ChemicalBook > CAS DataBase List > 5-Methyl-2-phenyl-1,2-dihydropyrazol-3-one

5-Methyl-2-phenyl-1,2-dihydropyrazol-3-one

Product Name
5-Methyl-2-phenyl-1,2-dihydropyrazol-3-one
CAS No.
89-25-8
Chemical Name
5-Methyl-2-phenyl-1,2-dihydropyrazol-3-one
Synonyms
PMP;Radicu;NSC-12;-3-one;Radicut;MCI-186;NSC-2629;Adaravone;EDARAVONE;NSC-26139
CBNumber
CB1287462
Molecular Formula
C10H10N2O
Formula Weight
174.2
MOL File
89-25-8.mol
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5-Methyl-2-phenyl-1,2-dihydropyrazol-3-one Property

Melting point:
126-128 °C(lit.)
Boiling point:
287 °C265 mm Hg(lit.)
Density 
1,12 g/cm3
refractive index 
1.6300 (estimate)
Flash point:
191°C/17mm
storage temp. 
2-8°C
solubility 
3.30g/l
pka
2.73±0.50(Predicted)
form 
Crystalline Powder
color 
Yellow to beige
PH
4.0-4.4 (H2O, 20℃)(saturated aqueous solution)
Water Solubility 
3 g/L (20 ºC)
Merck 
14,6713
BRN 
609575
InChIKey
QELUYTUMUWHWMC-UHFFFAOYSA-N
CAS DataBase Reference
89-25-8(CAS DataBase Reference)
NIST Chemistry Reference
3H-Pyrazol-3-one, 2,4-dihydro-5-methyl-2-phenyl-(89-25-8)
EPA Substance Registry System
1-Phenyl-3-methyl-5-pyrazolone (89-25-8)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36
WGK Germany 
1
RTECS 
UQ9625000
TSCA 
Yes
HS Code 
29331990
Hazardous Substances Data
89-25-8(Hazardous Substances Data)
Toxicity
LD50 orl-rat: 3500 mg/kg LONZA# 08FEB79
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H303May be harmfulif swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
443300
Product name
MCI-186
Packaging
500mg
Price
$74.92
Updated
2021/03/22
Sigma-Aldrich
Product number
PHR2348
Product name
Antipyrine Related Compound A
Purity
Pharmaceutical Secondary Standard; Certified Reference Material
Packaging
50MG
Price
$399
Updated
2021/03/22
Sigma-Aldrich
Product number
1040016
Product name
Antipyrine Related Compound A
Purity
United States Pharmacopeia (USP) Reference Standard
Packaging
25mg
Price
$1260
Updated
2021/03/22
TCI Chemical
Product number
M0687
Product name
3-Methyl-1-phenyl-5-pyrazolone
Purity
>98.0%(HPLC)(T)
Packaging
25g
Price
$19
Updated
2021/03/22
TCI Chemical
Product number
M0687
Product name
3-Methyl-1-phenyl-5-pyrazolone
Purity
>98.0%(HPLC)(T)
Packaging
500g
Price
$40
Updated
2021/03/22
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5-Methyl-2-phenyl-1,2-dihydropyrazol-3-one Chemical Properties,Usage,Production

Description

Edaravone was marketed in Japan for improving neurologic recovery following acute brain infarction. Currently, several agents classified as neuroprotectants and acting by diverse mechanisms (inhibition of glutamate release, blockade of calcium channels, lazaroids) have been marketed for treating the outcomes of brain damage due to trauma, ischemia or cardiac arrest. Edavarone is the first antioxidant with free radical scavenging activity to be introduced for this pathology. This previously described molecule (in particular as norantipyrine, one of three metabolites of antipyrine in mammals) can be simply prepared by direct cyclization of phenylhydrazine with alkylacetoacetate. Edarevone is a lipophilic agent, readily accessible to brain tissue, that is capable of reducing edema in the brain following ischemia by blocking the arachidonic acid cascade triggering peroxidative neurodegeneration. Interestingly, this agent has been shown to quench active oxygen species in endothelial cell homogenate, as well as inhibiting in vitro lipid peroxidative disintegration of membranes, so making this compound effective during reperfusion following ischemic injury. As an additional indication, phase III trials started with edaravone for increasing the chance of recovery after subarachnoid hemorrhage.

Chemical Properties

Off white to light yellow powder

Originator

Mitsubishi Pharma (Japan)

Uses

antioxidant, lipoxygenase inhibitor

Uses

Edaravone inhibits the disease activity in rheumatoid arthritis.

Definition

ChEBI: A pyrazolone that is 2,4-dihydro-3H-pyrazol-3-one which is substituted at positions 2 and 5 by phenyl and methyl groups, respectively.

brand name

Radicut

Hazard

Toxic by ingestion.

Biological Activity

A radical scavenger and antioxidant which is able to protect against the effects of ischemia, probably by inhibiting the lipoxygenase system. Protects against MPTP-induced neurotoxicity.

Safety Profile

Moderately toxic by ingestion andintraperitoneal routes. An eye irritant. When heated todecomposition it emits toxic fumes of NOx.

Purification Methods

Crystallise the pyrazolone from hot H2O, EtOH or EtOH/water (1:1). It complexes with metals. [Veibel et al. Acta Chim Scand 6 1066 1952, Beilstein 24 II 9, 24 III/IV 71.]

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5-Methyl-2-phenyl-1,2-dihydropyrazol-3-one Suppliers

Tianjin heowns Biochemical Technology Co., Ltd.
Tel
400 638 7771
Email
sales@heowns.com
Country
China
ProdList
14457
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57
Shandong Xinhua Pharmceutical Co.,LTD
Tel
0533-2196801
Fax
0533-2196817
Email
yaojianyong@xhzy.com
Country
China
ProdList
71
Advantage
60
Shanghai Aladdin Bio-Chem Technology Co.,LTD
Tel
021-20337333-801
Fax
021-50323701
Email
market@aladdin-e.com
Country
China
ProdList
24980
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Shanghai He Huan Chemical Co., Ltd.
Tel
021-60345187
Fax
021-60345187
Email
lzz841106@aliyun.com
Country
CHINA
ProdList
9846
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58
Shanghai Fulland Pharmaceuticals Ltd
Tel
021-50432069-
Email
sales2@fullandpharma.com
Country
China
ProdList
35
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J & K SCIENTIFIC LTD.
Tel
010-82848833- ;010-82848833-
Fax
86-10-82849933
Email
jkinfo@jkchemical.com;market6@jkchemical.com
Country
China
ProdList
96815
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76
Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel
21-61259100-
Fax
86-21-61259102
Email
sh@meryer.com
Country
China
ProdList
40264
Advantage
62
3B Pharmachem (Wuhan) International Co.,Ltd.
Tel
821-50328103-801
Fax
86-21-50328109
Email
3bsc@sina.com
Country
China
ProdList
15877
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69
future industrial shanghai co., ltd
Tel
400-0066-400;021-60496031
Fax
021-55660885
Email
sales@jonln.com;sales@jonln.com
Country
China
ProdList
1999
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65
Alfa Aesar
Tel
400-610-6006; 021-67582000
Fax
021-67582001/03/05
Email
saleschina@alfa-asia.com
Country
China
ProdList
30159
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84
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View Lastest Price from 5-Methyl-2-phenyl-1,2-dihydropyrazol-3-one manufacturers

Hebei Crovell Biotech Co Ltd
Product
Edaravone 89-25-8
Price
US $10.70/Kg/Bag
Min. Order
10g
Purity
99%
Supply Ability
10000kg
Release date
2021-07-22
WUHAN CIRCLE POWDER TECHNOLOGY CO.,LTD
Product
Edaravone 89-25-8
Price
US $0.00/KG
Min. Order
100g
Purity
98%+
Supply Ability
100kg
Release date
2020-10-22
Hebei Lingding Biological Technology Co., Ltd
Product
5-Methyl-2-phenyl-1,2-dihydropyrazol-3-one 89-25-8
Price
US $350.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
9000kg/per week
Release date
2021-10-27

89-25-8, 5-Methyl-2-phenyl-1,2-dihydropyrazol-3-oneRelated Search:


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