ChemicalBook > CAS DataBase List > Quinapril

Quinapril

Product Name
Quinapril
CAS No.
85441-61-8
Chemical Name
Quinapril
Synonyms
Asig;CI-906;Ectren;ACCUPRO;Koretic;ACCUPRIN;ACCUPRIL;Quniapril;Quinapril;PD-109452-2
CBNumber
CB1100985
Molecular Formula
C25H30N2O5
Formula Weight
438.52
MOL File
85441-61-8.mol
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Quinapril Property

Melting point:
120-130°C
Boiling point:
662.0±55.0 °C(Predicted)
Density 
1.217±0.06 g/cm3(Predicted)
pka
3.39±0.20(Predicted)
BCS Class
1
CAS DataBase Reference
85441-61-8(CAS DataBase Reference)
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Safety

Safety Statements 
22-24/25
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

American Custom Chemicals Corporation
Product number
API0005419
Product name
QUINAPRIL
Purity
95.00%
Packaging
5MG
Price
$637.79
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
API0005419
Product name
QUINAPRIL
Purity
95.00%
Packaging
50MG
Price
$747.05
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
API0005419
Product name
QUINAPRIL
Purity
95.00%
Packaging
100MG
Price
$886.53
Updated
2021/12/16
AvaChem
Product number
1632B
Product name
Quinapril
Packaging
100mg
Price
$35
Updated
2021/12/16
AvaChem
Product number
1632B
Product name
Quinapril
Packaging
250mg
Price
$65
Updated
2021/12/16
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Quinapril Chemical Properties,Usage,Production

Description

Quinapril is an orally active, non-sulfhydryl ACE inhibitor reportedly useful in the treatment of essential hypertension. The main claimed advantage of quinapril compared with other available ACE inhibitors is its side-effect profile. It is also effective in the management of congestive heart failure.

Originator

Warner-Lambert (USA)

Uses

Antihypertensive; enzyme inhibitor (angiotensin-converting).

Definition

ChEBI: Quinapril is a member of the class of isoquinolines that is (3S)-2-L-alanyl-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid in which the alpha-amino group of the alanyl residue has been substituted by a 1-ethoxycarbonyl-4-phenylbutan-2-yl group (the all-S isomer). A prodrug for quinaprilat (by hydrolysis of the ethyl ester to the corresponding carboxylic acid), it is used as an angiotensin-converting enzyme inhibitor (ACE inhibitor) used (generally as the hydrochloride salt) for the treatment of hypertension and congestive heart failure. It has a role as an EC 3.4.15.1 (peptidyl-dipeptidase A) inhibitor, a prodrug and an antihypertensive agent. It is a member of isoquinolines, a dicarboxylic acid monoester, an ethyl ester and a tertiary carboxamide.

brand name

Accupril (Pfizer); Quinapril (Lupin); Quinapril (Ranbaxy) ;Accupro.

Clinical Use

Angiotensin converting enzyme inhibitor:
Hypertension
Congestive heart failure

Drug interactions

Potentially hazardous interactions with other drugs
Anaesthetics: enhanced hypotensive effect.
Analgesics: antagonism of hypotensive effect and increased risk of renal impairment with NSAIDs; hyperkalaemia with ketorolac and other NSAIDs.
Antihypertensives: increased risk of hyperkalaemia, hypotension and renal failure with ARBs and aliskiren.
Bee venom extract: possible severe anaphylactoid reactions when used together.
Ciclosporin: increased risk of hyperkalaemia and nephrotoxicity.
Cytotoxics: increased risk of angioedema with everolimus.
Diuretics: enhanced hypotensive effect; hyperkalaemia with potassium-sparing diuretics.
ESAs: increased risk of hyperkalaemia; antagonism of hypotensive effect.
Gold: flushing and hypotension with sodium aurothiomalate.
Lithium: reduced excretion (possibility of enhanced lithium toxicity).
Potassium salts: increased risk of hyperkalaemia.
Tacrolimus: increased risk of hyperkalaemia and nephrotoxicity.

Metabolism

Quniapril is a prodrug which is metabolised in the liver to its active form, quinaprilat, and to minor inactive metabolites.
Quinaprilat is eliminated primarily by renal excretion.

Quinapril Preparation Products And Raw materials

Raw materials

Benzyl ester Trifluoroacetic acid Acetic acid Quinapril hydrochloride Quinazoline

Preparation Products

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View Lastest Price from Quinapril manufacturers

Zhuozhou Wenxi import and Export Co., Ltd
Product
Quinapril 85441-61-8
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-08-11
Shaanxi Dideu Medichem Co. Ltd
Product
Quinapril 85441-61-8
Price
US $0.00-0.00/Kg
Min. Order
1KG
Purity
99.0%
Supply Ability
500 MT
Release date
2020-05-09
Career Henan Chemical Co
Product
Quinapril 85441-61-8
Price
US $1.00/kg
Min. Order
1kg
Purity
95%-99%
Supply Ability
10kg
Release date
2018-12-18

85441-61-8, QuinaprilRelated Search:

Propyl butyrate 5,6,7,8-TETRAHYDROISOQUINOLINE Propyl gallate Phenylhydrazine Isoquinoline PHENYL VALERATE Quinapril benzyl ester maleate Carbonyl iron powder Quinapril hydrochloride Isoquinoline-1-carboxylic acid N-[S-(2-PYRIDYLTHIO)CYSTEAMINYL]ETHYLENEDIAMINE-N,N,N',N'-TETRAACETIC ACID, MONOAMIDE QUINAPRIL RELATED COMPOUND A ETHYL[3S-[2(R*),3A,11A BETA]]-1,3,4,6,11,11A-HEXAHYDRO-3-METHYL-1,4-DIOXO-ALPHA-(2-PHENYLETHYL)-2H-PYRAZINO[1,2-B]ISOQUINOLINE-2-ACETATE USP QUINAPRILAT Quinapril

  • QUINAPRIL HCL
  • PD-109452-2
  • CI-906
  • (3S)-2-[(2S)-2-[[(1S)-1-(ethoxycarbonyl)-3-phenylpropyl]amino]-1-oxopropyl]-1,2,3,4-tetrahydro-3-Isoquinolinecarboxylic acid
  • (S)-2-((S)-2-(((S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl)aMino)propanoyl)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid
  • ACCUPRIL
  • ACCUPRIN
  • ACCUPRO
  • 2-[2-(1-ethoxycarbonyl-3-phenyl-propyl)aminopropanoyl]-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid
  • (3s-(2(r*(r*)),3r*))-2-(2-((1-(ethoxycarbonyl)-3-phenylpropyl)amino)-1-oxopropyl)-1,2,3,4-tetrahydro-3-isoquinolinecarboxylic acid monohydrochloride
  • (3S)-2-[(2S)-2-[[(1S)-1-(ETHOXYCARBONYL)-3-PHENYLPROPYL]AMINO]-1-OXOPROPYL]-1,2,3,4-TETRAHYDRO-3-ISOQUINOLINECARBOXYLIC ACID HYDROCHLORIDE
  • Asig
  • S-1,2,3,4CTetrahydro-3-IsoquinolinecarboxylicAcid
  • Quniapril
  • 3-Isoquinolinecarboxylic acid, 2-(2S)-2-(1S)-1-(ethoxycarbonyl)-3-phenylpropylamino-1-oxopropyl-1,2,3,4-tetrahydro-, (3S)-
  • 3-Isoquinolinecarboxylic acid, 2-[(2S)-2-[[(1S)-1-(ethoxycarbonyl)-3-phenylpropyl]amino]-1-oxopropyl]-1,2,3,4-tetrahydro-, (3S)- (9CI)
  • 3-Isoquinolinecarboxylic acid, 2-[2-[[1-(ethoxycarbonyl)-3-phenylpropyl]amino]-1-oxopropyl]-1,2,3,4-tetrahydro-, [3S-[2[R*(R*)],3R*]]-
  • Ectren
  • Koretic
  • [3S-[2[R^<*>^ (R^<*>^)]，3R^<*>^]]-2-[2-[[1-(Ethoxycarbonyl)-3-phenylpropyl]amino]-1-oxopropyl]-1，2，3，4-tetrahydro-3-isoquinolinecarboxylic acid
  • Acequin：Acuitel
  • Korec：Quinazil
  • (3S)-2-[(2S)-2-[[(1S)-1-(Ethoxycarbonyl)-3-phenylpropyl]amino]propionyl]-1,2,3,4-tetrahydro-3-isoquinolinecarboxylic acid
  • (3S)-2-[(S)-2-[[(S)-1-(Ethoxycarbonyl)-3-phenylpropyl]amino]-1-oxopropyl]-1,2,3,4-tetrahydro-3-isoquinolinecarboxylic acid
  • Quinapril
  • (3S)-2-[(2S)-2-[[(1S)-1-carbethoxy-3-phenyl-propyl]amino]propanoyl]-3,4-dihydro-1H-isoquinoline-3-carboxylic acid
  • (3S)-2-[(2S)-2-[[(2S)-1-ethoxy-1-oxo-4-phenyl-butan-2-yl]amino]propanoyl]-3,4-dihydro-1H-isoquinoline-3-carboxylic acid
  • (3S)-2-[(2S)-2-[[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino]propanoyl]-3,4-dihydro-1H-isoquinoline-3-carboxylic acid
  • JSDRRTOADPPCHY-HSQYWUDLSA-N
  • (3S)-2-[(2S)-2-{[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino}propanoyl]-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid
  • Quinapril USP/EP/BP
  • 85441-61-8
  • 84551-61-8
  • C25H30N2O5