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Doxazosin

Product Name
Doxazosin
CAS No.
74191-85-8
Chemical Name
Doxazosin
Synonyms
UK 33274;UK 33,274;DOXAZOSIN;Doxazosin base;DOXAZOSINMESYTL;DOXAZOSIN(CARDULAR);Doxazosin USP/EP/BP;Doxazosin (UK 33274);Doxazosin Mesylate USP;DOXAZOSIN(SUBJECTTOPATENTFREE)
CBNumber
CB7216507
Molecular Formula
C23H25N5O5
Formula Weight
451.48
MOL File
74191-85-8.mol
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Doxazosin Property

Melting point:
289-290°C
Boiling point:
718.0±70.0 °C(Predicted)
Density 
1.371±0.06 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
Soluble in DMSO
form 
Powder
pka
6.52±0.50(Predicted)
CAS DataBase Reference
74191-85-8(CAS DataBase Reference)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H302Harmful if swallowed

H314Causes severe skin burns and eye damage

H373May cause damage to organs through prolonged or repeated exposure

H411Toxic to aquatic life with long lasting effects

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P273Avoid release to the environment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P330+P331IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P310Immediately call a POISON CENTER or doctor/physician.

P363Wash contaminated clothing before reuse.

P391Collect spillage. Hazardous to the aquatic environment

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

ApexBio Technology
Product number
B1209
Product name
Doxazosin
Packaging
100mg
Price
$142
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
API0002486
Product name
DOXAZOSIN
Purity
95.00%
Packaging
100MG
Price
$205.8
Updated
2021/12/16
ApexBio Technology
Product number
B1209
Product name
Doxazosin
Packaging
500mg
Price
$434
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
API0002486
Product name
DOXAZOSIN
Purity
95.00%
Packaging
1G
Price
$721.57
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
API0002486
Product name
DOXAZOSIN
Purity
95.00%
Packaging
2.5G
Price
$983.88
Updated
2021/12/16
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Doxazosin Chemical Properties,Usage,Production

Description

Doxazosin mesylate is a selective alpha, blocker indicated for the treatment of hypertension, reportedly of special benefit as a first-line agent in the most hypertonic patient population. Another advantage of doxazosin is its favorable effect on blood lipids; it significantly increases the HDL/total cholesterol ratio and decreases the total cholesterol as well as triglycerides levels.

Originator

Pfizer (United Kingdom)

Uses

ACIPHEX therapeutic Erosive or Ulcerative Gastroesophageal Reflux Disease

Definition

ChEBI: A member of the class of quinazolines that is quinazoline substituted by an amino group at position 4, methoxy groups at positions 6 and 7 and a piperazin-1-yl group at position 2 which in turn is substituted by a 2,3-dihydro-1,4-benzodioxin-2-ylcarbonyl roup at position 4. An antihypertensive agent, it is used in the treatment of high blood pressure.

brand name

Cardura (Pfizer);Carduran.

General Description

Doxazosin, 1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-(1,4-benzodioxan-2-ylcarbonyl)piperazine(Cardura), is a quinazoline compound that selectively inhibitsthe α1-subtype of α-adrenergic receptors. This agentis very useful in the management of hypertension associatedwith pheochromocytoma.

Clinical Use

Alpha-adrenoceptor blocker:
Hypertension
Benign prostatic hyperplasia (BPH)

Drug interactions

Potentially hazardous interactions with other drugs
Antidepressants: enhanced hypotensive effect with MAOIs.
Avanafil, vardenafil, sildenafil and tadalafil: enhanced hypotensive effect, avoid with tadalafil, start the others at the lowest possible dose.
Beta-blockers: enhanced hypotensive effect; increased risk of first dose hypotensive effect.
Calcium-channel blockers: enhanced hypotensive effect, increased risk of first dose hypotensive effect.
Diuretics: enhanced hypotensive effect, increased risk of first dose hypotensive effect.
Moxisylyte: possibly severe postural hypotension when used in combination.

Metabolism

Doxazosin is extensively metabolised in the liver, and excreted in faeces as inactive metabolites (6-hydroxydoxazosin) and a small amount of unchanged drug

Doxazosin Preparation Products And Raw materials

Raw materials

Preparation Products

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Doxazosin Suppliers

J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
94657
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LGM Pharma
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1-(800)-881-8210
Fax
615-250-9817
Email
inquiries@lgmpharma.com
Country
United States
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Syntechem Co.,Ltd
Tel
Fax
E-Mail Inquiry
Email
info@syntechem.com
Country
China
ProdList
12984
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Shanghai Fuhe Chemistry Technology Co., Ltd.
Tel
0086-21-67651709
Fax
0086-21-67651705
Email
cfx759@hotmail.com
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China
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T&W GROUP
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021-61551611 13296011611
Fax
+86 21-50676805
Email
contact@trustwe.com
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China
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S.Z. PhyStandard Bio-Tech. Co., Ltd.
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0755-83725681-603
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+86 755 28094224
Country
China
ProdList
4496
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Beijing HuaMeiHuLiBiological Chemical
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010-56205725
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010-65763397
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waley188@sohu.com
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China
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MedChemexpress LLC
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021-58955995
Fax
609-228-5909
Email
sales@medchemexpress.cn
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United States
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Nanjing Sunlida Biological Technology Co., Ltd.
Tel
025-57798810
Fax
025-57019371
Email
sales@sunlidabio.com
Country
China
ProdList
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LETOPHARM LIMITED
Tel
+86-21-5821 5861
Fax
+86-21-5106 2861
Email
sales@letopharm.com
Country
China
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View Lastest Price from Doxazosin manufacturers

Hebei Chuanghai Biotechnology Co,.LTD
Product
Doxazosin 74191-85-8
Price
US $1.90/KG
Min. Order
1KG
Purity
99%
Supply Ability
10 ton
Release date
2024-08-07
Zhuozhou Wenxi import and Export Co., Ltd
Product
Doxazosin 74191-85-8
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-10
Zhuozhou Wenxi import and Export Co., Ltd
Product
Doxazosin 74191-85-8
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-08

74191-85-8, DoxazosinRelated Search:


  • [4-(4-amino-6,7-dimethoxy-quinazolin-2- yl)piperazin-1-yl]-(2,5-dioxabi cyclo[4.4.0]deca-6,8,10-trien-4-yl)methanone
  • DOXAZOSIN
  • DoxazosinMesylate77883-43-3/Base
  • DOXAZOSIN(SUBJECTTOPATENTFREE)
  • [4-(4-amino-6,7-dimethoxy-2-quinazolinyl)-1-piperazinyl]-[(3S)-2,3-dihydro-1,4-benzodioxin-3-yl]methanone
  • Piperazine, 1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-[(2,3-dihydro-1,4-benzodioxin-2-yl)carbonyl]-
  • UK 33,274
  • UK 33274
  • 4-Amino-2-[4-(1,4-benzodioxan-2-carbonyl)piperazin-1-y1]-6,7-dimethoxy quinazoline
  • 1-(4-Amino-6,7-dimethoxy-2-quinazolinyl)-4-[(2,3-dihydro-1,4-benzodioxin-2-yl)carbonyl]piperazine
  • 1-(4-Amino-6,7-dimethoxyquinazolin-2-yl)-4-[(2,3-dihydro-1,4-benzodioxin-2-yl)carbonyl]piperazine
  • 6,7-Dimethoxy-2-[4-[(2,3-dihydro-1,4-benzodioxin-2-yl)carbonyl]-1-piperazinyl]quinazoline-4-amine
  • DOXAZOSINMESYTL
  • 1-(4-aMino-6,7-diMethoxy-quinazolin-2-yl)-4-(2,3-dihydro-benzo[1,4]dioxine-2-carbonyl)-piperazine
  • DOXAZOSIN(CARDULAR)
  • (4-(4-aMino-6,7-diMethoxyquinazolin-2-yl)piperazin-1-yl)(2,3-dihydrobenzo[b][1,4]dioxin-2-yl)Methanone
  • Doxazosin Mesylate USP
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  • COc5cc4nc(N3CCN(C(=O)C2COc1ccccc1O2)CC3)nc(N)c4cc5OC
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  • C23H25N5O5
  • API
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  • Doxazosin
  • Pharmaceutical