
- Product name
- DOXAZOSIN
- Purity
- 95.00%
- Packaging
- 100MG
- Price
- $205.8
- Updated
- 2021/12/16
- Product number
- B1209
- Product name
- Doxazosin
- Packaging
- 500mg
- Price
- $434
- Updated
- 2021/12/16
- Product number
- API0002486
- Product name
- DOXAZOSIN
- Purity
- 95.00%
- Packaging
- 1G
- Price
- $721.57
- Updated
- 2021/12/16
- Product number
- API0002486
- Product name
- DOXAZOSIN
- Purity
- 95.00%
- Packaging
- 2.5G
- Price
- $983.88
- Updated
- 2021/12/16
Doxazosin Chemical Properties,Usage,Production
Description
Doxazosin mesylate is a selective alpha, blocker indicated for the treatment of hypertension, reportedly of special benefit as a first-line agent in the most hypertonic patient population. Another advantage of doxazosin is its favorable effect on blood lipids; it significantly increases the HDL/total cholesterol ratio and decreases the total cholesterol as well as triglycerides levels.
Originator
Pfizer (United Kingdom)
Uses
ACIPHEX therapeutic Erosive or Ulcerative Gastroesophageal Reflux Disease
Definition
ChEBI: A member of the class of quinazolines that is quinazoline substituted by an amino group at position 4, methoxy groups at positions 6 and 7 and a piperazin-1-yl group at position 2 which in turn is substituted by a 2,3-dihydro-1,4-benzodioxin-2-ylcarbonyl roup at position 4. An antihypertensive agent, it is used in the treatment of high blood pressure.
brand name
Cardura (Pfizer);Carduran.
General Description
Doxazosin, 1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-(1,4-benzodioxan-2-ylcarbonyl)piperazine(Cardura), is a quinazoline compound that selectively inhibitsthe α1-subtype of α-adrenergic receptors. This agentis very useful in the management of hypertension associatedwith pheochromocytoma.
Clinical Use
Alpha-adrenoceptor blocker:
Hypertension
Benign prostatic hyperplasia (BPH)
Drug interactions
Potentially hazardous interactions with other drugs
Antidepressants: enhanced hypotensive effect with
MAOIs.
Avanafil, vardenafil, sildenafil and tadalafil: enhanced
hypotensive effect, avoid with tadalafil, start the
others at the lowest possible dose.
Beta-blockers: enhanced hypotensive effect;
increased risk of first dose hypotensive effect.
Calcium-channel blockers: enhanced hypotensive
effect, increased risk of first dose hypotensive effect.
Diuretics: enhanced hypotensive effect, increased risk
of first dose hypotensive effect.
Moxisylyte: possibly severe postural hypotension
when used in combination.
Metabolism
Doxazosin is extensively metabolised in the liver, and excreted in faeces as inactive metabolites (6-hydroxydoxazosin) and a small amount of unchanged drug
Doxazosin Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Doxazosin manufacturers
- Product
- Doxazosin 74191-85-8
- Price
- US $1.90/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 10 ton
- Release date
- 2021-08-26
- Product
- Doxazosin 74191-85-8
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.9%
- Supply Ability
- 100 Tons min
- Release date
- 2021-08-10
- Product
- Doxazosin 74191-85-8
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-10