Bunazosin hydrochloride
- Product Name
- Bunazosin hydrochloride
- CAS No.
- 52712-76-2
- Chemical Name
- Bunazosin hydrochloride
- Synonyms
- E-643;E 1015;E-1015;Detantol;Detantol-R;Bunazosin Hcl;Bunzaosin Hcl;Bunazosin, DETANTO;BUNAZOSIN HYDROCHLORIDE;Bunazosin hydrochloride USP/EP/BP
- CBNumber
- CB9189463
- Molecular Formula
- C19H28ClN5O3
- Formula Weight
- 409.91
- MOL File
- 52712-76-2.mol
Bunazosin hydrochloride Property
- Melting point:
- 280-282°
- storage temp.
- Sealed in dry,Room Temperature
- solubility
- DMSO (Slightly, Heated), Methanol (Slightly, Heated)
- form
- Solid
- color
- White to Off-White
- Stability:
- Hygroscopic
Safety
- Toxicity
- LD50 oral in rat: 980mg/kg
N-Bromosuccinimide Price
- Product number
- B689585
- Product name
- BunazosinHydrochloride
- Packaging
- 10mg
- Price
- $65
- Updated
- 2021/12/16
- Product number
- API0002269
- Product name
- BUNAZOSIN HYDROCHLORIDE
- Purity
- 95.00%
- Packaging
- 100MG
- Price
- $1370.41
- Updated
- 2021/12/16
- Product number
- API0002269
- Product name
- BUNAZOSIN HYDROCHLORIDE
- Purity
- 95.00%
- Packaging
- 1G
- Price
- $2355.15
- Updated
- 2021/12/16
- Product number
- CM193842
- Product name
- BunazosinHydrochloride
- Purity
- 95%
- Packaging
- 1g
- Price
- $1117
- Updated
- 2021/12/16
- Product number
- CD31001617
- Product name
- BunazosinHydrochloride
- Purity
- 95+%
- Packaging
- 1g
- Price
- $1186
- Updated
- 2021/12/16
Bunazosin hydrochloride Chemical Properties,Usage,Production
Description
Bunazosin hydrochloride is a selective αl-adrenergic antagonist related to prazosin and useful in the treatment of hypertension.
Originator
Eisai (Japan)
Uses
Bunazosin Hydrochloride is an α-1 adrenergic receptor antagonist that acts as an anti-cancer and anti-glaucoma drug.
Definition
ChEBI: Bunazosin hydrochloride is a member of quinazolines.
Manufacturing Process
17.0 g of 2-chloro-4-amino-6,7-dimethoxyquinazoline and 18.2 g of Nformylhomopiperazine
are added to 170 ml of butanol and the whole is
refluxed with stirring for 3 h. After completion of the reaction, the mixture is
cooled, and the crystals thus precipitated are filtered out, washed with a small
quantity of ethanol and air-dried. 25.0 g of crude 2-homopiperazino-4-amino-
6,7-dimethoxyquinazoline are obtained.
A solution of 2-homopiperazino-4-amino-6,7-dimethoxyquinazoline in 60 ml of
acetone is added dropwise to a solution of 2-butylcarboxylic acid chloride in
acetone under stirring and ice-cooling. After completion of the addition, the
stirring is continued for additional 1 h to complete the reaction. The crystals
thus precipitated are filtered out and the 1-(4-amino-6,7-dimethoxy-2-
quinazolinyl)hexahydro-4-(1-oxobutyl)-1H-1,4-diazepine, melting point 280-
282°C (recrystallized from a mixture of methanol-ethanol) is obtained.
brand name
DETANTOL
Therapeutic Function
Antihypertensive
Bunazosin hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
Bunazosin hydrochloride Suppliers
View Lastest Price from Bunazosin hydrochloride manufacturers
- Product
- Bunazosin hydrochloride 52712-76-2
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.9%
- Supply Ability
- 100 Tons min
- Release date
- 2021-08-10
- Product
- Bunazosin hydrochloride 52712-76-2
- Price
- US $0.00-0.00/Kg
- Min. Order
- 1KG
- Purity
- 99.0%
- Supply Ability
- 500 MT
- Release date
- 2020-05-09