Imidazo[1,2-a]pyridine-8-carboxaldehyde (9CI)
- Product Name
- Imidazo[1,2-a]pyridine-8-carboxaldehyde (9CI)
- CAS No.
- 136117-74-3
- Chemical Name
- Imidazo[1,2-a]pyridine-8-carboxaldehyde (9CI)
- Synonyms
- H-iMidazo[1,2-a]pyridine-8-carbaldehyde;IMidazo[1,2-a]pyridine-8-carboxaldehyde;imidazo[1,2-a]pyridine-8-carbaldehyde 97%;Imidazo[1,2-a]pyridine-8-carboxaldehyde (9CI)
- CBNumber
- CB01048997
- Molecular Formula
- C8H6N2O
- Formula Weight
- 146.15
- MOL File
- 136117-74-3.mol
Imidazo[1,2-a]pyridine-8-carboxaldehyde (9CI) Property
- Density
- 1.24±0.1 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- pka
- 4.15±0.50(Predicted)
- form
- powder
- color
- Yellow
Safety
- HS Code
- 2933399990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H317May cause an allergic skin reaction
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P333+P313IF SKIN irritation or rash occurs: Get medical advice/attention.
N-Bromosuccinimide Price
- Product number
- 115587
- Product name
- Imidazo[1,2-a]pyridine-8-carboxaldehyde
- Packaging
- 250.00mg
- Price
- $56
- Updated
- 2026/05/18
- Product number
- 115587
- Product name
- Imidazo[1,2-a]pyridine-8-carboxaldehyde
- Packaging
- 1.00g
- Price
- $69
- Updated
- 2026/05/18
- Product number
- 115587
- Product name
- Imidazo[1,2-a]pyridine-8-carboxaldehyde
- Packaging
- 5.00g
- Price
- $318
- Updated
- 2026/05/18
- Product number
- I1726
- Product name
- Imidazo[1,2-a]pyridine-8-carboxaldehyde
- Purity
- 95%
- Packaging
- 1g
- Price
- $49
- Updated
- 2026/05/06
- Product number
- I1726
- Product name
- Imidazo[1,2-a]pyridine-8-carboxaldehyde
- Purity
- 95%
- Packaging
- 5g
- Price
- $390
- Updated
- 2026/05/06
Imidazo[1,2-a]pyridine-8-carboxaldehyde (9CI) Chemical Properties,Usage,Production
Synthesis
133427-07-3
136117-74-3
DIBAL-H (1M in THF, 20 mL) was added slowly and dropwise to a toluene solution of methyl imidazo[1,2-a]pyridine-8-carboxylate (1.76 g, 10 mmol) at -78 °C. The reaction mixture was stirred continuously at -78 °C for 1 h. The reaction was subsequently quenched with methanol (2 mL) and saturated ammonium chloride solution (50 mL) and gradually warmed to room temperature. The mixture was continued to be stirred at room temperature for 1 hour and then diluted with dichloromethane (60 mL). The aqueous phase was extracted twice with dichloromethane (60 mL). The combined organic layers were dried with anhydrous magnesium sulfate and concentrated under reduced pressure. The residue was purified by silica gel column chromatography with 10% methanol/dichloromethane as eluent to afford imidazo[1,2-a]pyridine-8-carbaldehyde (0.8 g, 55% yield). Low resolution mass spectrometry (LRMS) showed (M+H)+ m/z 147.1.
References
[1] Chemical and Pharmaceutical Bulletin, 1991, vol. 39, # 6, p. 1556 - 1567
[2] Patent: WO2013/102142, 2013, A1. Location in patent: Paragraph 0165
Imidazo[1,2-a]pyridine-8-carboxaldehyde (9CI) Preparation Products And Raw materials
Raw materials
Preparation Products
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