IMIDAZO[1,2-A]PYRIDINE-2-CARBOXYLIC ACID ETHYL ESTER

Product Name: IMIDAZO[1,2-A]PYRIDINE-2-CARBOXYLIC ACID ETHYL ESTER
CAS No.: 38922-77-9
Chemical Name: IMIDAZO[1,2-A]PYRIDINE-2-CARBOXYLIC ACID ETHYL ESTER
Synonyms: ETHYL IMIDAZO[1,2-A]PYRIDINE-2-CARBOXYLATE;2-(Ethoxycarbonyl)imidazo[1,2-a]pyridine;ethyl 3-imidazo[1,2-a]pyridine-2-carboxylate;Ethyl imidazo[1,2-a]pyridine-2-carboxylate 97%;Ethyl imidazo[1,2-a]pyridine-2-carboxylate ,97%;Ethyl imidazo[1,2-a]pyridine-2-carboxylate;Imidazo-[1,2-A] pyridine-2-carboxylate ethyl ester;IMIDAZO[1,2-A]PYRIDINE-2-CARBOXYLIC ACID ETHYL ESTER
CBNumber: CB9320369
Molecular Formula: C10H10N2O2
Formula Weight: 190.2
MOL File: 38922-77-9.mol

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IMIDAZO[1,2-A]PYRIDINE-2-CARBOXYLIC ACID ETHYL ESTER Property

Melting point:: 79.5-83
Density: 1.22±0.1 g/cm3(Predicted)
storage temp.: Sealed in dry,Room Temperature
form: solid
pka: 3.28±0.50(Predicted)
Appearance: Off-white to light brown Solid
InChI: InChI=1S/C10H10N2O2/c1-2-14-10(13)8-7-12-6-4-3-5-9(12)11-8/h3-7H,2H2,1H3
InChIKey: GNFACXDTRBVZJE-UHFFFAOYSA-N
SMILES: C12=NC(C(OCC)=O)=CN1C=CC=C2
CAS DataBase Reference: 38922-77-9(CAS DataBase Reference)

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Safety

Risk Statements: 22-36/37/38
Safety Statements: 22-26-36/37/39
WGK Germany: 3
Hazard Note: Harmful
HazardClass: IRRITANT
HS Code: 29333990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 737550
Product name: Ethyl imidazo[1,2-a]pyridine-2-carboxylate
Purity: 97%
Packaging: 1g
Price: $101
Updated: 2023/01/07

TRC

Product number: E919218
Product name: Ethyl imidazo[1,2-a]pyridine-2-carboxylate
Packaging: 250mg
Price: $55
Updated: 2021/12/16

TRC

Product number: E919218
Product name: Ethyl imidazo[1,2-a]pyridine-2-carboxylate
Packaging: 1g
Price: $75
Updated: 2021/12/16

Matrix Scientific

Product number: 044881
Product name: Ethyl imidazo[1,2-a]pyridine-2-carboxylate
Purity: >95%
Packaging: 500mg
Price: $109
Updated: 2021/12/16

Frontier Specialty Chemicals

Product number: JK289695
Product name: Ethyl imidazo[1,2-a]pyridine-2-carboxylate
Purity: 97%
Packaging: 1g
Price: $47
Updated: 2021/12/16

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IMIDAZO[1,2-A]PYRIDINE-2-CARBOXYLIC ACID ETHYL ESTER Chemical Properties,Usage,Production

Chemical Properties

Off-white to brown solid

Synthesis

504-29-0

70-23-5

38922-77-9

Step 1: Synthesis of ethyl imidazo[1,2-a]pyridine-2-carboxylate Under magnetic stirring, 3 g (31.9 mmol) of 2-aminopyridine was dissolved in 65 mL of tetrahydrofuran. 4.44 mL (31.9 mmol) of ethyl 3-bromopyruvate was added slowly and solid precipitate formation was observed. The resulting non-homogeneous mixture was heated to reflux and stirred continuously for 4 hours. Upon completion of the reaction, it was cooled to room temperature and the solid product was isolated by filtration. The solid was dissolved in 65 mL of ethanol and again heated to reflux and stirred for 16 hours. The reaction mixture was cooled to room temperature and the solids were separated by filtration. The filtrate was placed in an ice bath to promote crystallization of the product until the liquid phase remained clear. The crystallized product was collected by filtration and washed with 30 mL of diisopropyl ether. Finally, the product was dried in a vacuum desiccator to afford 5.14 g (84% yield) of ethyl imidazo[1,2-a]pyridine-2-carboxylate as a white powder. Product characterization: LC-MS showed m/z=191 (MH+); UV purity was 99% at 254 nm.1H NMR (300 MHz, DMSO) δ 8.95 (s, 1H), 8.84 (d, J=6.8 Hz, 1H), 7.98-7.80 (m, 2H), 7.46 (t, J=7.2 Hz, 1H), 4.43 ( q, J=7.1Hz, 2H), 1.35 (d, J=7.1Hz, 3H).

References

[1] ACS Combinatorial Science, 2018, vol. 20, # 3, p. 164 - 171
[2] Patent: US2015/182507, 2015, A1. Location in patent: Paragraph 0204; 0205
[3] ACS Medicinal Chemistry Letters, 2015, vol. 6, # 3, p. 359 - 362
[4] European Journal of Medicinal Chemistry, 2018, vol. 143, p. 216 - 231
[5] ChemMedChem, 2017, vol. 12, # 3, p. 257 - 270

IMIDAZO[1,2-A]PYRIDINE-2-CARBOXYLIC ACID ETHYL ESTER Preparation Products And Raw materials

Raw materials

N-Bromosuccinimide Ethyl pyruvate Carbon tetrachloride Tetrahydrofuran 2-Aminopyridine

Preparation Products

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IMIDAZO[1,2-A]PYRIDINE-2-CARBOXYLIC ACID ETHYL ESTER Suppliers

Belgium 1 China 134 France 1 Germany 3 India 1 The Netherlands 1 Ukraine 2 United Kingdom 6 United States 29 Global 178

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View Lastest Price from IMIDAZO[1,2-A]PYRIDINE-2-CARBOXYLIC ACID ETHYL ESTER manufacturers

Henan Fengda Chemical Co., Ltd

Product: IMIDAZO[1,2-A]PYRIDINE-2-CARBOXYLIC ACID ETHYL ESTER 38922-77-9
Price: US $8.00-2.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: g-kg-tons, free sample is available
Release date: 2024-04-24

Career Henan Chemical Co

Product: IMIDAZO[1,2-A]PYRIDINE-2-CARBOXYLIC ACID ETHYL ESTER 38922-77-9
Price: US $7.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: JD 681
Release date: 2019-09-01

38922-77-9, IMIDAZO[1,2-A]PYRIDINE-2-CARBOXYLIC ACID ETHYL ESTERRelated Search:

IMIDAZO[1,2-A]PYRIDINE-2-CARBOXYLIC ACID IMIDAZO[1,2-A]PYRIDIN-3-CARBOXALDEHYDE IMIDAZO[1,2-A]PYRIDIN-8-YLAMINE Imidazo[1,2-a]pyridine IMIDAZO[1,2-A]PYRIDINE-3-CARBOXYLIC ACID IMIDAZO[1,2-A]PYRAZINE-2-CARBOXYLIC ACID Imidazo[1,2-b]pyridazine IMIDAZO[1,2-A]PYRIDINE-6-CARBOXYLIC ACID Imidazo[1,2-a]pyridine-5-carboxylic acid (9CI) IMIDAZO[1,2-A]PYRAZINE Imidazo[1,2-a]pyrimidine Imidazo[1,2-a]pyridine-7-methanol (9CI) Imidazo[1,2-a]pyridine-8-carboxaldehyde (9CI) Imidazo[1,2-a]pyrazin-3-ylamine Imidazo[1,2-a]pyridine-7-carboxylic acid (9CI) Imidazo[1,2-a]pyridine-6-carbaldehyde (1H-IMIDAZOL-2-YL)-METHANOL IMidazo[1,2-a]pyridine-3-aceticacid,ethylester

IMIDAZO[1,2-A]PYRIDINE-2-CARBOXYLIC ACID ETHYL ESTER

ETHYL IMIDAZO[1,2-A]PYRIDINE-2-CARBOXYLATE

Ethyl imidazo[1,2-a]pyridine-2-carboxylate 97%

Ethyl imidazo[1,2-a]pyridine-2-carboxylate ,97%

2-(Ethoxycarbonyl)imidazo[1,2-a]pyridine

Imidazo-[1,2-A] pyridine-2-carboxylate ethyl ester

ethyl 3-imidazo[1,2-a]pyridine-2-carboxylate

Ethyl imidazo[1,2-<i>a</i>]pyridine-2-carboxylate

38922-77-9

Heterocycle-Pyridine series

Esters

Fused Ring Systems