Quinidine sulfate dihydrate

Product Name: Quinidine sulfate dihydrate
CAS No.: 6591-63-5
Chemical Name: Quinidine sulfate dihydrate
Synonyms: Quinidin;Unii-J13S2394he;Pitayine Sodium;Chinidin Sodium;β-quinine Sodium;β-quinine Sodium;QUINIDINE SULFATE;(S) Quinine Sulfate;Quinidine sulfate CRS;QUINIDINE SULFATE 99+%
CBNumber: CB2471189
Molecular Formula: C20H26N2O6S
Formula Weight: 422.5
MOL File: 6591-63-5.mol

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Quinidine sulfate dihydrate Property

Melting point:: 212-214 °C (dec.)(lit.)
alpha: [α]D20 +260～+270° (c=5, dil. HCl.10min)
refractive index: 275 ° (C=2, 0.1mol/L HCl)
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
solubility: Slightly soluble in water, soluble in boiling water and in ethanol (96 per cent), practically insoluble in acetone.
color: White to Off-White
Water Solubility: Soluble in chloroform, water (11 mg/ml at 20°C), alcohol, and ethanol (50 mg/ml).
Sensitive: Light Sensitive
Merck: 14,8060
InChIKey: AKYHKWQPZHDOBW-ZAXYGKDDNA-N
SMILES: [C@@H]([C@@]1([H])C[C@@H]2CC[N@]1C[C@@H]2C=C)(C1=CC=NC2=CC=C(OC)C=C12)O.S(O)(O)(=O)=O |&1:0,1,4,7,9,r|
CAS DataBase Reference: 6591-63-5(CAS DataBase Reference)

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Safety

Hazard Codes: Xn
Risk Statements: 22-20/21/22
Safety Statements: 13-36
RIDADR: UN 2811 6.1/PG III
WGK Germany: 3
RTECS: VA5605000
TSCA: Yes
HazardClass: 6.1
PackingGroup: III
HS Code: 2939200050

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: Q0875
Product name: Quinidine sulfate salt dihydrate
Packaging: 10g
Price: $106
Updated: 2024/03/01

Sigma-Aldrich

Product number: PHR3233
Product name: Quinidine Sulfate
Purity: pharmaceutical secondary standard, certified reference material
Packaging: 1G
Price: $173
Updated: 2024/03/01

Sigma-Aldrich

Product number: 1595509
Product name: Quinidine sulfate
Purity: United States Pharmacopeia (USP) Reference Standard
Packaging: 500mg
Price: $436
Updated: 2024/03/01

Alfa Aesar

Product number: J60426
Product name: Quinidine sulfate dihydrate, 98+%
Packaging: 5g
Price: $50.65
Updated: 2024/03/01

Alfa Aesar

Product number: J60426
Product name: Quinidine sulfate dihydrate, 98+%
Packaging: 25g
Price: $185.65
Updated: 2024/03/01

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Quinidine sulfate dihydrate Chemical Properties,Usage,Production

Description

Quinidine sulfate dihydrate is a diastereomer of quinine and a Na+ channel blocker. Also a class I antiarrhythmic drug. Quinidine sulfate dihydrate is a white, odorless crystalline substance that has a bitter flavor. It has limited solubility in water and alcohol but dissolves easily in chloroform and ether. This compound is effective against bacteria resistant to erythromycin, including staphylococci and streptococci, and works by inhibiting cellular ATPases.

Chemical Properties

Quinidine sulfate dihydrate is white to light yellow crystal powde

Uses

antiarrhythmic, antimalarial

Uses

Quinidine sulfate dihydrate (cas# 6591-63-5) is the hydrated, sulfate salt of Quinidine (Q685000), a dextrorotatory stereoisomer of Quinine. Antiarrhythmic (class IA). Antimalarial.

Application

Quinidine sulfate salt dihydrate has been used as an antiarrhythmic drug to study its effects on phosphorylation and mutations in the cardiac sodium channel Nav1.5.

brand name

Cin-Quin (Solvay Pharmaceuticals); Quinidex (Wyeth); Quinora (Schering).

General Description

Quinidine sulfate dihydrate is the sulfateof an alkaloid obtained from various species ofCinchona and their hybrids. It is a dextrorotatory diastereoisomerof quinine. The salt crystallizes from wateras the dihydrate, in the form of fine, needlelike, white crystals.Quinidine sulfate contains a hydroxymethyl groupthat serves as a link between a quinoline ring and a quinuclidinemoiety. The structure contains two basic nitrogens,of which the quinuclidine nitrogen is the stronger base(pKa 10). Quinidine sulfate dihydrate is bitter and light sensitive.Quinidine sulfate dihydrates are nearly neutral or slightly alkaline. Itis soluble to the extent of 1% in water and more highly solublein alcohol or chloroform.

Hazard

Quinidine sulfate dihydrate is acutely toxic and photosensitising. The photosensitisation reaction to quinidine sulphate was reproducible in the photopic test and after oral administration plus ultraviolet A (UVA) irradiation. Eczematous dermatitis was induced after intradermal injection of quinidine sulfate dihydrate irradiated by UVA in vitro only in the presence of the patient's serum. Three workers exposed to quinidine sulphate developed allergic reactions within a short period of time (2-3 months).

Biochem/physiol Actions

Class IA antiarrhythmic; potassium channel blocker.

Clinical Use

Quinidine sulfate is the prototype of antiarrhythmicdrugs and a class IA antiarrhythmic agent according to theVaughan Williams classification. It reduces Na⁺ current bybinding the open ion channels (i.e., state A). The decreasedNa⁺entry into the myocardial cell depresses phase 4 diastolicdepolarization and shifts the intracellular threshold potentialtoward zero. These combined actions diminish thespontaneous frequency of pacemaker tissues, depress theautomaticity of ectopic foci, and, to a lesser extent, reduceimpulse formation in the SA node. This last action results inbradycardia. During the spike action potential, quinidinesulfate decreases transmembrane permeability to passiveinflux of Na⁺, thus slowing the process of phase 0 depolarization,which decreases conduction velocity. This is shownas a prolongation of the QRS complex of electrocardiograms.Quinidine sulfate also prolongs action potential duration,which results in a proportionate increase in the QTinterval. It is used to treat supraventricular and ventricularectopic arrhythmias, such as atrial and ventricular prematurebeats, atrial and ventricular tachycardia, atrial flutter, andatrial fibrillation.

Quinidine sulfate dihydrate Preparation Products And Raw materials

Raw materials

Preparation Products

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Quinidine sulfate dihydrate Suppliers

Belgium 1 Brazil 1 Canada 1 CHINA 103 Europe 1 France 1 Germany 1 India 12 Japan 3 Mexico 1 Slovakia 1 Spain 1 Switzerland 3 United Kingdom 5 United States 23 USA 1 Global 159

Finetech Industry Limited

Tel: 027-87465837 19945049750
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3B Pharmachem (Wuhan) International Co.,Ltd.

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Chengdu Ai Keda Chemical Technology Co., Ltd.

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Beijing HuaMeiHuLiBiological Chemical

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TOKYO CHEMICAL INDUSTRY CO., LTD.

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Fax: 03-3668-0520
Email: Sales-JP@TCIchemicals.com
Country: Japan
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View Lastest Price from Quinidine sulfate dihydrate manufacturers

hebei hongtan Biotechnology Co., Ltd

Product: Quinidine sulfate dihydrate 6591-63-5
Price: US $60.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 1000
Release date: 2024-03-25

Hebei Weibang Biotechnology Co., Ltd

Product: Quinidine sulfate dihydrate 6591-63-5
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 500000kg
Release date: 2024-10-29

Hebei Mojin Biotechnology Co., Ltd

Product: Quinidine sulfate dihydrate 6591-63-5
Price: US $0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 50000KG/month
Release date: 2023-11-30

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QUINIDINE SULFATE 99+%

QUINIDINESULFATE,DIHYDRATE,USP

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Pitayine Sodium

Chinidin Sodium

Quinidine sulfate dihydrate USP/EP/BP

β-quinine Sodium

(S)-[(2S,4S,5R)-5-ethenyl-1-azabicyclo[2.2.2]octan-2-yl]-(6-methoxyquinolin-4-yl)methanol

Quinidine Sulfate (1595509)

(S) Quinine Sulfate

bis((S)-[(2R,4S,5R)-5-ethenyl-1-azabicyclo[2.2.2]octan-2-yl](6-methoxyquinolin-4-yl)methanol) sulfuric acid dihydrate

Pentoxyverine dihydrate

Chinidin Sodium|||β-quinine Sodium|||Pitayine Sodium|||Quinidine sulfate

(S)-(6-methoxyquinolin-4-yl)((1S,2R,4S,5R)-5-vinylquinuclidin-2-yl)methanol sulfate hydrate(2:1:2)

6591-63-5

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C40H48N4O4H2O4S2H2O

2C20H24N2O2H2SO42H2O

2C20H24N2O22H2OH2O4S

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