Quinazoline
- Product Name
- Quinazoline
- CAS No.
- 253-82-7
- Chemical Name
- Quinazoline
- Synonyms
- PHENMIAZINE;1,3-BENZODIAZINE;5,6-Benzopyrimidine;QUINAZOLINE;Quinazoline 99%;Benzopyrimidine;Quinazoline >Quinazoline ,98%;Benzo[d]pyrimidine;benzo[a]pyrimidine
- CBNumber
- CB8181293
- Molecular Formula
- C8H6N2
- Formula Weight
- 130.15
- MOL File
- 253-82-7.mol
Quinazoline Property
- Melting point:
- 46-48 °C (lit.)
- Boiling point:
- 243 °C (lit.)
- Density
- 1.2002 (rough estimate)
- refractive index
- 1.6231 (estimate)
- Flash point:
- 224 °F
- storage temp.
- Sealed in dry,Room Temperature
- solubility
- H2O: freely soluble
- pka
- 3.43(at 20℃)
- form
- Crystalline Powder, Crystals and/or Chunks
- color
- Yellow to beige to brownish
- Water Solubility
- H2O: freely soluble
organic solvents: soluble - Merck
- 14,8053
- BRN
- 109370
- CAS DataBase Reference
- 253-82-7(CAS DataBase Reference)
- NIST Chemistry Reference
- Quinazoline(253-82-7)
- EPA Substance Registry System
- Quinazoline (253-82-7)
Safety
- Hazard Codes
- Xi
- Risk Statements
- 36/37/38
- Safety Statements
- 22-24/25-36-26-23
- WGK Germany
- 3
- HS Code
- 29339900
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
N-Bromosuccinimide Price
- Product number
- 123323
- Product name
- Quinazoline
- Purity
- 99%
- Packaging
- 1g
- Price
- $75.7
- Updated
- 2025/07/31
- Product number
- 123323
- Product name
- Quinazoline
- Purity
- 99%
- Packaging
- 5g
- Price
- $170.8
- Updated
- 2025/07/31
- Product number
- Q0055
- Product name
- Quinazoline
- Purity
- >98.0%(GC)(T)
- Packaging
- 1g
- Price
- $114
- Updated
- 2025/07/31
- Product number
- Q670100
- Product name
- Quinazoline
- Packaging
- 5g
- Price
- $120
- Updated
- 2021/12/16
- Product number
- Q670100
- Product name
- Quinazoline
- Packaging
- 25g
- Price
- $330
- Updated
- 2021/12/16
Quinazoline Chemical Properties,Usage,Production
Chemical Properties
Beige to brownish crystalline powder
Uses
Quinazoline was used to study the electrochemical behaviour of quinazoline using modern polarographic and voltammetric methods. It is the basic structural unit of pharmaceuticals and plays an important role in modern synthesis of antitumor drugs.
Definition
ChEBI: A mancude organic heterobicyclic parent that is naphthalene in which the carbon atoms at positions 1 and 3 have been replaced by nitrogen atoms.
General Description
Quinazolines has applications in medicinal chemistry due to their antibacterial, antifungal, anticonvulsant, anti-inflammatory and antitumor activities. It is the basic structural unit of pharmaceuticals and plays an important role in modern synthesis of antitumor drugs.
Biochem/physiol Actions
Genotoxicity of quinazoline was established by bacterial SOS Chromotest (Escherichia Coli).
Synthesis
5190-68-1
253-82-7
The general method for the synthesis of quinazoline from 4-chloroquinazoline was as follows: first, the halogenated heterocycle (0.66 mmol) was dissolved in anhydrous THF (13.2 mL) and degassed by drumming argon gas for several minutes. Subsequently, PdCl2 (dppf) (27.0 mg, 0.033 mmol, 5.0 mol%), TMEDA (0.130 g, 1.12 mmol, 1.7 equiv), and NaBH4 (42.4 mg, 1.12 mmol, 1.7 equiv) were added sequentially. The reaction mixture was stirred at room temperature for an appropriate time under argon protection, after which it was post-treated according to standard methods.
Purification Methods
Purify quinazoline by passage through an activated alumina column in *C6H6 or pet ether (b 40-60o). Distil it under reduced pressure, sublime it under vacuum and crystallise it from pet ether. The picrate has m 188-189o (from MeOH). [Armarego J Appl Chem 11 70 1961, Armarego Quinazolines, Fused Pyrimidines Part I Brown Ed, Wiley-Interscience 1967, Brown Quinazolines Supplement I Taylor Ed, Wiley-Interscience 1996, ISBN 0-471-14565-3; for covalent hydration see Albert & Armarego Adv Heterocycl Chem 4 1 1965, Beilstein 23 H 175, 23 II 177, 23 III/IV 1221.]
References
[1] Journal of Molecular Catalysis A: Chemical, 2014, vol. 393, p. 191 - 209
Quinazoline Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Quinazoline manufacturers
- Product
- Quinazoline 253-82-7
- Price
- US $98.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 100KG
- Release date
- 2018-08-04