ChemicalBook > CAS DataBase List > N-Hydroxysuccinimide

N-Hydroxysuccinimide

Product Name
N-Hydroxysuccinimide
CAS No.
6066-82-6
Chemical Name
N-Hydroxysuccinimide
Synonyms
NHS;HOSU;HONSU;HOSU/NHS;HOSU 25 G;AKOS 91864;NHS OR HONSU;HOSu Novabiochem;Hydroxysuccinimide;N-HYDROXYSUCCINIMDE
CBNumber
CB0391283
Molecular Formula
C4H5NO3
Formula Weight
115.09
MOL File
6066-82-6.mol
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N-Hydroxysuccinimide Property

Melting point:
95-98 °C(lit.)
Boiling point:
215.33°C (rough estimate)
Density 
1.4769 (rough estimate)
refractive index 
1.4080 (estimate)
storage temp. 
2-8°C
pka
7.81±0.20(Predicted)
form 
Liquid or Solid
color 
Clear yellow-brown to brown
PH
5-7 (50g/l, H2O, 20℃)
Water Solubility 
SOLUBLE
Sensitive 
Hygroscopic
BRN 
113913
Stability:
Stable. Incompatible with strong oxidizing agents, acid chlorides, acid anhydrides, strong bases. Protect from moisture.
InChIKey
NQTADLQHYWFPDB-UHFFFAOYSA-N
CAS DataBase Reference
6066-82-6(CAS DataBase Reference)
NIST Chemistry Reference
N-hydroxylsuccinimide(6066-82-6)
EPA Substance Registry System
2,5-Pyrrolidinedione, 1-hydroxy- (6066-82-6)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
22-24/25-26-36
WGK Germany 
3
Hazard Note 
Irritant
TSCA 
Yes
HS Code 
29251995
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
8.51056
Product name
HOSu
Purity
Novabiochem?
Packaging
25 g
Price
$18.8
Updated
2021/03/22
Sigma-Aldrich
Product number
8.04518
Product name
N-Hydroxysuccinimide
Purity
for synthesis
Packaging
25 g
Price
$33.76
Updated
2021/03/22
Sigma-Aldrich
Product number
8.51056
Product name
HOSu
Purity
Novabiochem?
Packaging
100 g
Price
$64.1
Updated
2021/03/22
Sigma-Aldrich
Product number
8.04518
Product name
N-Hydroxysuccinimide
Purity
for synthesis
Packaging
100 g
Price
$104.52
Updated
2021/03/22
Sigma-Aldrich
Product number
8.04518
Product name
N-Hydroxysuccinimide
Purity
for synthesis
Packaging
500 g
Price
$343.17
Updated
2021/03/22
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N-Hydroxysuccinimide Chemical Properties,Usage,Production

Chemical Properties

White to pale yellow

Uses

Reagent for preparation of active esters of amino acids.

Uses

Useful in the carbodiimide method for improved amidations and peptide couplings.

Uses

Additive used in the carbodiimide method for improved amidations and peptide couplings.

Uses

N-hydroxysuccinimide (NHS) is often used to assist carbodiimide-mediated peptide coupling by forming an active ester intermediate via condensation of the surface carboxyl group and NHS. The NHS-reactive ester intermediate is susceptible to nucleophilic attack by primary amines and results in the formation of stable amide bonds between the biomaterial surface and the N-terminus of the peptide.

Purification Methods

Recrystallise the imide from EtOH/ethyl acetate [Manesis & Goodmen J Org Chem 52 5331 1987]. [Beilstein 21/9 V 498.]

N-Hydroxysuccinimide Preparation Products And Raw materials

Raw materials

Preparation Products

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N-Hydroxysuccinimide Suppliers

Shanghai Chang Ming Pharmaceutical Co., Ltd.
Fax
021-34633972
Email
208006535@qq.com
Country
China
ProdList
11
Advantage
50
Chengdu HuaXia Chemical Reagent Co. Ltd
Tel
400-1166-196;028-84555506- ;028-84555506-
Fax
QQ:800101999
Email
cdhxsj@163.com;cdhxsj@163.com;cdhxsj@163.com
Country
China
ProdList
13362
Advantage
58
Shanghai Medpep Co., Ltd
Tel
021-65566949-
Fax
86-21-51861665
Email
market@medpep.com
Country
China
ProdList
176
Advantage
66
Shanghai Aladdin Bio-Chem Technology Co.,LTD
Tel
021-20337333-801
Fax
021-50323701
Email
market@aladdin-e.com
Country
China
ProdList
24980
Advantage
65
Shanghai Pin Research Chemical Co., Ltd.
Tel
Email
271793832@qq.com
Country
China
ProdList
36
Advantage
58
Shanghai Leju Biotechnology Co., Ltd.
Tel
021-56328558-
Fax
021-56328558
Email
sales2@reliablebiochem.com
Country
China
ProdList
292
Advantage
58
Nanjing Apicci Pharmaceutical Technology Co., Ltd.
Tel
;
Email
2853590738@qq.com;2853579352@qq.com
Country
China
ProdList
399
Advantage
58
Hubei xingongli Chemical Co., Ltd
Tel
027-59503710- ;027-59503710-
Fax
027-59503710
Email
1018282255@qq.com;1018285511@qq.com
Country
China
ProdList
9305
Advantage
58
Guangzhou Younan Technology Co., Ltd
Tel
020-31703347-
Fax
QQ:3283937693
Email
sales@ubiochem.com
Country
China
ProdList
2499
Advantage
58
Creasyn Finechem(Tianjin) Co., Ltd.
Tel
022-83945878-
Fax
022-83945176
Email
export@creasyn.com
Country
China
ProdList
670
Advantage
68
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View Lastest Price from N-Hydroxysuccinimide manufacturers

Hebei Crovell Biotech Co Ltd
Product
N-Hydroxysuccinimide 6066-82-6
Price
US $9.00/ASSAYS
Min. Order
1ASSAYS
Purity
99%
Supply Ability
10000kg
Release date
2021-07-06
Baoji Guokang Bio-Technology Co., Ltd.
Product
N-Hydroxysuccinimide 6066-82-6
Price
US $48.00/KG
Min. Order
25Kg/Drum
Purity
99%
Supply Ability
100T
Release date
2021-06-05
Hebei Yanxi Chemical Co., Ltd.
Product
N-Hydroxy succinimide 6066-82-6
Price
US $40.00/KG
Min. Order
1KG
Purity
99%min
Supply Ability
30tons/month
Release date
2020-09-14

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