Quinapril

Product Name: Quinapril
CAS No.: 85441-61-8
Chemical Name: Quinapril
Synonyms: Asig;CI-906;Ectren;ACCUPRO;Koretic;ACCUPRIN;ACCUPRIL;Quniapril;Quinapril;PD-109452-2
CBNumber: CB1100985
Molecular Formula: C25H30N2O5
Formula Weight: 438.52
MOL File: 85441-61-8.mol

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Quinapril Property

Melting point:: 120-130°C
Boiling point:: 662.0±55.0 °C(Predicted)
Density: 1.217±0.06 g/cm3(Predicted)
pka: 3.39±0.20(Predicted)
BCS Class: 1
CAS DataBase Reference: 85441-61-8(CAS DataBase Reference)

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Safety

Safety Statements: 22-24/25

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

American Custom Chemicals Corporation

Product number: API0005419
Product name: QUINAPRIL
Purity: 95.00%
Packaging: 5MG
Price: $637.79
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: API0005419
Product name: QUINAPRIL
Purity: 95.00%
Packaging: 50MG
Price: $747.05
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: API0005419
Product name: QUINAPRIL
Purity: 95.00%
Packaging: 100MG
Price: $886.53
Updated: 2021/12/16

AHH

Product number: API-1582
Product name: Quinapril
Purity: 98%
Packaging: 1g
Price: $710
Updated: 2021/12/16

AvaChem

Product number: 1632B
Product name: Quinapril
Packaging: 100mg
Price: $35
Updated: 2021/12/16

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Quinapril Chemical Properties,Usage,Production

Description

Quinapril is an orally active, non-sulfhydryl ACE inhibitor reportedly useful in the treatment of essential hypertension. The main claimed advantage of quinapril compared with other available ACE inhibitors is its side-effect profile. It is also effective in the management of congestive heart failure.

Originator

Warner-Lambert (USA)

Uses

Antihypertensive; enzyme inhibitor (angiotensin-converting).

Definition

ChEBI: Quinapril is a member of the class of isoquinolines that is (3S)-2-L-alanyl-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid in which the alpha-amino group of the alanyl residue has been substituted by a 1-ethoxycarbonyl-4-phenylbutan-2-yl group (the all-S isomer). A prodrug for quinaprilat (by hydrolysis of the ethyl ester to the corresponding carboxylic acid), it is used as an angiotensin-converting enzyme inhibitor (ACE inhibitor) used (generally as the hydrochloride salt) for the treatment of hypertension and congestive heart failure. It has a role as an EC 3.4.15.1 (peptidyl-dipeptidase A) inhibitor, a prodrug and an antihypertensive agent. It is a member of isoquinolines, a dicarboxylic acid monoester, an ethyl ester and a tertiary carboxamide.

brand name

Accupril (Pfizer); Quinapril (Lupin); Quinapril (Ranbaxy) ;Accupro.

Clinical Use

Angiotensin converting enzyme inhibitor:
Hypertension
Congestive heart failure

Drug interactions

Potentially hazardous interactions with other drugs
Anaesthetics: enhanced hypotensive effect.
Analgesics: antagonism of hypotensive effect and increased risk of renal impairment with NSAIDs; hyperkalaemia with ketorolac and other NSAIDs.
Antihypertensives: increased risk of hyperkalaemia, hypotension and renal failure with ARBs and aliskiren.
Bee venom extract: possible severe anaphylactoid reactions when used together.
Ciclosporin: increased risk of hyperkalaemia and nephrotoxicity.
Cytotoxics: increased risk of angioedema with everolimus.
Diuretics: enhanced hypotensive effect; hyperkalaemia with potassium-sparing diuretics.
ESAs: increased risk of hyperkalaemia; antagonism of hypotensive effect.
Gold: flushing and hypotension with sodium aurothiomalate.
Lithium: reduced excretion (possibility of enhanced lithium toxicity).
Potassium salts: increased risk of hyperkalaemia.
Tacrolimus: increased risk of hyperkalaemia and nephrotoxicity.

Metabolism

Quniapril is a prodrug which is metabolised in the liver to its active form, quinaprilat, and to minor inactive metabolites.
Quinaprilat is eliminated primarily by renal excretion.

Quinapril Preparation Products And Raw materials

Raw materials

Benzyl ester Trifluoroacetic acid Acetic acid Quinapril hydrochloride Quinazoline

Preparation Products

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Quinapril Suppliers

China 65 Europe 2 Germany 1 India 6 United Kingdom 8 United States 14 Global 96

Shanghai Boyle Chemical Co., Ltd.

Tel: 021-50182298 021-50180596
Fax: +86-21-57758967
Email: sales@boylechem.com
Country: China
ProdList: 2208
Advantage: 55

LGM Pharma

Tel: 1-(800)-881-8210
Fax: 615-250-9817
Email: inquiries@lgmpharma.com
Country: United States
ProdList: 2123
Advantage: 70

Syntechem Co.,Ltd

Tel
Fax: E-Mail Inquiry
Email: info@syntechem.com
Country: China
ProdList: 12984
Advantage: 57

Beijing HuaMeiHuLiBiological Chemical

Tel: 010-56205725
Fax: 010-65763397
Email: waley188@sohu.com
Country: China
ProdList: 12335
Advantage: 58

Nanjing Sunlida Biological Technology Co., Ltd.

Tel: 025-57798810
Fax: 025-57019371
Email: sales@sunlidabio.com
Country: China
ProdList: 3239
Advantage: 55

Wuhan DKY Technology Co.,Ltd.

Tel: 27-81302488 18007166089
Fax: 027-81302088
Email: info@dkybpc.com
Country: China
ProdList: 1672
Advantage: 58

Shanghai Meishui Chemical Technology Co., Ltd

Tel: 021-60549325 18616193163
Fax: 021-33250306
Country: China
ProdList: 4526
Advantage: 56

Amadis Chemical Company Limited

Tel: 571-89925085
Fax: 0086-571-89925065
Email: sales@amadischem.com
Country: China
ProdList: 131957
Advantage: 58

Wuhan Magic Biological Technology Co., Ltd.

Tel: 18872289958、027-52304252、3400508168
Fax: 027-52304252
Email: 3400508168@qq.com
Country: China
ProdList: 1910
Advantage: 55

Hubei Xinyuanshun Pharmaceutical Chemical Co., Ltd.

Tel: 027-51831887 15337167856
Fax: 027-51837635 QQ1165326703
Email: hubeixinyuanshun@163.com
Country: China
ProdList: 10295
Advantage: 58

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View Lastest Price from Quinapril manufacturers

Zhuozhou Wenxi import and Export Co., Ltd

Product: Quinapril 85441-61-8
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-08-11

Shaanxi Dideu Medichem Co. Ltd

Product: Quinapril 85441-61-8
Price: US $0.00-0.00/Kg
Min. Order: 1KG
Purity: 99.0%
Supply Ability: 500 MT
Release date: 2020-05-09

Career Henan Chemical Co

Product: Quinapril 85441-61-8
Price: US $1.00/kg
Min. Order: 1kg
Purity: 95%-99%
Supply Ability: 10kg
Release date: 2018-12-18

85441-61-8, QuinaprilRelated Search:

Propyl butyrate 5,6,7,8-TETRAHYDROISOQUINOLINE Propyl gallate Phenylhydrazine Isoquinoline PHENYL VALERATE Quinapril benzyl ester maleate Carbonyl iron powder Quinapril hydrochloride Isoquinoline-1-carboxylic acid N-[S-(2-PYRIDYLTHIO)CYSTEAMINYL]ETHYLENEDIAMINE-N,N,N',N'-TETRAACETIC ACID, MONOAMIDE QUINAPRIL RELATED COMPOUND A ETHYL[3S-[2(R*),3A,11A BETA]]-1,3,4,6,11,11A-HEXAHYDRO-3-METHYL-1,4-DIOXO-ALPHA-(2-PHENYLETHYL)-2H-PYRAZINO[1,2-B]ISOQUINOLINE-2-ACETATE USP QUINAPRILAT Quinapril

QUINAPRIL HCL

PD-109452-2

CI-906

(3S)-2-[(2S)-2-[[(1S)-1-(ethoxycarbonyl)-3-phenylpropyl]amino]-1-oxopropyl]-1,2,3,4-tetrahydro-3-Isoquinolinecarboxylic acid

(S)-2-((S)-2-(((S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl)aMino)propanoyl)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid

ACCUPRIL

ACCUPRIN

ACCUPRO

2-[2-(1-ethoxycarbonyl-3-phenyl-propyl)aminopropanoyl]-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid

(3s-(2(r*(r*)),3r*))-2-(2-((1-(ethoxycarbonyl)-3-phenylpropyl)amino)-1-oxopropyl)-1,2,3,4-tetrahydro-3-isoquinolinecarboxylic acid monohydrochloride

(3S)-2-[(2S)-2-[[(1S)-1-(ETHOXYCARBONYL)-3-PHENYLPROPYL]AMINO]-1-OXOPROPYL]-1,2,3,4-TETRAHYDRO-3-ISOQUINOLINECARBOXYLIC ACID HYDROCHLORIDE

Asig

S-1,2,3,4CTetrahydro-3-IsoquinolinecarboxylicAcid

Quniapril

3-Isoquinolinecarboxylic acid, 2-(2S)-2-(1S)-1-(ethoxycarbonyl)-3-phenylpropylamino-1-oxopropyl-1,2,3,4-tetrahydro-, (3S)-

3-Isoquinolinecarboxylic acid, 2-[(2S)-2-[[(1S)-1-(ethoxycarbonyl)-3-phenylpropyl]amino]-1-oxopropyl]-1,2,3,4-tetrahydro-, (3S)- (9CI)

3-Isoquinolinecarboxylic acid, 2-[2-[[1-(ethoxycarbonyl)-3-phenylpropyl]amino]-1-oxopropyl]-1,2,3,4-tetrahydro-, [3S-[2[R*(R*)],3R*]]-

Ectren

Koretic

[3S-[2[R^<*>^ (R^<*>^)]，3R^<*>^]]-2-[2-[[1-(Ethoxycarbonyl)-3-phenylpropyl]amino]-1-oxopropyl]-1，2，3，4-tetrahydro-3-isoquinolinecarboxylic acid

Acequin：Acuitel

Korec：Quinazil

(3S)-2-[(2S)-2-[[(1S)-1-(Ethoxycarbonyl)-3-phenylpropyl]amino]propionyl]-1,2,3,4-tetrahydro-3-isoquinolinecarboxylic acid

(3S)-2-[(S)-2-[[(S)-1-(Ethoxycarbonyl)-3-phenylpropyl]amino]-1-oxopropyl]-1,2,3,4-tetrahydro-3-isoquinolinecarboxylic acid

Quinapril

(3S)-2-[(2S)-2-[[(1S)-1-carbethoxy-3-phenyl-propyl]amino]propanoyl]-3,4-dihydro-1H-isoquinoline-3-carboxylic acid

(3S)-2-[(2S)-2-[[(2S)-1-ethoxy-1-oxo-4-phenyl-butan-2-yl]amino]propanoyl]-3,4-dihydro-1H-isoquinoline-3-carboxylic acid

(3S)-2-[(2S)-2-[[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino]propanoyl]-3,4-dihydro-1H-isoquinoline-3-carboxylic acid

JSDRRTOADPPCHY-HSQYWUDLSA-N

(3S)-2-[(2S)-2-{[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino}propanoyl]-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid

Quinapril USP/EP/BP

85441-61-8

84551-61-8

C25H30N2O5