Imidazo[1,2-a]pyridin-5-ylamine
- Product Name
- Imidazo[1,2-a]pyridin-5-ylamine
- CAS No.
- 66358-23-4
- Chemical Name
- Imidazo[1,2-a]pyridin-5-ylamine
- Synonyms
- 5-imidazo[1,2-a]pyridinamine;Imidazo[1,2-a]pyridin-5-a...;Imidazo[1,2-a]pyridin-5-amine;Imidazo[1,2-a]pyridin-5-amine
- CBNumber
- CB21012460
- Molecular Formula
- C7H7N3
- Formula Weight
- 133.15
- MOL File
- 66358-23-4.mol
Imidazo[1,2-a]pyridin-5-ylamine Property
- Melting point:
- 156-158°
- Density
- 1.32
- storage temp.
- Keep in dark place,Inert atmosphere,Room temperature
- form
- solid
- pka
- 8.98±0.50(Predicted)
- Appearance
- Off-white to light brown Solid
Safety
- HazardClass
- IRRITANT
- HS Code
- 2933998090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- I387528
- Product name
- Imidazo[1,2-a]pyridin-5-amine
- Packaging
- 100mg
- Price
- $65
- Updated
- 2021/12/16
- Product number
- 452238
- Product name
- Imidazo[1,2-a]pyridin-5-amine
- Packaging
- 25mg
- Price
- $305
- Updated
- 2021/12/16
- Product number
- CS-W019813
- Product name
- Imidazo[1,2-a]pyridin-5-amine
- Purity
- 99.84%
- Packaging
- 1g
- Price
- $26
- Updated
- 2021/12/16
- Product number
- 048025
- Product name
- Imidazo[1,2-a]pyridin-5-amine
- Purity
- >95%
- Packaging
- 500mg
- Price
- $49
- Updated
- 2021/12/16
- Product number
- 048025
- Product name
- Imidazo[1,2-a]pyridin-5-amine
- Purity
- >95%
- Packaging
- 1g
- Price
- $67
- Updated
- 2021/12/16
Imidazo[1,2-a]pyridin-5-ylamine Chemical Properties,Usage,Production
Synthesis
107-20-0
141-86-6
66358-23-4
The general procedure for the synthesis of imidazo[1,2-a]pyridin-5-amine from chloroacetaldehyde and 2,6-diaminopyridine was as follows: 2,6-diaminopyridine (5.0 g, 46 mmol) and chloroacetaldehyde (50% wt. aqueous solution, 6.4 mL, 50 mmol) were dissolved in anhydrous ethanol (120 mL). The reaction mixture was heated to reflux at 75°C for 1 hour. Upon completion of the reaction, the mixture was cooled to room temperature and the solvent was removed by concentration with a rotary evaporator. The concentrated residue was dissolved in a solvent mixture of saturated sodium bicarbonate solution and ethyl acetate. The aqueous phase was extracted with ethyl acetate (3 times), the organic phases were combined and dried with anhydrous magnesium sulfate. The dried organic phase was concentrated to give a brown solid product. Final isolation afforded 4.85 g of imidazo[1,2-a]pyridin-5-amine in 80% yield. The structure of the product was confirmed by 1H NMR (CDCl3) and mass spectrometry (MS): 1H NMR (CDCl3) δ 4.48 (s, 2H), 6.10 (dd, J = 7.2, 1.2 Hz, 1H), 7.10-7.20 (m, 2H), 7.42 (d, J = 1.2 Hz, 1H), 7.65 (d, J = 1.2 Hz. 1H); MS calculated value: 133, measured value: 134 (M + H).
References
[1] Patent: WO2005/44793, 2005, A2. Location in patent: Page/Page column 153-154
[2] Patent: WO2010/68452, 2010, A1. Location in patent: Page/Page column 28
[3] Patent: WO2010/68453, 2010, A1. Location in patent: Page/Page column 32
Imidazo[1,2-a]pyridin-5-ylamine Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Imidazo[1,2-a]pyridin-5-ylamine manufacturers
- Product
- Imidazo[1,2-a]pyridin-5-ylamine 66358-23-4
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 200kg
- Release date
- 2019-12-26