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N-Bromosuccinimide

Product Name
N-Bromosuccinimide
CAS No.
128-08-5
Chemical Name
N-Bromosuccinimide
Synonyms
NBS;NSC 16;NIBRIN;SUCCINBROMIDE;JACS-128-08-5;SUCCINBROMIMIDE;bromosuccinimide;N-Bromsuccinimid;Succinibromimide;N-BROMOBUTANIMIDE
CBNumber
CB2234049
Molecular Formula
C4H4BrNO2
Formula Weight
177.98
MOL File
128-08-5.mol
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N-Bromosuccinimide Property

Melting point:
175-180 °C (dec.)(lit.)
Boiling point:
221.4°C (rough estimate)
Density 
2.098
vapor pressure 
14.8 hPa (20 °C)
refractive index 
1.6060 (estimate)
storage temp. 
Store at +2°C to +8°C.
solubility 
14.8g/l (decomposition)
pka
-2.78±0.20(Predicted)
form 
Crystalline Powder
color 
White to light yellow
Odor
characteristic odour of bromine
Water Solubility 
Soluble in acetone, tetrahydrofuran, dimethyl formamide, dimethyl sulfoxide and acetonitrile. Slightly soluble in water and acetic acid. Insoluble in ether, hexane and carbon tetrachloride.
Sensitive 
Moisture Sensitive
Merck 
14,1438
BRN 
113916
Stability:
Stable. Incompatible with strong oxidizing agents, halogenated hydrocarbons.
InChIKey
PCLIMKBDDGJMGD-UHFFFAOYSA-N
CAS DataBase Reference
128-08-5(CAS DataBase Reference)
NIST Chemistry Reference
2,5-Pyrrolidinedione, 1-bromo-(128-08-5)
EPA Substance Registry System
N-Bromosuccinimide (128-08-5)
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Safety

Hazard Codes 
C,Xn
Risk Statements 
22-34-36/37/38
Safety Statements 
26-36/37/39-45-37/39
RIDADR 
UN 3261 8/PG 2
WGK Germany 
3
Hazard Note 
Harmful
TSCA 
Yes
HazardClass 
8
PackingGroup 
III
HS Code 
29251995
Hazardous Substances Data
128-08-5(Hazardous Substances Data)
Toxicity
LD50 orally in Rabbit: > 2000 mg/kg
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H290May be corrosive to metals

H302Harmful if swallowed

H314Causes severe skin burns and eye damage

H318Causes serious eye damage

Precautionary statements

P234Keep only in original container.

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P310Immediately call a POISON CENTER or doctor/physician.

P390Absorb spillage to prevent material damage.

P301+P330+P331IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

P406Store in corrosive resistant/… container with a resistant inner liner.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
8.01949
Product name
N-Bromosuccinimide
Purity
for synthesis
Packaging
5 g
Price
$28.58
Updated
2021/03/22
Sigma-Aldrich
Product number
B81255
Product name
N-Bromosuccinimide
Purity
99%
Packaging
5g
Price
$54.5
Updated
2021/03/22
Sigma-Aldrich
Product number
8.01949
Product name
N-Bromosuccinimide
Purity
for synthesis
Packaging
250 g
Price
$63.36
Updated
2021/03/22
Sigma-Aldrich
Product number
B81255
Product name
N-Bromosuccinimide
Purity
99%
Packaging
1kg
Price
$129
Updated
2021/03/22
Sigma-Aldrich
Product number
8.01949
Product name
N-Bromosuccinimide
Purity
for synthesis
Packaging
1 kg
Price
$178.52
Updated
2021/03/22
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N-Bromosuccinimide Chemical Properties,Usage,Production

Chemical Properties

white to light yellow crystalline powder

Uses

N-Bromosuccinimide is a brominated succinimide used as a chemical reagent in radical substitution and electrophilic addition reactions in organic synthesis.

Uses

NBS, is a chemical reagent used in organic chemistry in electrophilic addition reactions and radical substitution

Uses

In bromination of olefins; in oxidation of alcohols to aldehydes and ketones and of aldehydes to acid bromides.

Definition

ChEBI: A five-membered cyclic dicarboximide compound having a bromo substituent on the nitrogen atom.

Preparation

N-Bromosuccinimide (NBS) is a widely used mild brominating agent and used as chemical intermediate and building block for several chemical production processes, especially in pharma related applications.

1.62mol (160g) succinimide is dissolved in a mixture of 1.60mol (64g) NaOH, 300g crushed ice and 400ml water. Cool the mixture in an ice bath, and add 85ml (1.65 mol, 264g) Br2 at once while stirring violently. Stir for two more minutes, then filter the precipitated product and wash with ice water. Dry in a desiccator. Yield 75-81%.
Don't clean up NBS too much, the stinky yellow stuff still containing a bit of Br2 works best.

Safety Profile

Poison by intraperitoneal route. An irritating poison to skin, eyes, and mucous membranes. Reacts explosively with adme, dtallyl sulfide, and hydrazine hydrate. Explosive reaction with propiononitrile after heating to 105℃ for 24 hours. Violent reaction with dtbenzoyl peroxide + 4-tok acid. When heated to decomposition it emits toxic fumes of Brand NOx. See also BROMIDES and NITROGEN MONOXIDE.

Purification Methods

N-Bromosuccinimide (30g) is purified by dissolving rapidly in 300mL of boiling water and filtering through a fluted filter paper into a flask immersed in an ice bath, and left for 2hours. The crystals are filtered off, washed thoroughly with ca 100mL of ice-cold water and drained on a Büchner funnel before drying under vacuun over P2O5 or CaCl2 [Dauben & McCoy J Am Chem Soc 81 4863 1959]. This brominating agent has also been crystallised from acetic acid or water (10 parts), washed in water and dried in vacuo [Wilcox et al. J Am Chem Soc 108 7693 1986, Shell et al. J Am Chem Soc 108 121 1986, Phillips & Cohen J Am Chem Soc 108 2013 1986, Beilstein 21/9 V 543.]

N-Bromosuccinimide Preparation Products And Raw materials

Raw materials

Preparation Products

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N-Bromosuccinimide Suppliers

NANJING RUIJIE BIOTECHNOLOGY CO,LTD.
Tel
025-52126580-
Fax
025-52134280
Email
1220449729@qq.com
Country
China
ProdList
10
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Nanjing Apicci Pharmaceutical Technology Co., Ltd.
Tel
;
Fax
QQ2853590738
Email
2853590738@qq.com;2853579352@qq.com
Country
China
ProdList
404
Advantage
58
-
Tel
--
Fax
--
Email
17310985352@163.com
Country
China
ProdList
50
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58
ShangHai Zexin Chemical Technology Co., Ltd.
Tel
021-60136491-
Fax
021-60136492
Email
sales@zexinchem.cn
Country
China
ProdList
458
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55
Shanghai Aladdin Bio-Chem Technology Co.,LTD
Tel
021-20337333-801
Fax
021-50323701
Email
market@aladdin-e.com
Country
China
ProdList
24980
Advantage
65
Jiangsu Aikon Biopharmaceutical R&D co.,Ltd.
Tel
025-66099280-
Fax
(1)02557626880
Email
cfzhang@aikonchem.com
Country
China
ProdList
21578
Advantage
55
Shanghai Ze Chong Pharmaceutical Technology Co., Ltd.
Tel
186-21330623- ;199-46064200-
Email
sales@zechongchem.com;angel@zechongchem.com
Country
China
ProdList
93
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Shandong Vantage Specialty Chemicals Biotechnology Co., Ltd.
Tel
0536-2101172- ;
Fax
15336364684
Email
sdfantai@163.com;sdfantai@163.com
Country
China
ProdList
793
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Shouguang Jiasheng Chemical Co., Ltd.
Tel
0536-7971999- ;0536-7971999- ;536-7971999-
Fax
0536-7971999
Email
sgjiasheng@hotmail.com;sgjiasheng@hotmail.com;sgjiasheng@hotmail.com
Country
China
ProdList
278
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Quzhou mingfeng chemical co., ltd
Tel
0570-3062502- ;0570-3062509-
Fax
0570-3063388
Email
41774453@qq.com;173429701@qq.com
Country
China
ProdList
4370
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58
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View Lastest Price from N-Bromosuccinimide manufacturers

Hebei Crovell Biotech Co Ltd
Product
N-Bromosuccinimide / Nbs 128-08-5
Price
US $8.00/Kg/Bag
Min. Order
10g
Purity
99%
Supply Ability
10000kg
Release date
2021-06-18
Wuhan wingroup Pharmaceutical Co., Ltd
Product
N-Bromosuccinimide 128-08-5
Price
US $5.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
20 Tons
Release date
2021-07-07
Wuhan Boye Science And Technology Development Co., Ltd.
Product
N-Bromosuccinimide(NBS) 128-08-5
Price
US $0.00/Kg/Drum
Min. Order
100Kg/Drum
Purity
99%
Supply Ability
10tons
Release date
2021-04-25

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