Bunazosin hydrochloride

Product Name: Bunazosin hydrochloride
CAS No.: 52712-76-2
Chemical Name: Bunazosin hydrochloride
Synonyms: E-643;E 1015;E-1015;Detantol;Detantol-R;Bunazosin Hcl;Bunzaosin Hcl;Bunazosin, DETANTO;BUNAZOSIN HYDROCHLORIDE;Bunazosin hydrochloride USP/EP/BP
CBNumber: CB9189463
Molecular Formula: C19H28ClN5O3
Formula Weight: 409.91
MOL File: 52712-76-2.mol

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Bunazosin hydrochloride Property

Melting point:: 280-282°
storage temp.: Sealed in dry,Room Temperature
solubility: DMSO (Slightly, Heated), Methanol (Slightly, Heated)
form: Solid
color: White to Off-White
Stability:: Hygroscopic

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Safety

Toxicity: LD50 oral in rat: 980mg/kg

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC

Product number: B689585
Product name: BunazosinHydrochloride
Packaging: 10mg
Price: $65
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: API0002269
Product name: BUNAZOSIN HYDROCHLORIDE
Purity: 95.00%
Packaging: 100MG
Price: $1370.41
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: API0002269
Product name: BUNAZOSIN HYDROCHLORIDE
Purity: 95.00%
Packaging: 1G
Price: $2355.15
Updated: 2021/12/16

Chemenu

Product number: CM193842
Product name: BunazosinHydrochloride
Purity: 95%
Packaging: 1g
Price: $1117
Updated: 2021/12/16

Crysdot

Product number: CD31001617
Product name: BunazosinHydrochloride
Purity: 95+%
Packaging: 1g
Price: $1186
Updated: 2021/12/16

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Bunazosin hydrochloride Chemical Properties,Usage,Production

Description

Bunazosin hydrochloride is a selective αl-adrenergic antagonist related to prazosin and useful in the treatment of hypertension.

Originator

Eisai (Japan)

Uses

Bunazosin Hydrochloride is an α-1 adrenergic receptor antagonist that acts as an anti-cancer and anti-glaucoma drug.

Definition

ChEBI: Bunazosin hydrochloride is a member of quinazolines.

Manufacturing Process

17.0 g of 2-chloro-4-amino-6,7-dimethoxyquinazoline and 18.2 g of Nformylhomopiperazine are added to 170 ml of butanol and the whole is refluxed with stirring for 3 h. After completion of the reaction, the mixture is cooled, and the crystals thus precipitated are filtered out, washed with a small quantity of ethanol and air-dried. 25.0 g of crude 2-homopiperazino-4-amino- 6,7-dimethoxyquinazoline are obtained.
A solution of 2-homopiperazino-4-amino-6,7-dimethoxyquinazoline in 60 ml of acetone is added dropwise to a solution of 2-butylcarboxylic acid chloride in acetone under stirring and ice-cooling. After completion of the addition, the stirring is continued for additional 1 h to complete the reaction. The crystals thus precipitated are filtered out and the 1-(4-amino-6,7-dimethoxy-2- quinazolinyl)hexahydro-4-(1-oxobutyl)-1H-1,4-diazepine, melting point 280- 282°C (recrystallized from a mixture of methanol-ethanol) is obtained.

brand name

DETANTOL

Therapeutic Function

Antihypertensive

Bunazosin hydrochloride Preparation Products And Raw materials

Raw materials

Bunazosin Anisole 1-Formylhomopiperazine Butyryl chloride Benzonitrile Quinazoline

Preparation Products

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Bunazosin hydrochloride Suppliers

China 26 Europe 3 United Kingdom 2 United States 11 Global 42

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View Lastest Price from Bunazosin hydrochloride manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: Bunazosin hydrochloride 52712-76-2
Price: US $0.00-0.00/Kg
Min. Order: 1KG
Purity: 99.0%
Supply Ability: 500 MT
Release date: 2020-05-09

52712-76-2, Bunazosin hydrochlorideRelated Search:

Cimetidine Terazosin hydrochloride Terazosin hydrochloride capsule CYCLOHEPTANE 4-Amino-6,7-dimethoxyquinazoline Quinazoline 1-Formylhomopiperazine 1-propyl-1,4-diazepane 1-PYRIMIDIN-2-YL-1,4-DIAZEPANE Bunazosin N-ACETYLHOMOPIPERAZINE Bunazosin hydrochloride

1-[4-(4-amino-6,7-dimethoxyquinazolin-2-yl)-1,4-diazepan-1-yl]butan-1-one hydrochloride

BUNAZOSIN HYDROCHLORIDE

Bunzaosin Hcl

Bunazosin Hcl

Detantol

E-643

Bunazosin, DETANTO

1-(4-Amino-6，7-dimethoxyquinazolin-2-y1)-4-butyrylhexahydro-lH-1，4-diazepine hydrochloride

Detantol-R

1-[4-(4-amino-6,7-dimethoxy-2-quinazolinyl)-1,4-diazepan-1-yl]-1-butanone

Bunazosin hydrochloride USP/EP/BP

E 1015

E-1015

52712-76-2

72712-76-2

C19H27N5O3HCl

C19H28ClN5O3