Product Features Toxicity Limited use Chemical properties Uses Production method Category Toxicity grading Acute toxicity Stimulus data Flammability hazard characteristics Storage feature Extinguishing agents Occupational standards
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Anisole

Product Features Toxicity Limited use Chemical properties Uses Production method Category Toxicity grading Acute toxicity Stimulus data Flammability hazard characteristics Storage feature Extinguishing agents Occupational standards
Product Name
Anisole
CAS No.
100-66-3
Chemical Name
Anisole
Synonyms
MOB;ANISOL;Anizol;ANISLOE;ANISOLE;Amisale;FEMA 2097;7) ANISOLE;Anisole>Anisole ,99%
CBNumber
CB5100716
Molecular Formula
C7H8O
Formula Weight
108.14
MOL File
100-66-3.mol
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Anisole Property

Melting point:
-37 °C (lit.)
Boiling point:
154 °C (lit.)
Density 
0.995 g/mL at 25 °C (lit.)
vapor density 
3.7 (vs air)
vapor pressure 
10 mm Hg ( 42.2 °C)
FEMA 
2097 | ANISOLE
refractive index 
n20/D 1.516(lit.)
Flash point:
125 °F
storage temp. 
Store below +30°C.
solubility 
1.71g/l
form 
Liquid
color 
Clear colorless
Relative polarity
0.198
Odor
phenol, anise odor
Odor Threshold
0.057ppm
explosive limit
0.34-6.3%(V)
Water Solubility 
1.6 g/L (20 ºC)
JECFA Number
1241
Merck 
14,669
BRN 
506892
Stability:
Stable. Flammable. Incompatible with strong oxidizing agents.
InChIKey
RDOXTESZEPMUJZ-UHFFFAOYSA-N
CAS DataBase Reference
100-66-3(CAS DataBase Reference)
NIST Chemistry Reference
Benzene, methoxy-(100-66-3)
EPA Substance Registry System
Anisole (100-66-3)
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Safety

Hazard Codes 
Xn,Xi
Risk Statements 
10-38-20-36/37
Safety Statements 
37/39-26-16-24/25
RIDADR 
UN 2222 3/PG 3
WGK Germany 
2
RTECS 
BZ8050000
Autoignition Temperature
887 °F
TSCA 
Yes
HazardClass 
3
PackingGroup 
III
HS Code 
29093090
Hazardous Substances Data
100-66-3(Hazardous Substances Data)
Toxicity
LD50 orally in rats: 3700 mg/kg (Taylor)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H226Flammable liquid and vapour

H303May be harmfulif swallowed

H304May be fatal if swallowed and enters airways

H315Causes skin irritation

H319Causes serious eye irritation

H331Toxic if inhaled

H332Harmful if inhaled

H335May cause respiratory irritation

H412Harmful to aquatic life with long lasting effects

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P233Keep container tightly closed.

P240Ground/bond container and receiving equipment.

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P273Avoid release to the environment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P370+P378In case of fire: Use … for extinction.

P405Store locked up.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
8.01452
Product name
Anisole
Purity
for synthesis
Packaging
100 mL
Price
$28.77
Updated
2021/03/22
Sigma-Aldrich
Product number
8.01452
Product name
Anisole
Purity
for synthesis
Packaging
500 mL
Price
$41.62
Updated
2021/03/22
Sigma-Aldrich
Product number
96109
Product name
Anisole
Purity
analytical standard
Packaging
5 mL
Price
$54.8
Updated
2021/03/22
Sigma-Aldrich
Product number
W209708
Product name
Anisole
Purity
≥99%, FCC, FG
Packaging
1 kg
Price
$61.9
Updated
2021/03/22
Sigma-Aldrich
Product number
8.01452
Product name
Anisole
Purity
for synthesis
Packaging
1 L
Price
$72.7
Updated
2021/03/22
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Anisole Chemical Properties,Usage,Production

Product Features

Anisole, also known as anise ether, methoxybenzene methyl phenyl ether, is a colorless liquid with an odor of anise, sweet, naturally present in the tarragon oil, insoluble in water, soluble in alcohol, ether, acetone, soluble in benzene. It irritates the eyes and mucous membranes. It is obtained originally from distilled methyl salicylate or methoxybenzoate, is now mainly produced through the reaction of methylating agent of dimethyl sulfate with phenol in alkaline aqueous solution. Anisole is prone to start Electrophilic substitution reaction in aromatic nucleus, and condensed with formaldehyde to produce viscous oil or resin material, reacts with phosphorus trichloride to produce chlorine anisole and a small amount of o-chloro product, reacts with thionyl chloride to produce 2,4,6-trichloroanisole. In addition, anisole is heated to react with hydrobromic or hydroiodic, carbon-oxygen bond cleaves, phenol and halogenated methane is produced, which is an important method for determining methoxy group of benzene ring.
The above information is edited by the chemicalbook of Yan Yanyong.

Toxicity

GRAS (FEMA).
LD50 3700 mg/kg (rat, oral).

Limited use

FEMA (mg/kg): Soft drinks 9.0, cold 16, confectionery51, bakery 34.
limited in moderation (FDA§172.515,2000).

Chemical properties

It is a colorless liquid, with an aromatic odor, insoluble in water, soluble in alcohol, ether.

Uses

1. GB2760-1996 stipulates it as allowable usable spices in food. It is mainly used for the preparation of vanilla, fennel and beer flavor.
2. It is used for analyzing the reagents, solvents, and used for preparing perfumery and enteral pesticides.
3. It is used for the production of perfumes, dyes, pharmaceuticals, pesticides, also used as a solvent.
4. It is used in organic synthesis, also used as solvents, perfume and insect repellent.
5. It is used as solvents for recrystallization, fillers of thermostat, and used for measuring refractive index, as spices and organic synthesis intermediates.

Production method

It is produced through the reaction of methylating agent of dimethyl sulfate with phenol in alkaline aqueous solution. Phenol was mixed with sodium hydroxide solution, dimethyl sulfate was slowly added at below 10 ℃. And then heat to 40 ℃, reflux for 18h, then stand for separation of the oil and dried with anhydrous calcium chloride, vacuum distillation to obtain anisole.
It is derived by introducing the methyl chloride into the sodium phenol of liquid ammonia to react.
It is generated from heating phenol and methanol.
It is obtained from the reaction of phenol with dimethyl sulfate in the presence of sodium hydroxide.

Category

Flammable liquid

Toxicity grading

Moderate toxicity

Acute toxicity

Oral-rat LD50: 3700 mg/kg. Oral-Mouse LD50: 2800 mg/kg

Stimulus data

Skin-rabbit 500 mg/24 hours moderate

Flammability hazard characteristics

In case of fire, high temperature, strong oxidants, it is combustible. Burning discharges irritative smoke.

Storage feature

complete package, with care, warehouse ventilation, away from open flame, heat, and stored separately from oxidants

Extinguishing agents

Foam, carbon dioxide, dry sandy, soil

Occupational standards

STEL 10 mg/m3

Chemical Properties

Clear straw colored liquid

Chemical Properties

Anisole is a colorless to yellowish liquid with an agreeable, aromatic, spicy-sweet odor.

Chemical Properties

Anisole has a characteristic pleasant, anise-like, agreeable aromatic odor.Anisole is used in perfumery.

Occurrence

Reported found in apple juice and in the oil of Artemisia dracunculus var. turkestanica; also reported found in butter, Camembert cheese, roasted beef, olive (Olea europae), Malay apple, Jerusalem artichoke (Helianthus tuberosus), Bourbon vanilla, truffles, crab and sopadilla fruit (Achras sapota L.).

Uses

A biochemical for proteomics research.

Uses

In perfumery, in organic syntheses.

Definition

ChEBI: A monomethoxybenzene that is benzene substituted by a methoxy group.

Preparation

By reacting phenol and dimethyl sulfate in the presence of aqueous NaOH; by passing methyl chloride into a suspension of sodium phenolate in liquid ammonia

Aroma threshold values

Detection: 50 ppb

Synthesis Reference(s)

Canadian Journal of Chemistry, 40, p. 441, 1962 DOI: 10.1139/v62-070
Journal of the American Chemical Society, 88, p. 4271, 1966 DOI: 10.1021/ja00970a037
Organic Syntheses, Coll. Vol. 1, p. 58, 1941

General Description

A clear straw-colored liquid with an aromatic odor. Insoluble in water and the same density as water. Vapors heavier than air. Flash point 125°F. Boiling point 307°F. Moderately toxic by ingestion. A skin irritant. Used to make perfumes, flavorings and as a solvent.

Air & Water Reactions

Flammable. Ethers tend to form unstable peroxides when exposed to oxygen. Ethyl, isobutyl, ethyl tert-butyl, and ethyl tert-pentyl ether are particularly hazardous in this respect. Ether peroxides can sometimes be observed as clear crystals deposited on containers or along the surface of the liquid. Insoluble in water

Reactivity Profile

Ethers, such as Anisole can act as bases. They form salts with strong acids and addition complexes with Lewis acids. The complex between diethyl ether and boron trifluoride is an example. Ethers may react violently with strong oxidizing agents. In other reactions, which typically involve the breaking of the carbon-oxygen bond, ethers are relatively inert.

Health Hazard

Inhalation or contact with material may irritate or burn skin and eyes. Fire may produce irritating, corrosive and/or toxic gases. Vapors may cause dizziness or suffocation. Runoff from fire control or dilution water may cause pollution.

Safety Profile

Moderately toxic by ingestion and inhalation. A skin irritant. A flammable liquid. To fight fire, use foam, CO2, dry chemical. When heated to decomposition it emits acrid fumes.

Potential Exposure

Anisole is used as a solvent; a flavoring, vermicide, making perfumes; and in organic synthesis.

Shipping

UN2222 Anisole, Hazard Class: 3; Labels: 3- Flammable liquid.

Purification Methods

Shake anisole with half its volume of 2M NaOH, and the emulsion is allowed to separate. Repeat three times, then wash twice with water, dry over CaCl2, filter, dry over sodium wire and finally distil it from fresh sodium under N2 using a Dean-Stark trap (samples in the trap being rejected until free from turbidity) [Caldin et al. J Chem Soc, Faraday Trans 1 72 1856 1976]. Alternatively dry it with CaSO4 or CaCl2, or by refluxing with sodium or BaO with crystalline FeSO4 or by passage through an alumina column. Traces of phenols are removed by prior shaking with 2M NaOH, followed by washing with water. It has been be purified by zone refining. [Beilstein 6 IV 548.]

Incompatibilities

Incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explosions. Keep away from alkaline materials, strong bases, strong acids, oxoacids, epoxides.

Waste Disposal

Dissolve or mix the material with a combustible solvent and burn in a chemical incinerator equipped with an afterburner and scrubber. All federal, state, and local environmental regulations must be observed.

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Anisole Suppliers

HUAIAN DEPON CHEMICAL CO., LTD.
Fax
0517-82332537
Email
sales@deponchem.com
Country
China
ProdList
9
Advantage
12
Shanghai Aladdin Bio-Chem Technology Co.,LTD
Tel
021-20337333-801
Fax
021-50323701
Email
market@aladdin-e.com
Country
China
ProdList
24980
Advantage
65
Shanghai Xinyue Chemical Co., Ltd.
Email
645908973@qq.com
Country
China
ProdList
66
Advantage
58
Ningbo Bingxing Chemical Co., Ltd.
Tel
13738829766
Email
674305257@qq.com
Country
China
ProdList
16
Advantage
58
Shanghai Guoyuan Chemical Co., Ltd.
Tel
0512-55170668- ;0512-50323806-
Fax
0512-55170668
Email
shgyhg@139.com;474293744@qq.com
Country
China
ProdList
277
Advantage
58
Ningbo Hua Tuo Chemical Co., Ltd.
Tel
0574-88237971-
Fax
0574-88237323
Email
mia@sinotopchem.com
Country
China
ProdList
59
Advantage
58
Shaanxi Coal Chemical Industry Technology Research Institute Co., Ltd.
Tel
029-81772051-
Email
549981688@qq.com
Country
China
ProdList
18
Advantage
58
Kunshan zhonglaite Trading Co., Ltd
Tel
0512-55170668- ;0512-50323806-
Email
26886897@qq.com;474293744@qq.com
Country
China
ProdList
1710
Advantage
58
Shanghai Kangluo New Material Technology Co., LTD
Tel
021-51601195-
Fax
021-51105027
Email
180800400@qq.com
Country
China
ProdList
17
Advantage
58
J & K SCIENTIFIC LTD.
Tel
010-82848833- ;010-82848833-
Fax
86-10-82849933
Email
jkinfo@jkchemical.com;market6@jkchemical.com
Country
China
ProdList
96815
Advantage
76
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View Lastest Price from Anisole manufacturers

Shanxi Lianxu New Material Co., LTD
Product
Anisole 100-66-3
Price
US $100.00/Kg/Drum
Min. Order
1Kg/Drum
Purity
99%
Supply Ability
1000kg/month
Release date
2021-11-05
Hong Kong Tiansheng New Material Trading Co., Ltd
Product
Anisole 100-66-3
Price
US $15.99/KG
Min. Order
1KG
Purity
99%
Supply Ability
100KG
Release date
2021-11-19
Wuhan Mulei New Material Technology Co. Ltd
Product
Anisole 100-66-3
Price
US $20.00/Kg/Drum
Min. Order
25Kg/Drum
Purity
99.99%
Supply Ability
1 ton per week
Release date
2021-04-02

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