ChemicalBook > CAS DataBase List > Quinazoline

Quinazoline

Product Name: Quinazoline
CAS No.: 253-82-7
Chemical Name: Quinazoline
Synonyms: PHENMIAZINE;1,3-BENZODIAZINE;5,6-Benzopyrimidine;QUINAZOLINE;Quinazoline 99%;Benzopyrimidine;Quinazoline >Quinazoline ,98%;Benzo[d]pyrimidine;benzo[a]pyrimidine
CBNumber: CB8181293
Molecular Formula: C8H6N2
Formula Weight: 130.15
MOL File: 253-82-7.mol

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Quinazoline Property

Melting point:: 46-48 °C (lit.)
Boiling point:: 243 °C (lit.)
Density: 1.2002 (rough estimate)
refractive index: 1.6231 (estimate)
Flash point:: 224 °F
storage temp.: Sealed in dry,Room Temperature
solubility: H2O: freely soluble
pka: 3.43(at 20℃)
form: Crystalline Powder, Crystals and/or Chunks
color: Yellow to beige to brownish
Water Solubility: H2O: freely soluble
organic solvents: soluble
Merck: 14,8053
BRN: 109370
CAS DataBase Reference: 253-82-7(CAS DataBase Reference)
NIST Chemistry Reference: Quinazoline(253-82-7)
EPA Substance Registry System: Quinazoline (253-82-7)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 22-24/25-36-26-23
WGK Germany: 3
HS Code: 29339900

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 123323
Product name: Quinazoline
Purity: 99%
Packaging: 1g
Price: $75.7
Updated: 2025/07/31

Sigma-Aldrich

Product number: 123323
Product name: Quinazoline
Purity: 99%
Packaging: 5g
Price: $170.8
Updated: 2025/07/31

TCI Chemical

Product number: Q0055
Product name: Quinazoline
Purity: >98.0%(GC)(T)
Packaging: 1g
Price: $114
Updated: 2025/07/31

TRC

Product number: Q670100
Product name: Quinazoline
Packaging: 5g
Price: $120
Updated: 2021/12/16

TRC

Product number: Q670100
Product name: Quinazoline
Packaging: 25g
Price: $330
Updated: 2021/12/16

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Quinazoline Chemical Properties,Usage,Production

Chemical Properties

Beige to brownish crystalline powder

Uses

Quinazoline was used to study the electrochemical behaviour of quinazoline using modern polarographic and voltammetric methods. It is the basic structural unit of pharmaceuticals and plays an important role in modern synthesis of antitumor drugs.

Definition

ChEBI: A mancude organic heterobicyclic parent that is naphthalene in which the carbon atoms at positions 1 and 3 have been replaced by nitrogen atoms.

General Description

Quinazolines has applications in medicinal chemistry due to their antibacterial, antifungal, anticonvulsant, anti-inflammatory and antitumor activities. It is the basic structural unit of pharmaceuticals and plays an important role in modern synthesis of antitumor drugs.

Biochem/physiol Actions

Genotoxicity of quinazoline was established by bacterial SOS Chromotest (Escherichia Coli).

Synthesis

5190-68-1

253-82-7

The general method for the synthesis of quinazoline from 4-chloroquinazoline was as follows: first, the halogenated heterocycle (0.66 mmol) was dissolved in anhydrous THF (13.2 mL) and degassed by drumming argon gas for several minutes. Subsequently, PdCl2 (dppf) (27.0 mg, 0.033 mmol, 5.0 mol%), TMEDA (0.130 g, 1.12 mmol, 1.7 equiv), and NaBH4 (42.4 mg, 1.12 mmol, 1.7 equiv) were added sequentially. The reaction mixture was stirred at room temperature for an appropriate time under argon protection, after which it was post-treated according to standard methods.

Purification Methods

Purify quinazoline by passage through an activated alumina column in *C6H6 or pet ether (b 40-60o). Distil it under reduced pressure, sublime it under vacuum and crystallise it from pet ether. The picrate has m 188-189o (from MeOH). [Armarego J Appl Chem 11 70 1961, Armarego Quinazolines, Fused Pyrimidines Part I Brown Ed, Wiley-Interscience 1967, Brown Quinazolines Supplement I Taylor Ed, Wiley-Interscience 1996, ISBN 0-471-14565-3; for covalent hydration see Albert & Armarego Adv Heterocycl Chem 4 1 1965, Beilstein 23 H 175, 23 II 177, 23 III/IV 1221.]

References

[1] Journal of Molecular Catalysis A: Chemical, 2014, vol. 393, p. 191 - 209

Quinazoline Preparation Products And Raw materials

Raw materials

5-Nitroisoquinoline

Preparation Products

Quinapril Terazosin 7-chloro-1,3-dihydro-5-phenyl-2-oxo-2H-1,4-benzodiazepin-3-yl acetate Demoxepam Doxazosin Alfuzosin hydrochloride Bunazosin hydrochloride 4-Chloroquinazoline

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View Lastest Price from Quinazoline manufacturers

Career Henan Chemical Co

Product: Quinazoline 253-82-7
Price: US $98.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 100KG
Release date: 2018-08-04

253-82-7, QuinazolineRelated Search:

Cefazolin sodium salt 5-Methyl-2-phenyl-1,2-dihydropyrazol-3-one Cefazolin Sulfaquinoxaline 4-Hydroxyquinazoline Oxymetazoline Quinaldic acid 5-Hydroxyquinoxaline 6-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)quinoxaline Ethyl Quinazoline-4-acetate tert-Butyl Quinazoline-4-acetate 2-Quinoxalinecarboxylic acid methyl ester Quinoxaline QUINOLINE-4-CARBOXYLIC ACID Quinoline Quinidine sulfate dihydrate Quercetin dihydrate Quinic acid

1,3-Diazanaphthalene

4.5-Benzopyrimidine

Benzo(e)pyrimidine

1,3-Benzodiazine, Benzopyrimidine

5,6-Benzopyrimidine

Quinazoline ,98%

Benzo[d]pyrimidine

Benzopyrimidine

Quinazoline (6CI,8CI,9CI)

benzo[a]pyrimidine

Quinazoline 99%

PHENMIAZINE

QUINAZOLINE

1,3-BENZODIAZINE

Quinazoline &gt

quinazoline - [Q22663]

253-82-7

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