ChemicalBook > CAS DataBase List > Imidazo[1,2-a]pyridin-5-ylamine

Imidazo[1,2-a]pyridin-5-ylamine

Product Name
Imidazo[1,2-a]pyridin-5-ylamine
CAS No.
66358-23-4
Chemical Name
Imidazo[1,2-a]pyridin-5-ylamine
Synonyms
5-imidazo[1,2-a]pyridinamine;Imidazo[1,2-a]pyridin-5-a...;Imidazo[1,2-a]pyridin-5-amine;Imidazo[1,2-a]pyridin-5-amine
CBNumber
CB21012460
Molecular Formula
C7H7N3
Formula Weight
133.15
MOL File
66358-23-4.mol
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Imidazo[1,2-a]pyridin-5-ylamine Property

Melting point:
156-158°
Density 
1.32
storage temp. 
Keep in dark place,Inert atmosphere,Room temperature
form 
solid
pka
8.98±0.50(Predicted)
Appearance
Off-white to light brown Solid
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Safety

HazardClass 
IRRITANT
HS Code 
2933998090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
I387528
Product name
Imidazo[1,2-a]pyridin-5-amine
Packaging
100mg
Price
$65
Updated
2021/12/16
Usbiological
Product number
452238
Product name
Imidazo[1,2-a]pyridin-5-amine
Packaging
25mg
Price
$305
Updated
2021/12/16
ChemScene
Product number
CS-W019813
Product name
Imidazo[1,2-a]pyridin-5-amine
Purity
99.84%
Packaging
25g
Price
$345
Updated
2021/12/16
SynQuest Laboratories
Product number
3H30-1-TC
Product name
Imidazo[1,2-a]pyridin-5-amine
Purity
95%
Packaging
250mg
Price
$160
Updated
2021/12/16
ChemScene
Product number
CS-W019813
Product name
Imidazo[1,2-a]pyridin-5-amine
Purity
99.84%
Packaging
10g
Price
$172
Updated
2021/12/16
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Imidazo[1,2-a]pyridin-5-ylamine Chemical Properties,Usage,Production

Synthesis

107-20-0

141-86-6

66358-23-4

The general procedure for the synthesis of imidazo[1,2-a]pyridin-5-amine from chloroacetaldehyde and 2,6-diaminopyridine was as follows: 2,6-diaminopyridine (5.0 g, 46 mmol) and chloroacetaldehyde (50% wt. aqueous solution, 6.4 mL, 50 mmol) were dissolved in anhydrous ethanol (120 mL). The reaction mixture was heated to reflux at 75°C for 1 hour. Upon completion of the reaction, the mixture was cooled to room temperature and the solvent was removed by concentration with a rotary evaporator. The concentrated residue was dissolved in a solvent mixture of saturated sodium bicarbonate solution and ethyl acetate. The aqueous phase was extracted with ethyl acetate (3 times), the organic phases were combined and dried with anhydrous magnesium sulfate. The dried organic phase was concentrated to give a brown solid product. Final isolation afforded 4.85 g of imidazo[1,2-a]pyridin-5-amine in 80% yield. The structure of the product was confirmed by 1H NMR (CDCl3) and mass spectrometry (MS): 1H NMR (CDCl3) δ 4.48 (s, 2H), 6.10 (dd, J = 7.2, 1.2 Hz, 1H), 7.10-7.20 (m, 2H), 7.42 (d, J = 1.2 Hz, 1H), 7.65 (d, J = 1.2 Hz. 1H); MS calculated value: 133, measured value: 134 (M + H).

References

[1] Patent: WO2005/44793, 2005, A2. Location in patent: Page/Page column 153-154
[2] Patent: WO2010/68452, 2010, A1. Location in patent: Page/Page column 28
[3] Patent: WO2010/68453, 2010, A1. Location in patent: Page/Page column 32

Imidazo[1,2-a]pyridin-5-ylamine Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Imidazo[1,2-a]pyridin-5-ylamine manufacturers

Career Henan Chemical Co
Product
Imidazo[1,2-a]pyridin-5-ylamine 66358-23-4
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
200kg
Release date
2019-12-26

66358-23-4, Imidazo[1,2-a]pyridin-5-ylamineRelated Search:

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