ChemicalBook > CAS DataBase List > Enalapril
Enalapril
- Product Name
- Enalapril
- CAS No.
- 75847-73-3
- Chemical Name
- Enalapril
- Synonyms
- Vasotec;Renitec;G1ioten;Hipoartd;ENALAPRIL;Enalapril hydrate;Enalapril (MK-421);ELAPRILAT DIHYDRAT;Enalapril USP/EP/BP;Enalapril AldrichCPR
- CBNumber
- CB1295108
- Molecular Formula
- C20H28N2O5
- Formula Weight
- 376.45
- MOL File
- 75847-73-3.mol
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Enalapril Property
- Melting point:
- 142-147℃
- Boiling point:
- 582.4±50.0 °C(Predicted)
- Density
- 1.204±0.06 g/cm3(Predicted)
- RTECS
- TW3665500
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- solubility
- Soluble in DMSO
- form
- Powder
- pka
- pKa 2.97 (H2O t=25.0)(Approximate);5.35(H2O t=25.0)(Approximate)
- Water Solubility
- Soluble in water at 25mg/ml
- BCS Class
- 3
- CAS DataBase Reference
- 75847-73-3(CAS DataBase Reference)
- EPA Substance Registry System
- L-Proline, N-[(1S)-1-(ethoxycarbonyl)-3-phenylpropyl]-L-alanyl- (75847-73-3)
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Safety
- Safety Statements
- 22-24/25
- WGK Germany
- 3
- Hazardous Substances Data
- 75847-73-3(Hazardous Substances Data)
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N-Bromosuccinimide Price
Alfa Aesar
- Product number
- J60750
- Product name
- Enalapril
- Packaging
- 1g
- Price
- $93.65
- Updated
- 2024/03/01
Alfa Aesar
- Product number
- J60750
- Product name
- Enalapril
- Packaging
- 5g
- Price
- $369.65
- Updated
- 2024/03/01
Cayman Chemical
- Product number
- 16041
- Product name
- Enalapril
- Purity
- ≥98%
- Packaging
- 5g
- Price
- $165
- Updated
- 2021/12/16
Cayman Chemical
- Product number
- 16041
- Product name
- Enalapril
- Purity
- ≥98%
- Packaging
- 1g
- Price
- $48
- Updated
- 2021/12/16
Cayman Chemical
- Product number
- 16041
- Product name
- Enalapril
- Purity
- ≥98%
- Packaging
- 10g
- Price
- $270
- Updated
- 2021/12/16
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Enalapril Chemical Properties,Usage,Production
Uses
angiotensin converting enzyme inhibitor
Uses
It is used for hypertension and chronic cardiac insufficiency.
Uses
Enalapril is used in the treatment of hypertension, diabetic nephropathy, and some types of chronic heart failure. It has been proven to protect the function of the kidneys in hypertension, heart failure, and diabetes, and may be used in the absence of hypertension for its kidney protective effects. It is widely used in chronic kidney failure.
Definition
ChEBI: A dicarboxylic acid monoester that is ethyl 4-phenylbutanoate in which a hydrogen alpha to the carboxy group is substituted by the amino group of L-alanyl-L-proline (S-configuration).
Mechanism of action
Like captopril, enalapril selectively suppresses the rennin–angiotensin–aldosterone system, inhibits angiotensin-converting enzyme, and prevents conversion of angiotensin I into angiotensin II.
Synthesis
Enalapril, (S)-1-[N-[1-(ethoxycarbonyl)-3-phenylpropyl]-L-alanyl]-L-proline (22.7.12), is synthesized by reacting the benzyl ester of L-alanyl-L-proline with the ethyl ester of 3-benzoylacrylic acid, which forms the product 22.7.11, the reduction of which with hydrogen using a Raney nickel catalyst removes the protective benzyl group, giving the desired enalapril (22.7.12) [24]. Alternative methods of syntheses have also been proposed.
Enalapril Preparation Products And Raw materials
Raw materials
N-Hydroxysuccinimide
Enalapril maleate
Palladium carbon fine chemical catalyzer
Benzyl ester
Ethyl 2-oxo-4-phenylbutyrate
Maleic acid
Maleic anhydride
PROPYLENE
dipeptide
L-Alanyl-L-proline
Water
L-Proline
Bromobenzene
Concentrated sulfuric acid
Benzene
Ethyl acetate
D-Alanine
Acetic acid
Ethyl acrylate
DOWEX(R) 50WX4 HYDROGEN FORM
Sodium cyanoborohydride
Dicyclohexylcarbodiimide
Formamide
Preparation Products
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Enalapril Suppliers
- Tel
- 010-82848833 400-666-7788
- Fax
- 86-10-82849933
- jkinfo@jkchemical.com
- Country
- China
- ProdList
- 96815
- Advantage
- 76
- Tel
- 1-(800)-881-8210
- Fax
- 615-250-9817
- inquiries@lgmpharma.com
- Country
- United States
- ProdList
- 2123
- Advantage
- 70
- Tel
- Fax
- E-Mail Inquiry
- info@syntechem.com
- Country
- China
- ProdList
- 12984
- Advantage
- 57
- Tel
- 400-186-5138 13341702378
- Fax
- QQ：190129269
- winherb@126.com
- Country
- China
- ProdList
- 1007
- Advantage
- 58
- Tel
- 010-56205725
- Fax
- 010-65763397
- waley188@sohu.com
- Country
- China
- ProdList
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- Advantage
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- Tel
- 021-58170097
- info@topbiochem.com
- Country
- China
- ProdList
- 9458
- Advantage
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- Tel
- 021-58955995
- Fax
- 609-228-5909
- sales@medchemexpress.cn
- Country
- United States
- ProdList
- 4861
- Advantage
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- Tel
- 020-39119399 18927568969
- Fax
- 020-39119999
- isunpharm@qq.com
- Country
- China
- ProdList
- 4674
- Advantage
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- Tel
- 025-57798810
- Fax
- 025-57019371
- sales@sunlidabio.com
- Country
- China
- ProdList
- 3239
- Advantage
- 55
- Tel
- 27-81302488 18007166089
- Fax
- 027-81302088
- info@dkybpc.com
- Country
- China
- ProdList
- 1734
- Advantage
- 58
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View Lastest Price from Enalapril manufacturers
Sinoway Industrial co., ltd.
- Product
- Enalapril 75847-73-3
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 20tons
- Release date
- 2024-04-28
Zhuozhou Wenxi import and Export Co., Ltd
- Product
- Enalapril 75847-73-3
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-08-11
Zhuozhou Wenxi import and Export Co., Ltd
- Product
- Enalapril 75847-73-3
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-10
75847-73-3, EnalaprilRelated Search:
cis-4-Hydroxy-L-proline
Ethyl acrylate
L-PROLINE-(4-3H(N))
Ethylbenzene
Ethylparaben
D-Proline
Tris(trimethylsilyl)phosphate
Ethanol
Ethyl acetate
ENALAPRILAT-D5
ENALAPRILAT-D5, SODIUM SALT
Trandolapril
Indolapril
N2-1[(1S)-Ethoxycarbonyl-3-phenylpropyl]-N6-trifluoroacetyl-L-lysyl-L-proline
Spirapril
Enalapril maleate
Diethyl ether
Enalapril-D5 tert-Butyl Ester