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Alacepril

Product Name
Alacepril
CAS No.
74258-86-9
Chemical Name
Alacepril
Synonyms
du1219;Alapri;cetapril;Cetapfil;ALACEPRIL;Alacepril API;(s)-l-phenylalanin;Alacepril USP/EP/BP;N-[(S)-3-Acetylthio-2-methylpropanoyl]-L-Pro-L-Phe-OH;1-[(S)-3-Acetylthio-2-methylpropanoyl]-L-Pro-L-Phe-OH
CBNumber
CB9198959
Molecular Formula
C20H26N2O5S
Formula Weight
406.5
MOL File
74258-86-9.mol
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Alacepril Property

Melting point:
155-156°
alpha 
D25 -81.3° (c = 1.02 in ethanol)
Boiling point:
679.1±55.0 °C(Predicted)
Density 
1.281±0.06 g/cm3(Predicted)
storage temp. 
2-8°C
pka
3.56±0.10(Predicted)
CAS DataBase Reference
74258-86-9(CAS DataBase Reference)
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Safety

Toxicity
LD50 in rats, mice (mg/kg): >5000, >5000 orally; >3000, >3000 s.c.; ~2000, ~3000 i.p. (Iida, pp 7033-40)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Biosynth Carbosynth
Product number
FA158541
Product name
Alacepril
Packaging
10mg
Price
$120
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
API0001937
Product name
ALACEPRIL
Purity
95.00%
Packaging
1MG
Price
$152.25
Updated
2021/12/16
Biosynth Carbosynth
Product number
FA158541
Product name
Alacepril
Packaging
1mg
Price
$40
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
API0001937
Product name
ALACEPRIL
Purity
95.00%
Packaging
1G
Price
$1428
Updated
2021/12/16
Arctom
Product number
AS566841
Product name
Alacepril
Purity
≥95%
Packaging
5mg
Price
$44
Updated
2021/12/16
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Alacepril Chemical Properties,Usage,Production

Description

Alacepril is an angiotensin-converting enzyme (ACE) inhibitor useful in the treatment of essential and renal hypertension. Compared with captopril, alacepril is a weaker ACE inhibitor in vino, yet clinically it has a longer duration of action and appears to be more active due to an added component of norepinephrine antagonism.

Originator

Dainippon (Japan)

Definition

ChEBI: Alacepril is a thioacetate ester and a dipeptide. It has a role as an EC 3.4.15.1 (peptidyl-dipeptidase A) inhibitor.

Manufacturing Process

N-Methylmorpholine (1.03 g) was added to a solution of 1-(D-3-acetylthio-2- methylpropanoyl)-L-proline (2.65 g) in dry tetrahydrofuran (50 ml). The resulting solution was stirred and cooled at -20° to -15°C. Phenyl chloroformate (1.61 g) was added, and after 5 min, a solution of Lphenylalanine t-butyl ester hydrochloride (2.4 g) and N-methylmorpholine (1.03 g) in dry tetrahydrofuran (30 ml) was added. The mixture was stirred at -20° to -15°C for 1 h and then at room temperature overnight.
After removal of insoluble materials by filtration, the filtrate was concentrated under reduced pressure and the residue was dissolved in chloroform.
The chloroform solution was washed successively with 1 N sodium hydroxide, water, 10% citric acid, and water, dried and concentrated under reduced pressure. The residue was chromatographed on silica gel with chloroformmethanol (99:1) to give 4.2 g the 1-(D-3-acetylthio-2-methylpropanoyl)-Lprolyl- L-phenylalanine tert-butyl ester.
1-(D-3-Acetylthio-2-methylpropanoyl)-L-prolyl-L-phenylalanine tert-butyl ester (2.5 g) was dissolved in a mixture of anisole (18 ml) and trifluoroacetic acid (37 ml). The solution was allowed to stand at room temperature for 1 h and then concentrated to dryness under reduced pressure. The residue was crystallized from diethyl ether. The 1-(D-3-acetylthio-2-methylpropanoyl)-Lprolyl- L-phenylalanine was obtained (1.8 g), melting point 155°-156°C (recrystallization from ethanol/n-hexane).

brand name

Cetapril

Therapeutic Function

Antihypertensive

Alacepril Preparation Products And Raw materials

Raw materials

Preparation Products

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Alacepril Suppliers

LGM Pharma
Tel
1-(800)-881-8210
Fax
615-250-9817
Email
inquiries@lgmpharma.com
Country
United States
ProdList
2127
Advantage
70
Beijing HuaMeiHuLiBiological Chemical
Tel
010-56205725
Fax
010-65763397
Email
waley188@sohu.com
Country
China
ProdList
12338
Advantage
58
Jiangsu Aikon Biopharmaceutical R&D co.,Ltd.
Tel
025-66099280 17798518460
Fax
(1)02557626880
Email
cfzhang@aikonchem.com
Country
China
ProdList
19918
Advantage
55
ShangHai Movin Pharmaceutical Co., Ltd.
Tel
13681854265
Email
info@moenpharm.com
Country
China
ProdList
510
Advantage
55
Beijing Solarbio Science & Tecnology Co., Ltd.
Tel
010-50973185 4009686088
Email
3193328036@qq.com
Country
China
ProdList
29797
Advantage
68
Amadis Chemical Company Limited
Tel
571-89925085
Fax
0086-571-89925065
Email
sales@amadischem.com
Country
China
ProdList
132020
Advantage
58
Rhawn Reagent
Tel
400-400-1332688 18019345275
Fax
400-133-2688
Email
amy@rhawn.cn
Country
China
ProdList
15503
Advantage
58
Shijiazhuang Gantuo Biotechnology Co., Ltd
Tel
+8613373514458
Email
gantuo02@cngantuo.com
Country
China
ProdList
218
Advantage
58
Hefei TNJ Chemical Industry Co.,Ltd.
Tel
0551-65418684 +8618949823763
Fax
0086-551-65418684
Email
sales@tnjchem.com
Country
China
ProdList
25363
Advantage
58
Hebei Lingding Biotechnology Co., Ltd.
Tel
+86-18031140164 +86-19933155420
Email
erin@hbldbiotech.com
Country
China
ProdList
882
Advantage
58
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View Lastest Price from Alacepril manufacturers

Hebei Mingeng Biotechnology Co., Ltd
Product
Alacepril 74258-86-9
Price
US $200.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
1000kg/Month
Release date
2022-11-23
Hebei Lingding Biotechnology Co., Ltd.
Product
Alacepril 74258-86-9
Price
US $15.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
9000kg/per week
Release date
2021-09-07
Shijiazhuang Gantuo Biotechnology Co., Ltd
Product
Alacepril 74258-86-9
Price
US $100.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
1000 Kilogram/Kilograms per Week
Release date
2023-03-10

74258-86-9, AlaceprilRelated Search:


  • (s)-l-phenylalanin
  • 1-(d-3-acetylthio-2-methylpropanoyl)-l-prolyl-l-phenylalanine
  • cetapril
  • du1219
  • ALACEPRIL
  • L-Phenylalanine, 1-[(2S)-3-(acetylthio)-2-methyl-1-oxopropyl]-L-prolyl-
  • L-Phenylalanine, N-[1-[3-(acetylthio)-2-methyl-1-oxopropyl]-L-prolyl]-, (S)-
  • 2-[[1-(3-Acetylsulfanyl-2-methylpropanoyl)pyrrolidine-2-carbonyl]amino]-3-phenylpropanoic acid
  • (S)-N-[1-[3-(Aeetylthio)-2-methyl-1-oxopropyl]-L-prolyl]-L-phenylalanine
  • 1-[(S)-3-Acetylthio-2-methylpropanoyl]-L-Pro-L-Phe-OH
  • N-[(S)-3-Acetylthio-2-methylpropanoyl]-L-Pro-L-Phe-OH
  • N-[1-[(S)-3-(Acetylthio)-2-methyl-1-oxopropyl]-L-prolyl]-L-phenylalanine
  • Alacepril API
  • Cetapfil
  • Alacepril USP/EP/BP
  • (S)-2-((S)-1-((S)-3-(Acetylthio)-2-methylpropanoyl)pyrrolidine-2-carboxamido)-3-phenylpropanoic acid
  • antihypertensive effect,DU 1219,DU1219,Inhibitor,oral,long lasting,inhibit,Angiotensin-converting Enzyme (ACE),Alacepril
  • Alapri
  • 74258-86-9
  • C2OH26N2O5S
  • C20H26N2O5S
  • Active Pharmaceutical Ingredients