ChemicalBook > CAS DataBase List > Enalapril

Enalapril

Product Name
Enalapril
CAS No.
75847-73-3
Chemical Name
Enalapril
Synonyms
Vasotec;Renitec;G1ioten;Hipoartd;ENALAPRIL;Enalapril hydrate;Enalapril USP/EP/BP;Enalapril AldrichCPR;Enalapril Maleate USP24;(S)-N-[1-Ethoxycarbonyl)-3-phenylpropyl]-Ala-Pro
CBNumber
CB1295108
Molecular Formula
C20H28N2O5
Formula Weight
376.45
MOL File
75847-73-3.mol
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Enalapril Property

Melting point:
142-147℃
Boiling point:
582.4±50.0 °C(Predicted)
Density 
1.204±0.06 g/cm3(Predicted)
RTECS 
TW3665500
pka
pKa 2.97 (H2O t=25.0)(Approximate);5.35(H2O t=25.0)(Approximate)
Water Solubility 
Soluble in water at 25mg/ml
CAS DataBase Reference
75847-73-3(CAS DataBase Reference)
EPA Substance Registry System
L-Proline, N-[(1S)-1-(ethoxycarbonyl)-3-phenylpropyl]-L-alanyl- (75847-73-3)
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Safety

Safety Statements 
22-24/25
WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H317May cause an allergic skin reaction

H361Suspected of damaging fertility or the unborn child

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
CDS020548
Product name
Enalapril
Purity
AldrichCPR
Packaging
5mg
Price
$63.5
Updated
2018/11/13
Alfa Aesar
Product number
J60750
Product name
Enalapril
Packaging
1g
Price
$92.7
Updated
2021/03/22
Alfa Aesar
Product number
J60750
Product name
Enalapril
Packaging
5g
Price
$367
Updated
2021/03/22
Cayman Chemical
Product number
16041
Product name
Enalapril
Purity
≥98%
Packaging
1g
Price
$48
Updated
2018/11/15
Cayman Chemical
Product number
16041
Product name
Enalapril
Purity
≥98%
Packaging
5g
Price
$165
Updated
2018/11/15
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Enalapril Chemical Properties,Usage,Production

Uses

angiotensin converting enzyme inhibitor

Uses

It is used for hypertension and chronic cardiac insufficiency.

Definition

ChEBI: A dicarboxylic acid monoester that is ethyl 4-phenylbutanoate in which a hydrogen alpha to the carboxy group is substituted by the amino group of L-alanyl-L-proline (S-configuration).

Mechanism of action

Like captopril, enalapril selectively suppresses the rennin–angiotensin–aldosterone system, inhibits angiotensin-converting enzyme, and prevents conversion of angiotensin I into angiotensin II.

Chemical Synthesis

Enalapril, (S)-1-[N-[1-(ethoxycarbonyl)-3-phenylpropyl]-L-alanyl]-L-proline (22.7.12), is synthesized by reacting the benzyl ester of L-alanyl-L-proline with the ethyl ester of 3-benzoylacrylic acid, which forms the product 22.7.11, the reduction of which with hydrogen using a Raney nickel catalyst removes the protective benzyl group, giving the desired enalapril (22.7.12) [24]. Alternative methods of syntheses have also been proposed.

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Enalapril Suppliers

J & K SCIENTIFIC LTD.
Tel
010-82848833- ;010-82848833-
Fax
86-10-82849933
Email
jkinfo@jkchemical.com;market6@jkchemical.com
Country
China
ProdList
96815
Advantage
76
LGM Pharma
Tel
1-(800)-881-8210
Fax
615-250-9817
Email
inquiries@lgmpharma.com
Country
United States
ProdList
1938
Advantage
70
Nanjing Chemlin Chemical Co., Ltd
Tel
Fax
+86-25-83453306
Email
info@chemlin.com.cn
Country
China
ProdList
19992
Advantage
64
XiaoGan ShenYuan ChemPharm co,ltd
Tel
0712-2580635- ;0712-2580635
Email
1791901229@qq.com;1791901229@qq.com;
Country
China
ProdList
8958
Advantage
52
Syntechem Co.,Ltd
Tel
Please Email
Fax
E-Mail Inquiry
Email
info@syntechem.com
Country
China
ProdList
13009
Advantage
57
Beijing HuaMeiHuLiBiological Chemical
Tel
010-56205725;010-86181995
Fax
010-65763397
Email
waley188@sohu.com
Country
China
ProdList
12341
Advantage
58
Shanghai Topbiochem Technology Co., Ltd
Tel
021-58170097-
Email
sales@topbiochem.com
Country
China
ProdList
9542
Advantage
58
MedChemexpress LLC
Tel
609-228-6898
Fax
609-228-5909
Email
sales@medchemexpress.com
Country
United States
ProdList
4787
Advantage
58
Nanjing Sunlida Biological Technology Co., Ltd.
Tel
025-57798810- ;025-57798810-
Fax
025-57019371
Email
sales@sunlidabio.com;sales@sunlidabio.com
Country
China
ProdList
3814
Advantage
55
Shanghai TaoShu Biochemical Technology Co., Ltd.
Tel
021-33632979-
Fax
021-33632979
Email
service1@targetmol.com
Country
China
ProdList
7962
Advantage
58
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View Lastest Price from Enalapril manufacturers

Shaanxi Dideu Medichem Co. Ltd
Product
Enalapril 75847-73-3
Price
US $0.00-0.00/Kg
Min. Order
1KG
Purity
99.0%
Supply Ability
500 MT
Release date
2020-05-09
career henan chemical co
Product
Enalapril 75847-73-3
Price
US $1.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
1kg,5kg,100kg
Release date
2019-07-10

75847-73-3, EnalaprilRelated Search:


  • ENALAPRIL
  • (s)-1-(n-(1-(ethoxycarbonyl)-3-phenylpropyl)-l-alanyl)-l-proline
  • 1-(n-((s)-1-carboxy-3-phenylpropyl)-l-alanyl)-l-proline 1'-ethyl ester
  • 1-[2-(1-ETHOXYCARBONYL-3-PHENYL-PROPYL)AMINOPROPANOYL]PYRROLIDINE-2-CARBOXYLIC ACID
  • N-[(1S)-1-(Ethoxycarbonyl)-3-phenylpropyl]-L-alanyl-L-proline
  • Renitec
  • Vasotec
  • Enalapril Maleate USP24
  • L-Proline, 1-[N-[1-(ethoxycarbonyl)-3-phenylpropyl]-L-alanyl]-, (S)-
  • L-Proline, N-[(1S)-1-(ethoxycarbonyl)-3-phenylpropyl]-L-alanyl-
  • (-)-1-[N-[(S)-1-(Ethoxycarbonyl)-3-phenylpropyl]-L-alanyl]-L-proline
  • 1-[N-[(S)-1-(Ethoxycarbonyl)-3-phenylpropyl]-L-alanyl]-L-proline
  • N-[(1S)-1-(Ethoxycarbonyl)-3-phenylpropyl]-L-Ala-L-Pro-OH
  • N-[(S)-1-(Ethoxycarbonyl)-3-phenylpropyl]-L-Ala-L-Pro-OH
  • (S)-1-((S)-2-(((S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl)aMino)propanoyl)pyrrolidine-2-carboxylic acid
  • Enalapril AldrichCPR
  • (S)-1-[N-[1-(Ethoxyearbonyl)-3-phenylpropyl]-L-alanyl]-L-proline
  • G1ioten
  • Hipoartd
  • (2S)-1-[(2S)-2-[[(2S)-1-Ethoxy-1-oxo-4-phenylbutan-2-yl]amino]propanoyl]pyrrolidine-2-carboxylic acid
  • (S)-N-[1-Ethoxycarbonyl)-3-phenylpropyl]-Ala-Pro
  • Enalapril hydrate
  • Enalapril USP/EP/BP
  • 75847-73-3
  • C20H28N2O5
  • Angiotensin