Quinapril
- Product Name
- Quinapril
- CAS No.
- 85441-61-8
- Chemical Name
- Quinapril
- Synonyms
- Asig;CI-906;Ectren;ACCUPRO;Koretic;ACCUPRIN;ACCUPRIL;Quniapril;Quinapril;PD-109452-2
- CBNumber
- CB1100985
- Molecular Formula
- C25H30N2O5
- Formula Weight
- 438.52
- MOL File
- 85441-61-8.mol
Quinapril Property
- Melting point:
- 120-130°C
- Boiling point:
- 662.0±55.0 °C(Predicted)
- Density
- 1.217±0.06 g/cm3(Predicted)
- pka
- 3.39±0.20(Predicted)
- BCS Class
- 1
- CAS DataBase Reference
- 85441-61-8(CAS DataBase Reference)
Safety
- Safety Statements
- 22-24/25
N-Bromosuccinimide Price
- Product number
- API0005419
- Product name
- QUINAPRIL
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $637.79
- Updated
- 2021/12/16
- Product number
- API0005419
- Product name
- QUINAPRIL
- Purity
- 95.00%
- Packaging
- 50MG
- Price
- $747.05
- Updated
- 2021/12/16
- Product number
- API0005419
- Product name
- QUINAPRIL
- Purity
- 95.00%
- Packaging
- 100MG
- Price
- $886.53
- Updated
- 2021/12/16
- Product number
- API-1582
- Product name
- Quinapril
- Purity
- 98%
- Packaging
- 1g
- Price
- $710
- Updated
- 2021/12/16
- Product number
- 1632B
- Product name
- Quinapril
- Packaging
- 100mg
- Price
- $35
- Updated
- 2021/12/16
Quinapril Chemical Properties,Usage,Production
Description
Quinapril is an orally active, non-sulfhydryl ACE inhibitor reportedly useful in the treatment of essential hypertension. The main claimed advantage of quinapril compared with other available ACE inhibitors is its side-effect profile. It is also effective in the management of congestive heart failure.
Originator
Warner-Lambert (USA)
Uses
Antihypertensive; enzyme inhibitor (angiotensin-converting).
Definition
ChEBI: Quinapril is a member of the class of isoquinolines that is (3S)-2-L-alanyl-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid in which the alpha-amino group of the alanyl residue has been substituted by a 1-ethoxycarbonyl-4-phenylbutan-2-yl group (the all-S isomer). A prodrug for quinaprilat (by hydrolysis of the ethyl ester to the corresponding carboxylic acid), it is used as an angiotensin-converting enzyme inhibitor (ACE inhibitor) used (generally as the hydrochloride salt) for the treatment of hypertension and congestive heart failure. It has a role as an EC 3.4.15.1 (peptidyl-dipeptidase A) inhibitor, a prodrug and an antihypertensive agent. It is a member of isoquinolines, a dicarboxylic acid monoester, an ethyl ester and a tertiary carboxamide.
brand name
Accupril (Pfizer); Quinapril (Lupin); Quinapril (Ranbaxy) ;Accupro.
Clinical Use
Angiotensin converting enzyme inhibitor:
Hypertension
Congestive heart failure
Drug interactions
Potentially hazardous interactions with other drugs
Anaesthetics: enhanced hypotensive effect.
Analgesics: antagonism of hypotensive effect and
increased risk of renal impairment with NSAIDs;
hyperkalaemia with ketorolac and other NSAIDs.
Antihypertensives: increased risk of hyperkalaemia,
hypotension and renal failure with ARBs and
aliskiren.
Bee venom extract: possible severe anaphylactoid
reactions when used together.
Ciclosporin: increased risk of hyperkalaemia and
nephrotoxicity.
Cytotoxics: increased risk of angioedema with
everolimus.
Diuretics: enhanced hypotensive effect;
hyperkalaemia with potassium-sparing diuretics.
ESAs: increased risk of hyperkalaemia; antagonism
of hypotensive effect.
Gold: flushing and hypotension with sodium
aurothiomalate.
Lithium: reduced excretion (possibility of enhanced
lithium toxicity).
Potassium salts: increased risk of hyperkalaemia.
Tacrolimus: increased risk of hyperkalaemia and
nephrotoxicity.
Metabolism
Quniapril is a prodrug which is metabolised in the liver
to its active form, quinaprilat, and to minor inactive
metabolites.
Quinaprilat is eliminated primarily by renal excretion.
Quinapril Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Quinapril manufacturers
- Product
- Quinapril 85441-61-8
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-08-11
- Product
- Quinapril 85441-61-8
- Price
- US $0.00-0.00/Kg
- Min. Order
- 1KG
- Purity
- 99.0%
- Supply Ability
- 500 MT
- Release date
- 2020-05-09
- Product
- Quinapril 85441-61-8
- Price
- US $1.00/kg
- Min. Order
- 1kg
- Purity
- 95%-99%
- Supply Ability
- 10kg
- Release date
- 2018-12-18