5-Methyl-2-phenyl-1,2-dihydropyrazol-3-one

ChemicalBook > CAS DataBase List > 5-Methyl-2-phenyl-1,2-dihydropyrazol-3-one

5-Methyl-2-phenyl-1,2-dihydropyrazol-3-one

Product Name: 5-Methyl-2-phenyl-1,2-dihydropyrazol-3-one
CAS No.: 89-25-8
Chemical Name: 5-Methyl-2-phenyl-1,2-dihydropyrazol-3-one
Synonyms: PMP;EDARAVONE;1-Phenyl-3-methyl-5-pyrazolone;5-METHYL-2-PHENYL-2,4-DIHYDRO-3H-PYRAZOL-3-ONE;3-methyl-1-phenyl-1H-pyrazol-5(4H)-one;Norphenazone;3-METHYL-1-PHENYL-5-PYRAZOLONE;3-METHYL-1-PHENYL-2-PYRAZOLIN-5-ONE;MONOPYRAZOLONE;PHENYLMETHYLPYRAZOLON
CBNumber: CB1287462
Molecular Formula: C10H10N2O
Formula Weight: 174.2
MOL File: 89-25-8.mol

Less

5-Methyl-2-phenyl-1,2-dihydropyrazol-3-one Property

Melting point:: 126-128 °C(lit.)
Boiling point:: 287 °C265 mm Hg(lit.)
Density: 1,12 g/cm³
vapor pressure: 0.016Pa at 20℃
refractive index: 1.6300 (estimate)
Flash point:: 191°C/17mm
storage temp.: 2-8°C
solubility: 3.30g/l
pka: 2.73±0.50(Predicted)
form: Crystalline Powder
color: Yellow to beige
PH: 4.0-4.4 (H2O, 20℃)(saturated aqueous solution)
Water Solubility: 3 g/L (20 ºC)
Merck: 14,6713
BRN: 609575
Stability:: Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
InChIKey: QELUYTUMUWHWMC-UHFFFAOYSA-N
LogP: 0.75 at 24℃
CAS DataBase Reference: 89-25-8(CAS DataBase Reference)
NIST Chemistry Reference: 3H-Pyrazol-3-one, 2,4-dihydro-5-methyl-2-phenyl-(89-25-8)
EPA Substance Registry System: 1-Phenyl-3-methyl-5-pyrazolone (89-25-8)

Less

Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36
WGK Germany: 1
RTECS: UQ9625000
TSCA: Yes
HS Code: 29331990
Hazardous Substances Data: 89-25-8(Hazardous Substances Data)
Toxicity: LD50 orl-rat: 3500 mg/kg LONZA# 08FEB79

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P337+P313IF eye irritation persists: Get medical advice/attention.

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: PHR2348
Product name: Antipyrine Related Compound A
Purity: Pharmaceutical Secondary Standard; Certified Reference Material
Packaging: 50MG
Price: $534
Updated: 2024/03/01

Sigma-Aldrich

Product number: 443300
Product name: MCI-186
Packaging: 500mg
Price: $96.7
Updated: 2024/03/01

Sigma-Aldrich

Product number: 1040016
Product name: Antipyrine Related Compound A
Purity: United States Pharmacopeia (USP) Reference Standard
Packaging: 25mg
Price: $1300
Updated: 2024/03/01

TCI Chemical

Product number: M0687
Product name: 3-Methyl-1-phenyl-5-pyrazolone
Purity: >98.0%(HPLC)(T)
Packaging: 25g
Price: $21
Updated: 2024/03/01

TCI Chemical

Product number: M0687
Product name: 3-Methyl-1-phenyl-5-pyrazolone
Purity: >98.0%(HPLC)(T)
Packaging: 500g
Price: $43
Updated: 2024/03/01

Less

5-Methyl-2-phenyl-1,2-dihydropyrazol-3-one Chemical Properties,Usage,Production

Description

Edaravone was marketed in Japan for improving neurologic recovery following acute brain infarction. Currently, several agents classified as neuroprotectants and acting by diverse mechanisms (inhibition of glutamate release, blockade of calcium channels, lazaroids) have been marketed for treating the outcomes of brain damage due to trauma, ischemia or cardiac arrest. Edavarone is the first antioxidant with free radical scavenging activity to be introduced for this pathology. This previously described molecule (in particular as norantipyrine, one of three metabolites of antipyrine in mammals) can be simply prepared by direct cyclization of phenylhydrazine with alkylacetoacetate. Edarevone is a lipophilic agent, readily accessible to brain tissue, that is capable of reducing edema in the brain following ischemia by blocking the arachidonic acid cascade triggering peroxidative neurodegeneration. Interestingly, this agent has been shown to quench active oxygen species in endothelial cell homogenate, as well as inhibiting in vitro lipid peroxidative disintegration of membranes, so making this compound effective during reperfusion following ischemic injury. As an additional indication, phase III trials started with edaravone for increasing the chance of recovery after subarachnoid hemorrhage.

Description

MCI-186 is a free radical scavenger with diverse protective effects in vivo. Most notably, it reduces damage due to ischemia-reperfusion injury in lung, liver, and brain in animal models of transplant, infection, traumatic brain injury, and stroke. MCI-186 provides these protective effects, at least in part, by reducing reactive oxygen species, inhibiting apoptosis, and blocking nonenzymatic peroxidation and lipoxygenase activity.

Chemical Properties

Off white to light yellow powder

Originator

Mitsubishi Pharma (Japan)

Uses

3-Methyl-1-phenyl-2-pyrazolin-5-one used as reagent for detection of reducing carbohydrates by ESI/MALDI -MS.

Uses

antioxidant, lipoxygenase inhibitor

Uses

Edaravone inhibits the disease activity in rheumatoid arthritis.

Definition

ChEBI: A pyrazolone that is 2,4-dihydro-3H-pyrazol-3-one which is substituted at positions 2 and 5 by phenyl and methyl groups, respectively.

brand name

Radicut

General Description

A free radical scavenger and antioxidant that reduces post-ischemic brain injury. Inhibits iron-dependent peroxidation in rat brain homogenates (IC₅₀ = 15 μM). Inhibits mitochondrial permeability transition pore.

Hazard

Toxic by ingestion.

Flammability and Explosibility

Not classified

Biological Activity

A radical scavenger and antioxidant which is able to protect against the effects of ischemia, probably by inhibiting the lipoxygenase system. Protects against MPTP-induced neurotoxicity.

Biochem/physiol Actions

Product does not compete with ATP.

Safety Profile

Moderately toxic by ingestion andintraperitoneal routes. An eye irritant. When heated todecomposition it emits toxic fumes of NOx.

storage

Store at RT

Purification Methods

Crystallise the pyrazolone from hot H2O, EtOH or EtOH/water (1:1). It complexes with metals. [Veibel et al. Acta Chim Scand 6 1066 1952, Beilstein 24 II 9, 24 III/IV 71.]

References

1) Watanabe et al. (1994), Protective effects of MCI-186 on cerebral ischemia:possible involvement of free radical scavenging and antioxidant actions; J. Pharmacol. Exp. Ther., 268 1597 2) Yoshida et al. (2006) Neuroprotective effects of edaravone:a novel free radical scavenger in cerebrovascular injury; CNS Drug Reviews, 12 9 3) Kawasaki et al. (2007) Edaravone (3-Methyl-1-phenyl-2-pyrazolin-5-one), a Radical Scavenger, Prevents 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced Neurotoxicity in the Substantia Nigra but Not the Striatum; J. Pharmacol. Exp. Ther., 322 274

5-Methyl-2-phenyl-1,2-dihydropyrazol-3-one Preparation Products And Raw materials

Raw materials

Acetyl ketene AMMONIUM NITRITE, 20% SOLN Acetoacetamide Ammonium hydroxide Ethanol Acetoxyacetic acid Ammonium bisulfite Formaldehyde Formic acid Sodium nitrite Aniline Hydrochloric acid p-Toluidine METHANE Sulfuric acid Sodium carbonate Ammonia Sodium metabisulfite Dimethyl sulfate

Preparation Products

ACID YELLOW 17 sodium [2,4-dihydro-4-[(2-hydroxy-5-nitrophenyl)azo]-5-methyl-2-phenyl-3H-pyrazol-3-onato(2-)][1-[(2-hydroxy-4-nitrophenyl)azo]-2-naphtholato(2-)]cobaltate(1-) Neutral Bordeaux D-BN Tracid Light Yellow G DIFENZOQUAT METHYLSULFATE Mordant Red 7 Pyrazole 3,5-DIPHENYLPYRAZOLE

Less

5-Methyl-2-phenyl-1,2-dihydropyrazol-3-one Suppliers

Americas 1 Austria 1 Belgium 4 Canada 5 China 599 Czech Republic 1 Europe 5 France 3 Germany 8 Hungary 1 India 98 Italy 2 Japan 13 Slovakia 1 South Korea 4 Spain 2 Switzerland 3 The Netherlands 3 Ukraine 1 United Kingdom 20 United States 94 Global 869

Shandong Xinhua Pharmceutical Co.,LTD

Tel: 0533-2196801
Fax: 0533-2196817
Email: yaojianyong@xhzy.com
Country: China
ProdList: 70
Advantage: 60

Shanghai Aladdin Bio-Chem Technology Co.,LTD

Tel: 400-6206333 18521732826;
Fax: 021-50323701
Email: market@aladdin-e.com
Country: China
ProdList: 25015
Advantage: 65

Shanghai He Huan Chemical Co., Ltd.

Tel: 021-60345187 13917602471
Fax: 021-60345187
Email: lzz841106@aliyun.com
Country: China
ProdList: 9908
Advantage: 58

Shijiazhuang Kunen Trading Co.,Ltd

Tel: 0311-89683399 15373948596
Fax: 0311-89683399
Email: sales@kunenchem.com
Country: China
ProdList: 44
Advantage: 58

Jiangsu Simcere Pharmaceutical CO.,Ltd

Tel: 025-85566666-7321 15195996671
Email: API@simcere.com
Country: China
ProdList: 19
Advantage: 58

Wuhan Fortuna Chemical Co., Ltd

Tel: 027-027-59207852 13308628970
Fax: QQ:2779667926
Email: buy@fortunachem.com
Country: China
ProdList: 2640
Advantage: 58

Wuhan Blue Lotus Biotechnology Co

Tel: 13397278829
Email: 396628162@qq.com
Country: China
ProdList: 42
Advantage: 58

Guangdong wengjiang Chemical Reagent Co., Ltd.

Tel: 0751-2886750 13927877953
Fax: 0751-2886750
Email: 3005811397@qq.com
Country: China
ProdList: 13374
Advantage: 58

J & K SCIENTIFIC LTD.

Tel: 010-82848833 400-666-7788
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

Meryer (Shanghai) Chemical Technology Co., Ltd.

Tel: 4006608290; 18621169109
Fax: 86-21-61259102
Email: market03@meryer.com
Country: China
ProdList: 40241
Advantage: 62

3B Pharmachem (Wuhan) International Co.,Ltd.

Tel: 821-50328103-801 18930552037
Fax: 86-21-50328109
Email: 3bsc@sina.com
Country: China
ProdList: 15848
Advantage: 69

future industrial shanghai co., ltd

Tel: 400-0066400 13621662912
Fax: 021-55660885
Email: sales@jonln.com
Country: China
ProdList: 1998
Advantage: 65

Alfa Aesar

Tel: 400-6106006
Fax: 021-67582001/03/05
Email: saleschina@alfa-asia.com
Country: China
ProdList: 30132
Advantage: 84

TAIYUAN RHF CO.,LTD.

Tel: +86 351 7031519
Fax: +86 351 7031519
Email: sales@RHFChem.com
Country: China
ProdList: 2341
Advantage: 56

TCI (Shanghai) Development Co., Ltd.

Tel: 021-67121386
Fax: 021-67121385
Email: Sales-CN@TCIchemicals.com
Country: China
ProdList: 24539
Advantage: 81

ShangHai DEMO Chemical Co.,Ltd

Tel: 400-021-7337 2355568890
Fax: 0086-21-50182339
Email: sales@demochem.com
Country: China
ProdList: 2572
Advantage: 57

BeiJing Hwrk Chemicals Limted

Tel: 0757-86329057 18501085097
Fax: 010-89508210
Email: sales3.gd@hwrkchemical.com
Country: China
ProdList: 7583
Advantage: 55

Energy Chemical

Tel: 021-021-58432009 400-005-6266
Fax: 021-58436166
Email: sales8178@energy-chemical.com
Country: China
ProdList: 44751
Advantage: 61

Capot Chemical Co., Ltd

Tel: +86 (0) 571 85 58 67 18
Fax: 0086-571-85864795
Email: sales@capotchem.com
Country: China
ProdList: 18217
Advantage: 66

Beijing Ouhe Technology Co., Ltd

Tel: 010-82967028 13552068683
Fax: +86-10-82967029
Email: 2355560935@qq.com
Country: China
ProdList: 12426
Advantage: 60

Shanghai Longsheng chemical Co.,Ltd.

Tel: 021-58099652-8005 13585536065
Fax: 021-58099609
Email: bin.wu@shlschem.com
Country: China
ProdList: 9816
Advantage: 59

Nanjing Chemlin Chemical Co., Ltd

Tel: 025-83697070
Fax: +86-25-83453306
Email: info@chemlin.com.cn
Country: China
ProdList: 17938
Advantage: 64

Shanghai Hanhong Scientific Co.,Ltd.

Tel: 021-54306202 13764082696;
Email: info@hanhongsci.com
Country: China
ProdList: 42982
Advantage: 64

Chemsky（shanghai）International Co.,Ltd.

Tel: 021-50135380
Email: shchemsky@sina.com
Country: China
ProdList: 32344
Advantage: 50

XiaoGan ShenYuan ChemPharm co,ltd

Tel: 0712-0712-2580635 15527768850
Email: 1791901229@qq.com
Country: China
ProdList: 8849
Advantage: 52

Shandong Xiya Chemical Co., Ltd

Tel: 13355009207 13355009207
Fax: 0539-6365991
Email: 3007715519@qq.com
Country: China
ProdList: 18739
Advantage: 57

Syntechem Co.,Ltd

Tel
Fax: E-Mail Inquiry
Email: info@syntechem.com
Country: China
ProdList: 12990
Advantage: 57

BEST-REAGENT

Tel: 400-1166-196 18981987031
Fax: 028-84555506 800101999
Email: cdhxsj@163.com
Country: China
ProdList: 11726
Advantage: 57

Tianjin heowns Biochemical Technology Co., Ltd.

Tel: 400 638 7771
Email: sales@heowns.com
Country: China
ProdList: 14443
Advantage: 57

Sinopharm Chemical Reagent Co,Ltd.

Tel: 86-21-63210123
Fax: 86-21-63290778 86-21-63218885
Email: sj_scrc@sinopharm.com
Country: China
ProdList: 9823
Advantage: 79

Maya High Purity Chemicals

Tel: +86 (573) 82222445 (0)18006601000 452520369
Fax: +86 (573) 82222643
Email: sales@maya-r.com
Country: China
ProdList: 11714
Advantage: 57

Spectrum Chemical Manufacturing Corp.

Tel: 021-021-021-67601398-809-809-809 15221380277
Fax: 021-57711696
Email: marketing_china@spectrumchemical.com
Country: China
ProdList: 9664
Advantage: 60

Dalian Meilun Biotech Co., Ltd.

Tel: 0411-62910999 13889544652
Email: sales@meilune.com
Country: China
ProdList: 4647
Advantage: 58

BioBioPha Co., Ltd.

Tel: 0871-65217109 13211707573;
Fax: 0871-65215563
Email: y.liu@mail.biobiopha.com
Country: China
ProdList: 5654
Advantage: 65

ShangHai YuanYe Biotechnology Co., Ltd.

Tel: 021-61312847 13636370518
Fax: 021-55068248
Email: shyysw007@163.com
Country: China
ProdList: 4941
Advantage: 60

Chengdu Ai Keda Chemical Technology Co., Ltd.

Tel: 4008-755-333 18080918076
Fax: 028-86757656
Email: 800078821@qq.com
Country: China
ProdList: 9725
Advantage: 55

S.Z. PhyStandard Bio-Tech. Co., Ltd.

Tel: 0755-83725681-603
Fax: +86 755 28094224
Country: China
ProdList: 4505
Advantage: 50

Shanghai civi chemical technology co.,Ltd

Tel: 86-21-34053660
Fax: 86-21-34053661
Email: sale@labgogo.com
Country: China
ProdList: 9872
Advantage: 52

Thermo Fisher Scientific

Tel: 800-810-5118
Fax: +86-10-84193589
Email: cnchemical@thermofisher.com
Country: China
ProdList: 17779
Advantage: 75

Beijing HuaMeiHuLiBiological Chemical

Tel: 010-56205725
Fax: 010-65763397
Email: waley188@sohu.com
Country: China
ProdList: 12338
Advantage: 58

Beijing innoChem Science & Technology Co.,Ltd.

Tel: 400-810-7969 010-59572699
Fax: 010-59572688
Email: ningzi.li@inno-chem.com.cn
Country: China
ProdList: 6139
Advantage: 55

Shanghai Litong Chemical Technology Co.,Ltd.

Tel: 13598610367 0373-7129549
Fax: 0373-8369699
Email: 2468833170@qq.com
Country: China
ProdList: 932
Advantage: 58

Shanghai Jian Chao Chemical Technology Co., Ltd.

Tel: 021-50430803 18017383231
Fax: qq：2817624287
Email: 983544897@qq.com
Country: China
ProdList: 9352
Advantage: 55

Haoyuan Chemexpress Co., Ltd.

Tel: 021-58950125
Fax: (86) 21-58955996
Email: info@chemexpress.com
Country: China
ProdList: 7553
Advantage: 61

9ding chemical ( Shanghai) Limited

Tel: 4009209199
Fax: 86-021-52271987
Email: sales@9dingchem.com
Country: China
ProdList: 18216
Advantage: 56

The future of Shanghai Industrial Co., Ltd.

Tel: 021-61552785
Fax: 021-55660885
Email: sales@shshiji.com
Country: China
ProdList: 9552
Advantage: 55

Guangzhou Isun Pharmaceutical Co., Ltd

Tel: 020-39119399 18927568969
Fax: 020-39119999
Email: isunpharm@qq.com
Country: China
ProdList: 4428
Advantage: 55

Nanjing Sunlida Biological Technology Co., Ltd.

Tel: 025-57798810
Fax: 025-57019371
Email: sales@sunlidabio.com
Country: China
ProdList: 3750
Advantage: 55

TargetMol Chemicals Inc.

Tel: 021-33632979 15002134094
Fax: 021-33632979
Email: marketing@targetmol.com
Country: China
ProdList: 7934
Advantage: 58

Quzhou Juhua Friendship Co., Ltd

Tel: 0570-3066667
Fax: 0570-3063388
Country: China
ProdList: 3933
Advantage: 58

Less

View Lastest Price from 5-Methyl-2-phenyl-1,2-dihydropyrazol-3-one manufacturers

Hebei Saisier Technology Co., LTD

Product: 5-Methyl-2-phenyl-1,2-dihydropyrazol-3-one 89-25-8
Price: US $6.00/KG
Min. Order: 1KG
Purity: More than 99%
Supply Ability: 2000KG/Month
Release date: 2024-04-24

Henan Fengda Chemical Co., Ltd

Product: 5-Methyl-2-phenyl-1,2-dihydropyrazol-3-one 89-25-8
Price: US $100.00-1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: g-kg-tons, free sample is available
Release date: 2023-12-23

WUHAN CIRCLE POWDER TECHNOLOGY CO.,LTD

Product: Edaravone 89-25-8
Price: US $0.00/KG
Min. Order: 100g
Purity: 98%+
Supply Ability: 100kg
Release date: 2020-10-22

89-25-8, 5-Methyl-2-phenyl-1,2-dihydropyrazol-3-oneRelated Search:

PHENYL VALERATE Kresoxim-methyl Methanol Methyl acrylate Basic Violet 1 Cefazolin sodium salt Methyl acetate Acetonitrile Cefazolin Edaravone N-Oxide Paraquat dichloride Methylparaben Dihydromyrcenol Edaravone Glucuronide 1,2-Dihydro-5-methyl-2-phenyl-3H-pyrazol-3-one 4,5-dihydro-a-(hydroxyMethyl)-a,3-diMethyl-5-oxo-1-phenyl-1H-Pyrazole-4-Methanesulfonic acid BISPYRAZOLONE Edaravone Impurity 26

TIMTEC-BB SBB003801

PMP

MONOPYRAZOLONE

2,4-dihydro-5-methyl-2-phenyl-3h-pyrazol-3-on

2-Pyrazolin-5-one, 3-methyl-1-phenyl-

3H-Pyrazol-3-one,2,4-dihydro-5-methyl-

3-methyl-1-phenyl-2-pyrazolin-5-on

3-methyl-1-phenyl-5-pyrazolon

3-Methyl-1-phenylpyrazol-5-one

3-Methyl-1-phenylpyrazolin-5-one

5-Pyrazolone, 3-methyl-1-phenyl-

Developer Z

3-Methyl-1-pehnyl-2-pyrazolin-5-one

1-phenyl-3-methyl-5-pyrazolone(PMP)

Adaravone

3-Methyl-1-phenyl-2-pyrazolin-5-one, 98+%

1-Phenyl-3-methyl-1H-4,5-dihydropyrazol-5-one

Radicu

3-Methyl-1-phenyl-5-pyrazolido

3H-Pyrazol-3-one, 2,4-dihydro-5-methyl-2-phenyl-

N-demethylantipyrine

PHENYLMETHYLPYRAZOLON

3-methyl-1-pheny-1-1H-pyrazol-5(4H)-one

3-METHYL-1-PHENYL-2-PYRAZOLIN-5-ONE [NORANTIPYRINE]

Radicut

Methyl-1-phenyl-2-pyrazolin-5-one, 3-

3-methyl-1-phenyl-1H-pyrazol-5(4H)-one

1-Phenyl-3-methyl-2-prazolin-5-one

3-Methyl-1-phenylpyrazolin-5(4H)-one

5-Methyl-2-phenyl-1H-pyrazol-3-one

-1,2-dihydropyrazoL

MCI-186

EDARAVONE

C.I. Developer 1

AURORA KA-3365

2,4-dihydro-5-methyl-2-phenyl-3h-pyrazol-3-one

1-PHENYL-3-METHYL-5-OXO-2-PYRAZOLINE

1-PHENYL-3-METHYL-5-PYRAZALONE

5-METHYL-2-PHENYL-2,4-DIHYDRO-3H-PYRAZOL-3-ONE

5-METHYL-2-PHENYL-2,4-DIHYDRO-PYRAZOL-3-ONE

3-METHYL-1-PHENYL-5-PYRAZOLONE

3-METHYL-1-PHENYL-5-PYROZOLENE

3-METHYL-1-PHENYL-2-PYRAZOLIN-5-ONE

3-METHYL-1-PHENYL-2-PYRAZOLINE-5-ONE

AKOS B029819

developerz

Methylphenylpyrazolone

NCI-C03952

norantipyrine

Norphenazone

NSC-12

NSC-26139

NSC-2629

phenylmethylpyrazolone

1-Fenyl-3-methyl-2-pyrazolin-5-on

1-Phenyl-3-methyl-5-pyrazolon

1-Phenyl-3-methylpyrazolone

1-Phenyl-3-methylpyrazolone-5