Enalapril

ChemicalBook > CAS DataBase List > Enalapril

Product Name: Enalapril
CAS No.: 75847-73-3
Chemical Name: Enalapril
Synonyms: Vasotec;Renitec;G1ioten;Hipoartd;ENALAPRIL;Enalapril hydrate;Enalapril (MK-421);ELAPRILAT DIHYDRAT;Enalapril USP/EP/BP;Enalapril AldrichCPR
CBNumber: CB1295108
Molecular Formula: C20H28N2O5
Formula Weight: 376.45
MOL File: 75847-73-3.mol

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Enalapril Property

Melting point:: 142-147℃
Boiling point:: 582.4±50.0 °C(Predicted)
Density: 1.204±0.06 g/cm3(Predicted)
RTECS: TW3665500
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
solubility: Soluble in DMSO
form: Powder
pka: pKa 2.97 (H2O t=25.0)(Approximate);5.35(H2O t=25.0)(Approximate)
Water Solubility: Soluble in water at 25mg/ml
BCS Class: 3
CAS DataBase Reference: 75847-73-3(CAS DataBase Reference)
EPA Substance Registry System: L-Proline, N-[(1S)-1-(ethoxycarbonyl)-3-phenylpropyl]-L-alanyl- (75847-73-3)

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Safety

Safety Statements: 22-24/25
WGK Germany: 3
Hazardous Substances Data: 75847-73-3(Hazardous Substances Data)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H317May cause an allergic skin reaction

H361Suspected of damaging fertility or the unborn child

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

Alfa Aesar

Product number: J60750
Product name: Enalapril
Packaging: 1g
Price: $93.65
Updated: 2024/03/01

Alfa Aesar

Product number: J60750
Product name: Enalapril
Packaging: 5g
Price: $369.65
Updated: 2024/03/01

Cayman Chemical

Product number: 16041
Product name: Enalapril
Purity: ≥98%
Packaging: 5g
Price: $165
Updated: 2021/12/16

Cayman Chemical

Product number: 16041
Product name: Enalapril
Purity: ≥98%
Packaging: 1g
Price: $48
Updated: 2021/12/16

Cayman Chemical

Product number: 16041
Product name: Enalapril
Purity: ≥98%
Packaging: 10g
Price: $270
Updated: 2021/12/16

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Enalapril Chemical Properties,Usage,Production

Uses

angiotensin converting enzyme inhibitor

Uses

It is used for hypertension and chronic cardiac insufficiency.

Uses

Enalapril is used in the treatment of hypertension, diabetic nephropathy, and some types of chronic heart failure. It has been proven to protect the function of the kidneys in hypertension, heart failure, and diabetes, and may be used in the absence of hypertension for its kidney protective effects. It is widely used in chronic kidney failure.

Definition

ChEBI: A dicarboxylic acid monoester that is ethyl 4-phenylbutanoate in which a hydrogen alpha to the carboxy group is substituted by the amino group of L-alanyl-L-proline (S-configuration).

Mechanism of action

Like captopril, enalapril selectively suppresses the rennin–angiotensin–aldosterone system, inhibits angiotensin-converting enzyme, and prevents conversion of angiotensin I into angiotensin II.

Synthesis

Enalapril, (S)-1-[N-[1-(ethoxycarbonyl)-3-phenylpropyl]-L-alanyl]-L-proline (22.7.12), is synthesized by reacting the benzyl ester of L-alanyl-L-proline with the ethyl ester of 3-benzoylacrylic acid, which forms the product 22.7.11, the reduction of which with hydrogen using a Raney nickel catalyst removes the protective benzyl group, giving the desired enalapril (22.7.12) [24]. Alternative methods of syntheses have also been proposed.

Enalapril Preparation Products And Raw materials

Raw materials

N-Hydroxysuccinimide Enalapril maleate Palladium carbon fine chemical catalyzer Benzyl ester Ethyl 2-oxo-4-phenylbutyrate Maleic acid CIS-BUTENEDIOIC ANHYDRIDE PROPYLENE dipeptide L-Alanyl-L-proline Water L-Proline Bromobenzene Concentrated sulfuric acid Benzene Ethyl acetate D-Alanine Acetic acid Ethyl acrylate DOWEX(R) 50WX4 HYDROGEN FORM Sodium cyanoborohydride Dicyclohexylcarbodiimide Formamide

Preparation Products

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Enalapril Suppliers

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View Lastest Price from Enalapril manufacturers

Hebei Lingding Biotechnology Co., Ltd.

Product: Enalapril 75847-73-3
Price: US $200.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 9000kg/per week
Release date: 2021-09-02

Zhuozhou Wenxi import and Export Co., Ltd

Product: Enalapril 75847-73-3
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-08-11

Dideu Industries Group Limited

Product: Enalapril 75847-73-3
Price: US $1.10/g
Min. Order: 1g
Purity: 99.9%
Supply Ability: 100 Tons min
Release date: 2021-08-10

75847-73-3, EnalaprilRelated Search:

cis-4-Hydroxy-L-proline Ethyl acrylate L-PROLINE-(4-3H(N)) Ethylbenzene Ethylparaben D-Proline Tris(trimethylsilyl)phosphate Ethanol Ethyl acetate ENALAPRILAT-D5 ENALAPRILAT-D5, SODIUM SALT Trandolapril Indolapril N2-1[(1S)-Ethoxycarbonyl-3-phenylpropyl]-N6-trifluoroacetyl-L-lysyl-L-proline Spirapril Enalapril maleate Diethyl ether Enalapril-D5 tert-Butyl Ester

ENALAPRIL

(s)-1-(n-(1-(ethoxycarbonyl)-3-phenylpropyl)-l-alanyl)-l-proline

1-(n-((s)-1-carboxy-3-phenylpropyl)-l-alanyl)-l-proline 1'-ethyl ester

1-[2-(1-ETHOXYCARBONYL-3-PHENYL-PROPYL)AMINOPROPANOYL]PYRROLIDINE-2-CARBOXYLIC ACID

N-[(1S)-1-(Ethoxycarbonyl)-3-phenylpropyl]-L-alanyl-L-proline

Renitec

Vasotec

Enalapril Maleate USP24

L-Proline, 1-[N-[1-(ethoxycarbonyl)-3-phenylpropyl]-L-alanyl]-, (S)-

L-Proline, N-[(1S)-1-(ethoxycarbonyl)-3-phenylpropyl]-L-alanyl-

(-)-1-[N-[(S)-1-(Ethoxycarbonyl)-3-phenylpropyl]-L-alanyl]-L-proline

1-[N-[(S)-1-(Ethoxycarbonyl)-3-phenylpropyl]-L-alanyl]-L-proline

N-[(1S)-1-(Ethoxycarbonyl)-3-phenylpropyl]-L-Ala-L-Pro-OH

N-[(S)-1-(Ethoxycarbonyl)-3-phenylpropyl]-L-Ala-L-Pro-OH

(S)-1-((S)-2-(((S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl)aMino)propanoyl)pyrrolidine-2-carboxylic acid

Enalapril AldrichCPR

(S)-1-[N-[1-(Ethoxyearbonyl)-3-phenylpropyl]-L-alanyl]-L-proline

G1ioten

Hipoartd

(2S)-1-[(2S)-2-[[(2S)-1-Ethoxy-1-oxo-4-phenylbutan-2-yl]amino]propanoyl]pyrrolidine-2-carboxylic acid

(S)-N-[1-Ethoxycarbonyl)-3-phenylpropyl]-Ala-Pro

Enalapril hydrate

Enalapril USP/EP/BP

Enalaprilat dihydrat

EnalaprilQ: What is Enalapril Q: What is the CAS Number of Enalapril Q: What is the storage condition of Enalapril Q: What are the applications of Enalapril

Enalapril (MK-421)

ELAPRILAT DIHYDRAT

75847-73-3

C20H28N2O5

Angiotensin