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Pyridaphenthion

Product Name
Pyridaphenthion
CAS No.
119-12-0
Chemical Name
Pyridaphenthion
Synonyms
Ofun;Ofnak;ORESTE;Ofnack;OFUNACK;cl12503;CL 12503;AC-12503;ent23,968;ENT 23,968
CBNumber
CB2292780
Molecular Formula
C14H17N2O4PS
Formula Weight
340.33
MOL File
119-12-0.mol
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Pyridaphenthion Property

Melting point:
54.5～56.5℃
Boiling point:
416.2±28.0 °C(Predicted)
Density 
1.30±0.1 g/cm3(Predicted)
vapor pressure 
1.47×10-6 Pa (20 °C)
Flash point:
-4 °C
storage temp. 
APPROX 4°C
Water Solubility 
100mg l-1 （20°C）
pka
-2.09±0.40(Predicted)
BRN 
302741
CAS DataBase Reference
119-12-0(CAS DataBase Reference)
NIST Chemistry Reference
Phosphorothioic acid, o-(1,6-dihydro-6-oxo-1-phenyl-3-pyridazinyl) o,o-diethyl ester(119-12-0)
EPA Substance Registry System
Pyridaphenthion (119-12-0)
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Safety

Hazard Codes 
F,Xi,N,Xn
Risk Statements 
11-36-66-67-57-51/53-20/22
Safety Statements 
26-61-33-16
RIDADR 
2783
WGK Germany 
3
RTECS 
TF2275000
HazardClass 
6.1(a)
PackingGroup 
II
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
36895
Product name
Pyridaphenthion solution
Purity
10?μg/mL in ethyl acetate, PESTANAL?, analytical standard
Packaging
2ml
Price
$62
Updated
2022/05/15
Sigma-Aldrich
Product number
32538
Product name
Pyridaphenthion
Purity
PESTANAL?, analytical standard
Packaging
100mg
Price
$126
Updated
2022/05/15
AK Scientific
Product number
S535
Product name
Pyridaphenthion
Packaging
100mg
Price
$189
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
CHM0290691
Product name
PYRIDAPHENTHION
Purity
98.00%
Packaging
2.5G
Price
$1265
Updated
2021/12/16
AHH
Product number
MT-58329
Product name
Pyridaphenthion
Purity
98%
Packaging
2.5g
Price
$436
Updated
2021/12/16
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Pyridaphenthion Chemical Properties,Usage,Production

Description

Pyridaphenthion is a pale yellow solid, mp 54.5–56 ?C, vp 0.00147 mPa (20 ?C). Solubility in water is 100 mg/L (20 ?C). It is very soluble in acetone, methanol, and diethyl ether. Log Kow = 3.2.

Uses

Pyridaphenthion is used to control a wide range of chewing and sucking insects and mites in rice, vegetables, fruit and ornamentals.

Definition

ChEBI: Pyridaphenthion is an organic thiophosphate, an organothiophosphate insecticide and a pyridazinone. It has a role as an EC 3.1.1.7 (acetylcholinesterase) inhibitor and an agrochemical. It is functionally related to a 6-hydroxy-2-phenylpyridazin-3-one.

Safety Profile

Poison by intraperitoneal route. Moderately toxic by ingestion and skin contact. When heated to decomposition it emits very toxic fumes of SOx, POx, and NOx. Used to control chewing and suckmg insects on rice, fruits, vegetables, and cereals.

Metabolic pathway

Pyridaphentluon is photolytically transformed into the oxon and phenylmaleic hydrazide. In the mouse its metabolism involves oxidative dearylation, oxidative desulfuration to the oxon, de-ethylation and conjugation of phenylmaleic hydrazide produced as the ultimate product of stage I metabolism and is typical of many phosphorothioates. A marked difference between metabolism in mice and rats was shown, with rats excreting no desethylpyridaphenthion and excreting all of the phenyl-maleic hydrazide in an unconjugated form.

Metabolism

More than 70% of the dose administered to rats and mice was excreted within 24 h in the urine. The major metabolites excreted are phenylmaleic hydrazide and desethyl pyridafenthion-oxon. The half-life in soil is 11–24 d.

Degradation

The photolysis of pyridaphenthion on a glass slide irradiated with both short wavelength UV light and light of wavelength >300 nm was investigated by Tsao et al. (1989). Samples were irradiated for 48 hours at unrecorded light intensity as thin films spread on petri dishes or in solution in water, methanol or hexane under an oxygen atmosphere. The effects of photosensitisers was also assessed in the thin film experiments. The photoproducts were analysed by TLC, GC-MS and 1H NMR spectroscopy. Under thin film conditions pyridaphenthion was photodegraded more quickly with light >300 nm than by 254 um light and was degraded faster as a thin film than in solution. The main photoproducts from the glass surface and aqueous solution were pyridaphenthion oxon (2) and phenylmaleic hydrazide (3) (Scheme 1); the only other products were small amounts of polymers. Photosensitisers accelerated photolysis markedly with the most effective being a plant-derived natural product, cis-dehydromatricaria ester. It is notable that a simple chemical oxidation using 3-chloroperoxybenzoic acid gave the same two products, 2 and 3.

Toxicity evaluation

The acute oral LD50 for rats is 769–850 mg/kg. Inhalation LC50 (4 h) for rats is >1.13 mg/L air.

Pyridaphenthion Preparation Products And Raw materials

Raw materials

2-tert-Butyl-4,5-dichloro-3-2H-pyridazinone CIS-BUTENEDIOIC ANHYDRIDE THIOPHOSPHORYL CHLORIDE

Preparation Products

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Pyridaphenthion Suppliers

China 86 Europe 4 France 1 Germany 2 India 1 Japan 3 Switzerland 1 United Kingdom 3 United States 15 Global 116
Anhui Chizhou Sincerity Chemicals Co., Ltd
Tel
0566-3221916
Fax
0086-571-85084195
Email
sincerity@mail.chz.ah163.net
Country
China
ProdList
66
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J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
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76
Syntechem Co.,Ltd
Tel
Fax
E-Mail Inquiry
Email
info@syntechem.com
Country
China
ProdList
12990
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BEST-REAGENT
Tel
400-1166-196 18981987031
Fax
028-84555506 800101999
Email
cdhxsj@163.com
Country
China
ProdList
11726
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Chengdu Ai Keda Chemical Technology Co., Ltd.
Tel
4008-755-333 18080918076
Fax
028-86757656
Email
800078821@qq.com
Country
China
ProdList
9725
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55
Nanjing Sunlida Biological Technology Co., Ltd.
Tel
025-57798810
Fax
025-57019371
Email
sales@sunlidabio.com
Country
China
ProdList
3750
Advantage
55
TargetMol Chemicals Inc.
Tel
021-33632979 15002134094
Fax
021-33632979
Email
marketing@targetmol.com
Country
China
ProdList
7934
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TianJin Alta Scientific Co., Ltd.
Tel
022-65378550-8551
Fax
+86-022-2532-9655
Email
contact@altascientific.com
Country
China
ProdList
2773
Advantage
58
3B Scientific (Wuhan) Corporation Limited
Tel
0086-27-88063677 18186135292
Fax
027-88063656
Email
sales@3bsc.com
Country
China
ProdList
293
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HangZhou YuHao Chemical Technology Co., Ltd.
Tel
0571-82693216
Fax
0571-82880190
Email
info@yuhaochemical.com
Country
China
ProdList
2031
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58
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View Lastest Price from Pyridaphenthion manufacturers

Career Henan Chemical Co
Product
Pyridaphenthion 119-12-0
Price
US $1.00/KG
Min. Order
1KG
Purity
98%HPLC
Supply Ability
10tons
Release date
2020-01-20

119-12-0, PyridaphenthionRelated Search:

Pyridazine Clindamycin phosphate Phenyl salicylate PHENYL VALERATE Mefenpyr-diethyl Diethyl oxalate Ethylene glycol diethyl ether SULPHOSUCCINIC ACID ESTER Diethyl malonate Diphenylthiocarbazide Diphenyl ether Tris(2-chloroethyl) phosphate Celiprolol Phenylacetic acid 3-HYDROXY-1-PHENYL-6-PYRIDAZONE O,O,O-TRIETHYLPHOSPHOROTHIOATE 3-HYDROXY-1-METHYLPYRIDAZIN-6(1H)-ONE Diethyl ether

  • PYRIDAPHENTHION
  • OFUNACK
  • ORESTE
  • 3(2H)-Pyridazinone, 6-hydroxy-2-phenyl-, O-ester with O,O-diethyl phosphorothioate
  • 3(2h)-pyridazinone,6-hydroxy-2-phenyl-,o-esterwitho,o-diethylphosphoroth
  • American cyanamid 12,503
  • americancyanamid12,503
  • CL 12503
  • cl12503
  • DiethylO-(2,3-dihydro-3-oxo-2-phenyl-6-pyridazinyl)phosphorothioate
  • ENT 23,968
  • ent23,968
  • Ofunack(TM)
  • O-(1,6-dihydro-6-oxo-1-phenyl-3-pyridazinyl)O,O-diethylphosphorothioate
  • O-(1,6-Dihydro-6-oxo-1-phenylpyridazin-3-yl) O,O-diethyl phosphorothioate
  • o-(1,6-dihydro-6-oxo-1-phenylpyridazin-3-yl)o,o-diethylphosphorothioate
  • O,O-Diethyl O-(2,3-dihydro-3-oxo-2-phenyl-6-pyridazinyl)phosphorothioate
  • o,o-Diethyl o-(6-oxo-1-phenyl-1,6-dihydro-3-pyridazinyl) thiophosphate
  • o,o-diethylo-(2,3-dihydro-3-oxo-2-phenyl-6-pyridazinyl)phosphorothioate
  • O,O-Diethylphosphorothioate, O-ester with 6-hydroxy-2-phenyl-3(2H)-pyridazinone
  • o,o-diethylphosphorothioate,o-esterwith6-hydroxy-2-phenyl-3(2h)-pyridazino
  • Ofnack
  • Ofnak
  • Ofun
  • ofunack,e.c.(20%)
  • Phosphorothioic acid, O,O-diethyl ester, O-ester with 6-hydroxy-2-phenyl-3(2H)pyridazinone
  • Phosphorothioicacid,esters,O-(1,6-dihydro-6-oxo-1-phenyl-3-pyridazinyl)-O,O-diethylester
  • phosphorothioicacid,o,o-diethylester,o-esterwith6-hydroxy-2-phenyl-3(2h)p
  • Pyridafenthion
  • pyridiphenthion
  • yridazinone
  • O,O-diethyl O-(1,6-dihydro-6-oxo-1-phenylpyridazin-3-yl) thiophosphate
  • Pyridaphenthione
  • pyridaphenthio (jmaf)
  • O,O-Diethyl-O-(3-oxo-2-phenyldihydro-6-pyridazinyl)- phosphorodithionate
  • 6-Diethoxyphosphinothioyloxy-2-phenylpyridazin-3-one
  • O-(1,6-Dihydro-6-oxo-1-phenyl-3-pyridazinyl)phosphorothioic acid O,O-diethyl ester
  • O,O-Diethyl-O-thiophosphat
  • Pyridafethion
  • O-(1,6-Dihydro-6-oxo-1-phenylpyridazin-3-yl)-O,O-diethylphosphorothionate
  • Pyridaphenthion solution
  • Pyridaphenthion E.C.(20%)
  • O，O-dietyl-O-(2,3-dihydro-3-oxo-2-phenyl-dazine-6-yl) phosphorothionate
  • Pyridaphenthion Solution, 100ppm
  • AC-12503
  • Phosphorothioic acid O-(1,6-dihydro-6-oxo-1-phenylpyridazin-3-yl) O,O-diethyl
  • Thiophosphoric acid O,O-diethyl-O-(6-oxo-1-phenyl-1,6-dihydropyridazin-3-yl) ester
  • 6-diethoxythiophosphoryloxy-2-phenyl-pyridazin-3-one
  • Pyridahenthion
  • Pyridaphenthion 250mg [119-12-0]
  • Purity of Pyridaphenthione
  • O,O-diethyl O-(6-oxo-1-phenyl-1,6-dihydropyridazin-3-yl) phosphorothioate
  • PyridaphenthionSolution,100mg/L,1ml
  • Pyridaphenthion @100 μg/mL in MeOH
  • Pyridaphenthion@1000 μg/mL in Acetone
  • Phosphorothioic acid, O-(1,6-dihydro-6-oxo-1-phenyl-3-pyridazinyl) O,O-diethyl ester
  • PyridaphePyridaphenthionnthion
  • 4'-Tetramethoxyflavone