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Bunazosin hydrochloride

Product Name
Bunazosin hydrochloride
CAS No.
52712-76-2
Chemical Name
Bunazosin hydrochloride
Synonyms
E-643;E 1015;E-1015;Detantol;Detantol-R;Bunazosin Hcl;Bunzaosin Hcl;Bunazosin, DETANTO;BUNAZOSIN HYDROCHLORIDE;Bunazosin hydrochloride USP/EP/BP
CBNumber
CB9189463
Molecular Formula
C19H28ClN5O3
Formula Weight
409.91
MOL File
52712-76-2.mol
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Bunazosin hydrochloride Property

Melting point:
280-282°
storage temp. 
Sealed in dry,Room Temperature
solubility 
DMSO (Slightly, Heated), Methanol (Slightly, Heated)
form 
Solid
color 
White to Off-White
Stability:
Hygroscopic
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Safety

Toxicity
LD50 oral in rat: 980mg/kg
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC
Product number
B689585
Product name
BunazosinHydrochloride
Packaging
10mg
Price
$65
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
API0002269
Product name
BUNAZOSIN HYDROCHLORIDE
Purity
95.00%
Packaging
100MG
Price
$1370.41
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
API0002269
Product name
BUNAZOSIN HYDROCHLORIDE
Purity
95.00%
Packaging
1G
Price
$2355.15
Updated
2021/12/16
Chemenu
Product number
CM193842
Product name
BunazosinHydrochloride
Purity
95%
Packaging
1g
Price
$1117
Updated
2021/12/16
Crysdot
Product number
CD31001617
Product name
BunazosinHydrochloride
Purity
95+%
Packaging
1g
Price
$1186
Updated
2021/12/16
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Bunazosin hydrochloride Chemical Properties,Usage,Production

Description

Bunazosin hydrochloride is a selective αl-adrenergic antagonist related to prazosin and useful in the treatment of hypertension.

Originator

Eisai (Japan)

Uses

Bunazosin Hydrochloride is an α-1 adrenergic receptor antagonist that acts as an anti-cancer and anti-glaucoma drug.

Definition

ChEBI: Bunazosin hydrochloride is a member of quinazolines.

Manufacturing Process

17.0 g of 2-chloro-4-amino-6,7-dimethoxyquinazoline and 18.2 g of Nformylhomopiperazine are added to 170 ml of butanol and the whole is refluxed with stirring for 3 h. After completion of the reaction, the mixture is cooled, and the crystals thus precipitated are filtered out, washed with a small quantity of ethanol and air-dried. 25.0 g of crude 2-homopiperazino-4-amino- 6,7-dimethoxyquinazoline are obtained.
A solution of 2-homopiperazino-4-amino-6,7-dimethoxyquinazoline in 60 ml of acetone is added dropwise to a solution of 2-butylcarboxylic acid chloride in acetone under stirring and ice-cooling. After completion of the addition, the stirring is continued for additional 1 h to complete the reaction. The crystals thus precipitated are filtered out and the 1-(4-amino-6,7-dimethoxy-2- quinazolinyl)hexahydro-4-(1-oxobutyl)-1H-1,4-diazepine, melting point 280- 282°C (recrystallized from a mixture of methanol-ethanol) is obtained.

brand name

DETANTOL

Therapeutic Function

Antihypertensive

Bunazosin hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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Bunazosin hydrochloride Suppliers

Hangzhou Sage Chemical Co., Ltd.
Tel
+86057186818502 13588463833
Fax
Pls mail us for more information!
Email
info@sagechem.com
Country
China
ProdList
10269
Advantage
58
Wuhan DKY Technology Co.,Ltd.
Tel
27-81302488 18007166089
Fax
027-81302088
Email
info@dkybpc.com
Country
China
ProdList
2024
Advantage
58
HBCChem, Inc.
Tel
+1-510-219-6317
Fax
+1-650-486-1361
Email
sales@hbcchem.com
Country
United States
ProdList
10658
Advantage
60
Amadis Chemical Company Limited
Tel
571-89925085
Fax
0086-571-89925065
Email
sales@amadischem.com
Country
China
ProdList
132020
Advantage
58
Aikon International Limited
Tel
025-66113011 18112977050
Fax
(5)02557626880
Email
cb6@aikonchem.com
Country
China
ProdList
15495
Advantage
58
Wuhan FengyaoTonghui Chemical Products Co., Ltd.
Tel
027-87466105 15377573527
Email
2678564200@qq.com
Country
China
ProdList
17997
Advantage
58
TargetMol Chemicals Inc.
Tel
+1-781-999-5354 +1-00000000000
Email
marketing@targetmol.com
Country
United States
ProdList
19892
Advantage
58
ANHUI WITOP BIOTECH CO., LTD
Tel
+8615255079626
Email
eric@witopchemical.com
Country
China
ProdList
23556
Advantage
58
Dideu Industries Group Limited
Tel
+86-29-89586680 +86-15129568250
Email
1026@dideu.com
Country
China
ProdList
29831
Advantage
58
Dayang Chem (Hangzhou) Co.,Ltd.
Tel
571-88938639 +8617705817739
Fax
+86-571-88938652,+86-571- 88492614
Email
info@dycnchem.com
Country
CHINA
ProdList
52867
Advantage
58
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View Lastest Price from Bunazosin hydrochloride manufacturers

Dideu Industries Group Limited
Product
Bunazosin hydrochloride 52712-76-2
Price
US $1.10/g
Min. Order
1g
Purity
99.9%
Supply Ability
100 Tons min
Release date
2021-08-10
Shaanxi Dideu Medichem Co. Ltd
Product
Bunazosin hydrochloride 52712-76-2
Price
US $0.00-0.00/Kg
Min. Order
1KG
Purity
99.0%
Supply Ability
500 MT
Release date
2020-05-09

52712-76-2, Bunazosin hydrochlorideRelated Search:


  • 1-[4-(4-amino-6,7-dimethoxyquinazolin-2-yl)-1,4-diazepan-1-yl]butan-1-one hydrochloride
  • BUNAZOSIN HYDROCHLORIDE
  • Bunzaosin Hcl
  • Bunazosin Hcl
  • Detantol
  • E-643
  • Bunazosin, DETANTO
  • 1-(4-Amino-6,7-dimethoxyquinazolin-2-y1)-4-butyrylhexahydro-lH-1,4-diazepine hydrochloride
  • Detantol-R
  • 1-[4-(4-amino-6,7-dimethoxy-2-quinazolinyl)-1,4-diazepan-1-yl]-1-butanone
  • Bunazosin hydrochloride USP/EP/BP
  • E 1015
  • E-1015
  • 52712-76-2
  • 72712-76-2
  • C19H27N5O3HCl
  • C19H28ClN5O3