Imidazo[1,2-b]pyridazine
- Product Name
- Imidazo[1,2-b]pyridazine
- CAS No.
- 766-55-2
- Chemical Name
- Imidazo[1,2-b]pyridazine
- Synonyms
- 50G;200G;5KGS;2-b]pyridazine;1,5-Diazaindolizine;Cefazolam side chain;Imidazo1,2-pyridazine;Imdazo1,2-Bpyridazine;The iMidazopyridazine;Imidazo-[1,2-b]pyridazin;imidazo[2,1-f]pyridazine;IMIDAZO[1,2-B]PYRIDAZINE
- CBNumber
- CB2756635
- Molecular Formula
- C6H5N3
- Formula Weight
- 119.12
- MOL File
- 766-55-2.mol
Imidazo[1,2-b]pyridazine Property
- Melting point:
- 54℃
- Density
- 1.29±0.1 g/cm3(Predicted)
- storage temp.
- Inert atmosphere,Room Temperature
- solubility
- Soluble in dimethylformamide.
- form
- powder to crystal
- pka
- 5.30±0.30(Predicted)
- color
- White to Light yellow to Light orange
- λmax
- 222nm(MeOH)(lit.)
- InChI
- InChI=1S/C6H5N3/c1-2-6-7-4-5-9(6)8-3-1/h1-5H
- InChIKey
- VTVRXITWWZGKHV-UHFFFAOYSA-N
- SMILES
- C12=NC=CN1N=CC=C2
- CAS DataBase Reference
- 766-55-2(CAS DataBase Reference)
Safety
- Hazard Codes
- Xi
- HS Code
- 29335990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- I0742
- Product name
- Imidazo[1,2-b]pyridazine
- Purity
- >98.0%(GC)
- Packaging
- 1g
- Price
- $21
- Updated
- 2025/07/31
- Product number
- I0742
- Product name
- Imidazo[1,2-b]pyridazine
- Purity
- >98.0%(GC)
- Packaging
- 5g
- Price
- $63
- Updated
- 2025/07/31
- Product number
- I495520
- Product name
- Imidazo[1,2-b]pyridazine
- Packaging
- 500mg
- Price
- $75
- Updated
- 2021/12/16
- Product number
- 280312
- Product name
- Imidazo[1,2]pyridazine
- Packaging
- 50g
- Price
- $375
- Updated
- 2021/12/16
- Product number
- 069872
- Product name
- Imidazo[1,2-b]pyridazine
- Purity
- 95+%
- Packaging
- 5g
- Price
- $48
- Updated
- 2021/12/16
Imidazo[1,2-b]pyridazine Chemical Properties,Usage,Production
Chemical Properties
White crystalline powder
Uses
Imidazo[1,2-b]pyridazine is used as an intermediate of cefozopran, building block and in fused ring systems.
Synthesis
6775-78-6
766-55-2
General procedure for the synthesis of imidazo[1,2-b]pyridazine from 6-chloroimidazo[1,2-b]pyridazine: to a stirred mixed solution of 6-chloroimidazo[1,2-b]pyridazine (800 mg, 5.21 mmol) in methanol (20 mL) and tetrahydrofuran (20 mL) was sequentially added triethylamine (0.8 mL, 5.74 mmol) and Pd/C ( 100 mg, 0.094 mmol). The reaction mixture was placed under hydrogen atmosphere and stirred for 16 hours. Upon completion of the reaction, the mixture was filtered through diatomaceous earth and the diatomaceous earth bed was washed with methanol. The filtrates were combined and concentrated, and the concentrate was subsequently suspended in water and extracted with ethyl acetate (3 x 20 mL). The organic layers were combined, dried with anhydrous sodium sulfate, filtered and concentrated to give imidazo[1,2-b]pyridazine (550 mg, 87% yield) as an off-white solid. The product was analyzed by LCMS [m/z 120 (M + H)]; 1H NMR (300 MHz, DMSO-d6) δ 8.51 (dd, J = 4.53, 1.51 Hz, 1H), 8.29 (d, J = 0.76 Hz, 1H), 8.05-8.19 (m, 1H), 7.79 (d, J = 1.13 Hz, 1H), 7.22 (dd, J = 9.44, 4.53 Hz, 1H).
References
[1] Patent: WO2016/210036, 2016, A1. Location in patent: Page/Page column 106; 107
Imidazo[1,2-b]pyridazine Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Imidazo[1,2-b]pyridazine manufacturers
- Product
- Imidazo[1,2-b]pyridazine 766-55-2
- Price
- US $50.00/kg
- Min. Order
- 1kg
- Purity
- 0.99
- Supply Ability
- 10000
- Release date
- 2023-09-22
- Product
- Imidazo[1,2-b]pyridazine 766-55-2
- Price
- US $0.00/kg
- Min. Order
- 25kg
- Purity
- 98%
- Supply Ability
- Inquiry
- Release date
- 2022-10-21
- Product
- Imidazo[1,2-b]pyridazine 766-55-2
- Price
- US $300.00/kg
- Min. Order
- 10kg
- Purity
- 99%
- Supply Ability
- 500kg/month
- Release date
- 2022-05-05